AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureInformation ScienceHealth CareGeographicals
Fatty Acids, Omega-3Fatty Acids, UnsaturatedFatty Acids, Omega-6Docosahexaenoic AcidsDietary Fats, UnsaturatedEicosapentaenoic AcidFish Oilsalpha-Linolenic AcidFatty AcidsPlant OilsDietary FatsLinseed OilFatty Acids, MonounsaturatedLinoleic AcidDietary SupplementsFatty Acid DesaturasesDietSeafoodPhospholipidsArachidonic AcidCorn Oilgamma-Linolenic AcidSoybean OilAnimal FeedLipidsEuphausiaceaFlaxLinoleoyl-CoA DesaturaseLipid MetabolismTriglyceridesMeatStearoyl-CoA DesaturaseChromatography, GasFishesLiverLipid PeroxidationAnimal Nutritional Physiological PhenomenaEicosanoidsSafflower OilHydrogenationSterol Regulatory Element Binding Protein 1Food AnalysisAdipose TissueTrans Fatty AcidsFood QualityRats, WistarDental FistulaFatty Acids, EssentialRandom AllocationDouble-Blind MethodFish ProductsDiet, High-FatVitamin ELinoleic AcidsCholesterolDental Pulp ExposureFatty Acid SynthasesButyrivibrioBody WeightCharadriiformesPrenatal Nutritional Physiological PhenomenaEggsDiet RecordsMice, Inbred C57BLTunaErythrocytesCross-Over StudiesErythrocyte MembraneLeukotrienesLipid Metabolism DisordersMembrane LipidsSwineRNA, MessengerLinoleic Acids, ConjugatedThiobarbituric Acid Reactive SubstancesEnergy IntakeInflammationLipogenesisMembrane MicrodomainsOxidation-ReductionPPAR alphaFood HabitsBiological MarkersOrgan SizeBody CompositionPeritoneal CavityVitamin E DeficiencyPregnancyDiet SurveysFatty LiverRats, Sprague-DawleyOleic AcidProstaglandinsWeight GainMilk, HumanTh1-Th2 BalanceBrainNutritive ValueFatty Acids, NonesterifiedMethylmercury Compounds
IntakeEicosapentaenoic acidArachidonicPUFAsPOLYUNSATURATED FATTYMUFALinoleicIntakesAlpha-LinoDefined polyunsaturatedCell membranesCholesterolLCPUFAInflammationMUFAsAminoOily fishSupplementationConcentrationsAntioxidantsAnti-inflammatoryAtherosclerosisDietsInflammatoryDecreasesMetabolism2017OxidationProteinsStructurallyCompositionLong-chainGeneMetabolicSubstancesMembraneDesaturaseFatty acid profilesProgressionRelationRatioEssential
Intake18
  • Erythrocytes, compared with plasma, are considered more robust markers of n-3 (ω-3) polyunsaturated fatty acid (PUFA) intake, because dietary-induced change in fatty acid (FA) composition takes longer to complete. (ox.ac.uk)
  • Relationship of estimated dietary intake of n-3 polyunsaturated fatty acids from fish with peripheral nerve function after adjusting for mercury exposure. (cdc.gov)
  • However, few epidemiological studies have examined the effect of dietary n-3 PUFA intake from fish consumption on peripheral nerve function, and none have controlled for co-occurrence of methylmercury exposure from fish consumption. (cdc.gov)
  • Objectives We evaluated the effect of estimated dietary n-3 PUFA intake on peripheral nerve function after adjusting for biomarkers of methylmercury and elemental mercury in a convenience sample of 515 dental professionals. (cdc.gov)
  • We estimated daily intake (mg/day) of the total n-3 PUFA, n-3 docosahexaenoic acid (DHA), and n-3 eicosapentaenoic acid (EPA) based on a self-administrated fish consumption frequency questionnaire. (cdc.gov)
  • We found no consistent association between n-3 PUFA intake and sensory nerve conduction after adjusting for mercury concentrations in hair and urine although some positive associations were observed with the sural nerve. (cdc.gov)
  • Omega-3 fatty acid intake during pregnancy and risk. (cambridge.org)
  • Intake of omega-3 polyunsaturated fatty acids (PUFAs) has favorable effects, including reducing violent and aggressive behaviors, but its association with infant maltreatment is unknown. (cambridge.org)
  • Omega-3 PUFA intake during pregnancy was measured using a food frequency questionnaire. (cambridge.org)
  • Increasing PUFA intake is a common intervention for improving markers of male fertility. (nutraingredients-usa.com)
