Obesity metabolic improves cardiovascular cardiovascular physiological phenomena. Medical search. Frequent questions

There are several mechanisms of TEI that have shown to affect germline reprogramming, such as transgenerational increases in susceptibility to diseases, mutations, and stress inheritance. (wikipedia.org)
Obesity is considered a clinical state of impaired general heath in which the excessive increase in adipose tissue mass may be associated with metabolic disorders such as type 2 diabetes mellitus, hyperlipidemia, hypertension and cardiovascular diseases. (uzh.ch)
Many remain small to adulthood and are at an increased risk for developing metabolic diseases such as obesity and type 2 diabetes. (bcm.edu)
The inherent cell-type specificity of epigenetic regulation motivates development of techniques to isolate and study specific cell types of relevance to obesity and digestive diseases. (bcm.edu)
White adipose tissue (WAT) - a key contributor in many metabolic diseases - contributes about one fourth of a healthy human's body mass. (nature.com)
Integrating multi-omics approaches will enable a paradigm shift from the one size fits all approach towards precision obesity management, i.e. (1) precision prevention of the onset of obesity, (2) precision medicine and tailored treatment of obesity, and (3) precision risk reduction and prevention of secondary diseases related to obesity. (springermedizin.at)
In the modern world, the rise in chronic diseases and obesity has become a major health concern. (purenaturecures.com)
Obesity is a complex and multifactorial condition that significantly increases the risk of numerous diseases. (purenaturecures.com)
Obese individuals are at a higher risk of developing type 2 diabetes, cardiovascular diseases, hypertension, certain cancers, and musculoskeletal disorders. (purenaturecures.com)
This phenomenon, known as "adipose tissue dysfunction," leads to increased toxin exposure and may further exacerbate the risk of chronic diseases. (purenaturecures.com)
Toxic substances in our surroundings can disrupt normal metabolic processes, leading to weight gain and increasing the risk of chronic diseases. (purenaturecures.com)
This review describes, analyzes and compares the effects of different types of diets in reducing the onset of typical Western countries non-communicable diseases (NCDs) (cardiovascular diseases, tumors, chronic respiratory diseases, diabetes, etc.), thus increasing the average lifespan. (iospress.com)
Cardiovascular diseases (CVDs) account for most NCDs deaths (17.7 million people annually), followed by cancers (8.8 million), respiratory diseases (3.9 million) and diabetes (1.6 million) [ 1 ]. (iospress.com)
Next, data from animal and human studies on the involvement of the RAGE pathway in obesity, diabetes, and cardiovascular diseases are summarized. (bvsalud.org)
The potential cardiovascular benefits of certain GLP-1 medications make them even more invaluable, especially for diabetics vulnerable to heart diseases. (bmidoctors.com)
Obesity is defined as an expansion of white adipose (WAT) tissue that is associated with low grade inflammation which possibly contributes to the development of health complications such as diabetes, liver pathologies, dyslipidemia, cardiovascular diseases as well as some cancers [ 2 - 4 ]. (springer.com)
A lack of physical exercise plays a major role in the pathophysiology of vascular, metabolic, and metastatic diseases. (hrb.ie)
Excess body fat not only impacts physical appearance but also increases the risk of various chronic diseases, including cardiovascular disease, type 2 diabetes, and certain types of cancer. (well-choices.com)
Prolonged stress can increase the risk of cardiovascular diseases like heart disease and stroke. (fitelo.co)
Since this discovery, these vesicles have been identified as playing a role in a huge range of physiological and pathological functions in the human body, including ageing, cancer, infectious diseases and obesity 2 . (lemalab.co)
In an article published last year, scientists from the Institute of Metabolic and Cardiovascular Diseases in France 6 reviewed research on the influence of exercise on lipolysis. (lemalab.co)
As the human lifespan increases, the incidence of such diseases-including neurodegenerative disorders like Alzheimer's and Parkinson's, cardiovascular conditions, metabolic diseases like diabetes, musculoskeletal conditions like osteoporosis and osteoarthritis, and immune system disorders-also rises. (decodeage.com)
With life expectancy significantly increasing in recent decades, these diseases have become major public health issues. (decodeage.com)
However, recent research has shown an increasing interest in exosomes as a source of biomarkers for age-related neurodegenerative diseases. (decodeage.com)
After having moved with his wife to the small health-resort of Eugénie-les-Bains, which is well-known for treating metabolic diseases (overweight, obesity), he had observed that the people who had come here to loose weight were eating only a dish of badly seasoned grated carrots. (fondation-recherche-cardio-vasculaire.org)
Moreover, diseases related to systemic or local inflammation, including infections, cerebrovascular accidents, and obesity, have been proposed as risk factors for the development of AD. (biomedcentral.com)
Most neurodegenerative diseases are related to age, thus the most vulnerable population is elderly individuals, who are more likely to suffer from AD when external factors are present, such as obesity, which exacerbates inflammation [ 3 ]. (biomedcentral.com)
CPP and early menarche have been considered as risk factors for obesity and cardiovascular diseases during adulthood. (eurospe.org)
The odds are overwhelming that you will die as a result of one of the chronic diseases of aging that I call the Four Horsemen: heart disease, cancer, neurodegenerative disease, or type 2 diabetes and related metabolic dysfunction. (sameerbajaj.com)
This graph shows how little real mortality rates have improved since 1900, once you remove the top eight contagious/infectious diseases, which were largely controlled by the advent of antibiotics in the early twentieth century. (sameerbajaj.com)
These microbiomes support and maintain your health but also, when the microbiome is disturbed in some fashion, have been linked to hundreds of ailments such as cancers, and autoimmune and cardiovascular diseases. (kss.org.pl)
The current review focuses on the role of the eCB system in normal kidney function and various diseases, such as diabetes and obesity, that directly contributes to the development of renal pathologies. (degruyter.com)
Inflammation seems to be the major initiator of many processes that leads to self-healing as well as pathogenesis of major metabolic diseases, including, atherosclerosis, obesity, metabolic syndrome, type-2 diabetes, ischemic heart disease and stroke. (crimsonpublishers.com)
Now that I have clarified the role of inflammation in the initiation, promotion of metabolic diseases and their clinical complications, I would briefly describe how researchers are addressing this issue when it comes to diagnosis as well as management [3,4]. (crimsonpublishers.com)
Just like the pioneering Framingham heart study at Massachusetts, the studies at the Mission Hospital Mysore, India, has established a correlation between the low birth weight of the children and an increase in the incidence of cardio metabolic diseases in the "Mysore Cohort" [5]. (crimsonpublishers.com)
According to an NIH summary, the main basis of the Barker hypothesis is that under nutrition in pregnancy impairs fetal growth or promotes disproportionate fetal growth, and as a trade-off these adaptations that promote survival in adverse conditions, lead to limited physiological functions and development of adult diseases (CMDs) of fetal origin. (crimsonpublishers.com)
If these investigations (CNMH/KEM) develop a strong correlation between the maternal adipose tissue signals and the development of altered metabolism of the children from obese mothers, then one has to consider various strategies for the prevention of this well-known phenomenon of the fetal origin of adult diseases. (crimsonpublishers.com)
It can be enforced to identify phenomena related to the ANS in healthy subjects and patients with certain diseases, such as diabetes mellitus 8, 9 , chronic obstructive pulmonary disorder (COPD) 10 , epilepsy 11,12 and those referred to as "dynamical diseases 13 . (bvsalud.org)
Conversely, people with cardiovascular diseases more frequently suffer from serious mental disorders. (bvsalud.org)
The predisposing factors for the coexistence of mental illnesses and cardiovascular diseases are often entangled. (bvsalud.org)
Atrial fibrillation (AF) has strong associations with other cardiovascular diseases, such as heart failure, coronary artery disease (CAD), valvular heart disease, diabetes mellitus, and hypertension. (medscape.com)

