[ 1 , 2 ] These are the most common types of malignant ovarian cell tumors (see the following image). (medscape.com)
A study that investigated nuclear protein in the testis (NUT) expression in ovarian germ cell tumors found that most malignant ovarian germ celll tumors express NUT protein, albeit focally. (medscape.com)
See also {614327} for a tumor predisposition syndrome that may contribute to the development of malignant mesothelioma upon asbestos exposure and is caused by germline mutation in the BAP1 gene ( OMIM ) on chromosome 3p21. (mendelian.co)
Germ3
An ovarian dysgerminoma consists of primitive, undifferentiated germ cells. (medscape.com)
Although germ cell tumors arise from primordial ovarian and testicular germ cells, the pathogenesis of the ovarian germ cell tumors is unknown. (medscape.com)
[ 1 ] Primitive, unipotential germ cells are the precursors to ovarian dysgerminomas, whereas pleuripotential germ cells diverge along several lines of differentiation. (medscape.com)
WAGR2
In striking contrast, complete deletions of band 11p13 result in the Wilms tumor, aniridia, genitourinary malformations, and mental retardation (WAGR) syndrome, which is characterized by structural urinary tract abnormalities without nephropathy. (medscape.com)
Nephrogenic rests are also present in the predisposition syndromes of WAGR (Wilms tumor- aniridia - genital anomalies - retardation), Denys-Drash (nephropathy, intersex disorders), Beckwith-Wiedemann (hemihypertrophy, macroglossia, hypoglycemia) and isolated hemihypertrophy. (pedsurglibrary.com)
Nephrotic syndrome3
1] This condition clinically manifests as an early onset nephrotic syndrome and progresses to renal failure during the first 3 years of life. (medscape.com)
Nephropathy: Patients with Denys-Drash syndrome develop early-onset nephrotic syndrome, have a high prevalence of severe hypertension, and experience rapid progression to end-stage renal disease (ESRD). (medscape.com)
Nephropathy: Nephrotic syndrome usually manifests in infants aged 2 weeks to 18 months. (medscape.com)
Wilms5
Denys-Drash syndrome (DDS) is a rare disorder consisting of the triad of congenital nephropathy, Wilms tumor, and intersex disorders resulting from mutations in the Wilms tumor suppressor (WT1) gene. (medscape.com)
in the incomplete forms of the syndrome, the nephropathy is present with either Wilms tumor or intersex disorders, but the vast majority of patients with Denys-Drash syndrome are destined to develop Wilms tumor in any residual renal tissue. (medscape.com)
Worldwide, more than 200 cases of Denys-Drash syndrome have been reported since 1967 when Denys et al originally described a child with nephropathy, ambiguous genitalia, and Wilms tumor. (medscape.com)
Malignancy: The vast majority of patients with Denys-Drash syndrome are destined to develop Wilms tumor in the native kidneys and are at significant risk for development of gonadoblastoma in the dysgenetic gonads. (medscape.com)
The main neoplasms in the differential diagnosis of ovarian dysgerminoma are lymphoma/leukemia, yolk sac tumor , embryonal carcinoma , and Sertoli cell tumor. (medscape.com)
Differentiation2
Point mutations in the WT1 gene result in loss of its regulatory function, with the consequent abnormalities in glomerular formation and gonadal differentiation seen in Denys-Drash syndrome. (medscape.com)
Mutations that disrupt the second alternative splicing site of the WT1 gene alter the normal ratio of KTS-positive/negative isoforms from 2:1 to 1:2 and result in abnormalities in glomerular formation and gonadal differentiation seen in Frasier syndrome. (medscape.com)
Cancer1
See Ovarian Cancer and Borderline Ovarian Cancer for more information on these topics. (medscape.com)
When present, embryonal cell carcinoma exhibits more nuclear hyperchromasia and nuclear pleomorphism, amphophilic cytoplasm, high mitotic index, and necrosis than ovarian dysgerminomas. (medscape.com)
Polycystic7
4. Combined dexamethasone and human chorionic gonadotropin in diagnosis of polycystic ovarian disease. (nih.gov)
13. [The polycystic ovary syndrome associated with ovarian tumor]. (nih.gov)
NICHD encourages scientists interested in reproduction to lead the way in determining the genes and their mechanisms of action involved in the development of the gonads, reproductive ducts and genitalia, the processes of gametogenesis, normal and premature reproductive aging, and reproductive disorders such as infertility, cryptorchidism, endometriosis, and polycystic ovarian syndrome (PCOS). (nih.gov)
Research has shown how plant-based foods benefit women's health For instance, mint tea may lower testosterone in women with polycystic ovarian syndrome Eating two handfuls of nuts each week may also make a women's life longer as much as four hours of weekly jogging may. (jewishledger.com)
While a diagnosis of polycystic ovary syndrome (PCOS) with its associated metabolic disturbances was initially considered, serum total testosterone, androstenedione, and 17-hydroxyprogesterone (17-OHP) measured by liquid chromatography tandem mass spectrometry (LC-MS/MS) were significantly increased. (bvsalud.org)
The preliminary association study of ADIPOQ, RBP4, and BCMO1 variants with polycystic ovary syndrome and with biochemical characteristics in a cohort of Polish women. (edu.pl)
My "issues" began when I was in my late twenties, after over a year of poking, prodding and several embarrassing scans that were ordered and performed by all manner of doctors and technicians, I was diagnosed with (what was at that time) a rare illness called Polycystic Ovarian Syndrome. (spilledonthekitchentable.com)
Gonadal Dysgenesis2
Frasier syndrome (FS), a rare disease caused by inherited or de novo mutation in Wilm's Tumor suppressor gene 1 (WT1), is characterized by slow progressive nephropathy, XY gonadal dysgenesis (XY-DSD), and increased risk for gonadal tumors. (nih.gov)
Although germ cell tumors arise from primordial ovarian and testicular germ cells, the pathogenesis of the ovarian germ cell tumors is unknown. (medscape.com)
Although these tumors are thought to be hormonally inert, at least one case of precocious puberty occurring in association with ovarian dysgerminoma has been reported. (medscape.com)
2. Stein-Leventhal syndrome with masculinizing ovarian tumors. (nih.gov)
8. [Combined dexamethasone suppression and chorionic gonadotrophin stimulation test in the diagnosis of androgenic functional ovarian tumors]. (nih.gov)
5. Arrhenoblastomas and associated ovarian pathology. (nih.gov)
Cell2
When present, embryonal cell carcinoma exhibits more nuclear hyperchromasia and nuclear pleomorphism, amphophilic cytoplasm, high mitotic index, and necrosis than ovarian dysgerminomas. (medscape.com)
14. Ovarian hilus-cell tumours: their varying presentations. (nih.gov)
Medical1
This is an alphabetically sorted list of medical syndromes. (wikipedia.org)
Patients1
Phenotype and genotype in 103 patients with tricho-rhino-phalangeal syndrome. (edu.pl)
Association1
3. [An unusual virilizing association: arrhenoblastoma and Stein-Leventhal syndrome]. (nih.gov)
Girl1
19. Stein-Leventhal syndrome in a 12-year-old girl. (nih.gov)
Features1
In addition, variable developmental problems and schizoid features are also associated with this syndrome. (nih.gov)