• Background: The prevalence of different periampullary cancers (pancreatic ductal adenocarcinoma, distal cholangiocarcinoma, ampullary cancer and duodenal cancer) is heterogeneous in the literature. (lu.se)
  • Results: Among non-curative patients, 3704 (83.6 per cent) were diagnosed with pancreatic ductal adenocarcinoma. (lu.se)
  • Among patients treated with pancreatoduodenectomy, diagnosis was pancreatic ductal adenocarcinoma in 1380 (50.0 per cent), distal cholangiocarcinoma in 284 (10.3 per cent), ampullary cancer in 376 (13.6 per cent), duodenal cancer in 160 (5.8 per cent) and other diagnoses in 560 (20.3 per cent) patients. (lu.se)
  • The preoperative diagnosis corresponded to the postoperative in 1177 (67.5 per cent) patients for pancreatic ductal adenocarcinoma, 162 (37.4 per cent) patients for distal cholangiocarcinoma, 220 (61.3 per cent) patients for ampullary cancer and 120 (53.6 per cent) patients for duodenal cancer. (lu.se)
  • A higher rate of pancreatic ductal adenocarcinoma was seen in surgical specimens who underwent standardized evaluation, from 56.8 per cent to 64.3 per cent (P = 0.003). (lu.se)
  • Conclusion: The proportion of pancreatic ductal adenocarcinoma was higher in patients in a non-curative setting compared with patients who underwent surgery. (lu.se)
  • Standardized evaluation of the surgical specimen has increased pancreatic ductal adenocarcinoma, R1 and N1 rates. (lu.se)
  • During the progression of pancreatic ductal adenocarcinoma (PDAC), heterogeneous subclonal populations emerge that drive primary tumor growth, regional spread, distant metastasis, and patient death. (duke.edu)
  • A Comprehensive Transcriptional Signature in Pancreatic Ductal Adenocarcinoma Reveals New Insights into the Immune and Desmoplastic Microenvironments. (bsc.es)
  • Pancreatic ductal adenocarcinoma (PDAC) prognoses and treatment responses remain devastatingly poor due partly to the highly heterogeneous, aggressive, and immunosuppressive nature of this tumor type. (bsc.es)
  • Objective: Most patients with pancreatic ductal adenocarcinoma (PDAC) will experience recurrence after resection. (nanostring.com)
  • Here, we employed high-resolution mass spectrometry combined with immunoaffinity purification using anti-phosphotyrosine antibodies to profile tyrosine phosphoproteome across 13 pancreatic ductal adenocarcinoma PDX models. (ppbhg.org)
  • In summary, we present a comprehensive landscape of Diazepam-Binding Inhibitor Fragment, human tyrosine phosphoproteome with EphB4 Diazepam-Binding Inhibitor Fragment, human as a promising Diazepam-Binding Inhibitor Fragment, human therapeutic target in pancreatic ductal adenocarcinoma. (ppbhg.org)
  • Pancreatic Cancer Pancreatic cancer, primarily ductal adenocarcinoma, accounts for an estimated 64,050 cases and 50,550 deaths in the United States annually ( 1). (msdmanuals.com)
  • Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis, mainly because the tumors are detected too late for effective treatment or for developing suitable therapeutics. (elsevierpure.com)
  • Pancreatic ductal adenocarcinoma (PDAC) is associated with poor prognosis. (kcl.ac.uk)
  • Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related death and is one of the most difficult-to-treat cancers. (biomedcentral.com)
  • Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies. (huji.ac.il)
  • Two recent studies from Dr. Wenming Wu's group at the Department of General Surgery, Peking Union Medical College Hospital (PUMCH), applied single-cell RNA sequencing and whole-genome sequencing (WGS) to delineate heterogeneity of pancreatic tumors, including pancreatic ductal adenocarcinoma (PDAC) and pancreatic neuroendocrine tumor (PanNET). (biomedcentral.com)
  • Pancreatic ductal adenocarcinoma (PDAC) possesses a dense and fibrotic desmoplastic stroma. (alfaoncology.com)
  • Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma: An Update on Heterogeneity and Therapeutic Targeting. (alfaoncology.com)
  • Abstract The added value of capecitabine to adjuvant gemcitabine monotherapy (GEM) in pancreatic ductal adenocarcinoma (PD. (cn1699.cn)
  • Prevalence and Risk Factors of Germline Pathogenic Variants in Pancreatic Ductal Adenocarcinoma. (cdc.gov)
  • Adipocytes represent a major cell type in the mammary tumor microenvironment and are important for tumor growth. (jci.org)
  • Adipocyte-derived factors involved in tumor progression include proteins such as adiponectin, leptin, TNF-α, monocyte chemotactic protein-1 (MCP-1), IL-6, and ECM components that control tumor cell behavior within the tumor microenvironment. (jci.org)
  • Cancer research has been conducted using cultured cells as part of drug discovery testing, but conventional two-dimensional culture methods are unable to reflect the complex tumor microenvironment. (medsci.org)
