AnatomyChemicals and DrugsPhenomena and ProcessesInformation Science
ral Guanine Nucleotide Exchange Factorral GTP-Binding ProteinsGuanine Nucleotide Exchange Factorsrap GTP-Binding ProteinsRho Guanine Nucleotide Exchange Factorsras Guanine Nucleotide Exchange FactorsGuanine NucleotidesProto-Oncogene Proteins c-vavGuanosine Diphosphateras-GRF1cdc42 GTP-Binding ProteinGuanosine Triphosphaterac1 GTP-Binding Proteinras Proteinsrho GTP-Binding ProteinsADP-Ribosylation Factorsrac GTP-Binding Proteinsrap1 GTP-Binding ProteinsrhoA GTP-Binding ProteinGuanine Nucleotide-Releasing Factor 2GTPase-Activating ProteinsSOS1 ProteinGTP-Binding ProteinsADP-Ribosylation Factor 1GTP PhosphohydrolasesProtein Structure, TertiaryMolecular Sequence DataProtein BindingAmino Acid SequenceSignal TransductionSon of Sevenless ProteinsEukaryotic Initiation Factor-2Brab GTP-Binding ProteinsGuanineCOS CellsProteinsGuanine Nucleotide Dissociation InhibitorsSequence Homology, Amino AcidNucleotidesrab5 GTP-Binding ProteinsGTP-Binding Protein alpha Subunits, G12-G13MutationCoat Protein Complex IAdaptor Proteins, Signal Transducing
GEFsProteinsProteinProductsFibroblastKinaseTranscription factorMembranesDomain
GEFs1
  • All NSP proteins contain an NH 2 -terminal SH2 (Src homology domain 2) domain, a central proline/serine-rich domain, and a COOH-terminal domain with modest homology to Ras subfamily GDP-exchange factors (GEFs). (molvis.org)
Proteins6
  • Ras proteins are membrane-bound small GTPases that act as molecular transducers, coupling cell surface receptors to intracellular effector pathways to regulate cellular processes such as cell proliferation, differentiation, migration, and apoptosis [ 3 ] [ 4 ] . (encyclopedia.pub)
  • Ras proteins act as molecular switches that cycle between two conformational states: an active GTP-bound state and an inactive GDP-bound state. (encyclopedia.pub)
  • The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. (embl.de)
  • Regulators of small G-proteins like guanine nucleotide releasing factor GNRP (Ras-GRF) (which contains 2 PH domains), guanine nucleotide exchange proteins like vav, dbl, SoS and Saccharomyces cerevisiae CDC24, GTPase activating proteins like rasGAP and BEM2/IPL2, and the human break point cluster protein bcr. (embl.de)
  • Oxysterol binding proteins OSBP, S. cerevisiae OSH1 and YHR073w. (embl.de)
  • Several S. cerevisiae proteins involved in cell cycle regulation and bud formation like BEM2, BEM3, BUD4 and the BEM1-binding proteins BOI2 (BEB1) and BOI1 (BOB1). (embl.de)
Protein1
  • Mouse protein citron, a putative rho/rac effector that binds to the GTP-bound forms of rho and rac. (embl.de)
Products1
  • It also downplays the significant regulatory features that in-volve interactions between gene products, their local-ization, binding, posttranslational modification, degra-dation, etc. (pharmaceuticalintelligence.com)
Fibroblast3
  • 17. The chimeric protein tyrosine kinase ETV6-NTRK3 requires both Ras-Erk1/2 and PI3-kinase-Akt signaling for fibroblast transformation. (nih.gov)
  • Interestingly, although mTid-1 is found tyrosine-phosphorylated in v-src-transformed fibroblast cells, GAP selectively binds to the unphosphorylated form of mTid-1. (embl.de)
  • fibroblast growth factor receptor 2. (gsea-msigdb.org)
Kinase2
  • 12. The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue. (nih.gov)
  • 13. Hypoxic activation of nuclear factor-kappa B is mediated by a Ras and Raf signaling pathway and does not involve MAP kinase (ERK1 or ERK2). (nih.gov)
Transcription factor2
  • 15. Ras-Raf-Arf signaling critically depends on the Dmp1 transcription factor. (nih.gov)
  • ETS transcription factor ELK1 [Sour. (gsea-msigdb.org)
Membranes1
  • In immunofluorescence experiments, GAP and Tid-1 were shown to colocalize at perinuclear mitochondrial membranes in response to epidermal growth factor stimulation. (embl.de)
Domain2
  • 6. Blockade of RAS-Binding Domain Interactions Inhibits RAS Signaling. (nih.gov)
  • 9. Structure determination of the Ras-binding domain of the Ral-specific guanine nucleotide exchange factor Rlf. (nih.gov)