Optic nerve degeneration. Medical search. Frequent questions

Here, we investigate the contribution of autoimmune responses to axon and RGC degeneration in glaucoma using mice deficient for T and B cell function and a microbead-induced model of ocular hypertension. (arvojournals.org)
Glaucoma is actually a group of diseases, but the common feature among all types of glaucoma is optic nerve degeneration. (brightfocus.org)
Much like Alzheimer's disease is a neurodegenerative disease of the brain, glaucoma is considered a neurodegenerative disorder of the optic nerve. (brightfocus.org)
In optic nerve degeneration related to glaucoma, the optic disc displays changes that are characteristic of glaucoma, which your doctor may refer to as "cupping. (brightfocus.org)
There are also other physical features of the optic disc that can suggest glaucoma, such as thinning of the "rim," focal notches or loss of rim tissue, and bleeding (also called disc hemorrhages). (brightfocus.org)
The thinning of the rim that characteristically first affects regions of the optic disc in glaucoma is related to the typical visual field deficits seen in glaucoma patients. (brightfocus.org)
Some believe that in cases of normal-tension glaucoma , impaired blood flow to the optic nerve may be playing a more important role in the degenerative process. (brightfocus.org)
The most common causes of vision loss among the elderly are age-related macular degeneration, glaucoma, cataract and diabetic retinopathy. (xshotpix.com)
Primary open-angle glaucoma results in optic nerve damage and visual field loss. (xshotpix.com)
Glaucoma is a group of eye diseases characterized by damage to the optic nerve resulting in loss of peripheral (side) vision. (xshotpix.com)
To show the clinical benefits of machine learning in clinical vision sciences, several examples will be presented in glaucoma, age-related macular degeneration, and diabetic retinopathy, these ocular pathologies being the major causes of irreversible visual impairment. (vanguardngr.com)
Artificial Intelligence systems are available or in development for detecting several ophthalmic diseases, including Diabetic Retinopathy (DR), Wet Age-Related Macular Degeneration (AMD), cataract, and glaucoma. (vanguardngr.com)
Glaucoma patients suffer from high intraocular pressure, damage of the optic nerve head (ONH), retina nerve fibre layer (RNFL) defect, and gradual vision loss. (vanguardngr.com)
It helps in the diagnosis of age-related macular degeneration, glaucoma, and optic nerve damages. (emergenresearch.com)
This review focuses on the effects of oxidative stress and the role of a particular antioxidant system-the Keap1-Nrf2-ARE pathway-on ocular diseases, specifically age-related macular degeneration, cataracts, diabetic retinopathy, and glaucoma. (hindawi.com)
In ophthalmology, OCT has applications in scanning the retina to predict and diagnose retinal diseases such as age-related macular degeneration (AMD) and diabetic retinopathy , and it can scan the optic nerve and nerve fiber layer to track damage from glaucoma. (medscape.com)
Age-related eye diseases such as glaucoma, cataract, diabetic retinopathy, and age-related macular degeneration, are the leading causes of visual impairment and blindness in North America. (powershow.com)
Mitochondrial dysfunction in the optic nerve, which sends light signals to the brain and is critical for vision, can eventually lead to loss of cells and tissue damage, causing multiple eye diseases such as glaucoma, and macular degeneration, as well as other retinal damage. (ophthalmologytimes.com)
According to the news release, this is the first comprehensive study to look at FPF changes in the optic nerves in patients with different stages of glaucoma compared to healthy eyes. (ophthalmologytimes.com)
Levels of FPF correlated with other means of detecting glaucoma including visual field mean deviation, visual field pattern deviation, and retinal nerve fiber layer thickness. (ophthalmologytimes.com)

eSight users typically live with serious eye conditions such as macular degeneration, Stargardt's disease, diabetic retinopathy, optic nerve hypoplasia and more. (cnib.ca)
The most common ophthalmic disorders are age-related macular degeneration, macular edema, and diabetic neuropathy, among others. (emergenresearch.com)
OCT has been routinely used in measuring retinal thickness for the evaluation of ME caused by diseases such as age-related macular degeneration, diabetic retinopathy, hereditary retinal degenerations, retinal vein occlusion, after cataract surgery, epiretinal membrane (ERM) and uveitis. (bmj.com)
These implants can restore sight to completely blind patients -- though only if the blindness is caused by a faulty retina, as in macular degeneration (which millions of old people suffer from), diabetic retinopathy, or other degenerative eye diseases. (extremetech.com)
Basically, with macular degeneration and diabetic retinopathy, the light-sensitive rods and cones in your retina stop working. (extremetech.com)
This formula is made with a blend of 8 natural ingredients, which contains all the necessary and powerful nutrients and vitamins to fight the root cause of degrading eye conditions like macular degeneration, RP, cataracts, and even diabetic retinopathy. (bignewsnetwork.com)