  • However, the cellular environment under 2D culture is very different and often a poor reflection of the complex tumor microenvironment (TME) in vivo [ 1 ]. (medsci.org)
  • Simple Summary: The poor prognosis outcome of patients with KRAS mutations (KRASmut) was correlated with an immunosuppressive tumor microenvironment (TME). (nanostring.com)
  • In the metabolic symbiosis model, these cells have been proposed to overexpress MCT4 to release high amounts of lactate produced during anaerobic glycolysis into the tumor microenvironment. (hindawi.com)
  • Regardless of the therapeutic approach, the heterogeneity of pancreatic cancer cells and the complexity of its tumor microenvironment contribute to the emergence of drug resistance. (frontiersin.org)
  • The PDAC tumor microenvironment (TME) is characterized by a dense desmoplastic stroma, dominated by cancer-associated fibroblasts (CAF), extracellular matrix (ECM) and immune cells displaying immunosuppressive phenotypes. (kcl.ac.uk)
  • Despite major improvements in immunotherapeutic strategies, the immunosuppressive tumor microenvironment remains a major o. (cn1699.cn)
  • Liquid biopsy is a useful tool for accurately monitoring dynamic changes in tumor immune heterogeneity and the tumor microenvironment. (spandidos-publications.com)
  • Tumor cells are influenced by both genetic factors and environmental elements in the microenvironment, resulting in a complex regulation process ( 1 ). (spandidos-publications.com)
  • Various subclonal tumor cells have the ability to modify the tumor microenvironment in order to obtain adaptations. (spandidos-publications.com)
  • Furthermore, tumor heterogeneity has a significant impact on both the immune microenvironment and the infiltration of various immune cells within tumors, such as cytotoxic T lymphocytes (CTLs) ( 5 ), myeloid antigen-presenting cells ( 6 ) and cancer-associated fibroblasts (CAFs) ( 7 ). (spandidos-publications.com)
  • It has been discovered that the genetic structure of tumor cells and the components of the immune microenvironment interact with each other. (spandidos-publications.com)
  • This interaction results in a more complex alteration of both the heterogeneity of tumor cells and the heterogeneity of the tumor microenvironment. (spandidos-publications.com)
  • However, the tumour may evade immune responses through regulatory T-cell-mediated immune suppression in the tumour microenvironment, defective antigen presentation, and production of immunosuppressive cytokines (5). (cambridgemedicine.org)
  • We laid particular focus on those researches that reveal how exosomes regulate the tumor immune microenvironment (TIME) and how exosomal cargos affect the progression of HCC. (hindawi.com)
  • HCC-derived exosomes participate in changing tumor progression by regulating the tumor microenvironment and tumor immune status [ 14 , 15 ]. (hindawi.com)
  • Cancerous tumors are complex mixtures of malignant and non-malignant cells shaping the tumor microenvironment (TME). (nature.com)
  • Previous studies unraveled that extracellular adenosine concentration was elevated in the tumor microenvironment [ 8 ]. (biomedcentral.com)
  • Recently, CD73-adensine was found to be a significant pathway involved in the formation of immunosuppressive microenvironment in distinct tumors [ 3 ]. (biomedcentral.com)
  • In addition, heterogeneity of the tumor microenvironment was explored, and distinct subtypes of immune cells and fibroblasts in PDAC were characterized. (biomedcentral.com)
  • Exploring highly expressed pathways in stromal components, such as fibroblasts, will delineate the underlying mechanisms that are pivotal for tumor microenvironment maintenance. (biomedcentral.com)
  • The pancreatic tumor microenvironment (TME) mainly consists of extracellular matrix, resident and recruited cells, and cancer-associated fibroblasts (CAFs), which play a crucial role in tumor progression and metastasis, metabolism, angiogenesis, and treatment resistance (such as immunosuppression and chemoresistance). (alfaoncology.com)
  • γδ T cells recruited into the tumor microenvironment can act as effector cells to mediate cancer immune surveillance. (explorationpub.com)
  • Therefore, an in-depth understanding of γδ T cells that play conflicting roles in the tumor microenvironment is necessary. (explorationpub.com)
  • However, the genetics of metastases largely reflects that of the primary tumor in untreated patients, and PDAC driver mutations are shared by all subclones. (duke.edu)
  • We showed that when an iPS-like cell line, designated 10-22, derived from human recurrent PDAC, was injected into immunodeficient mice, the cells consistently recapitulated preinvasive, pancreatic intraepithelial neoplasia (PanIN) to invasive stages of human PDAC. (elsevierpure.com)