The rising prevalence of obesity is likely to result from contemporary environmental and lifestyle factors such as increased access to palatable foods and reduced requirements for physical exercise, when compared with ancient hunter-gatherer lifestyles characterised by unpredictable periods of feast and famine. (hindawi.com)
Since the 1970s, the worldwide prevalence of obesity has nearly tripled, also leading to an upsurge in associated comorbidities such as type 2 diabetes (Fig. 1a ) 2 . (nature.com)
Menopause-related decline in estrogen levels is accompanied by a change in adipose tissue distribution from a gynoid to an android and an increased prevalence of obesity in women. (bvsalud.org)
The prevalence of obesity has reached alarming levels globally, making it a significant public health concern. (well-choices.com)
Patients with narcolepsy, especially NT1, have been found to have a high prevalence of obesity and other metabolic derangements. (encyclopedia.pub)

Hence, even though physiological and pathophysiological phenomena are well described in dogs and cats, the underlying mechanisms are often not known and studies investigating causality specifically are scarce. (uzh.ch)
The underlying mechanisms are not completely understood but modulation of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG CoA)-reductase may play a central role as genetic data indicate that mutations resulting in lower HMG CoA-reductase activity are also associated with obesity, higher glucose concentrations and diabetes. (e-dmj.org)

Very interestingly, this statin induced increased risk for new onset type 2 diabetes is not detectable in subjects with familial hypercholesterolemia. (e-dmj.org)
Furthermore, patients with familial hypercholesterolemia seem to have a lower risk for type 2 diabetes, a phenomenon which seems to be dose-dependent (the higher the low density lipoprotein cholesterol, the lower the risk). (e-dmj.org)
Offering a novel approach to the management of chronic conditions, especially Type 2 diabetes and obesity, GLP-1 medications herald a transformative era, redefining the paradigms of therapeutic intervention. (bmidoctors.com)
The major focus of our research is to understand the mechanistic basis of the relationships between sub-optimal early life nutrition and subsequent increased risk of type 2 diabetes, obesity, and premature death. (cam.ac.uk)
The metabolic derangement that leads to type 2 diabetes also helps foster and promote heart disease, cancer, and Alzheimer's disease. (sameerbajaj.com)

