• Bryce Vissel's work spans neurodegenerative diseases including Alzheimer's, Parkinson's and spinal disorders as well as studies of the neural basis of learning and memory and movement mechanisms. (edu.au)
  • Scientists hope to be able to use them to address spinal cord injuries, cancer, diabetes and diseases such as Alzheimer's and Parkinson's. (foxnews.com)
  • Therapies based on the application of stem cells have great potential in the prevention and treatment of several diseases, such as cancer, diabetes, cardiovascular disease, spinal cord injuries, neurological diseases such as Parkinson's and Alzheimer's, and in the regeneration of various tissues and organs. (bvsalud.org)
  • According to FND Hope , a non-profit patient advocacy organization for people with FND, the symptoms of FND can be as debilitating as those of multiple sclerosis or Parkinson's disease . (medicalnewstoday.com)
  • Of great importance to the readers of this newsletter is that many neurologic disorders (including Parkinson's disease, multiple sclerosis, and spinal cord injury) are associated with constipation. (apdaparkinson.org)
  • As a result of dependence upon higher brain centers, certain lesions or diseases of the brain (eg, stroke, cancer, dementia) can result in a loss of voluntary control of the normal micturition reflex as well as symptoms such as urinary urgency. (medscape.com)
  • Specific disease conditions are also associated with OH including diabetes, MS, Parkinson's, and patients with a spinal cord injury. (aapmr.org)
  • Supporters of embryonic stem-cell research say their studies have shown promise to treat a range of debilitating conditions including diabetes, Parkinson's disease, cancers, and spinal cord injuries. (cnn.com)
  • In a study of 4,200 volunteers, researchers found that the disease occurs more in middle-aged and older people, those with a family history of diabetes, and African Americans. (medlineplus.gov)
  • In conclusion, we have found that using AAVrg's to knockout PTEN is an effective manipulation capable of restoring motor functions in chronic SCI and can enhance axon growth of currently unidentified axon populations when delivered acutely after injury. (bvsalud.org)
  • In late 2002, Professor Vissel returned to Garvan taking up a position as Head of the Neurodegenerative Diseases group in the Neuroscience Division. (edu.au)
  • There is an increased risk of cardiovascular disease (CVD) among individuals with SCI compared with the general population, though there is a paucity of evidence on sex differences. (ubc.ca)
  • We're actually developing products now," said Timothy Mayleben, chief executive of Aastrom, which is using cells derived from a patient's own bone marrow to develop treatments for cardiovascular disease. (ibtimes.com)
  • it happened to Max Truex, a former Olympic runner who suffered from Parkinson's disease. (ibtimes.com)
  • What is Parkinson's Disease? (apdaparkinson.org)
  • This section will help you understand the basics of Parkinson's Disease, how Parkinson's Disease affects the brain, its symptoms and ongoing research. (apdaparkinson.org)
  • We are committed to scientific research and have been a funding partner in many major Parkinson's disease scientific breakthroughs, investing more than $51 million in research since 1961. (apdaparkinson.org)
  • The American Parkinson Disease Association (APDA) is the largest grassroots network dedicated to fighting Parkinson's disease (PD) and works tirelessly to help the approximately one million with PD in the United States live life to the fullest in the face of this chronic, neurological disorder. (apdaparkinson.org)
  • My field of research is Parkinson's disease. (lu.se)
  • And I've spent my life looking at cel therapies and other therapeutic approaches to two diseases, Parkinson's disease and Huntington's disease. (lu.se)
  • So degeneration of dopamine neurons is a cardinal symptom of Parkinson's disease patients. (lu.se)
  • We were working on animal models in particular of Parkinson's disease. (lu.se)
  • Could removing the appendix lessen chances of Parkinson's disease? (medlineplus.gov)
  • This suggests that the appendix may store the protein and could be involved in Parkinson's disease development. (medlineplus.gov)
  • We also compare the behavior of mitochondria in different diseases and outline novel therapeutic strategies for addressing abnormal mitochondrial biological behavior to promote axonal regeneration in neurological diseases and injuries. (nih.gov)