Occasional findings include optic nerve atrophy. (wikipedia.org)
As dry AMD progresses to retinal atrophy and central retinal degeneration, loss of central vision often occurs. (medscape.com)
This optic nerve atrophy often begins in infancy or early childhood and results in vision impairment that worsens over time. (medlineplus.gov)
Anikster Y, Kleta R, Shaag A, Gahl WA, Elpeleg O. Type III 3-methylglutaconic aciduria (optic atrophy plus syndrome, or Costeff optic atrophy syndrome): identification of the OPA3 gene and its founder mutation in Iraqi Jews. (medlineplus.gov)
3-Methylglutaconic aciduria in the Iraqi-Jewish 'optic atrophy plus' (Costeff) syndrome. (medlineplus.gov)
The most commonly associated phenotype with OPA1 mutations is heterozygous optic atrophy, a heterozygous dominant trait that causes reduced visual clarity and sometimes blindness. (thermofisher.com)
By the time optic atrophy is detected, substantial optic nerve injury has already occurred. (msdmanuals.com)
Dominant optic atrophy is inherited in an autosomal dominant fashion. (msdmanuals.com)
Most patients with dominant optic atrophy have no associated neurologic abnormalities, although nystagmus and hearing loss have been reported. (msdmanuals.com)
Eventually, optic atrophy supervenes. (msdmanuals.com)
Diagnosis of dominant optic atrophy and Leber hereditary optic atrophy is mainly clinical. (msdmanuals.com)

Individuals with this condition usually start showing signs of nyctalopia (also known as night-blindness) during their early childhood, increase in sensitivity to blue light, progressive decrease of visual acuity in both eyes, cataract, peripheral vision loss, vitreous liquefaction and detachment, clumped pigment deposits of the fundus, either peripheral or central retinoschisis, cystic macular edema, and retinal degeneration. (wikipedia.org)
cataract, retinal degeneration, and nightblindness. (wikipedia.org)

More recently, a subset of OCT, the OCT Angiography is a modality that images integrity of the vasculature in the retina and optic nerve mainly assessing the blood perfusion. (aao.org)

There are types of optic nerve degeneration that are genetic and possibly hereditary - you need to know about that too. (agingcare.com)
Hereditary optic neuropathies result from genetic defects that cause vision loss and occasionally cardiac or neurologic abnormalities. (msdmanuals.com)
It is believed to be the most common of the hereditary optic neuropathies, with prevalence in the range of 1:10,000 to 1:50,000. (msdmanuals.com)
Vision loss in patients with Leber hereditary optic neuropathy typically begins between 15 and 35 years (range, 1 to 80 years). (msdmanuals.com)
Some patients with Leber hereditary optic neuropathy have cardiac conduction defects. (msdmanuals.com)

The Shaffer Grant allowed me to focus on understanding the molecular signaling pathways controlling axonal degeneration. (glaucoma.org)

Inherited retinal diseases (IRDs) are a clinically and genetically heterogeneous group of disorders that often lead to photoreceptor degeneration. (nature.com)
Others may be related to a reaction to medication, or nerve or muscle diseases. (health.govt.nz)

The rising adoption of smart devices increases the incidences of ophthalmic disorders, and the rising geriatric population is causing a surge in the patient pool of age-related macular degeneration. (emergenresearch.com)
It stands to reason, therefore, that neurodegenerative disorders might also cause degeneration of neurons in the retina. (aao.org)
ProVisine works to fulfill the body's nutritional needs to repair the tissue damage and creates a protective barrier against environmental and harmful toxins to further prevent eye disorders like macular degeneration, cataracts, myopia, and blurred vision. (bignewsnetwork.com)

However, it is possible to have elevated eye pressure or "ocular hypertension" and show no changes of optic nerve degeneration (although one would need to be monitored over time for signs of degeneration), and conversely it is possible to have normal eye pressure and significant optic nerve degeneration. (brightfocus.org)
ProVisine was designed to improve the function of optic nerves and ocular muscles. (bignewsnetwork.com)

The optic nerve is composed of approximately 1.5 million nerve fibers at the back of the eye that carry visual messages from the retina to the brain. (brightfocus.org)
These cells reside in the retina, but their output "cables" or "fibers," called axons, extend from the head of the optic nerve at the back of the eye to the brain. (brightfocus.org)
Usually, this phenotype is attributed to the degeneration of optic nerve fibers. (thermofisher.com)
The retina then sends these signals along the optic nerve (a cable of more than 1,000,000 nerve fibers) to the brain. (kidshealth.org)
Floaters are caused by vitreous opacities such as blood, glial cells torn from the optic nerve head, or aggregated collagen fibers, all of which can cast shadows on the retina. (aao.org)

mitochondrial networks associated with critical nerves seem to link schizophrenia and OPA1. (thermofisher.com)