Sleep is one of the basic physiological processes for human survival. (mdpi.com)
When these toxins accumulate, they can disrupt the endocrine system and metabolic processes, leading to weight gain and obesity. (purenaturecures.com)
This suggests that certain metabolic processes and the production of reactive oxygen species, are increased in the knockout worms, which speeds up the aging process. (elifesciences.org)
This meal-induced secretion ensures our body remains in sync with its energy requirements and metabolic processes. (bmidoctors.com)
Since the level of sugar , the source of energy necessary for the initiation of metabolic processes, decreases, the body starts to draw it from burning fat tissue and we can also count on inhibiting the feeling of hunger . (consumers-views.com)
Therefore, using a life-course ap- ical processes that occur over the in the etiology of childhood obesity. (who.int)
Several intricate mechanisms and processes contribute to this metabolic phenomenon. (well-choices.com)
2013). The disruption of the body's internal clock, known as the circadian rhythm, due to sleep deprivation can negatively impact metabolic processes, hormone regulation, and immune function (Taheri et al. (cheapessay.us)
External factors, including systemic inflammation, such as that observed in obesity, are likely to interfere with the brain's immune processes and further promote disease progression. (biomedcentral.com)

Sleep fragmentation results from the increase in overnight arousals and may be exacerbated by the increasing number of geriatric medical conditions, including sleep apnea, musculoskeletal disorders, and cardiopulmonary disease. (medscape.com)
Studies on sleep quality started later than those on sleep quantity, beginning in 1989 when Ford and Kamerow revealed that insomnia increases the risk of psychiatric disorders. (mdpi.com)
The modern world faces an ever-mounting challenge of metabolic disorders. (bmidoctors.com)
A mismatch between the circadian rhythm and the meals schedule, such as in circadian rhythm disorders , may increase insulin resistance. (wikipedia.org)
These intervention studies have provided vital clues as to the mechanism underlying the programming of offspring cardio-metabolic disorders in maternal obesity and we have shown rescue of some of the detrimental phenotypes in the offspring. (cam.ac.uk)
Their prevalence is higher in patients presenting cardiovascular risk factors.This review takes stock of the frequency, the mechanisms, and the implications of major cardiovascular risk factors in patients with serious mental disorders. (bvsalud.org)

Besides, obesity in childhood and adolescence can lead to social stigma and isolation, decreased life expectancy, a high frequency of sick leave, disability pension, and increased mortality. (springermedizin.at)
Genetic, environmental, behavioral and dietary factors influence the pathways that regulate aging and life expectancy, thus rendering longevity a very complex phenomenon. (iospress.com)
There is increasing evidence life expectancy and health, occurring an embodiment dynamic occurs dif- that chronic psychosocial stress may upstream of typically identified risk ferentially across the strata of SEP. (who.int)
The increase in the elderly population is a global phenomenon reflecting the increase in life expectancy that has changed the demographic profile of several countries. (who.int)
der the supervision of the Directorate is a global phenomenon reflecting the Malnutrition is common among of Social Security in Lattakia, which is increase in life expectancy that has residents of homes for the elderly and under the Ministry of Social Security. (who.int)
As advances in public health and health care have helped increase life expectancy, public health professionals and health care providers have the opportunity to improve the quality of life for older adults and their caregivers and reduce the burdens associated with aging. (cdc.gov)

In fact, diabetes in dogs is typically not associated with obesity because dogs present a type 1 diabetes-like syndrome. (uzh.ch)
Patients with metabolic syndrome (MetS) have an increased risk of cardiovascular disease. (biomedcentral.com)
It finds application not only in the fight against overweight or even pathological obesity, it is also recommended for people suffering from epilepsy , including its severe myoclonic variants , such as Dravet syndrome or Doose syndrome. (consumers-views.com)
Insulin resistance is considered a component of the metabolic syndrome . (wikipedia.org)
[1] Various genetic factors can increase risk, such as a family history of diabetes, and there are some specific medical conditions associated with insulin resistance, such as polycystic ovary syndrome . (wikipedia.org)
[2] Overconsumption of fat- and sugar-rich meals and beverages have been proposed as a fundamental factor behind the metabolic syndrome epidemic. (wikipedia.org)
To explore the correlation structure of individual components of the Metabolic Syndrome and identify combinations of correlated variables we used principal component analysis (PCA) in a multiethnic group of women with a history of GDM (pGDM) (185 European, 103 South Asian, 80 African Caribbean), recruited at 20.0 (18.2 22.1) months (geometric mean (95% CI)) after pregnancy and 482 control women of similar ethnicities. (endocrine-abstracts.org)
CB1 antagonism may have potential in the metabolic syndrome, with effects mediated through central orexigenic mechanisms and via peripheral action on white adipose tissue (WAT). (endocrine-abstracts.org)
Hence, many effects of nutrition on the development and progression of cancer lack 'specificity' in their association, and such alimentary cues also affect the risk of developing metabolic syndrome, a prelude to arteriosclerosis and neurodegeneration ( Fig. 1 ). (nature.com)

Obese dogs and cats show many features of human obesity. (uzh.ch)
Overweight or obese individuals (body mass index 25-30) have an increased risk of developing diabetes, coronary heart disease, and hypertension [ 2 , 3 ]. (hindawi.com)
We are using a combination of molecular and physiological techniques to define the metabolic parameters that mediate the effects of maternal obesity on hypothalamic development, and establish whether this disrupted development underlies the hyperphagia- and ultimately obesity- we observe in the offspring of obese mothers. (cam.ac.uk)
Sex-specific effects of maternal metformin intervention during glucose-intolerant obese pregnancy on body composition and metabolic health in aged mouse offspring. (cam.ac.uk)
Due to the increase in prevalence of childhood obesity, more obese children are referred to the endocrinologist for the hypothalamus-hypophysis-adrenal axis assessment. (eurospe.org)
As with chaotic globals an increase in response was detected by three measures of entropy in young obese. (bvsalud.org)