  • It's exciting to explore if eating fattier seafood could lead to increased PUFA intake and slower CKD progression. (medicalnewstoday.com)
  • This article at a glance This pilot study evaluated the concept that stratification of study participants can be useful for improving interpretations of the relationship between long-chain polyunsaturated fatty acid (LCPUFA) intake and biological effect. (fatsoflife.com)
  • Evaluation of RBC fatty acid content has become increasingly favored as a measure of n-3 polyunsaturated fatty acids (PUFA) intake. (cdc.gov)
  • If we also assume the recommended intake of 0.65g/d of EPA and DHA, plus an average of 2.35g/d of ALA (1.06% of calories), that's a total of 3g/d of n-3 fatty acid intake. (thehealthyskeptic.org)
  • In 207 men without hypertension, 175 men with hypertension, 406 women without hypertension and 232 women with hypertension, the risk of hypertension was positively and independently associated with the intake of cooking oil polar compounds (read polyunsaturated oils), and inversely related to blood levels of monounsaturated fatty acids (read primarily olive oil). (digitalnaturopath.com)
  • Higher intake of long-chain omega-3 polyunsaturated fatty acids (PUFA) was also inversely associated with risk of hearing loss. (worldhealth.net)
  • The study authors conclude that: "Regular fish consumption and higher intake of long-chain omega-3 [polyunsaturated fatty acids] are associated with lower risk of hearing loss in women. (worldhealth.net)
  • C-reactive protein level had a significant association with body mass index ( r = 0.18), adiposity ( r = 0.23), smoking ( r = 0.20), carbohydrate intake ( r = 0.19) and saturated fatty acid ( r = 0.20). (who.int)
Eicosapentaenoic acid7
  • The n-3 polyunsaturated fatty acids (PUFA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are found in high proportions in oily fish and fish oils. (nih.gov)
  • However, supplementation with eicosapentaenoic acid (EPA)/docosahexaenoic acid (DHA) omega 3 fatty acids have been studied in controlled trails (RCTs). (nutraingredients-usa.com)
  • The researchers found this protective association with three individual omega-3s from seafood, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and docosapentaenoic acid (DPA). (medicalnewstoday.com)
  • This article at a glance This study reports that the coagulation of blood leads to the formation of arachidonic acid (AA)-, eicosapentaenoic acid (EPA)- and docosahexaenoic acid (DHA)-derived specialized proresolving mediators (SPMs) that promote microbial clearance. (fatsoflife.com)
  • EPA ( eicosapentaenoic acid ) and DHA ( docosahexaenoic acid ) are considered the optimum movers and shakers for omega-3 health benefits. (naturalnews.com)
  • Amarin's synthetic ethyl eicosapentaenoic acid (EPA), icosapent ethyl ( Vascepa ), was given the FDA nod 2 years ago, and Lovaza (GlaxoSmithKline), which contains a combination of ethyl esters of omega 3 fatty acids, principally EPA and docosahexaenoic acid (DHA), has been available for the same indication for a number of years. (medscape.com)
  • The 2021 OMEMI trial (Omega-3 Fatty acids in Elderly with Myocardial Infarction) was a randomized clinical trial in which 1027 patients aged 70 to 82 years with recent (2 to 8 weeks) acute myocardial infarction were treated with 1.8 g of n-3 polyunsaturated fatty acids (PUFA) (930 mg eicosapentaenoic acid and 660 mg docosahexaenoic acid) or placebo (corn oil) daily in addition to standard of care. (msdmanuals.com)
Arachidonic28
  • Arachidonic acid (AA, sometimes ARA) is a polyunsaturated omega-6 fatty acid 20:4(ω-6), or 20:4(5,8,11,14). (wikipedia.org)
  • Its name derives from the Neo-Latin word arachis (peanut), but peanut oil does not contain any arachidonic acid. (wikipedia.org)
  • Some chemistry sources define 'arachidonic acid' to designate any of the eicosatetraenoic acids. (wikipedia.org)
  • Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of membranes of the body's cells, and is abundant in the brain, muscles, and liver. (wikipedia.org)
