• They are either irish homozygotes or piebald heterozygotes. (yaresville.com)
  • Poor metabolizers (*4 homozygotes), and intermediate metabolizers (*4 heterozygotes) had been significantly connected Canrenone with improved RFS (p=0.05) and (p=0.04), respectively, in comparison to extensive metabolizers in univariate evaluation. (scapca.org)
  • The most popular hereditary gamble factor is the legacy of the ε4 allele of apolipoprotein E (APO-E). The APO-Eε4 allele builds the gamble of the sickness by roughly multiple times in heterozygotes and by 8-15 times in homozygotes. (huberokororo.net)
  • Furthermore, numerous solid tumors were also observed in various regions of the surface skin of FVB/N-Trp53 em2Hwl /Korl KO mice, but were not detected in C57BL/6-Trp53 em1Hwl /Korl KO mice. (biomedcentral.com)
  • At 15 to 25 weeks of age, the homozygote variants of these mice were found to be dramatically susceptible to the development of multiple tumor types, and malignant lymphoma and sarcomas were frequently observed in the thymus and major visceral organs of these animals [ 9 ]. (biomedcentral.com)
  • 1] This article focuses on cutaneous paraneoplastic syndromes caused by solid tumors. (medscape.com)
  • Soft tissue sarcomas (STSs) are a heterogeneous group of malignant solid tumors derived from mesenchymal origin. (oncotarget.com)
  • On the other hand, there is not a unique genetic mutation for solid white plumage color. (wikipedia.org)
  • To identify the mutation responsible for renal disease, we sequenced genomic DNA from an affected animal using the Applied Biosystems SOLiD sequencing platform. (nih.gov)
  • In poultry standards, solid white is coloration of plumage in chickens (Gallus gallus domesticus) characterized by a uniform pure white color across all feathers, which is not generally associated with depigmentation in any other part of the body. (wikipedia.org)
  • There are several chicken breeds having solid white as the most typical plumage color, such as Leghorn, Dorking, Bresse Gauloise, Polish, Wyandotte and others. (wikipedia.org)
  • And there are many other breeds better known by their colored varieties, which also have a solid white variety, such as Plymouth Rock, Orpington, Rhode Island Red, Jersey Giant and others. (wikipedia.org)
  • Chicks down color of solid white chicken breeds can vary from a light creamy white, through different yellow shades, to a toasted orange. (wikipedia.org)
  • The absence of melanin in the plumage of solid white chicken breeds does not affect other body structures, except in the case of the albinos, which are easily recognized by their pink eye color. (wikipedia.org)
  • Most chicken plumage color genetic factors were manipulated during domestication by selection and crossings, which led to the modern chicken breeds, but there are no historical records of when or were the first chicken breeds with solid white plumage arose. (wikipedia.org)
  • In the creation of new white breeds, white color have been sometimes introduced from breeds of solid white plumage. (wikipedia.org)
  • There are two very well known autosomal major mutations leading to solid white plumage color, but also a number of complementary mutations properly combined may reduce or restrict pigment with a sufficient intensity to produce a final solid white plumage color, even in the absence of the major mutations for white. (wikipedia.org)
  • Most varieties of solid white plumage chickens belong to some of the first two major mutations leading to solid white plumage color. (wikipedia.org)
  • Although homozygotes I/I have always a solid white plumage color, heterozygous I/i+ chicks are generally black spotted, while the presence of black or partially black feathers on a whitish adult plumage is very common. (wikipedia.org)
  • Solid white varieties of Dorkings, Plymouth Rocks, Wyandottes, Minorcas, Orpingtons and other breeds are regarded as recessive whites because their white is completely recessive to any other color. (wikipedia.org)
  • The alpaca (Vicugna pacos) blue-eyed white phenotype (BEW) is characterized by two blue eyes and a solid white coat over the whole body. (datadryad.org)
  • In a larger cohort of 171 related individuals we identify an abundance of an allele (bew1) in grey animals and the occurrence of bew2 homozygotes that are solid white with pigmented eyes. (datadryad.org)
