• Examples of antibiotic oxazolidinones include: Linezolid (Zyvox), which is available for intravenous administration and also has the advantage of having excellent oral bioavailability. (wikipedia.org)
  • The first commercially available 1,3-oxazolidinone antibiotic was linezolid, discovered and developed by Pharmacia & Upjohn. (wikipedia.org)
  • Oxazolidinones are a class of compounds containing 2-oxazolidone in the structure. (wikipedia.org)
  • Linezolid is the first antibacterial drug in a new class of human-made antibiotics called oxazolidinones. (adam.com)
  • Note that cycloserine, while technically an oxazolidone, has a different mechanism of action and substantially different properties from the aforementioned compounds. (wikipedia.org)
  • See Linezolid#Pharmacodynamics) Some of the most important oxazolidinones are antibiotics. (wikipedia.org)
  • Examples of antibiotic oxazolidinones include: Linezolid (Zyvox), which is available for intravenous administration and also has the advantage of having excellent oral bioavailability. (wikipedia.org)
  • The first commercially available 1,3-oxazolidinone antibiotic was linezolid, discovered and developed by Pharmacia & Upjohn. (wikipedia.org)
  • Linezolid, the first oxazolidinone to be approved for clinical use, displays in-vitro activity (generally bacteriostatic) against many important resistant pathogens, including meticillin-resistant Staph aureus, vancomycin-resistant enterococci, and penicillin-resistant Strep pneumoniae. (nih.gov)
  • Linezolid is the first oxazolidinone anti-infective agent marketed in the United States. (nih.gov)
  • Using the terms linezolid, PNU-100766, and oxazolidinone, we performed a literature search of the following databases: MEDLINE (1966 to September 2000), HealthSTAR (1993 to September 2000), Iowa Drug Information Service (1966 to September 2000), International Pharmaceutical Abstracts (1970 to September 2000), PharmaProjects (January 2000 version), and meeting abstracts of the Infectious Diseases Society of America and the Interscience Conference on Antimicrobial Agents and Chemotherapy (1996 to 2000). (nih.gov)
  • Linezolid is a synthetic antibiotic belonging to a new class of antimicrobials called the oxazolidinones. (aafp.org)
  • Linezolid is the first in a new class of antimicrobials, the oxazolidinones. (cdc.gov)
  • The oxazolidinones, a new chemical class of synthetic antimicrobial agent, have a unique mechanism of inhibiting bacterial protein synthesis. (nih.gov)
  • effect of anomeric stereochemistry on the removal of the oxazolidinone group. (uchicago.edu)
  • Chiral oxazolidinones auxiliaries were found to be effective for completely controlling the stereochemistry of the products. (ttu.edu)
  • Note that cycloserine, while technically an oxazolidone, has a different mechanism of action and substantially different properties from the aforementioned compounds. (wikipedia.org)
  • Usually, the acid chloride substrate reacts with the oxazolidinone to form an imide. (wikipedia.org)
  • This was coupled with (S)-4-isopropyl-2-oxazolidinone to give a mixture of diastereomeric coronafacyl oxazolidinones, which were readily separable by silica-gel column chromatography to give 630 mg of optically pure (+)-coronafacic acid. (elsevierpure.com)
  • Oxazolidinone protection of N-acetylglucosamine confers high reactivity on the 4-hydroxy group in glycosylation. (uchicago.edu)
  • Variations in the oxazolidinone, protecting group, and imine components show this to be a quite general reaction. (ttu.edu)