  • Skeletal muscle is an especially active site of arachidonic acid retention, accounting for roughly 10-20% of the phospholipid fatty acid content typically. (wikipedia.org)
  • In addition to being involved in cellular signaling as a lipid second messenger involved in the regulation of signaling enzymes, such as PLC-γ, PLC-δ, and PKC-α, -β, and -γ isoforms, arachidonic acid is a key inflammatory intermediate and can also act as a vasodilator. (wikipedia.org)
  • Arachidonic acid is not one of the essential fatty acids. (wikipedia.org)
  • However, it does become essential if a deficiency in linoleic acid exists or if an inability to convert linoleic acid to arachidonic acid occurs. (wikipedia.org)
  • Some mammals lack the ability or have a very limited capacity to convert linoleic acid to arachidonic acid, making it an essential part of their diets. (wikipedia.org)
  • As linoleic acid consumption does not seem to affect levels of arachidonic acid in plasma/serum or erythrocytes, it is uncertain if humans can in fact convert linoleic acid to arachidonic acid. (wikipedia.org)
  • A commercial source of arachidonic acid has been derived, however, from the fungus Mortierella alpina. (wikipedia.org)
  • Arachidonic acid is freed from phospholipid by hydrolysis, catalyzed by the phospholipase A2 (PLA2). (wikipedia.org)
  • Arachidonic acid for signaling purposes appears to be derived by the action of group IVA cytosolic phospholipase A2 (cPLA2, 85 kDa), whereas inflammatory arachidonic acid is generated by the action of a low-molecular-weight secretory PLA2 (sPLA2, 14-18 kDa). (wikipedia.org)
  • Arachidonic acid is a precursor to a wide range of eicosanoids: The enzymes cyclooxygenase-1 and -2 (i.e. prostaglandin G/H synthase 1 and 2 {PTGS1 and PTGS2}) convert arachidonic acid to prostaglandin G2 and prostaglandin H2, which in turn may be converted to various prostaglandins, to prostacyclin, to thromboxanes, and to the 17-carbon product of thromboxane metabolism of prostaglandin G2/H2, 12-Hydroxyheptadecatrienoic acid (12-HHT). (wikipedia.org)
  • The enzyme 5-lipoxygenase catalyzes the oxidation of arachidonic acid to 5-hydroperoxyeicosatetraenoic acid (5-HPETE), which in turn converts to various leukotrienes (i.e., leukotriene B4, leukotriene C4, leukotriene D4, and leukotriene E4 as well as to 5-hydroxyeicosatetraenoic acid (5-HETE) which may then be further metabolized to 5-HETE's more potent 5-keto analog, 5-oxo-eicosatetraenoic acid (5-oxo-ETE) (also see 5-Hydroxyeicosatetraenoic acid. (wikipedia.org)
  • The enzyme 12-lipoxygenase (ALOX12) catalyzes oxidation of arachidonic acid to 12-hydroperoxyeicosatetraenoic acid (12-HPETE), which may then be metabolized to 12-hydroxyeicosatetraenoic acid (12-HETE) and to hepoxilins. (wikipedia.org)
  • Arachidonic acid is also a precursor to anandamide. (wikipedia.org)
  • Some arachidonic acid is converted into hydroxyeicosatetraenoic acids (HETEs) and epoxyeicosatrienoic acids (EETs) by epoxygenase. (wikipedia.org)
  • Typically, human inflammatory cells contain high proportions of the n-6 PUFA arachidonic acid and low proportions of n-3 PUFA. (nih.gov)
  • The significance of this difference is that arachidonic acid is the precursor of 2-series prostaglandins and 4-series leukotrienes, which are highly-active mediators of inflammation. (nih.gov)
  • Feeding fish oil results in partial replacement of arachidonic acid in inflammatory cell membranes by EPA. (nih.gov)
  • This change leads to decreased production of arachidonic acid-derived mediators. (nih.gov)
  • This action might come about through antagonism of the effects of arachidonic acid-derived mediators or through more direct actions on the intracellular signalling pathways which lead to activation of transcription factors such as nuclear factor kappa B (NFB). (nih.gov)