  • Irish homozygotes will "breed true" (as the expression goes) for the Mantle pattern, because these dogs have two copies of the gene that produces what is traditionally called "Irish markings" that we associated with white trim (tuxedo markings). (yaresville.com)
  • Typically in a litter where piebald is present you WILL get a wide, wide range of markings: from nearly solid puppies to nearly white puppies. (yaresville.com)
  • In contrast, if the breeder concentrates on producing Mantles who are Irish homozygotes, the range of markings is going to be much narrower & more stable in pattern: all the puppies can be expected to have some kind of recognizable Mantle markings: white on their extremities (legs, tail, muzzle), and all the puppies will have solid blankets and good head markings. (yaresville.com)
  • Everhart j, go v, johannes r, patients and as a single if investigations are involved, as in the population will contain p5 homozygotes with two associated facts, and this would increase it gradually. (riversideortho.com)
  • In immunocompromised populations, such as patients with AIDS and recipients of solid organ and hematopoietic stem cell transplants, BK polyomavirus (BKPyV) can reactivate and cause several diseases, which can lead to death in their severe forms. (biomedcentral.com)
  • One copy of the merle gene causes a marbling effect on the coat and creates lighter spots throughout the solid color coat. (karlaassed.com.br)
  • homogeneous reaction, any of a class of chemical reactions that occur in a single phase (gaseous, liquid, or solid), one of two broad classes of reactions-homogeneous and heterogeneous-based on the physical state of the substances present. (britannica.com)
  • The probe for Southern blot analysis is indicated by a solid bar . (biomedcentral.com)
  • The performance of the new at-line microextraction-LVI-GC-MS protocol was compared to standard solid-phase extraction (SPE) and LVI-GC-MS analysis. (who.int)
  • Det er 20 r siden Robinson (1989) skrev artikkelen hvor han beskrev en ny allele (h e ) som for rsaket hooded white spotting. (matmor.info)
  • homozygotes for the minor allele exhibited lower antibody responses while homozygotes for the major allele showed increased responses over time. (biomedcentral.com)
  • Although homozygotes I/I have always a solid white plumage color, heterozygous I/i+ chicks are generally black spotted, while the presence of black or partially black feathers on a whitish adult plumage is very common. (wikipedia.org)
  • Individuals carrying heterozygous ACAN mutations are indicated by solid symbols whereas unaffected individuals are indicated as open symbols. (nih.gov)
  • There are two very well known autosomal major mutations leading to solid white plumage color, but also a number of complementary mutations properly combined may reduce or restrict pigment with a sufficient intensity to produce a final solid white plumage color, even in the absence of the major mutations for white. (wikipedia.org)
  • Most varieties of solid white plumage chickens belong to some of the first two major mutations leading to solid white plumage color. (wikipedia.org)
  • To assess objective response rate of ceralasertib monotherapy in patients with other advanced solid tumor malignancies harboring pathogenic ATM mutations and/or loss of ATM expression by IHC (ATM Cohort). (ucbraid.org)
  • Studies have found that carriers of CYP3A5*1 consistently have higher clearance rates of tacrolimus than do CYP3A5*3 homozygotes. (medscape.com)
  • Similar to findings for Appaloosas, LP homozygotes had higher odds of uveitis compared with true solid (N/N) horses (LP/LP OR = 7.64, 95% CI [0.8 to +INF], p = 0.04) and age was also identified as a risk factor. (slu.se)
  • Blacks will likely not be solid Black, but mismarked black, sometimes even called "harlequin black" it is so common to black to harlequin breeding. (yaresville.com)
  • The expression is variable [min uthevelse], ranging from individuals with solid coloured dorsums but with roan coloured venters, to individuals with extensive roaning all over the body. (matmor.info)
  • Exposure to solid wood dust and also sulfur dioxide regularly surpassed field-work coverage limits. (mglursignaling.com)