Results: Supplementation with resveratrol (2.0 μmol/L) not only improved the nuclear maturation but also raised the blastocyst rate of porcine embryos' PA from oocytes that underwent HS by increasing their glutathione (GSH) level, reducing reactive oxygen species (ROS) and up-regulating the expression of Sirtuin 1 (SIRT1). (sagepub.com)
Moreover, reduced NAD+ levels from excessive PARP-1 activity leads to reduced sirtuin 1 (SIRT1) activity, a protein involved in cellular health maintenance and aging. (nmn.com)
What's more, this all leads to reduced activity of an enzyme linked to longevity called sirtuin 1 (SIRT1) that maintains the integrity of our DNA and the health of our cells. (nad.com)
Enzymes4
A dual knockout (DKO) mouse line with deficiencies in carnitine acetyltransferase (CrAT) and sirtuin 3 (Sirt3), enzymes that oppose Kac by buffering the acetyl group pool and catalyzing lysine deacetylation, respectively, was developed to model extreme mitochondrial Kac in cardiac muscle, as confirmed by quantitative acetyl-proteomics. (mitophysiology.org)
NAD+-dependent enzymes called sirtuins modulate telomere length, and decreased NAD+ levels affect sirtuin activity and are associated with short telomeres that induce cell death. (nmn.com)
To maintain telomere length, enzymes that are dependent on NAD+ called sirtuins activate protective gene programs. (nad.com)
Cell-based Sirtuin/HDAC enzyme activity measurements revealed that endogenous Sirtuin/HDAC enzymes were reduced by 40% compared to control. (iyte.edu.tr)
10.10381
doi: 10.1038/425132a.PMID: 12968159 No abstract available. (linode.com)
Protein2
Sirtuin 4, also known as SIRT4, is a mitochondrial protein which in humans is encoded by the SIRT4 gene. (wikipedia.org)
SIRT4 is member of the mammalian sirtuin family of proteins, which are homologs to the yeast Sir2 protein. (wikipedia.org)
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. (linode.com)
Inhibitors1
TY - JOUR T1 - Benzimidazoles as new scaffold of sirtuin inhibitors: green synthesis, in vitro studies, molecular docking analysis and evaluation of their anti-cancer properties. (unboundmedicine.com)
10.11261
doi: 10.1126/science.300.5621.881a.PMID: 12738822 No abstract available. (linode.com)
Sirtuin-3 (SIRT3) is a class III lysine deacetylase that is localized to the mitochondria and regulates mitochondrial respiration and oxidative stress resistance enzymes such as superoxide dismutase-2 (SOD2). (nih.gov)
Furthermore, NMN increases the activation of sirtuins (Sirt3 and Sirt6) - enzymes that use NAD+ as fuel, associated with improving antioxidant capacity and reducing inflammation. (nmn.com)
SIRT14
A5: Phosphorylation at S47 by mTOR causes the inhibition of SIRT1 (PMID: 21471201). (nih.gov)
association with SENP1, a nuclear desumoylase, reduces the activity of SIRT1 in response to genotoxic stress (PMID: 17934453). (nih.gov)
A9: Methylation of SIRT1 by Set7/9 at K233, K235, K236, and K238 inhibits the SIRT1-mediated deacetylation of p53 (PMID: 21245319). (nih.gov)
NAD-dependent protein deacetylase sirtuin-1 (SIRT1) was added to StoneMod database. (stonemod.org)
Activation of sirtuins1
Cell-type and context-specific activation of sirtuins increases resistance to metabolic, oxidative, and hypoxic stress in different tissues. (nih.gov)
Pathways5
Here, we review sirtuin biology and discuss how CR-triggered sirtuin-dependent pathways affect renal physiology and the pathogenesis of kidney diseases and related disorders. (nih.gov)
FUdR-induced hypertonic stress resistance was partially dependent on sirtuins and base excision repair (BER) pathways, while FUdR-induced lifespan extension under hypertonic stress conditions requires DAF-16, BER, and sirtuin function. (crsociety.org)
Enzymes called sirtuins, which control several biological pathways, are known to play a role in aging. (nih.gov)
