• On the other hand, the only one that induced heme oxygenase-1 expression was sulforaphane, a known activator of a HMOX1 inducer-NRF2. (hindawi.com)
  • Hesperetin attenuated acetaminophen-induced hepatotoxicity by inhibiting hepatocyte necrosis and apoptosis, oxidative stress and inflammatory response via upregulation of heme oxygenase-1 expression. (stembook.org)
  • 6 Martin D, Rojo A I, Salinas M, Diaz R, Gallardo G, Alam J, De Galarreta C M, Cuadrado A. Regulation of heme oxygenase-1 expression through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol. (thieme-connect.com)
  • Increased levels of HO-1 ameliorated oxidative stress and cell death. (jci.org)
  • Special cellular machinery should be activated to fight against increased reactive oxygen species (ROS) level to protect from oxidative injury. (springer.com)
  • Coarse, fine, and ultrafine particles (UFPs) were collected by ambient particle concentrators in the Los Angeles basin in California and used to study their chemical composition in parallel with assays for generation of reactive oxygen species (ROS) and ability to induce oxidative stress in macrophages and epithelial cells. (cdc.gov)
  • In addition, UV induces the generation of reactive oxygen species (ROS), which overwhelm the antioxidant defense system, resulting in oxidative stress and damage to cell structure, DNA, proteins and lipids ( 5 ). (spandidos-publications.com)
  • It is likely to act as a bioactive compound by exerting reactive oxygen species (ROS)-scavenging activity and/or binding to specific proteins such as oxidative enzymes and transcriptional factors in signal transduction pathways. (rsc.org)
  • Oxidative stress arises while the generation of reactive oxygen species (ROS) overload the neutralizing capacity of intrinsic antioxidants and antioxidative defenses. (encyclopedia.pub)
  • Oxidative stress produced through reactive oxygen species (ROS) enhancement is considered to play a key role in the development and maintenance of hypertension. (uba.ar)
  • Oxidative stress occurs when the generation of reactive oxygen species (ROS) in a system exceeds the system's ability to neutralize and eliminate them. (nih.gov)
  • The end products of its enzymatic activity possess anti-oxidative, anti-apoptotic and anti-inflammatory properties. (springer.com)
  • Quercetin is a typical anti-oxidative flavonoid ubiquitously distributed in vegetables. (rsc.org)
  • 14,15 Conversely, its pro-oxidant activity may enhance cellular defence against oxidants by stimulating the redox-regulated signal transduction pathway which leads to the gene expression of anti-oxidative enzymes such as heme oxygenase-1 (HO-1) and glutathione peroxidase (GPx). (rsc.org)
  • HO-1 and their products exert beneficial effects through the protection against oxidative injury, regulation of apoptosis, modulation of inflammation as well as contribution to angiogenesis. (springer.com)
  • However, oxidative stress could play salient role in the observed cellular and genetic toxicity and apoptosis-like effects which could be abrogated by antioxidant vitamins and flavonoids, including vitamin E, quercetin, kolaviron, myricetin and bioactive extractives with antioxidant effects. (frontiersin.org)
  • Information from concentrates on hereditary imperfections and pharmacological mediations has proposed that numerous atoms, fundamentally those controlling oxidative pressure, irritation, autophagy, apoptosis, and digestion, add to the pathogenesis of cardiotoxicity incited by disease treatment. (alliedacademies.org)
  • The major characteristics of Nrf2 are to some extent mimicked by Nrf2-dependent genes and their proteins including heme oxygenase-1 (HO-1), which besides removing toxic heme, produces biliverdin, iron ions and carbon monoxide. (springer.com)
  • The discovery of the antioxidant response element (ARE) have led to the conclusion that the battery of genes, including glutamate-cysteine ligase (GCL), thioredoxin reductase 1 (Txnrd1), NAD(P)H-quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HMOX1) is regulated through Nrf2 binding to this consensus binding sequence [ 3 ]. (springer.com)
  • To counterbalance oxidative stress and ensure redox homeostasis, a subgroup of non-small-cell lung cancers acquire stabilizing mutations in NFE2L2 , the gene encoding NRF2, the transcriptional regulator of the cellular antioxidant response, and inactivating mutations in its negative regulator, KEAP1. (nature.com)
