JBC 2021 (PMID=34303708) and Munoz-Munoz et al. (cazy.org)
mBio 2021 (PMID=34340552) showing lyase activity on aLRha-1,4-aDGlcA. (cazy.org)
Cystathionine4
The enzyme that produces H2S, cystathionine γ-lyase (CSE), is decreased in rat mesenteric artery endothelial cells (EC) following in vivo IH exposure. (unboundmedicine.com)
The observations that IH exposure decreases NFATc3 activation and CSE-dependent vasodilation support a role for NFAT in regulating endothelial H2S production.NEW & NOTEWORTHY This study identifies the calcium-regulated transcription factor nuclear factor of activated T cells as a novel regulator of cystathionine γ-lyase (CSE). (unboundmedicine.com)
PMID 18701025 ] Relationship between cystathionine gamma-lyase gene polymorphism and essential hypertension in Northern Chinese Han population. (snpedia.com)
Hepatocellular cystathionine γ lyase/hydrogen sulfide attenuates nonalcoholic fatty liver disease by activating farnesoid X receptor. (nih.gov)
Argininosuccinate3
Argininosuccinate lyase (ASL) catalyzes the fourth reaction in this cycle, resulting in the breakdown of argininosuccinic acid to arginine and fumarate. (bomiprot.org)
1. O'Brien, W. E. and Barr, R. H. (1981) 'Argininosuccinate lyase: purification and characterization from human liver', Biochemistry, 20(7), pp. 2056-2060. (bomiprot.org)
2.Nagamani SC, Erez A, Lee B. Argininosuccinate lyase deficiency. (bomiprot.org)
Pseudomonas3
The Trichomonas rHCYase is selective for homocysteine with respect to very low cysteinase activity in contrast to the alpha,gamma-lyase from Pseudomonas putida, which has very high cysteinase activity with respect to homocysteine. (unipr.it)
OBJECTIVES: This study was aimed at evaluating the use of whole cells of Escherichia coli carrying recombinant Pseudomonas fluorescens benzaldehyde lyase as biocatalysts for 5-HMF carboligation, recovery of the C 12 derivatives DHMF and BHMF, and testing the. (lu.se)
OBJECTIVES: This study was aimed at evaluating the use of whole cells of Escherichia coli carrying recombinant Pseudomonas fluorescens benzaldehyde lyase as biocatalysts for 5-HMF carboligation, recovery of the C 12 derivatives DHMF and BHMF, and testing the reactivity of the carbonyl groups for hydrazone formation for potential use as cross-linking agents in surface coatings. (lu.se)
Deficiency2
Background: 3-hydroxy-3-methylglutaryl-coenzyme A lyase deficiency (HMGCLD) is an autosomal recessive disorder of ketogenesis and leucine degradation due to mutations in HMGCL. (h-brs.de)
Kurnaz E, Kartal Baykan E, Türkyılmaz A, Yaralı O, Yavaş Abalı Z, Turan S, Bereket A, Çayır A, Guran T. Genotypic Sex and Severity of the Disease Determine the Time of Clinical Presentation in Steroid 17α-Hydroxylase/17,20-Lyase Deficiency. (abdullahbereket.com)
Enzyme4
Tyrosine ammonia lyase (EC 4.3.1.23, L-tyrosine ammonia-lyase, TAL or Tyrase) is an enzyme in the natural phenols biosynthesis pathway. (wikipedia.org)
4-hydroxybenzoate and chloride are produced when the enzyme 4-chlorobenzoate dehalogenase acts on the halide bond of 4-chlorobenzoate with H2O (PMID: 6497878). (foodcomex.org)
The T. vaginalis and P. putida alpha,gamma-lyases readily separate on a phenyl-Sepharose 6 FF column with the T. vaginalis enzyme eluting first. (unipr.it)
Since the transfer is intramolecular, the reaction is an elimination and, hence, the enzyme is a lyase, belonging in EC 4. (enzyme-database.org)
Pathway1
In the first step of this pathway, chorismate lyase transforms chorismate into 4-hydroxybenzoate and pyruvate (PMID 1644758). (foodcomex.org)
Purification1
I. O- Phosphorylethanolamine phospho-lyase: partial purification and characterization. (qmul.ac.uk)
Substrate1
Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer. (unc.edu)
Protein1
The recombinant homocysteine alpha,gamma-lyase (rHCYase) is expressed as the major protein in the host E. coli cells. (unipr.it)
Phosphate2
Metabolism of ethanolamine and 1-aminopropan-2-ol in species of Erwinia and the roles of amino alcohol kinase and amino alcohol o- phosphate phospho-lyase in aldehyde formation. (qmul.ac.uk)
Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. (proteopedia.org)
Mechanisms2
Another major difference to the pectate and other polysaccharide lyase mechanisms, is that divalent metal ions are not required by PL4 for catalysis. (cazypedia.org)
In most other polysaccharide lyase mechanisms a proton donor has not been identified. (cazypedia.org)
Activity5
Has a beta-lyase activity that nicks DNA 3' to the lesion. (proteopedia.org)
Several members of the family show hydrolase activity catalyzed by a non-invariant active site on the posterior side of the b-propeller structure while the lyase active site on the anterior surface is well conserved and shows similarities to PL24 and PL25. (cazy.org)