  • However, the heterogeneous initial populations, different cellular states, and active memory of pancreatic epithelial cells challenge for making iPSC-like lines from human PDAC. (elsevierpure.com)
  • With the awareness that CAF are the predominant cell type in PDAC driving tumorigenesis with various tumor supportive functions, efforts have been made to try to target them. (kcl.ac.uk)
  • With the help of sophisticated single cell analyses it is now appreciated that CAF in PDAC are a heterogenous population with both tumor supportive and tumor suppressive functions. (kcl.ac.uk)
  • However, PDAC is characterized by an abundant tumor stroma that includes a heterogeneous mixture of immune cells, fibroblasts, endothelial cells, neurons and some molecular events. (biomedcentral.com)
  • In this review, we discuss how infiltrating immune cells influence PDAC development and explore the contributions of complex components to the immune landscape of tumor tissue. (biomedcentral.com)
  • What makes the response of PDAC to immunotherapy different from the responses of other solid tumors is the specific host tissue. (biomedcentral.com)
  • applied single-cell RNA sequencing to 24 primary PDAC tumors and 11 control pancreases. (biomedcentral.com)
  • This elegant study provided valuable resources for deciphering heterogenous cell types in PDAC. (biomedcentral.com)
  • Scholars@Duke publication: Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis. (duke.edu)
  • Moreover, single-cell sequencing provides unique insights into the mechanisms of pancreatic cancer metastasis and cachexia, paving the way for developing novel preventive strategies. (frontiersin.org)
  • It unlocks novel dimensions by uncovering elusive cell populations and tumor heterogeneities for early detection, unraveling mechanisms of treatment resistance, tailoring therapies to individuals, and illuminating metastasis and cachexia pathways, thereby opening fresh avenues for preventive strategies. (frontiersin.org)
  • Tumor angiogenesis plays vital roles in the growth and metastasis of cancer. (cn1699.cn)
  • A number of studies have proved that exosomes are important mediators for the initiation, progression, angiogenesis, and metastasis of tumors [ 10 ]. (hindawi.com)
  • Significance of expression of CD109 in osteosarcoma and its involvement in tumor progression via BMP signaling. (nagoya-u.ac.jp)
  • In this paper, we reviewed the recent researches on the multiple roles of tumor-associated exosomes in the progression of HCC. (hindawi.com)
  • The infiltration of multiple types of tumor-promoting immune cells, including myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs), regulatory T cells (Tregs) and other immune cells, mediates immune evasion and tumor progression [ 9 ]. (biomedcentral.com)
  • Plasma circulating tumor DNA (ctDNA) sequencing has demonstrated clinical utility for tumor molecular profiling at initial diagnosis or tumor progression in advanced solid cancers and is being rapidly incorporated into. (koreamed.org)
  • As the major non-neoplastic component of pancreatic TME, CAFs not only promote the formation of the desmoplastic stroma by secreting extracellular matrix proteins but also regulate cancer progression by influencing cytokines/chemokine production. (alfaoncology.com)
  • The present study sought to provide information about periampullary cancers with regard to tumour types in curative and noncurative settings, preoperative diagnostic accuracy and the impact of a standardized evaluation of the surgical specimen on diagnosis, R status and lymph node assessment. (lu.se)
  • Colorectal cancers are one of the most prevalent tumour types worldwide and, despite the emergence of targeted and biologic therapies, have among the highest mortality rates. (researchgate.net)
  • Patients with advanced pancreatic cancers and weight loss may have general laboratory evidence of malnutrition (eg, low serum albumin or cholesterol level). (medscape.com)
  • Molecular imaging with whole‐body positron emission tomography (PET)/CT or PET/MRI utilizes metabolic and receptor‐based strategies for tumor detection in staging and restaging various cancers. (radiologykey.com)
  • Rare germline variants in pancreatic cancer and multiple primary cancers: an autopsy study. (cdc.gov)
  • Patients with SCA, specially with this pseudo solid-appearance, such as the present case, may have imaging findings that closely resemble those of patients with pancreatic neuroendocrine neoplasms (pNENs), metastatic renal cell carcinoma, solid pseudopapillary tumor or acinar cell carcinomas (1,4). (spg.pt)
