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Amino acidsConformationBiochemistryMitochondrialMetabolismMRNAAcids ResNascent chainLipid BiosynthesisAcidSubunitTranslocationTranscriptionMitochondriaMoleculesEnzymesGeneticRecombinant proteinsElongationLipidsEukaryoticBacteriaMechanismsSequencesStructuresTransfer RnaEscherichiaGenesInteractionTranslationRegulationGlycobiologyPutativeSignal transductionFunctionalIntracellularFunctionTranslationalGeneModificationsPathwaysStructuralAcylExpressionAffinityStructureMeshTranscriptionalChemicalMembraneBond formationComprises

Amino acids16

• Stepwise addition of amino acids to the growing polypeptide chain requires the coordinated movement of mRNA and tRNAs through the ribosome, a process known as translocation. (ox.ac.uk)
• Most of the structures that make up animals, plants and microbes are made from four basic classes of molecules: amino acids, carbohydrates, nucleic acid and lipids (often called fats). (wikipedia.org)
• Proteins are made of amino acids arranged in a linear chain joined by peptide bonds. (wikipedia.org)
• During translation, the ribosome reads the genetic code in mRNA and makes amino acids. (atthaiproperty.com)
• These amino acids are linked together by peptide bonds to form a protein. (atthaiproperty.com)
• Twenty alpha-amino acids are the subunits which are polymerized to form proteins . (lookformedical.com)
• The biosynthesis of PEPTIDES and PROTEINS on RIBOSOMES, directed by MESSENGER RNA, via TRANSFER RNA that is charged with standard proteinogenic AMINO ACIDS . (lookformedical.com)
• The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein. (lookformedical.com)
• Like amino acids and nucleic acids, sugars are the major contributors in nature many natural products contain oligosaccharides that are important for their biological and biochemical activity and carbohydrates have major roles in a wider range of biological processes including signal transduction mechanisms and immune responses. (biochemistryconferences.com)
• So the study of glycan structures is also complicated by the lack of a proper and direct template for their biosynthesis, contrary to the case with amino acids and proteins. (biochemistryconferences.com)
• Proteins consist of amino acids. (itwreagents.com)
• These amino acids are linked via so-called peptide bonds. (itwreagents.com)
• A peptide bond is a carboxylic acid-amide bond that connects two amino acids via the carboxy group of one amino acid and the amino group of the other amino acid. (itwreagents.com)
• The multiple combination possibilities of amino acids and also of peptides leads to an almost infinite possibility of structures and thus to many functions. (itwreagents.com)
• While the genetic material DNA only stores information, the protein molecules consisting of amino acids fulfil multiple tasks. (itwreagents.com)
• Maize protein is deficient in the essential amino acids lysine and tryptophan, which limits its value for monogastric animals. (biomedcentral.com)

Conformation4

• de Marcos-Lousa C, P Sideris D, Tokatlidis K. (2006) Translocation of mitochondrial inner-membrane proteins: conformation matters. (forth.gr)
• It is of fundamental importance in determining PROTEIN CONFORMATION . (lookformedical.com)
• Protein conformation is critically linked to function and often controlled by interactions with regulatory factors. (cipsm.de)
• Here we report the selection of camelid-derived single-domain antibodies (nanobodies) that modulate the conformation and spectral properties of the green fluorescent protein (GFP). (cipsm.de)

Biochemistry2

• The protein sample was dialyzed against 2 volumes of 500 ml of dialysis buffer (50 mm Tris-HCl, pH 7.6, 50 mm KCl, 2.5 mm MgCl2, 0.1 mm EDTA, 10% glycerol and 7 mm ;ME) for 1 h.Cells carrying a plasmid encoding the His6-tagged human mitochondrial MetRS were grown as described (23Spencer A.C. Heck A.H. Takeuchi N. Watanabe K. Spremulli L.L. Biochemistry. (ncsu.edu)
• Protein Biochemistry is the collection of methods that allows science and medicine to explore and understand the proteome. (itwreagents.com)

Mitochondrial8

• The co-chaperone Hep1 is required to prevent the aggregation of mitochondrial Hsp70 proteins. (cipsm.de)
• The hmtRNAMet serves both in translational initiation and elongation in human mitochondria making this tRNA of particular interest in mitochondrial protein synthesis. (ncsu.edu)
• The mitochondrial genome encodes 13 proteins necessary for energy production, two rRNAs and all of the 22 tRNAs required for the synthesis of these proteins (1Attardi G. Int. Rev. Cytol. (ncsu.edu)
• The diseases associated with mitochondrial tRNA mutations may arise from failure in the processing of the tRNA (13Levinger L. Jacobs O. James M. Nucleic Acids Res. (ncsu.edu)
• As a result of this dual role, mitochondrial Met-tRNAMet must be recognized by the mitochondrial Met-tRNA transformylase (MTFmt) and be brought as fMet-tRNAMet to the ribosome for translational initiation (19Spencer A.C. Spremulli L.L. Nucleic Acids Res. (ncsu.edu)
• However, small amounts of the aminoacylated 8U→C mutated hmtRNAMet could be isolated, permitting a limited investigation of additional steps in translation.In the mammalian mitochondrial system, the Met-tRNAMet must be formylated by the mitochondrial transformylase (MTFmt) to be used in initiation (19Spencer A.C. Spremulli L.L. Nucleic Acids Res. (ncsu.edu)
• Diversity and Similarity of Termination and Ribosome Rescue in Bacterial, Mitochondrial, and Cytoplasmic Translation. (umassmed.edu)
• Differentially expressed candidate genes for ageing previously identified in the human blood transcriptome up-regulated in PP cows were mainly associated with T-cell function ( CCR7 , CD27 , IL7R , CAMK4 , CD28 ), mitochondrial ribosomal proteins ( MRPS27 , MRPS9 , MRPS31 ), and DNA replication and repair ( WRN ). (biomedcentral.com)