  • 18:3n6) increased in all lipid fractions after hempseed oil, with no significant increases of arachidonic acid (20:4n6) in any lipid fractions after either oil. (researchgate.net)
  • hempseed oil, with no significant increases of arachidonic acid (20:4n6) in any lipid fractions after either oil. (researchgate.net)
  • 5 ) It even suppresses the formation of arachidonic acid, which could help improve inflammatory skin conditions such as atopic dermatitis and psoriasis. (chriskresser.com)
  • 2013. Novel liquid chromatography-mass spectrometry method shows that vitamin E deficiency depletes arachidonic and docosahexaenoic acids in zebrafish (Danio rerio) embryos. . (oregonstate.edu)
  • This enzyme, encoded by CYP2J2 gene, metabolizes ARACHIDONIC ACID to epoxyeicosatrienoic acids (EETs) which produce biological effects including VASODILATION. (bvsalud.org)
PUFAs5
  • Compare HF meals rich in either monounsaturated fatty acids (MUFAs), polyunsaturated fatty acids (PUFAs), or saturated fatty acids (SFAs) on the satiety hormone, peptide YY (PYY), and subjective feelings of hunger and fullness. (nih.gov)
  • Another class of biomolecules of nutritional value from macroalgae is the essential ω3 fatty acids, which are composed of long-chain PUFAs. (scirp.org)
  • Hempseed oil is a rich and balanced source of omega-6 and omega-3 polyunsaturated fatty acids (PUFAs). (researchgate.net)
  • The researchers analyzed data from 19 studies from 12 countries to assess the association between long-chain omega-3 polyunsaturated fatty acids (n-3 PUFAs) and CKD. (medicalnewstoday.com)
  • Olive oil also contains saturated fatty acids (8-14%), polyunsaturated fatty acids ( PUFAs at 4-20%), and other important minor constituents, particularly antioxidants , such as vitamin E and polyphenols. (digitalnaturopath.com)
POLYUNSATURATED FATTY20
  • The grass-legume mixture decreases the total concentration of unsaturated fatty acids in meat without influencing the concentration of polyunsaturated fatty acids. (scielo.br)
  • Background: Some clinical studies have suggested that ingestion of n-3 polyunsaturated fatty acids (PUFA) has neuroprotective effects on peripheral nerve function. (cdc.gov)
  • Changes in dietary fatty acids, specifically the polyunsaturated fatty acids of the ω-3 and ω-6 families and some derived eicosanoids from lipoxygenases, cyclooxygenases, and cytochrome P-450, seem to control the activity of transcription factor families involved in cancer cell proliferation or cell death. (springer.com)
  • Role of dietary polyunsaturated fatty acids (PUFA) on tumorigenesis. (springer.com)
  • Polyunsaturated fatty acids and inflammation. (springer.com)
  • Cytochrome p450-dependent metabolism of ω-6 and ω-3 long-chain polyunsaturated fatty acids. (springer.com)
  • Epidemiological studies suggest that diets rich in omega-3 polyunsaturated fatty acids reduce cancer incidence. (jci.org)
  • Our data suggest that modulation of prostate cancer development by polyunsaturated fatty acids is mediated in part through Bad-dependent apoptosis. (jci.org)
  • In this study, the contents of nutritional compounds from nine common North Atlantic red macroalgae were compared: the lipid content was low and constant among the species, whereas the fatty acid profiles indicated that these species constitute interesting sources of polyunsaturated fatty acids (PUFA). (scirp.org)
  • A large family of lipids from the category of polyunsaturated fatty acids, also called essential fatty acids, which play a great role against skin hypersensitivity and dryness, inflammation and also have antioxidant properties. (isolee.com)
  • This article at a glance This prospective multi-ethnic cohort study has examined the relationships between various polyunsaturated fatty acids in plasma phospholipids with the development of atherosclerosis over a 10 year period in adults that were free of cardiovascul. (fatsoflife.com)
  • Free radicals attack the polyunsaturated fatty acids (PUFA) in the cell membranes of tissues. (preparedfoods.com)
