• 4-Aminosalicylic acid is believed to work by blocking the ability of bacteria to make folic acid. (wikipedia.org)
  • Paser is most commonly used in patients with Multi-drug Resistant TB (MDR-TB) or when isoniazid and rifampin use is not possible due to a combination of resistance and/or intolerance. (rxlist.com)
  • Its mechanism of action is not fully known, but isoniazid may inhibit the synthesis of mycolic acid, resulting in disruption of the bacterial cell wall. (medscape.com)
  • PASER (aminosalicylic acid) granules are a delayed release granule preparation of aminosalicylic acid (p-aminosalicylic acid: 4-aminosalicylic acid) for use with other anti- tuberculosis drugs for the treatment of all forms of active tuberculosis due to susceptible strains of tubercle bacilli. (rxlist.com)
  • PASER granules are the free base of aminosalicylic acid and do NOT contain sodium or a sugar. (rxlist.com)
  • PASAR granules are supplied as off-white tan-colored granules with an average diameter of 1.5 mm and an average content of 60% aminosalicylic acid by weight. (rxlist.com)
  • It is sold in the US as "Paser" by Jacobus Pharmaceutical, which comes in the form of 4 g packets of delayed-release granules. (wikipedia.org)
  • Paser (aminosalicylic acid) is an anti- tuberculosis drug used to treat tuberculosis in combination with other active agents. (rxlist.com)
  • 4-Aminosalicylic acid, also known as para-aminosalicylic acid (PAS) and sold under the brand name Paser among others, is an antibiotic primarily used to treat tuberculosis. (wikipedia.org)
  • Thyroid goitre is also a side-effect because aminosalicylic acid inhibits the synthesis of thyroid hormones. (wikipedia.org)
  • It is normally involved in the metabolism of every cell of the body, especially affecting DNA synthesis and regulation, but also fatty acid synthesis and energy production. (wikidoc.org)
  • During pregnancy, Paser should be used only if prescribed. (rxlist.com)
  • The U.S. Food and Drug Administration (FDA) assigned 4-aminosalicylic acid to pregnancy category C, indicating that it is not known whether it will harm an unborn baby. (wikipedia.org)
  • It was initially thought that resistance of 4-aminosalicylic acid came from a mutation affecting dihydrofolate reductase (DHFR). (wikipedia.org)
  • the protective acid-resistant outer coating is rapidly dissolved in neutral media so a mildly acidic food such as orange, apple , or tomato juice, yogurt, or apple sauce should be used. (rxlist.com)
  • The drug should be taken with acid food or drink (orange, apple or tomato juice). (wikipedia.org)
  • The main use for 4-aminosalicylic acid is for the treatment of tuberculosis infections. (wikipedia.org)
  • What Are Side Effects of Paser? (rxlist.com)
  • Our Paser (aminosalicylic acid) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
  • What Drugs, Substances, or Supplements Interact with Paser? (rxlist.com)
  • Paser may interact with other drugs. (rxlist.com)
  • 4-aminosalicylic acid has also been used in the treatment of inflammatory bowel disease (ulcerative colitis and Crohn's disease), but has been superseded by other drugs such as sulfasalazine and mesalazine. (wikipedia.org)
  • Paser may decrease the amount of substances (such as vitamin B12 ) in your body. (rxlist.com)
  • The multivitamins also contained 150 mg of vitamin C. After 6 months, methylmalonic acid (MMA) levels, the most specific marker for B12 activity of a food or supplement, went from 164 nmol/l to 169 nmol/l which is essentially no change and by itself would indicate no benefit of the multivitamin. (veganhealth.org)
  • 4-aminosalicylic acid has been shown to be a pro-drug and it is incorporated into the folate pathway by dihydropteroate synthase (DHPS) and dihydrofolate synthase (DHFS) to generate a hydroxyl dihydrofolate (Hydroxy-H2Pte and Hydroxy-H2PteGlu) antimetabolite, which competes with dihydrofolate at the binding site of dihydrofolate reductase (DHFR). (wikipedia.org)
  • PASER (aminosalicylic acid) is indicated for the treatment of tuberculosis in combination with other active agents. (rxlist.com)
  • In the United States, 4-aminosalicylic acid is indicated for the treatment of tuberculosis in combination with other active agents. (wikipedia.org)
  • The packets contain 4 grams of aminosalicylic acid for oral administration three times a day by sprinkling an apple sauce or yogurt to be eaten without chewing. (rxlist.com)
  • The main use for 4-aminosalicylic acid is for the treatment of tuberculosis infections. (wikipedia.org)
  • In the United States, 4-aminosalicylic acid is indicated for the treatment of tuberculosis in combination with other active agents. (wikipedia.org)
  • Aminosalicylic acid was introduced to clinical use in 1944. (wikipedia.org)
  • The two major considerations in the clinical pharmacology of aminosalicylic acid are the prompt production of a toxic inactive metabolite under acid conditions and the short serum half life of one hour for the free drug. (pharmacycode.com)
  • 4-Aminosalicylic acid, also known as para-aminosalicylic acid (PAS) and sold under the brand name Paser among others, is an antibiotic primarily used to treat tuberculosis. (wikipedia.org)