The disease is typically seasonal, linked to the host-seeking activity of Ixodes ricinus (predominantly nymphs), the principal European tick vector species. (nih.gov)
Human granulocytic anaplasmosis ( HGA ) is a tick-borne , infectious disease caused by Anaplasma phagocytophilum , an obligate intracellular bacterium that is typically transmitted to humans by ticks of the Ixodes ricinus species complex, including Ixodes scapularis and Ixodes pacificus in North America. (mdwiki.org)
Other close relatives, members of the TBEV serocomplex, include Omsk hemorrhagic fever virus, Kyasanur Forest disease virus, Alkhurma virus, Louping ill virus and Langat virus. (wikipedia.org)
TBEV is a positive-sense single-stranded RNA virus, contained in a 40-60 nm spherical, enveloped capsid. (wikipedia.org)
TBEV in the blood of the host infects the tick through the midgut, from where it can pass to the salivary glands to be passed to the next host. (wikipedia.org)
In non-adult ticks, TBEV is transmitted transtadially by infecting cells that are not destroyed during molting, thus the tick remains infectious throughout its life. (wikipedia.org)
We aimed to identify the epidemiological and molecular characteristics of tick-borne encephalitis virus (TBEV) associated with fatal meningoencephalitis in Mongolia. (who.int)
Ticks collected from Selenge and Bulgan provinces were also tested for TBEV by RT-PCR. (who.int)
The closest relatives of this virus are Far-Eastern TBEV isolates. (who.int)
Infection of the vector begins when a tick takes a blood meal from an infected host. (wikipedia.org)
In humans, the infection begins in the skin (with the exception of food-borne cases, about 1% of infections) at the site of the bite of an infected tick, where Langerhans cells and macrophages in the skin are preferentially targeted. (wikipedia.org)
The symptoms of an infection range from subclinical to mild flu-like disease to lethal encephalitis. (helmholtz-hzi.de)
The infection rate of the parental and chimeric virus were evaluated in primary mouse neurons, astrocytes, mouse embryonic fibroblasts, and in vivo. (helmholtz-hzi.de)
Immunological scars after cure of hepatitis C virus infection: Long-HepC? (resist-cluster.de)
TBE virus infection is a risk for certain travelers and for laboratory workers who work with the virus. (cdc.gov)
This report summarizes the epidemiology of and risks for infection with TBE virus, provides information on the immunogenicity and safety of TBE vaccine, and summarizes the recommendations of the Advisory Committee on Immunization Practices (ACIP) for use of TBE vaccine among U.S. travelers and laboratory workers. (cdc.gov)
The most recognized clinical manifestation of TBE virus infection is acute neurologic disease, which usually results in hospitalization, often permanent neurologic or cognitive sequelae, and sometimes death. (cdc.gov)
2016) Zika virus infection in pregnant women in Barcelona, Spain. (vircell.com)
Recombinant feline leukemia virus (FeLV) variants establish a limited infection with altered cell tropism in specific-pathogen-free cats in the absence of FeLV subgroup A helper virus. (lookformedical.com)
Subsequent hematology and histology results were within normal limits, however, in the absence of detectable viremia, virus expression, or significant seroconversion, rFeLV proviral DNA was detected in bone marrow tissue of 4/4 (100%) cats at 45 weeks postinoculation (pi), indicating these rFeLVs established a limited but persistent infection in the absence of FeLV-A. Altered cell tropism was also noted. (lookformedical.com)
Clinically, HGA is essentially indistinguishable from human monocytic ehrlichiosis , the infection caused by Ehrlichia chaffeensis , and other tick-borne illnesses such as Lyme disease may be suspected. (mdwiki.org)
might be helpful for the prevention and/or treatment of the Corona virus infection. (edzardernst.com)
Flavivirus2
Tick-borne encephalitis (TBE) virus is a tickborne flavivirus that is focally endemic in a geographic region extending from western and northern Europe through to northern and eastern Asia ( 1 ). (cdc.gov)
Tick-borne encephalitis (TBE) is a serious acute neuroinfection of humans caused by a tick-borne flavivirus. (nih.gov)
20231
In May 2023, the U.S. Food and Drug Administration (FDA) approved two respiratory syncytial virus (RSV) vaccines (RSVPreF3 and RSVpreF) for the prevention of lower respiratory tract disease caused by RSV. (msdmanuals.com)
Pathogens3
DMT's mission is to study emerging and re-emerging viral pathogens that cause hemorrhagic fever, encephalitis and respiratory distress, with an aim of developing diagnostics, treatments, and vaccines. (nih.gov)
Anaplasma phagocytophilum shares its tick vector with other human pathogens, and about 10% of patients with HGA show serologic evidence of coinfection with Lyme disease , babesiosis , or tick-borne meningoencephalitis . (mdwiki.org)
Infections can be caused by a wide range of pathogens , most prominently bacteria and viruses . (wikipedia.org)