  • NRF2 accumulation upon oxidative stress can activate the transcription of haem oxygenase 1 (HO1), which catabolizes haem. (nature.com)
  • The role of several antioxidants in pain relief, by attenuating ROS generation and/or by activating the endogenous antioxidant system triggered by the nuclear factor erythroid-2 related factor 2 (Nrf2), heme oxygenase 1 (HO-1), NADPH quinone oxidoreductase 1, superoxide dismutase, glutathione peroxidase 1, and/or the catalase signaling pathway, has been demonstrated. (mdpi.com)
  • Heme oxygenase-1 (HO-1), one of the targets of Nrf2-ARE, plays an important role in regulating OS and is protective in a variety of human and animal models of kidney disease. (ewha.ac.kr)
  • Upregulation of cellular HO-1 levels is signature of oxidative stress for its downstream effects particularly under pro-oxidative status. (encyclopedia.pub)
  • Previous studies have revealed that the delayed cardioprotective mechanisms underlying IPC are complex and involve upregulation of endogenous cardioprotective proteins and oxidative stress inhibition ( 5 - 7 ). (spandidos-publications.com)
  • Heme oxygenase 1 (HMOX1, commonly HO-1) is a member of the heat shock protein (HSP) family identified as HSP32. (wikipedia.org)
  • Both conditions can be accompanied by decreased levels of heme oxygenase-1 (HMOX1), cytoprotective, heme-degrading enzyme. (hindawi.com)
  • Heme oxygenase-1 (Hmox1) is a stress-inducible protein crucial in heme catabolism. (springer.com)
  • Heme oxygenase-1 (Hmox1) catalyzes the conversion of heme to biliverdin, carbon monoxide (CO), and ferrous iron (Fe 2+ ). (springer.com)
  • Myocyte-restricted Hmox1 transgenic mice exposed to MI exhibited significantly improved survival and LV function, lower interstitial fibrosis and oxidative stress. (springer.com)
  • Oxidative stress is referred as a pro-oxidative circumstance, occurring at the imbalance between oxidants and antioxidants in favor of the oxidants, which has been implicated in governing normal physiological activities and pathological processes. (encyclopedia.pub)
  • Upon loss of attachment, ATF4 activated a coordinated program of cytoprotective autophagy and antioxidant responses, including induced expression of the major antioxidant enzyme heme oxygenase 1 (HO-1). (jci.org)
  • The following points highlight the five main enzymes involved in oxidative process. (biologydiscussion.com)
  • Rieske oxygenases are examples of enzymes with the ability to perform precise mono- or dioxygenation reactions on a variety of substrates. (nature.com)
  • Understanding the structural features of Rieske oxygenases responsible for control over selectivity is essential to enable the development of this class of enzymes for biocatalytic applications. (nature.com)
  • Decades of research has illuminated the critical features common to Rieske oxygenases, however, structural information for enzymes that functionalize diverse scaffolds is limited. (nature.com)
  • In the Rieske oxygenase class, work to date has been conducted on a small sample of enzymes, specifically those that perform dioxygenation of aromatic rings. (nature.com)
  • Rieske oxygenases in particular are underexplored in this regard, with only twelve available structures of different enzymes in the Protein Data Bank 21 . (nature.com)
  • In this perspective, we advance the hypothesis that such hole hopping through Tyr/Trp chains could protect oxygenase, dioxygenase, and peroxidase enzymes from oxidative damage. (caltech.edu)
  • Heme oxygenase, or haem oxygenase, (HMOX, commonly abbreviated as HO) is an enzyme that catalyzes the degradation of heme to produce biliverdin, ferrous ion, and carbon monoxide. (wikipedia.org)
  • Oxidative stress generated during such stressful conditions may damage DNA and proteins, and as a consequence the cellular processes are disturbed. (springer.com)
  • Electron flow through biological molecules: does hole hopping protect proteins from oxidative damage? (caltech.edu)
  • There is now some evidence that chronic fatigue syndrome is accompanied by an activation of the inflammatory response system and by increased oxidative and nitrosative stress. (nel.edu)
  • Our findings suggest that fine PM enhances allergic inflammatory response in pulmonary tissue through mechanisms involving increased oxidative stress. (cdc.gov)
  • OxPAPC also induced expression of cyclo-oxygenase-2 (COX2), as well as 32 different oxylipins, including those generated in the cyclo-oxygenase/lipoxygenase pathways and capable of regulating either ASM contraction or airway inflammation. (ersjournals.com)