  • EUS-FNA alone may not accurately differentiate SCA from other pancreatic neoplasms, making the preoperative diagnosis a challenge (1,2), thus leading to unnecessary surgical resections in many cases. (spg.pt)
  • Hence, the adipocyte, as a major constituent of the mammary tumor stroma ( 3 ), is a likely contributor to tumor growth. (jci.org)
  • On average, the stroma constitutes over 70% of the tumor mass. (biomedcentral.com)
  • CAFs are characterized by tissue-resident, spindle-shaped, originating from different pancreatic cell types, including resident fibroblasts (the most prominent source), pancreatic stellate cells (PSCs), bone marrow-derived cells (BMDCs), and epithelial cells. (alfaoncology.com)
  • The impact of cancer-associated fibroblasts on major hallmarks of pancreatic cancer. (alfaoncology.com)
  • Moreover, PanDrugs2 now considers cancer genetic dependencies to extend tumor vulnerabilities providing therapeutic options for untargetable genes. (bsc.es)
  • Further therapeutic advances and prospective trials are needed to better define the optimal role of adjuvant and neoadjuvant treatment in patients with resectable pancreatic cancer. (cancernetwork.com)
  • and R.P.G. interest in developing novel therapeutic strategies in the treatment and management of pancreatic cancer. (ppbhg.org)
  • Chimeric antigen receptor (CAR) T-cell therapy is a novel therapeutic T-cell engineering option, where T-cells obtained from a patient's blood are engineered ex vivo to express specific tumour antigen receptors. (cambridgemedicine.org)
  • Here, we offer different preclinical models of pancreatic CAFs to help our global customers develop successful CAF-targeted therapeutic regimens. (alfaoncology.com)
  • Oncogenic drivers and therapeutic vulnerabilities in KRAS wild-type pancreatic cancer. (cdc.gov)
  • The Landscape and Therapeutic Targeting of BRCA1, BRCA2 and Other DNA Damage Response Genes in Pancreatic Cancer. (cdc.gov)
  • Surgical resection is currently the sole curative treatment for pancreatic cancer. (frontiersin.org)
  • Surgery is the primary mode of treatment for pancreatic cancer. (medscape.com)
  • Overall, the age-adjusted incidence of neuroendocrine tumors increased sixfold from 1973 (1.09 per 100,000) to 2012 ((6.98 per 100,000), possibly because of increased early detection. (medscape.com)
  • Both the incidence and the death rates for pancreatic cancer are increasing. (medscape.com)
  • Malignant gliomas are the most common primary malignant brain tumors with an increasing incidence of up to nine per 100,000 habitants over the last years [ 1 , 2 ]. (hindawi.com)
  • Globally, the three regions with the highest age-standardized incidence rates of pancreatic cancer are Western Europe (17.2 per100,000 person-years), Eastern Europe (15.5 per100,000 person-years), and North America (16.2 per100,000 person-years), followed by Australia (14.6 per100,000 person-years) and East Asia (11.8 per100,000 person-years) ( 1 - 3 ). (frontiersin.org)
  • Patients who underwent biliary stenting alone, biliary and pancreatic stenting, and no stenting prior to pancreaticoduodenectomy were the three study cohort groups and their records were scrutinized for the incidence of postoperative pancreatic fistula. (thieme-connect.de)
  • Why should biliary or pancreatic stenting affect the incidence of POPF? (thieme-connect.de)
  • ABSTRACT: Also referred to as "osteoclast-rich, clear cell sarcoma-like tumor of the gastrointestinal tract (CCSLGT)," malignant gastrointestinal neuroectodermal tumor is a newly described, rare, aggressive sarcoma that commonly arises in the small bowel, stomach, and colon. (bvsalud.org)
  • Abstract Estrogen receptor-positive breast cancer is a highly prevalent but heterogeneous disease among women. (cn1699.cn)
  • Finally, MCT4 inhibition mitigates the induction of angiogenesis, suggesting that MCT4 also plays a crucial role in tumor-related angiogenesis. (hindawi.com)
  • Thus, tumor heterogeneity has an important role in tumor development. (spandidos-publications.com)
  • Recent studies revealed that CD73 plays a pivotal role in tumor escape from immune surveillance. (biomedcentral.com)
  • Renal cell carcinoma (RCC) is a common malignant tumor of the urinary system. (cn1699.cn)
  • Although nonfunctional islet cell tumors are not uncommon at autopsy, most islet cell tumors with clinical manifestations are functional. (medscape.com)
  • Functioning tumors produce a clinical syndrome as a result of excessive hormone production. (medscape.com)
  • Clinical features of the syndrome depend on tumor cell type. (medscape.com)
  • Spheroids made from oral cancer cell lines appeared to have tumor-like characteristics that may reflect their clinical significance. (medsci.org)