A compound called nicotinamide adenine dinucleotide (NAD + ), which regulates key signaling pathways in the cell, is known to interact with sirtuins and declines with age. (nih.gov)
First, synthesis of NAD+ requires the use ATP by Na/NMNATs in both the de novo and salvage pathways (PMID: 16959969). (nih.gov)
SIRT42
Sirtuin 4, also known as SIRT4, is a mitochondrial protein which in humans is encoded by the SIRT4 gene. (wikipedia.org)
SIRT4 is member of the mammalian sirtuin family of proteins, which are homologs to the yeast Sir2 protein. (wikipedia.org)
Proteins3
Sirtuins (silent information regulator 2 [Sir2] proteins) belong to an ancient family of evolutionary conserved nicotinamide adenine dinucleotide (NAD)(+)-dependent enzymes with deacetylase and/or mono-ADP-ribosyltransferase activity. (nih.gov)
We have discussed elsewhere - click here - the crucial role of NAD in the performance of the sirtuins (say "sir-TWO-ins"), a family of proteins known as the longevity genes, which regulate cellular aging, as well as mitochondrial function and inflammation among other processes. (nutrioplongevity.com)
NAD+ plays key roles in transferring electrons for multiple metabolic reactions, and proteins called sirtuins rely on it for their capabilities in maintaining DNA integrity and metabolism. (ihealthworldwide.com)
10.10021
Genes Chromosomes Cancer 52(1):56-68, PMID: 22987659, 10.1002/gcc.22006. (nih.gov)
Mitochondrial1
In this chapter, we discuss the conserved mechanisms of aging that may underlie the changes observed in the aging brain, with a focus on mitochondrial function and oxidative stress, autophagy and protein turnover, insulin/IGF signaling, target of rapamycin (TOR) signaling, and sirtuin function. (qigonginstitute.org)
There are 18 HDAC enzymes in mammalian cells that can be sub-divided according to the presence of Zn2+-dependent (Class I, II and IV) or NAD+-dependent (Class III/Sirtuins) catalytic domains. (le.ac.uk)
Recent research by the group and others indicates that boosting the activity of the histone deacetylate enzymes known as sirtuins, via a combination of nicotinamide riboside (NR) and pterostilbene, has neuroprotective effects in ALS and may delay clinical disease progression. (neuro-sysmed.no)
SIR21
At least seven Sir2 homologs, sirtuins (SIRT) 1 to 7 have been identified in mammals. (nih.gov)
10.10931
Nucleic Acids Res 28(1):235-242, PMID: 10592235, 10.1093/nar/28.1.235. (nih.gov)
10.10562
N Engl J Med 366(3):243-249, PMID: 22168587, 10.1056/NEJMoa1110296. (nih.gov)
N Engl J Med 350(15):1505-1515, PMID: 15071125, 10.1056/NEJMoa031766. (nih.gov)
10.10971
Am J Ther 17(3):274-283, PMID: 20216208, 10.1097/MJT.0b013e3181c08081. (nih.gov)
HDACs1
Rössl A, Denoncourt A, Lin MS, Downey M . A synthetic non-histone substrate to study substrate targeting by the Gcn5 HAT and sirtuin HDACs. (academictree.org)
Nicotinamide3
Rössl A, Bentley-DeSousa A, Tseng YC, Nwosu C, Downey M . Nicotinamide Suppresses the DNA Damage Sensitivity of Saccharomyces cerevisiae Independently of Sirtuin Deacetylases. (academictree.org)
A71: Nicotinamide mononucleotide adenylyltransferase (NMNAT, EC 2.7.7.1) utilizes NMN and ATP to produce NAD+ and pyrophosphate (PPi) (PMID: 19403820). (nih.gov)
PMID: 19236849) helps to stimulate its deacetylation activity. (nih.gov)
Antioxidant1
Resveratrol is a polyphenol, which, in animal studies has been shown to decrease atherosclerosis, improve cardiovascular health and physical capacity, in part through its effects on Sirtuin 1 signaling and through an improved antioxidant capacity. (ironmagazine.com)
Regulation1
Acetylome profiling reveals overlap in the regulation of diverse processes by sirtuins, gcn5, and esa1. (academictree.org)
Article1
This corrects the article on p. 1968 in vol. 14, PMID: 36310707. (bvsalud.org)