Excess body fat not only affects physical health but also has profound effects on various physiological systems. (purenaturecures.com)
The process of burning body fat is a complex metabolic phenomenon that involves various physiological and biochemical mechanisms. (well-choices.com)

However, in the course of overweight and obesity, adverse changes occur in the structure and function of adipocytes. (bvsalud.org)
One of the cornerstones of fast and, above all, permanent weight loss is a well-chosen weight loss diet , because it is thanks to it that you can cope with growing overweight and obesity . (consumers-views.com)
Overweight and obesity are common among girls with Central Precocious Puberty (CPP). (eurospe.org)

Evidence from genome-wide association studies highlight the importance of genetic and epigenetic factors in the development of obesity and how they in turn affect the transcriptome, metabolites, microbiomes, and proteomes. (springermedizin.at)
These phenomena contribute to the development of obesity-related complications, which also affect the major tropic axes regulating the endocrine glands. (bvsalud.org)
Numerous data indicate that the accumulation of AGEs in the extracellular matrix plays a key role in the development of obesity-related adipose tissue dysfunction. (bvsalud.org)
A differential response in the development of obesity complications exists depending on WAT depot distribution. (springer.com)
In this review, we aim to describe the relationships and discussed sequence of events associated with hypoxia, ECM remodeling and inflammation in the development of obesity and associated complications. (springer.com)

As mentioned earlier, environmental toxins can contribute to obesity by disrupting metabolic pathways. (purenaturecures.com)
Therefore, inhibiting the production and accumulation of AGEs, as well as interfering with the metabolic pathways they activate, may be a promising therapeutic strategy for restoring normal adipose tissue function and, thus, combating obesity-related comorbidities. (bvsalud.org)
These compounds replicate the physiological effects of fasting by activating similar molecular pathways. (healthnews.com)
Research conducted at the University of Southern California (USC), including studies led by Dr. Valter Longo, has shown that fasting and fasting mimetics can activate cellular pathways that promote cellular rejuvenation, metabolic flexibility, longevity, and overall health. (healthnews.com)
Our research shows that exposure to maternal obesity results in disruption of early hypothalamic development, and altered anatomy and the expression of key feeding pathways in adulthood. (cam.ac.uk)

Despite recent progress in our understanding of the physiological mechanisms regulating body weight and energy expenditure, obesity remains a major worldwide health crisis with an array of vascular, metabolic, and psychosocial consequences [ 1 , 2 ]. (hindawi.com)
Obesity is a state in which energy intake chronically exceeds energy expenditure. (hindawi.com)
Obesity is commonly characterized as the accumulation of body fat that results when energy intake exceeds energy expenditure, although individuals respond differently to this imbalance due to genetic predisposition. (springermedizin.at)
The main cause of obesity is energetic imbalance due to increased caloric intake and little expenditure. (hrb.ie)
In 2005, undeveloped countries such as Costa Rica spent two million dollars on NSAIDs, which represented an increase of 25% from the expenditure in 2001 [ 6 ]. (biomedcentral.com)
It might seem logical that increased energy expenditure, such as that during athletic training and performance, increases energy intake. (medscape.com)
Food deprivation increases hunger, but the same low energy availability, when caused by energy expenditure from exercise, does not increase appetite. (medscape.com)
[ 15 ] In one study, a 20% increase in energy expenditure during 40 weeks of marathon training did not result in an increase in energy intake. (medscape.com)
[ 16 , 17 ] Even female monkeys with induced amenorrhea secondary to increased energy expenditure must be offered special treats in order to persuade them to consume enough food to restore normal menstrual function. (medscape.com)

Une recherche documentaire a été effectuée dans PubMed de 1980 à 2021 en utilisant diverses combinaisons de termes MeSH comme tabac, diabète, hypertension, dyslipidémie, trouble dépressif majeur, trouble bipolaire, schizophrénie. (bvsalud.org)

Obesity-related adipose tissue dysfunction translates into a change in the profile of secreted adipokines, and it impairs steroidogenesis. (bvsalud.org)
However, there is increasing evidence that weight reduction is an effective treatment for obesity-related adipose tissue dysfunction, thereby restoring endocrine function. (bvsalud.org)
This narrative review summarizes data on the involvement of the RAGE pathway in adipose tissue dysfunction in obesity and the development of its metabolic complications. (bvsalud.org)

Alongside, obesity, often dubbed the '21st-century pandemic,' weaves a complex tapestry of health complications, ranging from cardiovascular ailments to psychological distress. (bmidoctors.com)
Moreover, the mere control of blood sugar doesn't address the multifactorial complications of diabetes, which often include cardiovascular risks. (bmidoctors.com)
Obesity is defined as an excess accumulation of white adipose tissue associated with a low grade inflammation which is one contributor to obesity complications such as diabetes. (springer.com)
In this review, we aim to describe two hypotheses trying to explain the sequence of events linking fibrosis, inflammation and obesity complications. (springer.com)
the effects of hypoxia and fibrosis may also play a role in obesity complications via notably ectopic-lipid accumulation in non-adipocyte cells. (springer.com)
Since diabetes is associated with cardiovascular and kidney complications, we investigated the influence of SBE on blood glucose, blood pressure and renal function in some experimental animal paradigms. (endocrine-abstracts.org)
This type of early detection of gene expression could be really a game changer for millions of South Asians who are on track of developing CMDs and other obesity-related clinical complications. (crimsonpublishers.com)