  • Emerging single-cell sequencing technologies will undoubtedly enhance our understanding of the complex biology of pancreatic cancer and pave the way for new directions in its clinical diagnosis and treatment. (frontiersin.org)
  • However, the study of tumor immune heterogeneity holds great potential for clinical immunotherapy. (spandidos-publications.com)
  • A portion of these patients are highly susceptible to DNA damaging therapeutics, however, responses are heterogeneous and clinical resistance evolves. (huji.ac.il)
  • Our results demonstrate heterogeneous responses to DNA damaging agents/PARPi in BRCA-associated PDX thus reflecting the wide clinical spectrum. (huji.ac.il)
  • Compared with solid tumor sampling, the bone marrow or peripheral blood of leukemia patients is easier to access, and therefore an accurate and practical prognostic signature for leukemia patients has potential for more direct clinical application. (nature.com)
  • Since most hematological malignancies are very heterogeneous diseases, robust patient-specific prognostic signatures are required for clinical applications. (nature.com)
  • However, the clinical application of tumor-infiltrating γδ T cells has certain limitations. (explorationpub.com)
  • Do polygenic risk scores add to clinical data in predicting pancreatic cancer? (cdc.gov)
  • Utility of Comprehensive Genomic Profiling Tests for Patients with Incurable Pancreatic Cancer in Clinical Practice. (cdc.gov)
  • Presently, the standard first-line treatment for advanced pancreatic cancer is gemcitabine-based chemotherapy. (frontiersin.org)
  • Combination chemotherapy regimens, such as FOLFIRINOX and nab-paclitaxel plus gemcitabine, have demonstrated improved survival rates in advanced pancreatic cancer ( 7 , 8 ). (frontiersin.org)
  • Overall, PUREE is a highly accurate and versatile method for estimating tumor purity and interrogating tumor heterogeneity from bulk tumor gene expression data, which can complement genomics-based approaches or be used in settings where genomic data is unavailable. (nature.com)
  • The technique holds tremendous potential in improving the diagnosis and treatment of pancreatic cancer. (frontiersin.org)
  • Overall, single-cell sequencing has immense potential in promoting early diagnosis, guiding personalized treatment, and preventing complications of pancreatic cancer. (frontiersin.org)
  • Early diagnosis is crucial for improving the outcomes of pancreatic cancer, yet it remains a challenge due to the manifestation of non-specific symptoms primarily in the advanced stages of the disease. (frontiersin.org)
  • Currently, early diagnosis of pancreatic cancer relies on serum markers, such as CA 19-9 and CEA, as well as imaging techniques like CT and MRI. (frontiersin.org)
  • Applications of single-cell sequencing technology in the diagnosis and treatment of pancreatic cancer. (frontiersin.org)
  • Single-cell sequencing technology transforms the landscape of pancreatic cancer diagnosis and therapy. (frontiersin.org)
  • Pseudo solid-appearing pancreatic serous microcystic adenomas: Histologic diagnosis with the EUS core biopsy fork-tip needle. (spg.pt)
  • Contrast-enhanced harmonic EUS using specific software (with low mechanical index capabilities) is already established as a procedure useful for the differential diagnosis of focal pancreatic masses. (abdominalkey.com)
  • Compared to normal colon tissue, primary tumors were associated with increased expression of ALDH1B1 (p=0.008). (jcancer.org)
  • In primary tumors, mutations in driver genes frequently provide a survival advantage and give rise to a dominant clonal population. (spandidos-publications.com)
  • No universally agreed-upon algorithm exists in the radiologic investigation of pancratic neuroendocrine (islet cell) tumors of the pancreas. (medscape.com)
  • Evidence has shown that endoscopic ultrasonography (EUS) can be used to accurately diagnose and localize primary endocrine tumors of the pancreas, especially insulinomas and gastrinomas. (medscape.com)
  • Gross section of an adenocarcinoma of the pancreas measuring 5 × 6 cm resected from the pancreatic body and tail. (medscape.com)
  • The RT approach in this trial was considered low-dose and antiquated by contemporary standards due to the use of a split-course technique and the use of large treatment fields, which encompassed the entire pancreas/pancreatic bed and the celiac, pancreaticosplenic, peripancreatic, and retroperitoneal regional lymph nodes. (cancernetwork.com)
  • The authors present the case of a 83-year-old man with a computed tomography (CT) scan done for other purposes showing the presence of a hyperenhancing, discretely heterogeneous nodular lesion in the neck of the pancreas, with slightly irregular margins, measuring 30x20mm. (spg.pt)