  • Essential FA, mainly polyunsaturated fatty acids (PUFA), may modulate gene expression in diverse biological processes thought regulating transcription factors (TF), including peroxisome proliferator receptors (PPAR) , liver X receptors (LXR) , and sterol regulatory element-binding proteins ( SREBP ) 3 . (nature.com)
  • In the last decade, it has been shown that metformin, thiazolidinediones, vitamin E, ezetimibe, n-3 polyunsaturated fatty acids, renin-angiotensin system (RAS) blockers, and antiobesity drugs may improve hepatic pathophysiological disorders as well as clinical parameters. (hindawi.com)
  • Selection efforts focused on adaptation to plant-based diets, particularly the ability to synthesize polyunsaturated fatty acids (PUFA), are now emerging in aquaculture. (usda.gov)
  • N-3 polyunsaturated fatty acids (n-3 PUFA) are natural antioxidants that influence cell signaling and inflammation. (academicjournals.org)
  • Women with preterm infants showed breast milk long chain polyunsaturated fatty acids concentrations consistent with worldwide levels and a high ratio of linoleic acid to alpha-linolenic acid that might be beneficial for language development in the premature infant. (bvsalud.org)
  • The third trimesters of gestation is a vulnerable period for nutritional insults, such as essential fatty acids (EFA) and long chain polyunsaturated fatty acids (LCPUFA), necessary for optimal development of the central nervous system (CNS) and organ membranes 4 . (bvsalud.org)
  • A cytochrome P450 enzyme involved in oxidizing POLYUNSATURATED FATTY ACIDS (PUFA) to PUFA epoxides which function as potent lipid mediators. (bvsalud.org)
  • Among these signaling lipids, a particular group of oxygenated polyunsaturated fatty acids (PUFA), so called lipid mediators, has been thoroughly investigated over several decades. (cdc.gov)
MUFA4
  • 0.05) for the MUFA-rich meal (MUFA: 534.5±27.2 pg/mL/5 h) vs. the SFA-rich or PUFA-rich meals (SFA: 607.3±51.6 pg/mL/5h, PUFA: 633.1±35.8 pg/mL/5 h). (nih.gov)
  • Six saturated FA (SFA), four monounsaturated FA (MUFA), and eleven polyunsaturated FA (PUFA) (21 FA in total) are measured using selected ion monitoring. (cdc.gov)
  • Its oils are rich sources of unsaturated fatty acids, such as monounsaturated (MUFA) and polyunsaturated (PUFA) fatty acids, which are previously associated with the prevention of health disorders because of their anti-inflammatory effects and cell membrane properties and structure 2 . (nature.com)
  • The major fatty acid of olive oil is oleic acid, a monounsaturated fatty acid ( MUFA ) constituting 55-83% of total fatty acids . (digitalnaturopath.com)
Linoleic4
Intakes7
  • Plasma and erythrocyte fatty acids reflect intakes of saturated and n-6 PUFA within a similar time frame. (ox.ac.uk)
  • The extent to which this applies to intakes of saturated fatty acid (SFA) or n-6 PUFA is unclear. (ox.ac.uk)
  • These results suggest plasma and erythrocyte FAs reflect intakes of SFA and n-6 PUFA over a similar period of time. (ox.ac.uk)
  • Results: The estimated median intakes of total n-3 PUFA, n-3 EPA, and n-3 DHA were 447, 105, and 179 mg/day, respectively. (cdc.gov)
  • Studies going back 50 years have shown that people who eat at least two portions of fish a week, or who have optimal intakes of long-chain omega 3 fatty acids (e.g. (hsis.org)
  • As oily fish intakes are so low in the UK, an omega-3 supplement is a practical way to increase intakes to recommended levels and ensure we benefit from these important fatty acids. (hsis.org)
  • It's likely that the success and failure of different clinical trials using similar doses of EPA and DHA were influenced by differing background intakes of the n-6 fatty acids. (thehealthyskeptic.org)
Alpha-Lino2
  • The role of the major plant-derived n-3 PUFA, alpha-linolenic acid (ALA), on the risk of atherosclerotic cardiovascular (ASCVD) remains unclear, but most studies have reported no association. (aau.dk)