The novel system provides a promising tool for wide-ranging applications in mechanistic research of WAT-related biology, in studying of pathophysiological mechanisms in obesity and diabetes, and in R&D of pharmaceutical industry. (nature.com)
Furthermore, the precise pathophysiological characteristics underlying the association of different cardiovascular risk factors in MetS remain elusive [ 5 ]. (biomedcentral.com)

Chronic sleep deprivation has been linked to a range of medical conditions, including cardiovascular disease, obesity, and diabetes (Cappuccio et al. (cheapessay.us)

Together, these projects will advance our understanding of how the liver regulates glucose production using neural, hormonal, and intracellular mechanisms, and increase the overall body of knowledge. (bcm.edu)
This persons contraception status increases thrombogenicity due to reduced endogenous oestrogen status secondary to germ cells destruction by contraception, over that her consumption of hormonal pills to postpone menstruation further decreases endogenous oestrogen, increased vulnerability for pulmonary thromboembolism. (scirp.org)
The achievement, at a global level, of a "healthy aging phenotype" defined as "the condition of being alive, while having highly preserved functioning metabolic, hormonal and neuroendocrine control systems at the organ, tissue and molecular levels" [ 10 ], is the most ambitious objective that modern science should achieve. (iospress.com)
This induces metabolic and hormonal changes that. (hrb.ie)

However, very little data are available on IS of circulating cells of MetS patients although clinical data show that inhibited mTOR, with specific inhibitors such as Serolimus or Everolimus after kidney transplantation, significantly increase the presence of de novo thrombotic micro-angiopathy with artery lesion characterized by intimal cell proliferation, necrosis and narrowed lumen. (biomedcentral.com)

Our review discusses genetic and endocrine factors in obesity, discusses obesity induced changes in lipid metabolism and includes some recent findings on the role of gut microbiota in obesity. (uzh.ch)
Other researchers have reported that fat metabolism is increased when exercising the day after a workout, compared to exercising after a rest day, even when exactly the same activity is performed. (lemalab.co)
In a similar manner, exercising in the fasted state-or after a high-protein breakfast 8 -has been shown to increase whole-body fat metabolism 9 . (lemalab.co)
Oxidation occurs when LDL particles interact with reactive oxygen species (ROS) and free radicals- highly reactive small molecules, which are regularly produced due to normal metabolism but increased during disease or toxin exposure. (adonis-foods.de)

There is result in for alarm for the reason that stomach unwanted fat could be pathological or physiological. (iab2016.com)
It is pathological in the sense that it is damaging to the overall body and physiological in the sense that it is not harmful. (iab2016.com)

Using a national sample, this study investigated racial variation in the association between family income and childhood obesity in White and Black families. (mdpi.com)

Moreover, obesity triggers a state of chronic inflammation, as adipose tissue releases pro-inflammatory cytokines. (purenaturecures.com)
Our analyses revealed that inflammation reduces overall microbiome diversity and increased variation between individuals. (kss.org.pl)
In various mouse and rat models of obesity and type 1 and 2 diabetes mellitus, eCBs generated in various renal cells activate CB 1 receptors and contribute to the development of oxidative stress, inflammation, and renal fibrosis. (degruyter.com)