  • Approximately 75% of all pancreatic carcinomas occur within the head or neck of the pancreas, 15-20% occur in the body of the pancreas, and 5-10% occur in the tail. (medscape.com)
  • Gross section of an adenocarcinoma of the pancreas measuring 5 X 6 cm resected from the pancreatic body and tail. (medscape.com)
  • Pancreatic Cancer Screening for At-risk Individuals (Pancreas Scan Study): Yield, Harms and Outcomes from a Prospective Multi-Center Study. (cdc.gov)
  • SPPT) is a rare exocrine pancreatic neoplasm, tumor' of the pancreas.4 not conflict of interests. (bvsalud.org)
  • Taking into consideration the large numbers of cytotoxic medications found in the treating neoplastic illnesses presently, much information is certainly missing to anticipate the anti-tumor response from the web host reliably. (treatmentforprostatecancer.info)
  • Review of genetic and pharmacogenetic differences in cytotoxic and targeted therapies for pancreatic cancer in African Americans. (cdc.gov)
  • Moreover, ETP expression was associated with aggressive mammary tumor growth and high metastatic growth. (jci.org)
  • Nonfunctioning tumors usually are larger and present because of their size or metastatic spread. (medscape.com)
  • One patient who had 50-gene panel only also had his metastatic site (esophagus) of his tumor tested with FoundationOne. (cancerindex.org)
  • The proportion of malignant cancer cells in the tumor mass, herein referred to as tumor purity, also impacts genomic analysis such as the estimation of clonal composition 6 and tumor mutation burden 7 , critical for predicting treatment outcomes and selecting patients for immunotherapy. (nature.com)
  • The 5 year disease-free survival (DFS) per tumor origin was: 94% for PMP-LG, 85% for PMP-HG, 100% for benign multicyst peritoneal mesothelioma (MPM), 37.4% for colonic origin, and 54%(at 3 years) for ovarian origin. (unav.edu)
  • The 5-year overall survival of patients with pancreatic cancer is approximately 5%, with potentially resectable disease representing the curable minority. (cancernetwork.com)
  • Besides, upregulated MCT4 has been linked to altered tumor metabolism as well as to increased growth and survival in breast and pancreatic cancer [ 33 , 34 ]. (hindawi.com)
  • However, there has only been one previous functional study investigating MCT4 in glioblastoma (GBM) neurospheres, mainly focusing on tumor growth and survival dependent on the oxygen level [ 14 ]. (hindawi.com)
  • The second-generation CAR T-cells consist of one additional co-stimulatory component (mainly CD28, CD137 or CD134) in the intracellular domain, which amplifies anti-tumour responses in vivo (8). (cambridgemedicine.org)
  • Treatment responses of patients with acute myeloid leukemia (AML) are known to be heterogeneous, posing challenges for risk scoring and treatment stratification. (nature.com)
  • These studies indicate the importance of the pyroptosis process in tumor development and treatment responses. (nature.com)
  • The 5-year DFS per tumor origin was: 96% for perforated low grade appendiceal mucinous neoplasm (LAMN II) and 68.1% for colon origin. (unav.edu)
  • In addition, intrinsic differences in subclonal tumor cells that arise from random mutations can create distinct niches within limited lesions. (spandidos-publications.com)
  • These studies reveal a wide range of genetic tumor heterogeneity in both spatial and temporal dimensions, encompassing diverse single-nucleotide mutations, insertions, deletions and copy number variations ( 9 , 10 ). (spandidos-publications.com)
  • By contrast, mutations in noncoding regions do not provide significant growth advantages during tumor evolution ( 11 ). (spandidos-publications.com)
  • Patients with deleterious germline mutations: A heterogeneous population for pancreatic cancer screening? (cdc.gov)
  • Prevalence of Germline Mutations in Cancer Predisposition Genes in Patients with Pancreatic Cancer or Suspected Related Hereditary Syndromes: Historical Prospective Analysis. (cdc.gov)
  • Glioblastoma (GBM) is characterized by significant genetic heterogeneity among tumor cells. (spandidos-publications.com)
  • Multiregional whole-exome or genome sequencing has revealed that there is significant variation in the genetic makeup of tumor cells across different anatomical locations and within the same tumor over time ( 4 ). (spandidos-publications.com)
  • To evaluate tumor-specific genetic changes using next-generation sequencing (NGS) panels. (cancerindex.org)
  • Genetic counselling referral practices for patients with pancreatic adenocarcinoma: A French retrospective multicentre observational cohort study (CAPANCOGEN). (cdc.gov)
  • Feasibility of the Genetic Information Assistant Chatbot to Provide Genetic Education and Study Genetic Test Adoption Among Pancreatic Cancer Patients at Johns Hopkins Hospital. (cdc.gov)