  • Likewise, the knowledge of stem cell biology is crucial to the development of stem cell therapies, based on tissue engineering applied to dentistry, seeking the regeneration of dental tissues damaged or lost by caries, trauma or genetic diseases. (bvsalud.org)
  • We offer women's health services to meet your specific needs such as disease screenings, mental health treatment, recovery from military sexual trauma, maternity care and female-specific medical equipment. (va.gov)
  • [ 1 ] Neurogenic bladder is a term applied to urinary bladder malfunction due to neurologic dysfunction emanating from internal or external trauma, disease, or injury. (medscape.com)
  • Neurological rehabilitation is a doctor-supervised program for patients with diseases, injuries or disorders of the nervous system. (deaconess.com)
  • Many drugs used to treat neurologic disorders and other diseases may worsen symptoms of constipation. (apdaparkinson.org)
  • Despite its frequency, it often remains unrecognized until the patient develops sequelae, such as anorectal disorders or diverticular disease. (medscape.com)
  • Glycogen-storage disease type II (GSD II), also known as Pompe disease, is part of a group of metabolic diseases called lysosomal storage disorders (LSDs). (medscape.com)
  • as yet, there is no evidence for a possible role of nitric oxide in chronic megacolon unrelated to inflammatory bowel disease. (medscape.com)
  • Restoring function in chronic stages of spinal cord injury (SCI) has often been met with failure or reduced efficacy when regenerative strategies are delayed past the acute or sub-acute stages of injury. (bvsalud.org)
  • We found that a single injection of retrogradely transported adeno-associated viruses (AAVrg) to knockout the phosphatase and tensin homolog protein (PTEN) in chronic SCI can effectively target both damaged and spared axons and transiently restore locomotor functions in near-complete injury models. (bvsalud.org)
  • AAVrg's were injected to deliver cre recombinase and/or a red fluorescent protein (RFP) under the human Synapsin 1 promoter (hSyn1) into the spinal cords of C57BL/6 PTENFloxΔ/Δ mice to knockout PTEN (PTEN-KO) in a severe thoracic SCI crush model at both acute and chronic time points. (bvsalud.org)
  • Regardless of whether treatment was initiated at the time of injury (acute), or three months after SCI (chronic), mice with limited hindlimb joint movement gained hindlimb weight support after treatment. (bvsalud.org)
  • Asthma is the most common chronic respiratory disease, especially among children. (who.int)
  • Although asthma has a relatively low fatality rate compared to other chronic diseases, according to WHO estimates, 300 million people suffer from asthma and 255 000 people died of asthma in 2005. (who.int)
  • X-rays and MRI scans can identify whether symptoms are related to brain injuries or neurological abnormalities. (medicalnewstoday.com)
  • [ 15 , 20 ] Possible reasons include higher risk of injury to the pelvic floor from childbirth [ 22 ] and the general willingness of women to report their symptoms and respond to surveys. (medscape.com)
  • The MBI is one of the nation's most comprehensive and technologically advanced centers devoted to discovering how the normal brain operates, and how we can repair the brain following injury, disease or aging. (wikipedia.org)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • Wallukat et al concluded that measuring the levels of beta1-autobodies, beta2-autoantibodies, and muscarinergic2 autoantibodies may be useful for potentially identifying patients at high risk of developing life-threatening complications of Chagas disease, but they cautioned further studies are needed. (medscape.com)
  • In another study, Sanchez-Mejias et al examined the potential roles of the EDNRB and EDN3 genes in the pathogenesis of Hirschsprung disease in 196 Spanish patients. (medscape.com)
  • We hope that these cells will, in the future, provide a treatment not only for these two untreatable diseases -- Stargardt's disease and macular degeneration -- but for patients suffering from a range other debilitating eye diseases. (foxnews.com)
  • PM&R physicians are also experts in treating diseases commonly associated with OH such as MS, Parkinson's, and Spinal Cord Injured patients. (aapmr.org)
  • Aastrom Biosciences Inc recently presented promising results from a mid-stage trial of its treatment for patients with critical limb ischemia, a disease in which blood flow to the extremities is restricted, at the American Heart Association's annual meeting. (ibtimes.com)
  • A new treatment using electrical currents to stimulate the spinal cord helped patients with limited ability to use their arms and hands. (medlineplus.gov)