Additionally, we collected parameters associated with metabolic health in obesity (waist-hip ratio, waist-height ratio, leptin levels, body fat percentage, fat mass index, insulin resistance) to investigate recently proposed mechanistic explanatory models of why olfaction may be altered in obesity. (frontiersin.org)
Moreover, we found weak to moderate negative correlations between OB volume and BMI and related measures of metabolic health, especially leptin, body fat percentage, waist-height ratio and insulin resistance. (frontiersin.org)
This project is expected to have a positive impact by providing novel information that will be directly useful in optimizing the nutritional management of premature and low birth weight infants and improving their long-term metabolic health and growth. (bcm.edu)
Obesity and its numerous adverse health consequences have taken on global, pandemic proportions. (nature.com)
The global obesity pandemic poses one of today's biggest challenges to public health. (nature.com)
The obesity epidemic is one of the most important public health concerns in the world today. (springermedizin.at)
Apart from the associated health problems for individuals living with obesity, the social, medical, and economic costs can also be a burden on societies. (springermedizin.at)
Secondly, even those public health initiatives that are directed towards obesity prevention and management show little evidence of success and efficacy at the population level. (springermedizin.at)
The connection between toxicity, obesity, and disease underscores the importance of understanding the impact of environmental factors on our health. (purenaturecures.com)
Conversely, obesity can worsen the effects of toxins, creating a feedback loop that perpetuates health issues. (purenaturecures.com)
Overall, this work reinforces the evidence that specific eating habits, in addition to healthy and active lifestyles, are crucial to increase people's health span and to achieve an optimal longevity. (iospress.com)
Combining the phenomenon of aging and good health is therefore one of the biggest social challenges of today's world. (iospress.com)
Next, their role in regulating adipogenesis and adipose tissue activity in health and the course of obesity is described. (bvsalud.org)
From modulating insulin release to controlling our appetite, the GLP-1 hormone is integral to our body's sugar management and overall metabolic health. (bmidoctors.com)
A growing number of studies are finding how fasting mimetics may improve not only overall health but increase lifespan and healthspan too. (healthnews.com)
The fasting-mimetic diet has been found to improve many health concerns, such as insulin resistance, cellular rejuvenation, and metabolic flexibility. (healthnews.com)
Understanding the mechanisms by which the body burns body fat is crucial for developing effective strategies to combat obesity and promote overall health. (well-choices.com)
Sleep is a fundamental physiological process that plays a vital role in maintaining optimal health and functioning. (cheapessay.us)
2008). Elevated cortisol levels can have detrimental effects on various bodily systems, including immune function and cardiovascular health. (cheapessay.us)
Yogic practices help improve muscular strength, increase body flexibility, boost respiratory and cardiovascular functions, alleviate stress, anxiety and depression, relieve chronic pain and integrate your physical, emotional and spiritual health. (livayur.com)
Risk factors for insulin resistance include obesity , sedentary lifestyle , family history of diabetes, various health conditions, and certain medications. (wikipedia.org)
In the thermal health resort of Eugénie-les-Bains, today the whole village is motivated for welcoming the patients with obesity or metabolic syndromes in need of special care. (fondation-recherche-cardio-vasculaire.org)
For example, the house has a special programme for teaching the patient's therapy, authorized by the regional health-agency of Aquitaine for the patients with obesity and/or metabolic syndromes. (fondation-recherche-cardio-vasculaire.org)
Addressing our metabolic health can lower the risk of each of the Horsemen. (sameerbajaj.com)
gut microbiome at a detailed genetic and functional (transcriptomic, proteomic and metabolic) level, providing new insights into the importance of the gut microbiome in human health, and they are able to map microbiome variability between species, individuals and populations. (kss.org.pl)
The U.S. Department of Health and Human Services recommends increasing the proportion of infants initially breastfed, exclusively breastfed through 6 months of life, and continuing breastfeeding through at least 1 year of life as key public health goals ( 87 ). (cdc.gov)

Obesity is a multifactorial chronic disease that cannot be addressed by simply promoting better diets and more physical activity. (springermedizin.at)
While genetics and lifestyle factors have been widely studied, there is a growing body of research that suggests a connection between toxicity, obesity, and disease. (purenaturecures.com)
Given the intricate link between toxicity, obesity, and disease, taking proactive steps to minimize exposure to environmental toxins becomes essential. (purenaturecures.com)
Although the protective effects of socioeconomic status (SES) on obesity and cardiovascular disease are well established, these effects may differ across racial and ethnic groups. (mdpi.com)
Obesity is a risk factor for both susceptibility to infections including postoperative infections and other nosocomial infections and the occurrence of a more severe disease course. (hrb.ie)
In an article published by Boston University, Andrew Thurston sheds light on a groundbreaking study that establishes a strong correlation between experiencing racism and an increased risk of heart disease among Black women. (stanford.edu)
Ayurveda does not consider Jara a disease but a natural phenomenon like hunger and thirst. (livayur.com)
These impairments in cardiac function could lead to increased risk of heart disease in later life. (cam.ac.uk)
In their findings, a disrupted intestinal flora was associated with individuals having a higher risk of cardiovascular disease [17, 18]. (kss.org.pl)
Here we discuss the molecular mechanisms through which alimentary cues modulate metabolic, microbial and neuroendocrine circuitries and thus affect the probability of developing premalignant lesions that progress to clinically manifested disease and the response to therapeutic intervention. (nature.com)
However, long-term exposure that does not lead to immediate symptoms can still result in cumulative physiological effects that may ultimately cause serious disease. (ecopolitan.com)
This test is part of an early breast disease detection and prevention program that provides women an opportunity to greatly increase their chances of addressing early. (ecopolitan.com)
It stems from studies assessing long-term dietary risks for cardiovascular disease (CVD) in the middle of the 20th century, such as the Framingham and Seven Countries studies, to name a few. (adonis-foods.de)
The increase in the elderly population disease and stroke ( 10 , 11 ). (who.int)
The risk for cardiovascular disease increases with age and might increase with CHC use. (cdc.gov)
To increase knowledge among women and healthcare providers about uterine cancer, the Centers for Disease Control and Prevention's National Comprehensive Cancer Control Program (NCCCP) partnered with the Inside Knowledge: Get The Facts About Gynecologic Cancer campaign to present facilitated discussions about uterine cancer with women and providers. (cdc.gov)
In a 15-year prospective cohort study of 132,250 Japanese subjects, Xu et al found that anemia and chronic kidney disease, alone and in combination, were associated with an increased risk of new-onset AF. (medscape.com)

When applied to obesity prevention and management, each omics type could potentially help to detect specific biomarkers in people with risk profiles and guide healthcare professionals and decision makers in developing individualized treatment plans according to the needs of the individual before the onset of obesity. (springermedizin.at)