  • Plant-derived omega-3s, such as alpha-linolenic acid (ALA), which is found mainly in nuts and seeds, had no effect on CKD risk. (medicalnewstoday.com)
Defined polyunsaturated1
  • To determine the influence of fatty acids on prostate cancer risk in animals with a defined genetic lesion, we used prostate-specific Pten-knockout mice, an immune-competent, orthotopic prostate cancer model, and diets with defined polyunsaturated fatty acid levels. (jci.org)
Cell membranes2
  • 2002). The Omega-3 Index is a measure of EPA (C20:5 n-3) and DHA (C22:6 n-3) in the blood, and expressed as a percent of 21 fatty acids, in specifically the red blood cell membranes (Harris, et al. (cdc.gov)
  • Special attention has been focused on PUFA, specifically LA and ALA, given their functions of maintaining cell membranes under normal conditions, as well as their brain functions and the transmission of nerve impulses 2 , 4 . (nature.com)
Cholesterol2
  • Uptake of long chain fatty acids is regulated by dynamic interaction of FAT/CD36 with cholesterol/sphingolipid enriched microdomains (lipid rafts). (springer.com)
  • Monounsaturated fatty acids - as contained in olive oil - reduce total and LDL cholesterol concentrations without reducing the levels of HDL cholesterol, thus leading to favorable changes in the serum lipid profile and possibly to changes in the physico-chemical properties of lipoproteins. (digitalnaturopath.com)
LCPUFA1
  • Long-chain PUFA of the n-6 and n-3 series in liver TAG, AA/LA ratio, EPA + DHA)/ALA in liver TAG, n-3 LCPUFA in phospholipids, total PUFA, n-3 PUFA, n-6 PUFA, AA, EPA, DHA. (wjgnet.com)
Inflammation2
MUFAs2
  • MUFAs, palmitoleic acid (16:1 n9), and oleic acid (18:1 n9) in NASH compared to control group. (wjgnet.com)
  • However, evidence suggests that the multiple components of the Mediterranean diet, i.e. low saturated fatty acids (SFAs), high monounsaturated fatty acids (MUFAs), and carbohydrate, fiber, and micronutrient content have favorable blood pressure effects, and therefore that this diet is desirable for health. (digitalnaturopath.com)
Amino9
  • In non-pregnant populations, certain distinct serum metabolites, such as the levels of branched-chain amino acids (BCAAs), as well as those of phenylalanine, glutamate and several lipids, have been associated with an elevated risk of type 2 diabetes (Long et al. (springer.com)
  • The dominating essential and non-essential amino acids were lysine and leucine, aspartic acid, glutamic acid, and arginine, respectively. (scirp.org)
  • The amino acid score of the nine algae varied from 44% to 92%, the most commonly first limiting amino acid being histidine. (scirp.org)
  • Omega-3 rich oil and an interesting amino acids profile were detected in the seeds as well as the presence of a high content of polyphenolic compounds, including two structurally new compounds (phenylpropane derivatives) which were isolated and structurally characterized. (ac.be)
  • Natural Collagen Amino Acids in their free form: selected for their great capacity to moisturize and reduce natural moisture loss, thus helping to hydrate the skin. (isolee.com)
  • The Recommended Dietary Allowance (RDA) for sulphur-containing amino acids (precursors to glutathione) is 1.1 g/day for women and 1.4 g/day for men, which is equivalent to 2.7 and 3.3g of glutathione/day. (preparedfoods.com)
  • Some 99% of Americans consume above this recommendation for sulphur-containing amino acids. (preparedfoods.com)
  • Therefore, supplementation with amino acids and N-acetylcysteine to increase glutathione in the body will likely only benefit individuals that do not consume enough of these amino acids or who are under oxidative stress. (preparedfoods.com)
  • Existing studies have confirmed that ferroptosis involves the metabolisms of the Fe, lipids, amino acid, each mechanism is mutually independent but interrelated, and they are formed a complex regulatory network. (frontiersin.org)