  • Targeted transcriptional profiling showed no effects on pathways involved inmitochondrial biogenesis, function, or oxidative stress. (medscape.com)
  • There is recent data which indicates the ability of peroxynitrite (ONOO-) to modulate the expression of HO-1 and suggests that the heme oxygenase pathway contributes to protection against the cytotoxic action of ONOO- which is a potent oxidizing agent generated by the interaction of nitric oxide (NO) and the superoxide anion. (ihcworld.com)
  • Sofalcone up-regulates the nuclear factor (erythroid-derived 2)-like 2 /heme-oxygenase-1 pathway, reduces sFlt-1 and quenches endothelial dysfunction: a potential therapeutic for preeclampsia. (nbmrf.org.au)
  • A member of the P450 superfamily, this enzyme catalyzes the first oxidative step of the phenylpropanoid pathway in higher PLANTS by transforming trans-cinnamate into p-coumarate. (bvsalud.org)
  • c) It catalyzes the oxidative deamination of the unnatural (D-) forms of amino acids. (biologydiscussion.com)
  • c) It catalyzes the oxidative deamination of naturally occurring L-amino acids. (biologydiscussion.com)
  • Heme oxygenase-1 (HO-1) or HSP32 is the inducible isoform of heme oxygenase which catalyzes the NADPH, O2 and cytochrome P450 reductase dependent oxidation of heme to carbon monoxide, iron and billiverdin that is immediately reduced to bilirubin. (ihcworld.com)
  • Thoracic aortic segments were excised, and the NAD(P)H oxidase subunits expression, oxidative stress parameters, and heme oxygenase-1 abundance were evaluated. (uba.ar)
  • Hypertensive animals had an increase in the activity and expression of NAD(P)H oxidase and, as a consequence, in the oxidative stress parameters. (uba.ar)
  • UFPs were most potent toward inducing cellular heme oxygenase-1 (HO-1) expression and depleting intracellular glutathione. (cdc.gov)
  • Pretreatment of cells with N-acetyl-L-cysteine (NAC), an agent known to counteract oxidative stress, attenuates the cellular p53 response to UV ( 4 ). (spandidos-publications.com)
  • p38 acts as a stress-activated MAPK that is preferentially activated by diverse cellular stressors, including UV-B-induced oxidative stress ( 9 ). (spandidos-publications.com)
  • DJ-1 may act as an antioxidant and be important for cellular defense in response to oxidative stress ( 13 - 16 ). (spandidos-publications.com)
  • 6). Lung tissue, bronchoalveolar lavage fluid (BALF) and plasma were analyzed for cellular inflammation, cytokines, immunoglobulin E and heme oxygenase-1 (HO-1) expression. (cdc.gov)
  • Heme oxygenase 2 (HMOX2 or HO-2) is a constitutive isoform that is expressed under homeostatic conditions in the testes, gastrointestinal tract, endothelial cells and the brain. (wikipedia.org)
  • 3 Satoh T, Saitoh S, Hosaka H, Kosaka K. Simple ortho- and para-hydroquinones as neuroprotective compounds against oxidative stress associated with a specific transcriptional activation. (thieme-connect.com)
  • Subsequent research suggested that DJ-1 has various potential functions, including transcriptional regulation, oxidative stress inhibition, acting as a chaperone or protease and mitochondrial regulation ( 12 ). (spandidos-publications.com)
  • The premise for this study is the increasing awareness that various PM components induce pulmonary inflammation through the generation of oxidative stress. (cdc.gov)
  • Quercetin aglycone is assumed to emerge in the target site by the action of β-glucuronidase activity under oxidative stress such as inflammation. (rsc.org)
  • CEE significantly influenced CYP1A2, CYP2D6, and CYP-mediated dapsone oxidative metabolism but not CYP2C19, CYP2E1, or N-acetyltransferase 2 metabolism in postmenopausal women. (nih.gov)
  • free" iron increases oxidative stress and regulates the expression of many mRNAs by affecting the conformation of iron regulatory protein (IRP)-1 and its binding to iron regulatory elements (IREs) in the 5'- or 3' -UTRs of the mRNAs. (ihcworld.com)
  • Nuclear factor kappa beta (NFkappabeta) is the major upstream, intracellular mechanism which regulates inflammatory and oxidative stress mediators. (nel.edu)
  • Fig. 1: Extent of characterization of the Rieske oxygenase enzyme superfamily. (nature.com)
  • However, very limited insight currently exists into the mechanisms by which oxidative stress promotes the development of asthma. (ersjournals.com)