The signs of degeneration were more marked in the central zone than in the peripheral zone and they were more prominent in the 1 wpo group than in the 4 wpo group. (nel.edu)

Therefore, the retinal ganglion cell plays a critical role as the output nerve cell of the eye that transmits visual information to the brain. (brightfocus.org)
Optic nerve section in the newborn rat results in a rapid apoptotic degeneration of most axotomized retinal ganglion cells (RGCs). (nih.gov)
Here, we used the σR1-knockout mouse ( Sigmar1 −/− ) to demonstrate unambiguously the role of the σR1 in protecting the retinal ganglion cells against degeneration after acute damage to the optic nerve. (molvis.org)
Retinal ganglion cell death was induced by acute optic nerve crush in wild-type and Sigmar1 −/− mice. (molvis.org)
Quantification of cells remaining after optic nerve crush showed that 86.8±7.9% cells remained in the wild-type ganglion cell layer, but only 68.3±3.4% survived in the Sigmar1 −/− , demonstrating a significant difference between the wild-type and the Sigmar1 −/− in crush-induced ganglion cell loss. (molvis.org)
Our data indicated faster retinal ganglion cell death in Sigmar1 −/− than in wild-type mice under the stresses caused by optic nerve crush, providing direct evidence for a role of the σR1 in alleviating retinal degeneration. (molvis.org)
In retinitis pigmentosa patients a slow and progressive degeneration of photoreceptors is observed, while about 30% of the retina's ganglion cells remain intact. (medgadget.com)
These ganglion cells are connected to the visual cortex of the brain via the optic nerve. (medgadget.com)

The normal optic nerve has a healthy appearing "rim" of tissue, which is assessed by both the contour of the rim as well as the color. (brightfocus.org)
Strengthens nerve impulses and positively affects the functional state of the nervous tissue of the visual center. (kalinka-store.com)
These tests involve the doctor shining a beam of bright light into the dilated eye to check for problems in the retina, the blood vessels, the area where the optic nerve connects to the retina, and the choroid, which is a thin layer of tissue connecting blood vessels and nerves to other parts of the eye. (medicalnewstoday.com)
The normal retinal tissue has different reflectivity patterns on OCT. The nerve fibres and the retinal pigment epithelium display high reflectivity. (bmj.com)
[7] [8] However, whether this loss of tissue represents primary neurodegeneration within the retina itself or instead secondary retrograde degeneration due to neuronal and axonal loss in the brain has not yet been determined. (aao.org)

Ophthalmoscopic examination may show telangiectatic microangiopathy, swelling of the nerve fiber layer around the optic disk, and an absence of leakage on fluorescein angiography. (msdmanuals.com)

The prevalence of age-related macular degeneration is increasing in Asia due to increase in life expectancy and rising incidents of diabetes among the younger population. (powershow.com)

The work of my small laboratory in the national program for prevention of mental retardation by early diagnosis of congenital hypothyroidism, and finally screening of early markers of initial stages of dementia en elderly people. (bvsalud.org)

birth defects: coloboma of choroid or optic nerve disc, etc. (who.int)

In optic neuritis (ON), transient thickening of the macular retinal nerve fibre layer (RNFL) can be observed. (lu.se)

The axons of the optic nerve are bundled and insert in the back of the eye, and this "optic disc" is seen in the back of the eye along with blood vessels. (brightfocus.org)
This is because the axons of the optic nerve leave the eye by passing through a structure called the "lamina cribrosa," which is a mesh-like structure composed of pores or holes through which the axon bundles must cross. (brightfocus.org)
The most prominent sign of the degeneration was loss or lack of the healthy myelinated axons. (nel.edu)

What we do know is that there is likely mechanical damage at the site where the optic nerve inserts into the back of the eye. (brightfocus.org)
The increased pressure can damage the optic nerve. (southsidemedical.net)
During this test, a doctor uses special eye drops to dilate the pupils, allowing them to examine the retina for disease and see any optic nerve damage. (medicalnewstoday.com)
Once structural damage to the optic nerve has occurred, it is currently not possible to reverse," he said in the statement. (ophthalmologytimes.com)
Optic nerve damage is usually permanent and in some cases progressive. (msdmanuals.com)