Oily fish2
  • The key dietary source of omega 3 fatty acids is oily fish. (hsis.org)
  • The important implication from our study is that adequate consumption of seafood and oily fish (where most such blood omega-3 fatty acids come from) may help to prevent or delay the development of chronic kidney disease. (medicalnewstoday.com)
Supplementation3
  • Plus, a recently updated meta-analysis of 40 studies with a combined total of 135,267 participants [2] found that supplementation with omega-3 fatty acids was associated with a 13% reduction in risk of heart attack, a 10% risk reduction in CHD events, a 35% risk reduction in fatal heart attack and a 9% risk reduction in CHD death. (hsis.org)
  • Clinical studies have reported that oral fish oil supplementation has beneficial effects in rheumatoid arthritis and among some patients with asthma, supporting the idea that the n-3 PUFA in fish oil are anti-inflammatory. (nih.gov)
  • Omega-3 fatty acid supplementation and cardiovascular disease. (oregonstate.edu)
Concentrations1
  • Omega-3 fatty acid concentrations in red blood cells were linked with brain structure and cognitive function in midlife, an exploratory cross-sectional study showed. (justcarehealth.com)
Antioxidants2
  • Natural source of antioxidants (squalene and vitamin E), it is also rich in phytosterols with anti-inflammatory action and essential fatty acids, resulting in an extremely rich oil to reinforce the protective lipid barrier of the skin. (isolee.com)
  • From the collected findings, the review provides preconceptual guidelines for men based upon a Mediterranean diet high in omega 3 fatty acids, antioxidants, vitamins and minimally processed foods and minimising exposure to environmental pollutants and radiation. (nutraingredients-usa.com)
Anti-inflammatory2
  • This response alone is a potentially beneficial anti-inflammatory effect of n-3 PUFA. (nih.gov)
  • The two compounds described here for the first time, were named amolsamic acids A&B. The seeds and amolsamic acids showed an interesting antioxidant potential, and a strong anti-inflammatory activity on neutrophils, MPO and HRP models. (ac.be)
Atherosclerosis1
  • In this way, olive oil with its high monounsaturated fatty acid content may contribute to the prevention and management of hypercholesterolaemia, a dominant risk factor for the development of atherosclerosis, and to the prevention of CHD. (digitalnaturopath.com)
Diets3
  • We compared the pattern of change over time in the fatty acid composition of plasma, erythrocyte, buccal cell, and adipose tissue lipids when changing between diets high in SFA or n-6 PUFA. (ox.ac.uk)
  • An increased proportion of omega (n)-6:n-3 PUFA, which is observed typically in Western diets, leads to a wide range of pathologies, such as cardiovascular, inflammatory, autoimmune, and diabetic diseases. (nature.com)
  • Western diets typically are low in omega-3 fatty acids. (msdmanuals.com)
Inflammatory2
  • Effect of dietary fatty acids on inflammatory gene expression in healthy humans. (springer.com)
  • Previous studies already demonstrated that some fatty acids are linked with inflammatory response, preventing metabolic diseases. (nature.com)
Decreases1
  • Vitamin E deficiency decreases long-chain PUFA in zebrafish (Danio rerio). (oregonstate.edu)
Metabolism3
  • Knowledge of the mechanisms by which fatty acids control specific gene expression may identify important risk factors for cancer and provide insight into the development of new therapeutic strategies for a better management of whole body lipid metabolism. (springer.com)
  • 2011. Fatty acid regulation of hepatic lipid metabolism. . (oregonstate.edu)
  • GL) may differ from the commercial Saint John River (SJR) strain in terms of PUFA metabolism. (usda.gov)
20171
  • 2017. Docosahexaenoic acid blocks progression of western diet-induced nonalcoholic steatohepatitis in obese Ldlr-/- mice. . (oregonstate.edu)
Oxidation1
