AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaInformation ScienceNamed GroupsHealth Care
Peripheral Blood Stem Cell TransplantationHematopoietic Stem Cell TransplantationTransplantation, AutologousTransplantation, HomologousHematopoietic Stem Cell MobilizationTransplantation ConditioningStem Cell TransplantationLeukapheresisHematologic NeoplasmsGraft vs Host DiseaseGranulocyte Colony-Stimulating FactorMelphalanAntigens, CD34Blood Component RemovalCombined Modality TherapyBone Marrow TransplantationGraft SurvivalCyclophosphamideHematopoietic Stem CellsBusulfanMultiple MyelomaMyeloablative AgonistsTreatment OutcomeAntineoplastic Combined Chemotherapy ProtocolsStem CellsCord Blood Stem Cell TransplantationTransplantation ChimeraRecurrenceTissue DonorsRemission InductionLymphoma, Non-HodgkinAntineoplastic Agents, AlkylatingEtoposideHistocompatibilityThiotepaPOEMS SyndromeWhole-Body IrradiationHistocompatibility TestingDisease-Free SurvivalInfectionTransplantation, IsogeneicImmunosuppressive AgentsVidarabineRetrospective StudiesHematopoiesisAmyloidosisSalvage TherapyLeukemiaIfosfamideBlood CellsSurvival RateVincristineSurvival AnalysisCarmustineCytarabineGraft vs Leukemia EffectHodgkin DiseaseLeukemia, Myeloid, AcutePlatelet CountTime FactorsBlood Cell CountMyelodysplastic SyndromesCytomegalovirus InfectionsAnemia, AplasticLymphomaCytophagocytosisLiver TransplantationLymphocyte DepletionLeukemia, Myelogenous, Chronic, BCR-ABL PositiveNeoplasmsFatal OutcomeFeasibility StudiesFollow-Up StudiesLivedo ReticularisHistiocytosis, Non-Langerhans-CellHematologic DiseasesBlood DonorsOpportunistic InfectionsDoxorubicinPrecursor Cell Lymphoblastic Leukemia-LymphomaCyclosporineBone MarrowHLA AntigensImmunophenotypingImmunosuppressionRecombinant ProteinsBone Marrow PurgingProspective StudiesMesenchymal Stem Cell TransplantationPilot ProjectsLymphoma, T-CellPrednisoneCarboplatinBone Marrow DiseasesAntigens, CDNeoplasm, ResidualPrognosisLeukocyte CountAntineoplastic AgentsBlood Group Incompatibility
HSCTMarrow transplantationChemotherapyDonorsPBSCTTransplantsMononuclear cellsDonorGranulocyte-macropOutcomesHigh-doseAllogeneic hematopoietic stem cRegimenPost-transplantationEngraftmentApheresisTransplantHematopoetic stemSurvivalPBSCsCyclophosphamideAbstractOncologyMobilization and collection2022Progenitor cellHaploidenticalHeart-transplantationSickle cell diDonor'sAplasticSafety and EfficacyHaematopoietic cellMultiple myeloma patientsDiffuse Large B-Autoimmune2020CentersUndergoUmbilical2021Bone marrow functionPatients with acuteCordAcuteLymphomaDonation2019CD34RituximabTherapeutic
HSCT19
  • Thus, we studied the safety, efficacy, and feasibility of transfer of gene modified donor T-cells shortly after allo-HSCT in two clinical trials between 2002 and 2007 and here we compare the results to unmodified donor leukocyte infusion (DLI). (frontiersin.org)
  • The aim of these trials was to provide patients with the protection of T-cells after T-cell-depleted allo-HSCT in the matched or mismatched donor setting with an option to delete transduced T-cells, if severe aGvHD occurred within the trial period. (frontiersin.org)
  • Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is applied successfully to the treatment of many hematopoietic malignancies, but remains limited by severe acute graft-versus-host-disease (aGvHD). (frontiersin.org)
  • Allogeneic hematopoietic stem cell transplantation (HSCT) remains the only curative therapy for sickle cell disease (SCD). (haematologica.org)
  • The purpose of this study was to investigate Karnofsky performance status (KPS) scores and visual analogue scale (VAS) scores to explain which domains in the standardized self-reported quality of life (QOL) are instrumental for long-term hematopoietic stem cell transplantation (HSCT) survivors. (bvsalud.org)
  • Background This study aimed to determine incidence of kidney complications in pediatric allogeneic hematopoietic stem cell transplantation (HSCT) patients. (hacettepe.edu.tr)
  • We report the national data on the outcomes of hematopoietic stem cell transplantation (HSCT) for thalassemia major (TM) patients in Turkey on behalf of the Turkish Pediatric Stem Cell Transplantation Group. (hacettepe.edu.tr)
