Mesylate is considered a leaving group in nucleophilic substitution reactions. (wikipedia.org)
Nacsa, E. D. "The Development of Catalytic Nucleophilic Substitution Reactions: Challenges, Progress and Future Directions. (psu.edu)
Chloride2
Mesylates are generally prepared by treating an alcohol and methanesulfonyl chloride in the presence of a base, such as triethylamine. (wikipedia.org)
PEG-halide (chloride, bromide, iodide, tosylate and mesylate) reacts with deprotonated carboxyl groups i.e. (creativepegworks.com)
Functional3
Mesylate esters are a group of organic compounds that share a common functional group with the general structure CH3SO2O−R, abbreviated MsO−R, where R is an organic substituent. (wikipedia.org)
Related to mesylate is the mesyl (Ms) or methanesulfonyl (CH3SO2) functional group. (wikipedia.org)
The reaction of 1-alkynes with Cy 2 NH and paraformaldehyde mediated by CuI (0.5 equiv) in refluxing dioxane produces terminal allenes in much higher yields than previously reported protocols and many functional groups such as mesylate, hydroxyl group, ether, amide, etc. are tolerated. (organic-chemistry.org)
Salt2
In organosulfur chemistry, a mesylate is any salt or ester of methanesulfonic acid (CH3SO3H). (wikipedia.org)
When modifying the international nonproprietary name of a pharmaceutical substance containing the group or anion, the spelling used is sometimes mesilate (as in imatinib mesilate, the mesylate salt of imatinib). (wikipedia.org)
Groups1
Whereas mesylates are often hydrolytically labile, mesyl groups, when attached to nitrogen, are resistant to hydrolysis. (wikipedia.org)
Substitution reactions1
Mesylate is considered a leaving group in nucleophilic substitution reactions. (wikipedia.org)
Tosylates1
One way we've seen how to do this is by converting alcohols to alkyl sulfonates, such as tosylates or mesylates . (esterlium.net)
Methanesulfonyl3
Mesylates are generally prepared by treating an alcohol and methanesulfonyl chloride in the presence of a base, such as triethylamine. (wikipedia.org)
Related to mesylate is the mesyl (Ms) or methanesulfonyl (CH3SO2) functional group. (wikipedia.org)
Whereas mesylates are often hydrolytically labile, mesyl groups, when attached to nitrogen, are resistant to hydrolysis. (wikipedia.org)
Mesilate1
When modifying the international nonproprietary name of a pharmaceutical substance containing the group or anion, the spelling used is sometimes mesilate (as in imatinib mesilate, the mesylate salt of imatinib). (wikipedia.org)
Ester1
In organosulfur chemistry, a mesylate is any salt or ester of methanesulfonic acid (CH3SO3H). (wikipedia.org)
Alcohol3
WebNotice, though, that unlike the halogenation reactions above, conversion of an alcohol to a tosylate or mesylate proceeds with retention of configuration at the electrophilic carbon. (urlbacklinks.com)
WebHow to convert an alcohol into a mesylate or tosylate, making it a good leaving group. (urlbacklinks.com)
Heat the alcohol with a strong non-nucleophilic acid like H 2 SO 4 or H 3 PO 4 [1 operation]. (esterlium.net)
Electrophilic1
Poly(ethylene glycol) (PEG) derivatives activated with electrophilic groups are useful for coupling to nucleophilic groups, such as amino groups, of biologically active molecules. (allindianpatents.com)
Leaving group1
Mesylate is a very good leaving group for nucleophilic substitution reaction. (creativepegworks.com)
Carbon1
Equation presented) Exposure of (E)-β-alkylvinyl(phenyl)-λ3-iodanes to thioamides in dichloromethane at room temperature was found to result in a bimolecular nucleophilic substitution (SN2) at the vinylic carbon atom to give inverted (Z)-enethiols and/or (Z)-S-vinylthioimidonium salts. (lookchem.com)