Exposure to ticks3
The key factors in the risk-benefit assessment for vaccination are likelihood of exposure to ticks based on activities and itinerary (e.g., location, rurality, season, and duration of travel or residence). (cdc.gov)
ACIP recommends TBE vaccine for U.S. persons who are moving or traveling to an area where the disease is endemic and will have extensive exposure to ticks based on their planned outdoor activities and itinerary. (cdc.gov)
The diagnosis of Lyme disease is based o nits symptoms, physical findings (e.g., the characteristic skin rash, which looks like a bull's eye), and a history of being in an area where exposure to ticks is possible. (scienceblogs.com)
In een vruchtbaarheidsonderzoek bij ratten zijn geen effecten gebleken op de vruchtbaarheid en de paring na intraperitoneale toediening van tazobactam [SKP Piperacilline/Tazobactam EG 04 2021]. (cybele.be)
De peri-/postnatale ontwikkeling was verstoord (verminderd gewicht van jonge dieren, verhoogd aantal doodgeboren dieren, verhoogde mortaliteit bij jonge dieren, toename van het aantal foetussen met vertraagde ossificatie en variatie in ribben) in combinatie met maternale toxiciteit na intraperitoneale toediening van tazobactam of de combinatie piperaczilline / tazobactam bij ratten [RCP Piperacilline/Tazobactam EG 04 2021]. (cybele.be)
De vruchtbaarheid van de F1-generatie (= eerste generatie) en de embryonale ontwikkeling van de F2-generatie (= jonge ratten geboren uit de eerste generatie) waren niet aangetast nadat verstoorde ontwikkeling was gezien tengevolge van het toedienen toxische doses van de combinatie piperacilline / tazobactam [SKP Piperacilline/Tazobactam EG 04 2021]. (cybele.be)
Hemorrhagic fever1
In Uganda, we focus on vector-borne diseases including Crimean-Congo hemorrhagic fever and Rift Valley fever. (nih.gov)
Tick-borne encephalitis (TBE) is a viral infectious disease that is transmitted by a bite from an infected tick and can progress to death. (who.int)
We found that the chimeric virus specifically infected primary neurons more efficiently compared to wild-type (WT) Torö and this correlated with enhanced pathogenicity and higher levels of viral RNA in vivo. (helmholtz-hzi.de)
The research objectives are to study the viral lifecycle and the virus-induced host responses to identify targets of intervention and to develop measures of prevention. (nih.gov)
Background and Objectives: The Wakayama prefecture is endemic for two types of tick-borne rickettsioses: Japanese spotted fever (JFS) and scrub typhus (ST). Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne hemorrhagic viral disease with a high mortality rate and is often difficult to differentiate from such rickettsioses. (referencecitationanalysis.com)
Persulcatus1
[6] In Europe, the I. ricinus is the main tick vector, and I. persulcatus is the currently known tick vector in Asia. (mdwiki.org)
Acute3
TBE virus can cause acute neurologic disease, which usually results in hospitalization, often permanent neurologic or cognitive sequelae, and sometimes death. (cdc.gov)
The outcome of epilepsia partialis continua is variable and is highly dependent on the underlying cause: seizures are more likely to remit in patients with stroke or other acute insults than in patients with chronic encephalitis. (medlink.com)
Many of his cases with epilepsia partialis continua in Siberia (Kozhevnikov was practicing in Moscow) had acute encephalitis, and a few had cysticercosis. (medlink.com)
Diseases1
Data on fatal TBE cases were documented by the National Center for Zoonotic Diseases (NCZD), which has registered tick-borne diseases since 2005. (who.int)
Incidence1
In Mongolia, the incidence and fatality rates of tick-borne encephalitis (TBE) have been increasing. (who.int)
Strains1
This page lists the EVAg products having been related to the scientific publication PMID 27548676 ( "Utilisation of ISA Reverse Genetics and Large-Scale Random Codon Re-Encoding to Produce Attenuated Strains of Tick-Borne Encephalitis Virus within Days" , PLoS ONE - 2016/08/22). (european-virus-archive.com)
Vaccine8
The envelope protein of tick-borne encephalitis virus influences neuron entry, pathogenicity, and vaccine protection. (helmholtz-hzi.de)
Stable and Highly Immunogenic MicroRNA-Targeted Single-Dose Live Attenuated Vaccine Candidate against Tick-Borne Encephalitis Constructed Using Genetic Backbone of Langat Virus. (helmholtz-hzi.de)
In addition, TBE vaccine may be considered for persons who might engage in outdoor activities in areas where ticks are likely to be found, with a decision to vaccinate made on the basis of an assessment of their planned activities and itinerary, risk factors for a poor medical outcome, and personal perception and tolerance of risk. (cdc.gov)
In the laboratory setting, ACIP recommends TBE vaccine for laboratory workers with a potential for exposure to TBE virus. (cdc.gov)
West Nile Virus planning the demonstration of vaccine efficacy. (cdc.gov)