  • Allogeneic hematopoietic stem cell transplantation (HSCT) is a potentially curative treatment for patients affected by Wiskott-Aldrich syndrome (WAS). (hacettepe.edu.tr)
  • Abstract Background: Allogeneic hematopoietic stem cell transplantation (HSCT) alters the diversity of the intestinal bacterial microbiota. (hacettepe.edu.tr)
  • Second-line chemotherapy regimens vary, depending on whether hematopoietic stem cell transplantation (HSCT) is being considered. (medscape.com)
  • This is a single arm pilot study using TCR alpha/beta+ T cell-depleted peripheral blood stem cells (PBSC) from closely matched unrelated donors or partially matched/haploidentical related donors for hematopoietic stem cell transplant (HSCT) in patients with acquired and inherited bone marrow failure (BMF) syndromes. (sparkcures.com)
  • Hematopoietic stem cell transplantation (HSCT) is a standard clinical practice for more than 50 years. (gov.rs)
  • Hematopoietic stem cell transplantation (HSCT) or Bone Marrow Transplantation (BMT) has significantly improved the survival rates of patients suffering from hematological malignancies. (lidsen.com)
  • Related HLA-haploidentical HSCT continues to be applied increasingly more recently however the reconstitution of T lymphocyte subsets and its own medical significance in patients received related HLA-haploidentical non T-cell depleted high-dose peripheral blood hematopoietic SCT (RHNT-PSCT) are incompletely described. (cancer-ecosystem.com)
  • The Hematopoietic stem cell transplantation (HSCT) is used in children as a definitive treatment for various oncological, immune deficiencies, hemoglobinopathy, and malignancies diseases that involve the hematological system, congenital metabolism disorders, among others. (bvsalud.org)
  • This is a quantitative, retrospective, observational, descriptive and analytical quantitative approach approaching the medical records of children and adolescents submitted to HSCT in a referral hospital service for this type of transplantation in the state of Rio Grande do Sul North (RN). (bvsalud.org)
  • The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. (bvsalud.org)
  • The profile of the clinical variables presented by the children and adolescents of this study shows that the most prevalent diagnosis was ALL, the most frequent toxicities were gastrointestinal, cardiac, respiratory and hematological, the most common HSCT was allogeneic peripheral blood and the greatest cause of mortality was sepsis. (bvsalud.org)
  • Hematopoietic stem cell transplantation not responded to other therapeutic modalities, with (HSCT) is used in children as a definitive treatment an increase in survival after transplantation, for different oncological, immune deficiencies, contributing to its use (YEILIPEK, 2014). (bvsalud.org)
Marrow transplantation9
Chemotherapy12
  • Stem cells can be destroyed through cancer treatments such as chemotherapy or radiation, as well as any blood-related diseases, such as leukemia, lymphoma, neuroblastoma and multiple myeloma. (wikipedia.org)
  • OUTLINE: Patients receive 2 courses of reinduction chemotherapy followed by bone marrow biopsy and aspirate prior to peripheral blood stem cell (PBSC) harvest. (knowcancer.com)
  • Purpose: To determine the tolerability and feasibility of double-cycle, high-dose chemotherapy followed by peripheral blood stem-cell transplantation (PBSCT) after conventional chemotherapy or chemoradiotherapy for small cell lung cancer (SCLC). (the-medical-dictionary.com)
  • Combination chemotherapy with cisplatin and etoposide (cisplatin-etoposide [PE]) has long been the mainstay of treatment for small cell lung cancer (SCLC). (the-medical-dictionary.com)
  • Phase II trial of induction chemotherapy of pemetrexed plus split-dose cisplatin followed by pemetrexed maintenance for untreated non-squamous non-small-cell lung cancer. (shengsci.com)
  • abstract： PURPOSE:We conducted a phase II trial to evaluate the efficacy and safety of induction chemotherapy of pemetrexed plus split-dose cisplatin followed by pemetrexed maintenance for advanced non-squamous non-small-cell lung cancer (NSCLC). (shengsci.com)