  • Diverse genetic spectrum among patients who met the criteria of hereditary breast, ovarian and pancreatic cancer syndrome. (cdc.gov)
  • Adherence to NCCN Genetic Testing Guidelines in Pancreatic Cancer and Impact on Treatment. (cdc.gov)
  • iii) to accelerate the conversion of anti-tumor type 1 macrophages into pro-tumor type 2 macrophages [ 9 ]. (biomedcentral.com)
  • We investigated the impact on tumor malignancy in F98 glioma cells using in silico analysis, in vitro cell culture assays, and ex vivo vascular organotypic glioma impact model (VOGIM) [ 35 ] by implanting F98 cells into rat brain slices. (hindawi.com)
  • Chemotherapy and radiation therapy are the cornerstone of therapy for unresectable pancreatic cancer. (frontiersin.org)
  • The impact of inflammatory cytokines tumour necrosis factor-α and transformation growth factor-β on this model, as well as other variables such as hypoxia and the anti-fibrosis drug Halofuginone were assessed. (edu.au)
  • Besides, recent efforts have focused on developing targeted therapies for pancreatic cancer, including drugs that target specific molecular alterations like the KRAS oncogene, which is frequently mutated in pancreatic cancer ( 9 - 11 ). (frontiersin.org)
  • The heterogeneity of glioblastoma can suppress immune cell function and lead to immune evasion, which presents a challenge in developing effective molecular therapies for tumor cells. (spandidos-publications.com)
  • Contemporary anti-cancer therapies purpose at inducing immunogenic tumor cell loss of life. (treatmentforprostatecancer.info)
  • Surgery is the only potentially curative treatment modality for early-stage pancreatic cancer. (medscape.com)
  • Because the suggestions for drug screening process in antineoplastic remedies need evaluation of individual tumors xenotransplanted into immune-compromised 4-Aminohippuric Acid mice (5), the function from the immune system continues to be neglected (6), producing studies centered on the interplay between disease fighting capability and dying cells required. (treatmentforprostatecancer.info)
  • Even though developed for AML patients, our pan-cancer analyses demonstrate a wider application of the IPRP signature for prognostic prediction and analysis of tumor-immune interplay also in multiple solid tumors. (nature.com)
  • We carried out transfection experiments using three pancreatic cancer cell lines (MiaPaCa-2, BxPC-3, and SW1990) and one pancreatic duct epithelial cell line (HPDE6c7). (nagoya-u.ac.jp)
  • Endoscopic ultrasound (EUS) showed an apparently solid, hypoechoic, well-demarcated but with irregular margins, round, hypervascular lesion, measuring 21x24mm, adjacent to the main pancreatic duct (MPD) though no communication, obstruction or dilation were noticed (Figure 1). (spg.pt)
  • Stent placement can not only induce pancreatic and bile duct wall inflammation but also introduce infection into the biliopancreatic system, and this may be responsible. (thieme-connect.de)
  • Collagen VI (COL6) is highly expressed in adipose tissue, upregulated in the obese state, and enriched in breast cancer lesions and is a stimulator of mammary tumor growth. (jci.org)
  • These effects were partially mediated through enhanced TGF-β signaling, which contributes to tissue fibrosis and epithelial-mesenchymal transition (EMT) of tumor cells. (jci.org)
  • Cellular deconvolution algorithms have been applied to a variety of samples collected from saliva, buccal, cervical, PBMC, brain, kidney, and pancreatic cells, and many studies have shown that estimating and incorporating the proportions of cell types into various analyses improves the interpretability of high-throughput omics data and reduces the confounding effects of cellular heterogeneity, also known as tissue heterogeneity, in functional analysis of omics data. (wikipedia.org)
  • H-E staining showed tumor tissue-like structures specific to each cell line. (medsci.org)
  • In the future, it may become possible to produce tumor spheroids from tissue samples of oral cancer patients, and then apply them to drug screening and to develop individualized diagnostic and treatment methods. (medsci.org)
  • Therefore, it is difficult to propose that 2D culture accurately reflects the original growth state of tumor tissue. (medsci.org)
  • DeMixT uses probabilistic modeling to infer proportions of stromal and cancer-cell components from a set of input samples, comprising both tumor and normal-tissue samples 8 . (nature.com)
  • Immune cells engage in extensive and dynamic crosstalk with stromal components in the tumor tissue in addition to tumor cells, which subsequently impacts tumor suppression or promotion to a large extent. (biomedcentral.com)