  • Many of the trials focus on heart disease and inflammatory conditions, some of the biggest markets in medicine. (ibtimes.com)
  • These nanovesicles can cross the blood-spinal cord barrier (BSCB) and deliver SeNPs and Met to the site of injury to exert anti-inflammatory and reactive oxygen species scavenging effects. (bvsalud.org)
  • In vitro cellular experiments and in vivo animal experiments demonstrated that SeNPs-Met-MVs decreased reactive oxygen species (ROS) and malondialdehyde (MDA) levels, increased superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities, and reduced the expression of inflammatory (TNF-α, IL-1ß, and IL-6) and apoptotic (cleaved caspase-3) cytokines in spinal cord tissue after SCI. (bvsalud.org)
  • Some scientists believe embryonic stem cells could help treat many diseases and disabilities because of their potential to develop into many different cell types in the body. (cnn.com)
  • The goal of this project is to develop and characterize aerolysin-based nanopores as sensing devices to be applied for genome sequencing, proteomic analysis and disease diagnosis. (epfl.ch)
  • In fact, black adults in the U.S. were twice as likely as white adults to develop the disease. (medlineplus.gov)
  • Assembly called upon WHO to develop an approach that can be used to register and publish contributions of the private sector to the achievement of global targets for noncommunicable diseases. (who.int)
  • We provide immediate, walk-in care for minor injuries and non-emergency illnesses that are not life-threatening but need early attention. (va.gov)
  • Exclusions included mild health states, motor impairment, borderline intellectual disability, mild hearing loss, mild vision loss and minor injuries, assuming people with these conditions would be less likely to require rehabilitation. (who.int)
  • In October, Geron Corp enrolled the first patient in the first approved study of human embryonic stem cells, to treat people whose spinal cords have been crushed. (foxnews.com)
  • The central nervous system is composed of the brain, brain stem, and the spinal cord. (medscape.com)
  • Spinal cord injury (SCI) can result in paralysis of trunk muscles, which can affect sitting balance. (researchgate.net)
  • 1 After sustaining a spinal cord injury (SCI), denervation of trunk muscles can dramatically impair seated balance control and severely limit range of stability. (researchgate.net)
  • To demonstrate how WHO's engagement with private sector entities for the prevention and control of noncommunicable diseases provides a clear benefit to public health, the Secretariat indicated that it would respond when transmitting the reports in documents EB146/7 and EB146/7 Add.1 to the Seventy-third World Health Assembly. (who.int)
  • The engagement of the Secretariat with private sector entities for the prevention and control of noncommunicable diseases will be fully coordinated with all other private sector engagement, through mechanisms defined in WHO's strategy to engage with the private sector (which is being developed) and in line with the provisions of the Framework of Engagement with Non-State Actors. (who.int)
  • Routine cross-notification between the veterinary and human health surveillance systems should be part of any zoonotic disease prevention and control programme, and close collaboration between the two health sectors is particularly important during epidemiological and outbreak investigations. (who.int)
  • The controversial 2-1 decision Friday is a victory for supporters of federally funded testing for a range of diseases and illnesses. (cnn.com)
  • All-cause mortality and life expectancy are key endpoint measures of individual health after a spinal cord injury (SCI). (karger.com)
  • Acupuncture is used in the management of disease and the maintenance of health, based on over 3000 years of history in the Far East. (manchesterneurophysio.co.uk)
  • ICORD is a world leading health research centre focused on spinal cord injury. (ubc.ca)
  • Located at Vancouver General Hospital in the Blusson Spinal Cord Centre, ICORD is supported by UBC Faculty of Medicine and Vancouver Coastal Health Research Institute. (ubc.ca)
  • The 1990-2019 Global Burden of Diseases data from the Institute for Health Metrics and Evaluation based in Seattle, Washington, United States of America, was used to estimate the need for rehabilitation services by presenting the prevalence, and associated years lived with disability, of 25 health conditions - disease causes, impairments and sequelae - that are amenable to rehabilitation at some point in the course of disease. (who.int)