  • High-dose chemotherapy alongside peripheral blood stem cell (PBSC) infusion has become the standard of care in different hematologic malignancies. (uni-koeln.de)
  • The transplantation of ex vivo expanded mobilized peripheral blood haematopoietic stem cells (PBSC), in place of unmanipulated cells following high dose chemotherapy, reduces the period of cytopenia associated with the therapy's hemotoxicity. (edu.au)
  • To investigate effects of the preautografting administration of rituximab on the mobilization and engraftment of peripheral blood stem cells (PBSC), we retrospectively analyzed the outcomes of 43 newly diagnosed diffuse-large B-cell lymphoma patients who received CHOP chemotherapy with or without rituximab as a first-line treatment before autologous PBSC transplantation (PBSCT). (elsevierpure.com)
  • Chemotherapy and stem-cell transplantation in patients with multiple myeloma: a practice guideline of the Cancer Care Ontario Practice Guidelines Initiative. (cancertreatmenttoday.org)
  • All patients received multi-agent induction chemotherapy for 6 cycles, including an initial 2 cycles of high-dose cyclophosphamide plus topotecan followed by blood stem cell collection. (oncologynurseadvisor.com)
  • After completion of induction chemotherapy, patients were randomly assigned to receive a single autologous HCT with CEM (carboplatin, etoposide, melphalan) chemotherapy or a double/tandem autologous HCT with thiotepa plus cyclophosphamide prior to the first transplantation followed by a modified CEM regimen prior to the second. (oncologynurseadvisor.com)
Donors22
  • Transduced cells were transfused either after day +60 (matched donors) or on day +42 (haploidentical donors). (frontiersin.org)
  • PBSC donors are given a course of GCSF prior to PBSC collection. (wikipedia.org)
  • T cell preparation: Patients and donors undergo apheresis to obtain peripheral blood mononuclear cells (PBMCs), which are expanded in culture. (knowcancer.com)
  • Approximately 70% of patientswith life-threatening diseasestreatable with allogeneic bloodstem cell transplantation do not havematched related donors. (cancernetwork.com)
  • The NMDP performs thistask by maintaining a registry of morethan 4.9 million volunteer donors ofmarrow and peripheral blood stemcells (PBSC) and 12 cord blood bankscontaining more than 25,000 units ofumbilical cord blood. (cancernetwork.com)
  • The incidence of severe adverse events (SAEs) and associated risk factors in hematopoietic cell transplantation donors needs to be clarified for related donors (relatives of the transplant recipient), whose criteria for donation are more lenient than for unrelated donors. (bvsalud.org)
  • Data from related donors registered in the Japanese national data registry database between 2005 and 2021 were evaluated to determine the association of short-term SAE incidence with donor characteristics at registration.Fourteen of 4339 bone marrow (BM) donors (0.32%) and 54 of 10,684 peripheral blood stem cell (PBSC) donors (0.51%) experienced confirmed SAEs during the short donation period. (bvsalud.org)
  • Past medical history was a common risk factor for SAEs in both BM and PBSC donors. (bvsalud.org)
  • Age of 60 years or older and female sex were identified as risk factors for SAEs in PBSC donors. (bvsalud.org)
  • Female sex was also a risk factor for poor mobilization, which resulted in discontinuation of PBSC collection.Although donors should be selected carefully, a certain level of safety is ensured for related donors in Japan. (bvsalud.org)
  • none of the blood donors test- pensated occupational disease. (cdc.gov)
  • Protecting the Selfless: Toward More Comprehensive Care for Pediatric Related Stem Cell Donors. (childrensmercy.org)
  • Children often serve as hematopoietic stem cell donors, most commonly for their siblings. (netlify.app)
  • Yes or No - only after careful risk and value assessment with Human stem cell research and Regenerative Informed consent for donors. (netlify.app)
  • Nelly Zarate, a risk management framework liaison for DHR Health, was the only woman of the Umbilical cord blood contains stem cells, which can be used as an alternative to bone marrow to av C Sia · 2004 · Citerat av 6 - The generation of autoantibodies to islet cells can be observed for as many as 10 years transplant donated by diabetic HLA-identical siblings, or allogeneic donors [21, 22]. (netlify.app)