At 2 to 8 weeks after microbead injection, the degrees of RGC and axon degeneration were assessed quantitatively using electron microscopy and immunohistochemistry with a primary antibody against an RGC specific marker. (arvojournals.org)
Light and electron microscopy showed no alterations in the fine structure of treated optic nerves. (nih.gov)
Hematologic staining and electron microscopy did not show noticeable proliferation and degeneration of the retina. (molvis.org)

If it is central acuity from macular degeneration she may be legally blind, but with the right peripheral cues will be able to ambulate and perform many self care skills. (agingcare.com)

Retinal imaging takes a digital picture of the eye and shows detailed imaging of the retina, optic disk, and blood vessels of the eye. (emergenresearch.com)
The vitreous is also firmly attached at the margin of the optic nerve head, at the macula, along major vessels, at the margins of lattice degeneration, and at chorioretinal scars. (aao.org)
The entire optic disk or, at times, only the temporal portion is pale without visible vessels. (msdmanuals.com)

To further investigate the roles of T cell-mediated responses in glaucomatous RGC and axon degeneration, CD4+ T cells isolated from C57BL/6J wild-type mice that were induced to develop high IOP were adoptively transferred to Rag1-/- mice. (arvojournals.org)
Adoptive transfer of CD4+ T cells isolated from high IOP C57BL/6J mice significantly facilitated the axon and RGC degeneration in Rag1-/- mice as compared to Rag1-/- mice received cell transfer from the normal IOP group. (arvojournals.org)

Auditory and olfactory findings in patients with USH2A-related retinal degeneration-Findings at baseline from the rate of progression in USH2A-related retinal degeneration natural history study (RUSH2A). (cdc.gov)

Given that the eye possesses clear optics and shares many neural and vascular similarities to the brain, it offers a direct window to cerebral pathology. (frontiersin.org)
Without a retina or optic nerve, the eye can't communicate with the brain, making vision impossible. (kidshealth.org)
When macula is damaged, its functioning process of recording the images and sending a brain signal via the optic nerve suffers. (powershow.com)
A lot of work is being done on understanding how the retina, optic nerve, and brain process and perceive images -- so who knows what the future might hold. (extremetech.com)

This separation from the optic nerve head is often accompanied by symptoms associated with the appearance of a Weiss ring. (aao.org)

When light enters the eye, the retina changes the light into nerve signals. (kidshealth.org)

Photo showing how degeneration of the optic nerve narrows the field of vision, starting with loss of vision in the periphery, which then ultimately also causes loss of central vision. (brightfocus.org)
Cupping" is the result of changes in the optic nerve related to optic nerve degeneration, where there is a backward bowing of the central part of the disc. (brightfocus.org)
Age-related macular degeneration is characterized by the loss of central vision. (xshotpix.com)
When Macula or central portion of your eye deteriorates, the condition is called Macular degeneration. (powershow.com)

Age-related macular degeneration (AMD) is a condition that causes progressive vision loss. (medicalnewstoday.com)
It is thought to be optic abiotrophy, premature degeneration of the optic nerve leading to progressive vision loss. (msdmanuals.com)

Nonexudative (dry) age-related macular degeneration (AMD or ARMD) accounts for more than 90% of patients diagnosed with AMD. (medscape.com)
Patients with primary Sjögren syndrome show loss of WM microstructural integrity, probably related to both Wallerian degeneration and demyelination. (ajnr.org)

It is a type of progressive vitreotapetoretinal degeneration. (wikipedia.org)

Ultra structural evidence of axonal regeneration following intracranial transection of optic nerve. (nel.edu)

Another contributing factor may be blood flow to the optic nerve. (brightfocus.org)

in most eyes, the evolving PVD remains subclinical for years until separation from the optic nerve head margin (the area of Martegiani) occurs. (aao.org)

Macular Degeneration (AMD) has been identified as a common condition affecting people more than 50 years old. (powershow.com)

Anatomy24

Diseases29

Chemicals and Drugs3

Analytical, Diagnostic and Therapeutic Techniques and Equipment11

Psychiatry and Psychology4

Phenomena and Processes7

Disciplines and Occupations1

Technology, Industry, Agriculture1

Glaucoma20

Diabetic6

Atrophy11

Cataract2

Retina and optic nerve1

Hereditary5

Axonal degeneration1

Diseases2

Disorders3

Ocular2

Fibers5

Mitochondrial1

Signs of degeneration1

Ganglion8

Tissue5

Fiber layer1

Prevalence1

Diagnosis1

Choroid1

Fibre layer1

Axons3

Damage5

Electron microscopy3

Peripheral1

Vessels3

Mice2

Findings1

Brain4

Symptoms1

Signals1

Central4

Vision loss2

Patients2

Progressive1

Structural1

Blood1

Occurs1

Common1