Inactivating Mutations in Irc7p Are Common in Wine Yeasts, Attenuating Carbon-Sulfur β-Lyase Activity and Volatile Sulfur Compound Production. (yeastgenome.org)
4-Hydroxybenzoic acid has estrogenic activity and stimulated the growth of breast cancer cell lines (PMID: 16021681). (foodcomex.org)
T5 and T6 treated plants exhibited higher accumulation of total phenol content and increased activity of Phenylammonia lyase (PAL), Peroxidase (PO), Chitinase (Chi) and Polyphenol oxidase (PPO) as compared to control (T1) plants. (nih.gov)
Abasic1
Key Amino Acid Residues of Mitochondrial Transcription Factor A Synergize with Abasic (AP) Site Dynamics To Facilitate AP-Lyase Reactions. (nih.gov)
Escherichia1
Homocysteine alpha,gamma-lyase from the anaerobic protozoan parasite Trichomonas vaginalis has been cloned from genomic DNA using PCR methods and expressed in Escherichia coli with a vector containing the T7 promoter. (unipr.it)
Ammonia-lyase5
Tyrosine ammonia lyase (EC 4.3.1.23, L-tyrosine ammonia-lyase, TAL or Tyrase) is an enzyme in the natural phenols biosynthesis pathway. (wikipedia.org)
T A L {\displaystyle {\xrightarrow {TAL}}} + Ammonia + H+ L-tyrosine = trans-p-hydroxycinnamate + NH3 EC 4.3.1.24 (phenylalanine ammonia-lyase) EC 4.3.1.25 (phenylalanine/tyrosine ammonia-lyase) Louie GV, Bowman ME, Moffitt MC, Baiga TJ, Moore BS, Noel JP (December 2006). (wikipedia.org)
GapMind also includes two other pathways: an oxidative pathway via glucosaminate ammonia-lyase, and # a transmembrane transacetylase (NagX) pathway. (lbl.gov)
Glucosaminate is then taken up and converted to 2-keto-3-deoxygluconate by an # ammonia-lyase (EC:4.3.1.9) and phosphorylated (by kdgK) to enter the Entner-Doudoroff pathway. (lbl.gov)
Cheniany M, Ganjeali A. Developmental role of phenylalanine-ammonia-lyase (PAL) and cinnamate 4-hydroxylase(C4H) genes during adventitious rooting of Juglans regia L. microshoots[J]. Acta Biol Hung, 2016,67:379-392. (casb.org.cn)
Isocitrate lyase8
Aspergillus fumigatus does not require fatty acid metabolism via isocitrate lyase for development of invasive aspergillosis. (leibniz-hki.de)
Schöbel F, Ibrahim-Granet O, Avé P, Latgé JP, Brakhage AA, Brock M (2007) Aspergillus fumigatus does not require fatty acid metabolism via isocitrate lyase for development of invasive aspergillosis. (leibniz-hki.de)
Previous studies on pathogenic microorganisms, i.e., the bacterium Mycobacterium tuberculosis and the yeast Candida albicans, have revealed an essential role for isocitrate lyase in pathogenicity. (leibniz-hki.de)
In this study, we generated an isocitrate lyase deletion strain to test whether this strain shows attenuation in virulence. (leibniz-hki.de)
Results have revealed that isocitrate lyase from A. fumigatus is not required for the development of invasive aspergillosis. (leibniz-hki.de)
In a murine model of invasive aspergillosis, the wild-type strain, an isocitrate lyase deletion strain, and a complemented mutant strain were similarly effective in killing mice. (leibniz-hki.de)
Additionally, thin sections of lung tissue from patients with invasive aspergillosis stained with anti-isocitrate lyase antibodies remained negative. (leibniz-hki.de)
In the first step of this pathway, chorismate lyase transforms chorismate into 4-hydroxybenzoate and pyruvate (PMID 1644758). (foodb.ca)
It is also reported that the glucosaminate dehydratase has # some aldolase activity, producing glyceraldehye and pyruvate (PMID:7766176). (lbl.gov)
20191
3. Wei J, Leit S, Kuai J, Therrien E, Rafi S, Harwood Jr HJ, DeLaBarre B, Tong L. (2019) An allosteric mechanism for potent inhibition of human ATP-citrate lyase. (guidetopharmacology.org)
20001
Objetivo: describir la comparación de medidas de asociación, modelos estadísticos y grado de heterogeneidad en metanálisis de revisiones sistemáticas de intervenciones farmacológicas en cardiología, publicadas entre 2000-2005 y 2011-2016. (bvsalud.org)
Enzymes1
There are three human enzymes with HMG-CoA lyase activity that are able to synthesize ketone bodies in different subcellular compartments. (nih.gov)
Sequence1
And MetaCyc linked Q51969 (MONOMER-11695) from P. putida to ech, but the sequence shown in the paper ( PMID:12115060 , Fig. 3) is different. (lbl.gov)
Catalyzes1
The mitochondrial HMG-CoA lyase was the first to be described, and catalyzes the cleavage of 3-hydroxy-3-methylglutaryl CoA to acetoacetate and acetyl-CoA, the common final step in ketogenesis and leucine catabolism. (nih.gov)
Text1
Total count of NCBI Gene Reference Into Function hits for target listed in parenthesis, and summary table with links to publications per PMID with the specific text in article that includes the reported target. (nih.gov)