  • Female donors of child-bearing age 30 May 2020 The risks of this type of stem cell donation are minimal. (netlify.app)
  • 28 Apr 2020 In the case of allogeneic donors, the stem cells must be a good match for the the lysed red cell material can cause clinical complications. (netlify.app)
  • Stem cell transplantation for severe autoimmune disorders, with side effects and attitudes towards second donation: A comparison of related and unrelated haematopoietic stem cell donors, J Clin Apher. (netlify.app)
  • Peripheral Blood versus Bone Marrow from Unrelated Donors: Bone Marrow allografts have improved Long-term Overall and Graft-versus-Host Disease, Relapse-Free Survival. (stembook.org)
  • Infections following Transplantation of Bone Marrow or Peripheral-Blood Stem Cells from Unrelated Donors. (stembook.org)
  • Experiments were performed on PBMC samples of patients that were: a) subjected to mobilization of stem cells from bone marrow, b) not subjected to mobilization, and c) healthy donors (control group). (gov.rs)
  • We describe 2 cases of successful kidney transplantation from SARS-CoV-2 positive donors. (lidsen.com)
PBSCT10
  • Peripheral blood stem cell transplantation (PBSCT), also called "Peripheral stem cell support", is a method of replacing blood-forming stem cells. (wikipedia.org)
  • Studies suggest that PBSCT has a better outcome in terms of the number of hematopoietic stem cell (CD34+ cells) yield. (wikipedia.org)
  • Since allogeneic PBSCT involves transformation of blood between different individuals, this naturally carries more complications than autologous PBSCT. (wikipedia.org)
  • If the total blood volume of the donor is less than that of the recipient (such as when a child is donating to an adult), multiple PBSCT sessions may be required for adequate collection. (wikipedia.org)
  • Determine the feasibility and efficacy of a reduced-intensity conditioning regimen comprising alemtuzumab, fludarabine, melphalan, and thiotepa followed by allogeneic peripheral blood stem cell transplantation (PBSCT) in patients with hematologic malignancies. (knowcancer.com)
  • Determine the safety of LMB-2 immunotoxin-treated, selectively-depleted donor T cells, administered after allogeneic PBSCT, in these patients. (knowcancer.com)
  • In order to assess the incidence and analyze reasons which cause prolongation of hospital stay in patients engrafted after peripheral blood stem cell transplantation (PBSCT), we performed this retrospective analysis. (nature.com)
  • Estimate the failure-free survival rate in a cohort of relapsed Hodgkin's lymphoma and non-Hodgkin's lymphoma patients after retrieval therapy which includes peripheral blood stem cell transplantation (PBSCT) in patients who achieve a complete remission or partial remission. (knowcancer.com)
  • In cases of unrelated HCT, PBSC transplantation (PBSCT) still comprises only a very small percentage, which reflects the fact that unrelated PBSCT did not come into use in Japan until 2010. (apbmt.org)
  • Larger studies are required to determine the impact of rituximab on the mobilization and function of PBSC as well as whether a survival advantage exists in patients who undergo auto-PBSCT with rituximab. (elsevierpure.com)
Transplants5
  • blood stem cell (PBSC) transplants, Barbara L. Haller, for which DNA was extracted from Patricia M. Denn, serum specimens collected at 6 and Christopher S. Hall,* Parvoviruses in 12 months, respectively, after trans- and Julie L. Gerberding plantation. (cdc.gov)
  • No surgery or 12 Jun 2020 Side Effects of Blood Cell Transplants. (netlify.app)
  • Collection failures, defined as the inability to collect three sufficient PBSC transplants, were rare ( n = 3, 2%), with no occurrences in the isatuximab-RVd and elotuzumab-RVd groups. (biomedcentral.com)
  • A tandem autologous transplant, also known as a double autologous transplant, requires the patient to undergo two planned autologous stem cell transplants within 6 months. (cancertreatmenttoday.org)
  • Several studies have reported the impact of organ transplants on bone metabolism, electrolytes and blood profile. (lidsen.com)