  • Real-time EUS elastography provides qualitative and semi-quantitative data about tissue stiffness, possibly allowing differentiation of benign and malignant tumors. (abdominalkey.com)
  • Thus, malignant tumors are usually stiffer as compared with benign masses, whereas the strain information induced by small tissue deformations can be computed and displayed in real time. (abdominalkey.com)
  • PUREE was trained on gene expression data and genomic consensus purity estimates from 7864 solid tumor samples. (nature.com)
  • PUREE predicted purity with high accuracy across distinct solid tumor types and generalized to tumor samples from unseen tumor types and cohorts. (nature.com)
  • Here we developed PUREE, which uses a weakly supervised learning approach to infer tumor purity from a tumor gene expression profile. (nature.com)
  • Existing methods that estimate tumor purity from a tumor gene expression profile adopt different analytical strategies (Supplementary Note 1 , 2 ). (nature.com)
  • In summary, our data highlight MCT4 /SLC16A3 as a key gene for distinct hallmarks of tumor malignancy in glioma cells. (hindawi.com)
  • Gene features of PUREE were further validated using single-cell RNA-seq data from distinct tumor types. (nature.com)
  • This finding provides new insight into understanding how distinct tumor types regulate their immune heterogeneity. (biomedcentral.com)
  • METHODS: We found through analysis of the public database that ROBO4, one of the axon guidance molecules among the SLIT/ROBO family, is significantly downregulated in primary pancreatic cancer tissues compared with adjacent normal tissues. (nagoya-u.ac.jp)
  • PanDrugs is a methodology that facilitates the interpretation of tumor molecular alterations and guides the selection of personalized treatments. (bsc.es)
  • Patient-derived tumor xenografts (PDXs) in mice serve as potentially valuable preclinical models as they maintain the histological and molecular heterogeneity of the original human tumor. (ppbhg.org)
  • Precision Oncology in Pancreatic Cancer: Experiences and Challenges of the CCCMunich Molecular Tumor Board. (cdc.gov)
  • ParetoTI theory identified four tumour archetypes within the tetrahedron, corresponding to the three previously reported molecular groups, and the fourth enriched for the aggressive supra-carcinoids. (who.int)
  • Its effect on postoperative pancreatic fistula is variably reported in literature. (thieme-connect.de)
  • Simultaneous biliary and pancreatic drainage is rarely performed for very selected indications and its effects on postoperative pancreatic fistula are largely unknown. (thieme-connect.de)
  • However, the patients who underwent both biliary and pancreatic stenting had a significant increase in postoperative pancreatic fistula compared with the not stented ( p = 0.003). (thieme-connect.de)
  • Conclusion Preoperative biliary drainage alone has no significant influence on postoperative pancreatic fistula except when combined with pancreatic stenting. (thieme-connect.de)
  • We need more such studies from other centers to confirm that the rare event of preoperative biliary and pancreatic stenting has indeed this harmful effect on healing of postoperative pancreatic anastomosis. (thieme-connect.de)
  • The effect of preoperative biliary drainage (PBD) prior to pancreaticoduodenectomy (PD) on postoperative pancreatic fistula (POPF) is variably reported in literature. (thieme-connect.de)
  • All patients underwent curative resection of pancreatic adenocarcinoma without evidence of intraperitoneal disease. (cancernetwork.com)
  • Results Sixty-two patients underwent biliary stenting alone, 5 patients underwent both biliary and pancreatic stenting, and 237 patients were not stented in the adenocarcinoma group without chronic pancreatitis. (thieme-connect.de)
  • Smaller panel, similar results: genomic profiling and molecularly informed therapy in pancreatic cancer. (cdc.gov)
  • In line with this observation, elevated extracellular lactate concentrations up to 40 mM and corresponding low extracellular pH (pH e ) have been found in solid tumors under hypoxic conditions [ 18 - 22 ]. (hindawi.com)
  • Current research has demonstrated that extracellular vesicles (EVs) and circulating tumor cells (CTCs) are very closely re. (cn1699.cn)
  • Imaging studies revealed a mixed neoplasm neoplasia inusual in the pancreatic body and tail. (bvsalud.org)
  • The pancreatic fistula rate was similar in the patients who underwent biliary stenting alone when compared with the group which was not stented. (thieme-connect.de)
  • They may manifest as sporadic tumors or as part of certain syndromes, including multiple endocrine neoplasia type 1 (MEN 1) and von Hippel-Lindau (VHL) disease. (medscape.com)
  • una neoplasia mixta en el cuerpo y cola pancreática. (bvsalud.org)