Research has shown that certain environmental toxins, like bisphenol A (BPA) found in plastics, phthalates in personal care products, and perfluoroalkyl substances (PFAS) used in non-stick cookware, have been associated with increased adiposity (fat storage) and a higher risk of obesity. (purenaturecures.com)

This narrative review presents the impact of adipose tissue on endocrine gland activity both in the physiological state and in obesity-related dysfunction. (bvsalud.org)
This narrative review aims to summarize the role of estrogen in adipose tissue development, physiology, and in obesity-related dysfunction. (bvsalud.org)
Despite previous theories on the causes of menstrual dysfunction and the increased risk of stress fractures in the female athlete, studies have shown that the primary mechanism of menstrual disturbance in the female athlete is low energy availability. (medscape.com)

By simulating the GLP-1 hormone, these drugs harness its benefits and augment them, crafting a potent strategy to combat diabetes and obesity. (bmidoctors.com)

It also discusses how functional (related to excess adiposity) changes in the endocrine system can be restored with effective treatment of obesity. (bvsalud.org)

On this notion, it has been shown that individuals with obesity show several alterations in the olfactory system. (frontiersin.org)

Recent studies have improved our understanding of energy homeostasis by identifying sophisticated neurohumoral networks which convey signals between the brain and gut in order to control food intake. (hindawi.com)
In energy homeostasis, not only does WAT act as the main storage site of excess dietary energy (Fig. 1c ), it also performs crucial endocrine and metabolic functions (Fig. 1d ) 7 , 8 . (nature.com)
As a result, these SCFA contribute to improved glucose homeostasis and insulin sensitivity. (kss.org.pl)

Our laboratory research shows that psychological stress actually ages cells, a phenomenon that is highlighted by measuring the length of the ends of chromosomes, namely telomeres. (jomaisonjo.com)
Each subject was subjected to physiological and psychological analyses. (jomaisonjo.com)

These unfavorable phenomena can be partially restored by hormone replacement therapy, suggesting a significant role for estrogen in the regulation of adipocytes' function. (bvsalud.org)
Classically the fat mass expansion results with an increase in the volume (hypertrophy) and the number (hyperplasia) of adipocytes [ 5 , 6 ]. (springer.com)

We have shown that increased weight gain observed in offspring exposed to maternal obesity is associated with hyperphagia, implicating altered central regulation of food intake as an underlying cause. (cam.ac.uk)

B. Examination by physician A physician performed and recorded the results of a medical examination giving special attention to specified findings related to nutrition, to hearing, to the thyroid gland,and to the cardiovascular, respiratory, neurological and musculoskeletal systems. (cdc.gov)

The decline of aging C. elegans male's mating behavior is correlated with the increased excitability of the cholinergic circuitry that executes copulation. (elifesciences.org)
The decline could be due to physiological alterations toward a non-optimal state, which leads to the failure of proper behavioral execution. (elifesciences.org)
As the aging process, a complex biological phenomenon witnessed across unicellular and multicellular eukaryotic organisms leads to a functional decline induced by the progressive dysregulation of cellular and organismal functions. (decodeage.com)
Background: Puberty is associated with a physiological decline in insulin sensitivity. (eurospe.org)
Taking DHEA by mouth does not seem to improve mental function or decrease mental decline in healthy older people, people with HIV, or in healthy young adults. (medlineplus.gov)

Therefore, it is urgent to uncover the molecular mechanism(s) underlying the physiological changes, so that certain actions could prevent or postpone the non-optimal modifications that occur during aging. (elifesciences.org)
However, you can control your biological ageing, which is based on the physiological changes that occur in the body due to cellular and molecular factors (1). (livayur.com)
There are a large number of epidemiological studies suggesting that such relationships exist- for example from children exposed to maternal obesity or under-nutrition- however the molecular mechanisms mediating such phenomena are not understood. (cam.ac.uk)

Aging changes in the musculoskeletal system, such as cell senescence and alterations in the matrix of joint tissues, can increase the susceptibility to OA. (decodeage.com)

Body Weight and Metabolic Rate Changes in Narcolepsy" Encyclopedia , https://encyclopedia.pub/entry/37574 (accessed December 06, 2023). (encyclopedia.pub)

This review discusses briefly the use of animal models for the study of obesity and its comorbidities. (uzh.ch)

Background: Neuroendocrine tumors from adrenal and extra-adrenal chromaffin cells are characterized by overproduction of catecholamines (CA), leading to the increase of urinary O-methylated metabolites (uO-Met) excretion, reliable biomarkers for the initial screening, diagnosis and monitoring of patients with pheochromocytoma and paragangliomas (PPGLs).Objective: To develop and validate a UHPLC-MS/MS method for the simul. (eurospe.org)

In this biological orchestra, our metabolic system holds a prominent position. (bmidoctors.com)
social and biological phenomena. (who.int)

Indeed, IS is a very complex phenomenon which is influenced not only by the cellular metabolic status but also interacts with circulating molecules such as hormones (including insulin), nutrients and inflammatory molecules. (biomedcentral.com)
mTOR and mTOR homologues are activated by both specific cytosolic signals which monitor cellular metabolic status and by extracellular circulating molecules. (biomedcentral.com)
One of the most interesting phenomena that has emerged over the last decade is 'cellular crosstalk', a process by which our cells and organs communicate. (lemalab.co)