Mononuclear cells2
  • mononuclear cells (PBMCs). (cdc.gov)
  • Main goal of this work is to investigate metabolic status of peripheral blood mononuclear cells (PBMC) in patients with solid tumors (neuroblastoma, Ewing sarcoma) and lymphoma (Hodgkin and nonHodgkin). (gov.rs)
Donor19
  • Donor-T-cells were transduced with the replication-deficient retrovirus SFCMM-3, expressing HSV-TK and the truncated ΔLNGFR for selection of transduced cells. (frontiersin.org)
  • Donor chimerism was stabilized after transfusion of the transduced cells in all patients treated. (frontiersin.org)
  • Thus, prophylactic transfusion of donor T-cells has been included in many protocols, despite the increased risk for acute GvHD ( Kolb, 2008 ). (frontiersin.org)
  • Immature hematopoietic stem cells in the circulating blood that are similar to those in the bone marrow are collected by apheresis from a donor (PBSC collection). (wikipedia.org)
  • The apheresis procedure typically lasts for 4-6 hours, depending on the blood volume of the donor. (wikipedia.org)
  • For example, calculations must be made to ensure consistency in the amount of total blood volume between the donor and recipient. (wikipedia.org)
  • OUTLINE: This is a dose-escalation study of LMB-2 immunotoxin-treated, selectively-depleted donor T cells. (knowcancer.com)
  • LMB-2 immunotoxin is added to the PBMCs in order to selectively deplete T cells from the donor PBMCs. (knowcancer.com)
  • LMB-2 immunotoxin-treated, selectively-depleted donor T cells: Patients receive LMB-2 immunotoxin-treated, selectively-depleted donor T cells IV over 30-60 minutes on approximately day 28. (knowcancer.com)
  • Cohorts of 3-6 patients receive escalating dose of LMB-2 immunotoxin-treated, selectively-depleted donor T cells until the maximum tolerated dose (MTD) is determined. (knowcancer.com)
  • The rest of the blood is returned back to the patient or donor. (bonemarrowtest.com)
  • Apheresis produces no side effects or discomfort for the blood stem cell donor. (bonemarrowtest.com)
  • The administration of blinatumomab after allo-HCT is expected to enhance the antileukaemic effect on residual CD19-positive blasts by donor-derived CD3-positive T-cells. (bvsalud.org)
  • First blood stem cells are extracted from the donor. (netlify.app)
  • Put it simply, they can become any type of cell When you register as a potential donor, you're routinely asked to confirm that you would be willing to donate both peripheral stem cells and/or bone marrow (to 15 Feb 2011 Are there any risks or side effects of G-CSF? (netlify.app)
  • The Effect of Aging and Pre-Donation Comorbidities on the Related PBSC Donor Experience: A Report from the Related Donor Safety Study (RDSafe). (stembook.org)
  • Various factors including age, sex, performance status (PS), disease status, cytogenetic risk, donor type, graft source, sex mismatch between the donor and the recipient, and year of transplantation were all shown to impact OS 2 . (apbmt.org)
  • The study proposes the use of Fludarabine, Busulfan, Anti Thymocyte Globulin Rabbit (ATG) and Total Body Irradiation as a preparative regimen before hematopoietic stem cell transplant from unrelated donor peripheral blood stem cells (PBSC). (mycancergenome.org)
  • Division chief Liang Zhixing designated heart transplantation as the key research project and assigned dedicated staff to the "donor heart excision group," "myocardial conservation group," "implant operation group," "patient care group," and "support group. (chinaorganharvest.org)
Granulocyte-macrop1
Outcomes5
  • In a population of adults with de novo AML in first or second CR, we compared outcomes after dUCBT (n = 165) and after haplo-PTCY PBSC (n = 544) performed between January 2013 and December 2018. (unisr.it)
  • We reviewed data from 24 transplant centers in Asia, Australia, Europe, and North America to determine the outcomes of stem cell collection including methods used, cell yields, effects on disease activity, and complications in patients with autoimmune diseases. (northwestern.edu)
  • Monocyte subpopulation recovery as predictors of hematopoietic cell transplantation outcomes. (stembook.org)