  • PUFA oxidation occurs via a free radical chain mechanism that proceeds through several stages leading to a series of complex chemical changes. (preparedfoods.com)
Proteins2
  • Membrane proteins implicated in long-chain fatty acid uptake by mammalian cells: CD36, FATP and FABPm. (springer.com)
  • PUFA alter membrane physical characteristics and the activity of membrane-bound proteins. (cdc.gov)
Structurally2
  • It is structurally related to the saturated arachidic acid found in cupuaçu butter. (wikipedia.org)
  • The n-3 PUFA are structurally and functionally distinct from the n-6 PUFA. (nih.gov)
Composition5
  • however, the pentadecanoic acid composition of buccal cell lipids did not differ between the diet periods. (ox.ac.uk)
  • To assess the quality of biodiesel produced, fatty acid methyl esters (FAME) composition was studied. (hindawi.com)
  • L'objectif de ce travail était d'étudier la composition des graines de P. vulgaris afin d'en déterminer non seulement le potentiel nutritionnel (teneur en lipides, protéines, minéraux), mais aussi la présence de métabolites spéciaux et d'en déterminer les pouvoirs antioxydant et anti-inflammatoire. (ac.be)
  • to study how the fatty acid composition of breast milk in breast-fed premature infants is associated with cognitive, language, and motor development. (bvsalud.org)
  • Fatty acid composition of breast milk samples from the first week postpartum was analyzed using gas-liquid chromatography. (bvsalud.org)
Long-chain1
  • This is why the European Food Safety Authority approved heart health claims for long chain omega-3 fatty acids) including the claim that omega-3s contribute to "the normal function of the heart", "normal triglycerides", and "normal blood pressure. (hsis.org)
Gene1
  • This article reviews the current knowledge and experimental research about the mechanisms by which fatty acids and their derivatives control specific gene expression involved during carcinogenesis. (springer.com)
Metabolic2
Substances1
  • The beneficial health effects of olive oil are due to both its high content of monounsaturated fatty acids and its high content of antioxidant substances. (digitalnaturopath.com)
Membrane3
  • Fatty acids specifically related to the anisotropic properties of plasma membrane from rat urothelium. (springer.com)
  • Dietary fatty acids and membrane protein function. (springer.com)
  • Dietary fatty acids (FA) are components of the lipids, which contribute to membrane structure, energy input, and biological functions related to cellular signaling and transcriptome regulation. (nature.com)
Desaturase1
  • Introducing an omega-3 desaturase, which converts omega-6 to omega-3 fatty acids, into the Pten-knockout mice reduced tumor growth similarly to the omega-3 diet. (jci.org)
Fatty acid profiles3
  • Fatty acid profiles were measured in plasma triglyceride, cholesteryl and phospholipid fractions. (researchgate.net)
  • Dietary hempseed oil caused significant changes in plasma fatty acid profiles and improved clinical symptoms of atopic dermatitis. (researchgate.net)
  • changes in plasma fatty acid profiles and improved clinical symptoms of atopic dermatitis. (researchgate.net)
Progression1
  • We found that omega-3 fatty acids reduced prostate tumor growth, slowed histopathological progression, and increased survival, whereas omega-6 fatty acids had opposite effects. (jci.org)
Relation1
  • In response to the findings of a new clinical trial [1] regarding the high-dose omega-3 fatty acids, EPA and DHA, in relation to heart health outcomes, Dr Carrie Ruxton, dietitian from the health & Food Supplements Information Service notes: "This latest clinical trial does not provide information on the potential benefits of omega-3 fatty acids in lower doses, as recommended for the general population. (hsis.org)
Ratio1
  • The mixed grass with legumes presented a higher concentration of saturated fatty acids and saturated:unsaturated ratio in the meat. (scielo.br)
Essential7