  • Disability weights range from 0 (i.e., perfect health) to 1 (i.e., death) and represent the severity of the disease. (who.int)
  • All Global Burden of Diseases years lived with disability estimates were corrected for comorbidity using simulation methods and assumed a multiplicative model for coexisting health states, to account for the cumulative effect of comorbidities (1). (who.int)
  • Without enzyme replacement therapy (ERT), classic infantile-onset Pompe disease commonly results in death within the first year of life due to cardiac disease from progressive left ventricular (LV) outflow obstruction. (medscape.com)
  • The highly pathogenic avian influenza is a highly contagious disease affecting wild birds and poultry with occasional infections in human. (who.int)
  • They can be tracked to show if we have diseases like cancer. (medlineplus.gov)
  • Pompe disease (GSD II) has a broad clinical spectrum. (medscape.com)
  • From the lab-based cellular level of understanding injury to rehabilitation and recovery, our researchers are dedicated to the development and translation of more effective strategies to promote prevention, functional recovery, and improved quality of life after spinal cord injury. (ubc.ca)
  • Novitas invested $4 million in Amorcyte Inc, a company recently acquired by NeoStem Inc that is developing a treatment for heart disease. (ibtimes.com)
  • Excessive glycogen storage within lysosomes interrupts normal functioning of other organelles and leads to cellular injury. (medscape.com)
  • Context Recovery of seated balance is a rehabilitation priority for people with motor-complete spinal cord injury (mcSCI). (researchgate.net)
  • Although asthma cannot be cured, appropriate management can control the disease and enable people to enjoy a good quality of life. (who.int)
  • Classification is based on age of onset, organ involvement, severity, and the rate of disease progression. (medscape.com)
  • Constipation is a symptom rather than a disease, generally defined as when bowel movements occur three or fewer times a week and are difficult to pass. (medscape.com)
  • In addition to the neurologic disease itself, reduced mobility may aggravate constipation. (apdaparkinson.org)
  • In the classic infantile form of Pompe disease, clinically significant glycogen storage occurs in cardiac muscle. (medscape.com)
  • A series of pathological changes after spinal cord injury (SCI) are usually associated with oxidative stress, inflammation, and apoptosis. (bvsalud.org)
  • He spent 10 years at Salk, where he authored a number of seminal studies describing molecular mechanisms that regulate synaptic function and their role in behaviour and neurological diseases. (edu.au)
  • Normal voiding is essentially a spinal reflex modulated by the central nervous system (brain and spinal cord), which coordinates function of the bladder and urethra. (medscape.com)
  • Yeah, the idea is based on the possibility to replace the lost dopamine neurons with new cel s that would take over the function from the cel s that are lost to the disease. (lu.se)
  • Restoring function in the chronically injured spinal cord remains a critical challenge. (bvsalud.org)
  • NECTAR - the network for European CNS transplantation and restoration was founded over 25 years ago with the aim of bringing together European groups who share the common goal of protecting, repairing, and restoring the central nervous system from damage caused by degenerative disease or injury. (lu.se)
  • In December 1991, Luttge came across an excerpt from an obscure newsletter, Commerce Business Daily, announcing a call for proposals for a competitive Department of Defense (DoD) grant to build a major national brain and spinal cord research center. (wikipedia.org)
  • Founded in 1961, APDA has raised and invested more than $252 million to provide outstanding patient services and educational programs, elevate public awareness about the disease, and support research designed to unlock the mysteries of PD and ultimately put an end to this disease. (apdaparkinson.org)
  • Internal medicine doctors (internists) prevent, diagnose, and treat adult diseases. (va.gov)
  • Cardiac involvement is less likely among individuals with disease onset at an older age. (medscape.com)
  • Mortality and longevity studies of spinal cord injury (SCI) are essential for informing healthcare systems and policies. (karger.com)
  • Severe disease and death may result from a complication of pneumonia. (who.int)