  • Cell therapy is currently emerging as a potential new treatment for post MI patients with the assumption that recolonization of the areas of scarred myocardium with exogenously supplied surrogates or precursors of cardiomyocytes can restore function and ultimately affect clinical outcomes. (escardio.org)
  • Because pilot studies of tandem autologous HCT demonstrated tolerable toxicity and potential efficacy and because prior trials have demonstrated that dose intensification improves outcomes, researchers decided to explore tandem transplantation in patients with high-risk neuroblastoma. (oncologynurseadvisor.com)
High-dose2
Allogeneic hematopoietic stem c1
  • Role of Reduced-Intensity Conditioning Allogeneic Hematopoietic Stem-Cell Transplantation in Older Patients With De Novo Myelodysplastic Syndromes: An International Collaborative Decision Analysis. (stembook.org)
Regimen3
  • After achieving the second remission, the patient received a killer cell immunoglobulin-like receptor ligand-mismatched CBT with a reduced-intensity conditioning regimen and has been in remission for 52 months. (bvsalud.org)
  • When corrected for patient weight and apheresis volume, progenitor cell yields tended to vary by underlying disease, prior medication history and mobilization regimen. (northwestern.edu)
  • The secondary objectives are to evaluate the relapse-free and overall survival after hematopoietic stem cell transplant as well as to evaluate the incidence of acute and chronic graft-versus-host disease after this preparative regimen. (mycancergenome.org)
Post-transplantation3
  • After completion of study treatment, patients are followed weekly for 100 days post-transplantation and then periodically for survival. (knowcancer.com)
  • Unmanipulated haploidentical hematopoietic stem cell transplantation (HCT) with post-transplantation cyclophosphamide as graft-versus-host disease (GVHD) prophylaxis (haplo-PTCY) and unrelated double-unit umbilical cord blood transplantation (dUCBT) are feasible options for treating patients with high-risk acute myelogenous leukemia (AML). (unisr.it)
  • The assessment follow-up period will include an initial 2 years of active end-point evaluations, where the subjects will be evaluated at 3-, 6-, 9-, 12-, 18- and 24-months post-transplantation. (ucsd.edu)
Engraftment4
  • The patient received peripheral blood stem cells (PBSC) and had successful engraftment with complete hematological recovery. (lvhn.org)
  • Cell therapy is a potential new treatment for post MI patients, but the main challenges are : the necessity to preserve immune competency and to gain adequate nutrition and homing signals necessary for stem cells' engraftment and survival. (escardio.org)
  • Repair of scar tissue constitutes a challenge for cardiac stem cell therapy due to lack of adequate nutrition and homing signals necessary for stem cells' engraftment and survival. (escardio.org)
  • These results indicated no adverse effect of rituximab on the mobilization and engraftment of PBSC. (elsevierpure.com)
Apheresis2
  • 20x10(6)/mu l peripheral CD34+ cells after mobilization but prior to apheresis. (uni-koeln.de)
  • Poor mobilizers given plerixafor collected more CD34+ cells during the first apheresis session, leading to a decrease in the average number of apheresis sessions needed. (uni-koeln.de)
Transplant11
  • An early example of a successful peripheral stem cell transplant was carried out in the wake of the 1999 Tokaimura nuclear accident. (wikipedia.org)
  • The child is normal with sustained remission on day +218 post stem cell transplant. (lvhn.org)
  • Biol Blood Marrow Transplant. (childrensmercy.org)
  • The doctor performing the transplant will decide which procedure will be used to extract the stem cells based on what he or she thinks will be best for the recipient. (netlify.app)
  • Late-occurring Venous Thromboembolism in Allogeneic Blood or Marrow Transplant Survivors - a BMTSS-HiGHS2 Risk Model. (stembook.org)
  • Transplant Cell Ther. (stembook.org)
  • Follistatin and Soluble Endoglin Predict 1-year Non-Relapse Mortality after Allogeneic Hematopoietic Cell Transplant. (stembook.org)