The purpose of this review is to provide an overview of the different types of omics data: genomics, epigenomics, transcriptomics, proteomics, metabolomics and illustrate how a multi-omics approach can be fundamental for the implementation of precision obesity management. (springermedizin.at)
Major impairment of IS was confirmed by reduced upstream and downstream mTOR molecules which regulate fundamental cells metabolic functions. (biomedcentral.com)

For example, histone H3K4 trimethylation (H34me3) and a network of lipid metabolic genes interact to increase the transcription response to TEI obesogenic effects. (wikipedia.org)
The speed of progression is also related to events outside of us as well as natural physiological effects over the years. (jomaisonjo.com)
Using higher doses or using it long-term can increase the risk of serious side effects including cancer. (medlineplus.gov)

Nevertheless, our results provide first indications that obesity is associated with brain anatomical changes in the OBs. (frontiersin.org)

Since a body of literature implies that olfactory perception and function is hampered in obesity, we here investigate neuroanatomical correlates of this phenomenon. (frontiersin.org)
Simultaneously, obesity can exacerbate the impact of toxins by altering their distribution within the body. (purenaturecures.com)
One of the more commonly recommended is the ketogenic diet, putting the body into a specific physiological state of ketosis , but this is a long-term process, lasting up to 10 days . (consumers-views.com)
The biggest obstacle that every person struggling with obesity has to face is excess body fat , sometimes even reaching several dozen kilograms . (consumers-views.com)
Under this term we understand the increased production of ketone bodies by the body, produced mainly in the liver with a simultaneous drop in blood glucose levels. (consumers-views.com)
Most of us it seems simply impossible, but looking at the definition of the phenomenon of ketosis, we immediately see that providing the body with more fats in place of carbohydrates will significantly contribute to faster weight loss . (consumers-views.com)
During stressful times, the body releases the hormone cortisol, which can increase appetite and lead to overeating, especially foods high in fat, sugar, or calories. (fitelo.co)
When stressed, the body activates the "fight or flight" response, leading to an increase in heart rate and high blood pressure . (fitelo.co)
Bahammam, A.S. Body Weight and Metabolic Rate Changes in Narcolepsy. (encyclopedia.pub)
the relationship between narcolepsy and other metabolic measures, such as body fat/muscle distribution and metabolic rate independent of BMI, is not well documented, and the available evidence is inconsistent. (encyclopedia.pub)
Besides, concern has been raised by the potential impact of GnRH analogues (GnRH-a) treatment on body weight and metabolic profile.Objective and hypotheses: To evaluate. (eurospe.org)
It, then, should not come as a surprise that the amount of LDL is closely correlated with how much fat your body consumes and uses for metabolic purposes. (adonis-foods.de)
Therefore, if the circulating quantity of LDL is high, the chance of its oxidation increases accordingly, as ROS are produced by your body on a regular basis, which causes plaque formation and atherosclerosis. (adonis-foods.de)
Taking DHEA by mouth daily for up to 2 years doesn't seem to improve body shape, bone strength, muscle strength, or quality of life in people older than 60 who have low DHEA levels. (medlineplus.gov)
Because fat stores are associated with less body water than are protein and glycogen stores, the weight gain resulting from an increase in protein or glycogen stores more than counterbalances the weight loss resulting from the equivalent energy reduction in fat stores that occurs in low energy availability. (medscape.com)

It can also be termed abdominal obesity, android weight problems or truncal being overweight. (iab2016.com)
Background and AimIt is known that the variability of testosterone concentrations is predictive of both truncal and peripheral obesity in healthy men. (endocrine-abstracts.org)

In this study, the authors showed that leptin increases serine-138 phosphorylation of insulin receptor substrates-1 (IRS-1). (biomedcentral.com)

In elderly persons, the time spent in stage N3 sleep decreases, and the time in stage N2 compensatorily increases. (medscape.com)

Latency to fall asleep and the number and duration of overnight arousal periods increase. (medscape.com)

We showed that OB volume was significantly lower in participants with obesity when compared to those of normal weight. (frontiersin.org)

Anatomy1

Organisms1

Diseases14

Chemicals and Drugs4

Analytical, Diagnostic and Therapeutic Techniques and Equipment14

Phenomena and Processes47

Technology, Industry, Agriculture1

Information Science1

Health Care5

Diseases41

Prevalence of obesity5

Underlying mechanisms2

Type 2 diabet5

Processes9

Disorders6

Life expectancy6

Syndrome9

Obese6

Various physiological2

Overweight and obesity3

Development of obesity5

Pathways5

Expenditure9

Hypertension1

Adipose tissue dysfunction3

Complications7

Pathophysiological2

Including cardiovascular disease1

Hormonal4

Clinical1

Metabolism4

Pathological2

Childhood1

Inflammation3

Health26

Disease17

Prevention1

Risk of obesity1

Dysfunction3

Diabetes and obesity1

Treatment of obesity1

Individuals with obesity1

Homeostasis3

Psychological2

Adipocytes2

Regulation1

Respiratory1

Decline5

Molecular3

Alterations1

20231

Comorbidities1

Neuroendocrine1

Biological2

Cellular3

Fundamental2

Effects3

Anatomical1

Body15

Truncal2

Leptin1

Decreases1

Arousal1

Significantly1