DMT's main vaccine platform is the recombinant vesicular stomatitis virus (VSV) system. (nih.gov)
The first vaccine was a killed mumps virus vaccine developed in 1948 and used in the United States from 1950-1978. (en-academic.com)
A vaccine is a suspension of whole (live or inactivated) or fractionated bacteria or viruses rendered nonpathogenic. (msdmanuals.com)
Infections2
West Nile virus (WNV) infections with neutralizing antibody titers in US plasma-derived intravenous immune globulin titers (i.e., the reciprocal dilution of a 1:2 series resulting released during 2003-2008. (cdc.gov)
Arthropods such as ticks , mites , fleas , and lice , can also cause human disease, which conceptually are similar to infections, but invasion of a human or animal body by these macroparasites is usually termed infestation . (wikipedia.org)
Bites5
71.4% of deaths resulted from tick bites in Bulgan province. (who.int)
Tick bites occurred between April and June in forested areas. (who.int)
The case fatality rate differed between two provinces where tick bites occurred. (who.int)
All persons who travel to areas where TBE is endemic should be advised to take precautions to avoid tick bites and to avoid the consumption of unpasteurized dairy products because alimentary transmission of TBE virus can occur. (cdc.gov)
Hence, we hypothesize the apparent discrepancy between peak nymphal tick activity and greatest risk of contracting TBE is due to the effect of temperature on virus replication in the tick vector. (nih.gov)
In the US, I. scapularis is the tick vector in the East and Midwest states, and I. pacificus in the Pacific Northwest. (mdwiki.org)
Virology1
DMT's general work philosophy/strategy combines areas such as 'molecular biology', 'tissue culture', 'immunology' and 'animal models' with the goal to develop vaccines and therapeutics for emerging zoonotic viruses, the mission of the Laboratory of Virology, Division of Intramural Research (DIR) and NIAID. (nih.gov)
Species2
species ticks but can also be acquired less frequently by alimentary transmission. (cdc.gov)
All subsequent preparations have been live virus attenuated by multiple passages through animal cells of one or more species. (en-academic.com)
Blood meal from an infected1
[8] [9] A tick that has a blood meal from an infected reservoir becomes infected themselves. (mdwiki.org)
Endemic2
Tick-borne encephalitis (TBE) virus is focally endemic in parts of Europe and Asia. (cdc.gov)
The risk for exposure to infected ticks is highest for persons who are in areas where TBE is endemic during the main TBE virus transmission season of April-November and who are planning to engage in recreational activities in woodland habitats or who might be occupationally exposed. (cdc.gov)
Lethal1
[5] It is an enveloped RNA virus and is highly infectious and lethal. (mdwiki.org)
Subtype1
1 Reported case fatality rates (CFR) differ based on virus subtypes: 20-40% for the Far-Eastern subtype, 6-8% for the Siberian subtype and 1-2% for the European subtype. (who.int)
Symptoms1
If an infected tick then latches onto a human the disease is then transmitted to the human host and A. phagocytophilum symptoms can arise. (mdwiki.org)
20171
2017) Evaluación de un nuevo ensayo de quimioluminiscencia para la detección de anticuerpos IgM e IgG frente al virus dengue. (vircell.com)
Recombinant1
In vitro analysis of the recombinant FeLV-B-like viruses (rFeLVs) employed in this study confirmed these viruses were replication competent prior to their use in an in vivo study without FeLV-A helper virus. (lookformedical.com)
Hepatitis3
Structural insights into hepatitis C virus neutralization. (resist-cluster.de)
2018) Valoración de un nuevo ensayo quimioluminiscente en comparación con ELISA en la detección de IgG contra el virus de la hepatitis E. Revista de la Sociedad Andaluza de Microbiología y Parasitología Clínica. (vircell.com)
All travelers to India should be protected against hepatitis A (see Chapter 4 , Hepatitis A). Although some assume that those born in India would have been exposed to hepatitis A in childhood and thus be immune, this may no longer be true, particularly for younger people. (unboundmedicine.com)
Replication1
The data support the use of weather-based forecasts of tick attack risk (based on daytime ambient temperature) supplemented with weekly average temperature (as a proxy for virus replication) to provide much-needed real-time forecasts of TBE risk. (nih.gov)
Cases2
A time shift of 21 days between infected tick bite and recorded disease onset provided the optimal model for comparing the number of cases of TBE with numbers of questing nymphs. (nih.gov)
Mean annual distribution of TBE cases and tick counts showed a similar bimodal distribution. (nih.gov)
Vaccines1
Overall, our research activities are targeted towards a better understanding of virus biology and virus-induced host responses to foster the development of vaccines and therapeutics. (nih.gov)
Found1
These ticks are found in the US, Europe, and Asia. (mdwiki.org)