  • Stem cells are collected once before the initial transplant and half are used for each procedure. (cancertreatmenttoday.org)
  • Risk factors for the development of orthostatic hypotension during autologous stem cell transplant in patients with multiple myeloma. (astct.org)
  • The transplant group includes quite a few experts and specialists in kidney and multi-organ transplantation, such as Wang Dongwen and Liu Chun. (chinaorganharvest.org)
  • Between 1997 and 2006, he studied abdominal surgery at the Peking Union Medical College Cancer Hospital under the Chinese Academy of Medical Sciences, digestive surgery at the Toyama Medical and Pharmaceutical University (now University of Toyama) in Japan, and organ transplant at the Beijing Armed Police Corps Hospital Organ Transplantation Research Institute. (chinaorganharvest.org)
Hematopoetic stem1
  • The bone morrow contains several stem cell types including hematopoetic stem cells, endothelial progenitor cells, mesenchymal (stromal) stem cells and multipotent adult progenitor cells. (escardio.org)
Survival2
PBSCs2
  • Although donation of bone marrow (BM) or peripheral blood stem cells (PBSCs) from children to family members undergoing allogeneic transplantation are well-established procedures, studies detailing levels of pain, symptoms, and long-term recovery are lacking. (childrensmercy.org)
  • The number of related HCTs has remained stable, while the use of peripheral blood stem cells (PBSCs) has now largely replaced that of bone marrow (BM). (apbmt.org)
Cyclophosphamide2
  • Methods of PBSC mobilization included G-CSF (5, 10, or 16 μg/kg/day) or cyclophosphamide (2 or 4 g/m 2 ) with either G-CSF (5 or 10 μg/kg/day) or GM-CSF (5 μg/kg/day). (northwestern.edu)
  • Three patients died as a result of cyclophosphamide-based stem cell collection (2.6% of patients mobilized with cyclophosphamide). (northwestern.edu)
Abstract1
  • abstract： PURPOSE:M30 and M65 ELISAs are proposed as surrogate biomarkers of tumour cell death in patients and are being applied increasingly in the pharmacodynamic (PD) evaluation of anticancer drugs during clinical trials. (shengsci.com)
Oncology1
  • If this reveals an irregularity in the blood count, the patient may be referred to a specialist in haematology and/or oncology. (aa-pnh.org)
Mobilization and collection4
  • Eligible subjects will undergo hematopoietic stem cell (HSC) mobilization and collection (leukapheresis). (ucsd.edu)
  • This analysis aims to evaluate the effects of prolonged lenalidomide induction and isatuximab- or elotuzumab-containing quadruplet induction therapies on PBSC mobilization and collection. (biomedcentral.com)
  • The patients were evaluated based on PBSC mobilization and collection parameters, including overall collection results, CD34 + cell levels in peripheral blood, leukapheresis (LP) delays, overall number of LP sessions, and the rate of rescue mobilization with plerixafor. (biomedcentral.com)
  • However, during stem cell mobilization and -collection, no study-specific therapeutic intervention was performed. (biomedcentral.com)
20223
Progenitor cell1
  • Trends in the approaches to, and results of, progenitor cell mobilization are suggested by this survey. (northwestern.edu)
Haploidentical1
  • 2002 until 2007), two were included in TK007 (2005-2009) and six serves as a control group for outcome after haploidentical transplantation without HSV-TK-transduced DLI. (frontiersin.org)
Heart-transplantation1
Sickle cell di2
  • Dr. Keith Hoots, the Division Director at the Division of Blood Diseases and Resources (DBDR) opened the meeting by greeting the Sickle Cell Disease Advisory committee (SCDAC) members. (nih.gov)
  • In 1999 there were 2 major obstacles for curing adults with sickle cell disease. (nih.gov)
Donor's2
  • A simple, painless process in which blood is drawn from a patient's or donor's arm and circulated through a filter which removes stem cells from the blood. (bonemarrowtest.com)
  • A bone marrow donation happens in one of two ways: In the first, blood is from a donor's arm, put in a machine where stem cells are separated, and returned Thus much of the promise of stem cells depends on women choosing to donate oocytes to the research effort. (netlify.app)
Aplastic1