  • Heme oxygenase (HO)-1 is a stress-inducible enzyme protecting cells against oxidative stress, and mechanisms have been considered to depend exclusively on its enzyme activity. (elsevierpure.com)
  • These results provided evidence that gene transfection of the activity-lacking mutant HO-1 protects cells against oxidative stress through multiple mechanisms involving up-regulation of catalase and glutathione contents. (elsevierpure.com)
  • [ 4 ] This possible role of bilirubin in early protection against oxidative injury, coupled with identification of multiple neonatal mechanisms to preserve and potentiate bilirubin production, has led to speculation about an as-yet-unrecognized beneficial role for bilirubin in the human neonate. (medscape.com)
  • DJ‑1 protein, as a multifunctional intracellular protein, has been demonstrated to serve a critical role in regulating cell survival and oxidative stress. (spandidos-publications.com)
  • This study aimed to examine if the protein lacking catalytic activities could also display such resistance against oxidative stress. (elsevierpure.com)
  • HO-1 expression, a sensitive marker for oxidative stress, is directly correlated with the high organic carbon and polycyclic aromatic hydrocarbon (PAH) content of UFPs. (cdc.gov)
  • However, activation of heme oxygenase-1 (HO-1) can upregulate ferritin expression, which binds to ferrous iron and detoxifies its pro-oxidant effect. (encyclopedia.pub)
  • Interestingly, either losartan or minoxidil administration blunted those parameters, indicating that arterial pressure is the key factor in the development of oxidative stress in the hypertensive aorta. (uba.ar)
  • 12 Kraft A D, Johnson D A, Johnson J A. Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult. (thieme-connect.com)
  • ONOO- rapidly decomposes to a highly reactive hydroxyl radical and nitrogen dioxide, both of which cause oxidative damage. (ihcworld.com)
  • Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. (cdc.gov)
  • We suggest that antihypertensive drug administration at the beginning of this pathology delays the oxidative stress generation, thus preventing the aggravation of this disease. (uba.ar)
  • Furthermore, growing evidence suggests that oxidative stress plays a pivotal role in the development of insulin resistance and vice versa. (nih.gov)
  • Oxidative stress is highly implicated in the development of chronic pain and the associated emotional disorders. (mdpi.com)
  • The kit includes three detection probes: NO Detection Reagent (Red, Ex/Em 650/670 nm), Oxidative Stress Detection Reagent (Green, Ex/Em 490/525 nm) for total ROS detection, and Superoxide Detection Reagent (Orange, Ex/Em 550/620 nm). (enzolifesciences.com)
  • Excitation and emission spectra of Oxidative Stress Detection Reagent (green), Superoxide Detection Reagent (blue), and NO Detection Reagent (red). (enzolifesciences.com)
  • Genetic and pharmacological studies have identified aldose reductase, heme oxygenase-1 (HO-1), and Mn-superoxide dismutase (MnSOD) as critical mediators of the antioxidative stress effects of late preconditioning ( 8 - 10 ). (spandidos-publications.com)
  • Oxidative stress is a major pathogenic driver in many diseases, and evidence to date suggests the obstructive lung disease asthma is no exception. (ersjournals.com)
  • Oxidative stress (OS) plays an important role in the pathophysiology of CKD. (ewha.ac.kr)
  • We conducted an ancillary study to the CALERIE 2 randomized controlled trial to examine the effects of 12 months of 25% CR on in vivo skeletal muscle mitochondrial energetics, mitochondrial content, and markers of oxidative stress. (medscape.com)
  • For years researchers have known that free radicals can cause cell degeneration, especially in the brain, and oxidative stress has been implicated in a growing list of human diseases, such as Alzheimer's disease, Parkinson's disease and cancer. (nih.gov)
  • Oxidative stress was found to be associated with type 2 diabetes mellitus (T2DM), which (i) represents another prevalent disease associated with obesity and often aging, and (ii) is considered to be a risk factor for AD development. (nih.gov)
  • Single cells and organisms may adapt to harmful oxidative stress conditions, through stress-activated factors. (springer.com)
  • This activates cascade of events which, in the end, affects oxidative status of the cells and provides robust protection against oxidative challenge. (springer.com)