  • Cell production may be reduced during the course of the disease ( hypoplastic ) or completely absent ( aplastic ). (aa-pnh.org)
Safety and Efficacy1
  • This study is a Phase 1/2 clinical trial that will assess the safety and efficacy of enriched gene-corrected hematopoietic stem cells isolated from patients affected with cystinosis . (ucsd.edu)
Haematopoietic cell1
  • INTRODUCTION: Relapsed and refractory B-cell acute lymphoblastic leukaemia (R/R-B-ALL) is linked to a significant relapse rate after allogeneic haematopoietic cell transplantation (allo-HCT) in children, adolescents and young adults (CAYA). (bvsalud.org)
Multiple myeloma patients1
  • While quadruplet induction therapies deepen responses in newly diagnosed multiple myeloma patients, their impact on peripheral blood stem cell (PBSC) collection remains incompletely understood. (biomedcentral.com)
Diffuse Large B-1
  • Treatment recommendations for patients with diffuse large B-cell lymphoma (DLBCL) begin with evaluating the extent of the disease, performance status of the patient, and histologic subtypes. (medscape.com)
Autoimmune2
  • However, several weeks later, the cells were found to have been mutated by the radiation still present within the patient's body, and were observed carrying out autoimmune responses. (wikipedia.org)
  • Studies have shown that a subtype of lymphocyte in the body's own immune system attacks cells in the bone marrow, and this autoimmune process prevents the development of new blood cells. (aa-pnh.org)
20203
Centers3
Undergo2
Umbilical1
  • The use of umbilical cord blood (UCB) has been steadily increasing, and UCB transplantation (UCBT) currently accounts for one-third of all allogeneic HCTs. (apbmt.org)
20213
Bone marrow function2
Patients with acute2
Cord2
  • The patient received HLA-matched cord blood transplantation (CBT) and relapsed 18 months later. (bvsalud.org)
  • Process optimization was continued using cord blood (CB) CD34+ cells. (edu.au)
Acute1
Lymphoma1
  • The diagnosis of diffuse large cell lymphoma is usually confirmed after positive findings are obtained from a lymph node biopsy specimen. (medscape.com)
Donation8
  • The increase in white blood cell proliferation as a result of the Filgrastim ensures a better results from the donation. (wikipedia.org)
  • This is the procedure used for a Peripheral Blood Stem Cell (PBSC) Donation. (bonemarrowtest.com)
  • There is a possibility of side effects or complications Below are answers to common questions about stem cell donation. (netlify.app)
  • Myth 3: Stem cell donation is inconvenient. (netlify.app)
  • Leading up to the time of the stem cell donation, most people are able to give themselves injections of filgrastim at home, so they don't need to go to the doctor every day. (netlify.app)
  • Back to top Myth 2: Making a stem cell donation is difficult and painful. (netlify.app)
  • essay Research paper on cognitive technology stem cell controversy essay, essay New year's resolution essay for student blood donation camp report essay. (netlify.app)
  • This has had a negative impact on organ donation and transplantation rates. (lidsen.com)
20192
CD342
  • CD34-selection of stem cells reduces the risk of aGvHD, but also leads to increased infectious complications and relapse. (frontiersin.org)
  • There was no difference in the number of CD34 + cells among PBSC between the non-rituximab and the rituximab groups. (elsevierpure.com)
Rituximab1
  • Although B-cells were completely depleted from PBSC in the rituximab group, we found no difference in the expression of CXCR-4, VLA-4 and c-Kit on PBSC, indicating that rituximab did not affect the expression of these adhesion molecules, which might be involved in the mechanism of mobilization. (elsevierpure.com)
Therapeutic2
  • As such, stem cell therapy cannot be regarded as a valid therapeutic option for patients with cardiovascular disease in the present era of evidenced-based medicine, yet it holds great hope for the future. (escardio.org)
  • To determine therapeutic potential of hematopoietic stem cell (HSC), we need to understand better correlation between the metabolic/energy status of the cells and stages of stem cell differentiation during hematopoiesis. (gov.rs)