Metabolism5

• Many proteins are enzymes that catalyze the chemical reactions in metabolism. (wikipedia.org)
• Beta-oxidative pathway of fatty acids, brief account of biosynthesis of triglycerides, cholesterol & its metabolism. (aadharinstitute.com)
• Originally discovered as a chief regulatory protein of glucose and lipid metabolism and cell differentiation, the peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated transcription factor of the nuclear hormone receptor superfamily 8 . (nature.com)
• Recently, the sterol regulatory element binding protein SrbA was found to be essential for adaptation to iron starvation, thereby linking regulation of iron metabolism, ergosterol biosynthesis, azole drug resistance, and hypoxia adaptation. (frontiersin.org)
• As mono or diiron center as well as incorporated into heme or iron-sulfur clusters, this metal is an indispensable cofactor for a variety of cellular processes including electron transport, amino acid metabolism, and biosynthesis of DNA and sterols. (frontiersin.org)

MRNA13

• They are described as distinct regions of RNA molecules that are able to recruit the eukaryotic ribosome to the mRNA. (wikipedia.org)
• Many proteins involved in mitosis are encoded by IRES mRNA. (wikipedia.org)
• Lack of essential proteins contributes to the death of the cell, as does translation of IRES mRNA sequences coding proteins involved in controlling cell death. (wikipedia.org)
• When an IRES segment is located between two reporter open reading frames in a eukaryotic mRNA molecule (a bicistronic mRNA), it can drive translation of the downstream protein coding region independently of the 5'-cap structure bound to the 5' end of the mRNA molecule. (wikipedia.org)
• Here, we review current understanding of the kinetics and mechanics of translocation, with particular emphasis on the structure of a functional mammalian ribosome stalled during translocation by an mRNA pseudoknot. (ox.ac.uk)
• When a cell needs a new protein, the DNA molecule is transcribed into mRNA and then translated into a protein product. (atthaiproperty.com)
• The first step of protein synthesis is transcription, which is when the RNA polymerase enzyme creates mRNA from a piece of DNA. (atthaiproperty.com)
• mRNA is a single-stranded nucleic acid that has the same structure as DNA but differs in several ways. (atthaiproperty.com)
• Once the mRNA is in the cytoplasm it can enter a ribosome, where the next step of protein synthesis takes place. (atthaiproperty.com)
• Because alternative RNA splicing allows different types of mRNA molecules to be created from a single gene, it generates the diversity of protein function and structure that is essential to complex organisms. (genomicglossaries.com)
• More than half of all human genes are alternatively spliced, so it is expected that alternative pre- mRNA splicing will be responsible for the identification of more than 90 percent of all human proteins. (genomicglossaries.com)
• Highly specific and effective gene silencing of any disease can be achieved by an accurate knowledge of the target mRNA sequence and rational design of its complementary antisense agents for the downregulation of its protein message. (genomicglossaries.com)
• Members of this family include the signal-transducing G protein beta subunit, as well as other proteins that regulate signal transduction, transcription, pre-mRNA splicing, cytoskeletal organization, and vesicular fusion. (embl.de)

Acids Res5

• However, chemical and enzymatic probing has lead to the idea that these tRNAs have retained the basic cloverleaf structure of canonical tRNAs but that they lack several conserved tertiary interactions leading to a weaker three-dimensional structure (4Watanabe Y.-I. Kawai G. Yokogawa T. Hayashi N. Kumazawa Y. Ueda T. Nishikawa K. Hirao I. Miura K.-I. Watanabe K. Nucleic Acids Res. (ncsu.edu)
• 22: 5378-5384Crossref PubMed Scopus (56) Google Scholar, 5Yokogawa T. Watanabe Y.-I. Kumazawa Y. Ueda T. Hirao I. Miura K.-I. Watanabe K. Nucleic Acids Res. (ncsu.edu)
• 19: 6101-6105Crossref PubMed Scopus (68) Google Scholar, 6Wakita K. Watanabe W. Yokogawa T. Kumazawa Y. Nakamura S. Ueda T. Watanabe K. Nishikawa K. Nucleic Acids Res. (ncsu.edu)
• E. coli BL21 cells, carrying the pET15-bovine MTFmt plasmid construct, were grown as described (19Spencer A.C. Spremulli L.L. Nucleic Acids Res. (ncsu.edu)
• 33: 241-252Crossref PubMed Scopus (30) Google Scholar, 35Yarian C.S. Basti M.M. Cain R.J. Ansari G. Guenther R.H. Sochacka E. Czerwinska G. Malkiewicz A. Agris P.F. Nucleic Acids Res. (ncsu.edu)

Nascent chain1

• Expression of the Escherichia coli tryptophanase operon depends on ribosome stalling during translation of the upstream TnaC leader peptide, a process for which interactions between the TnaC nascent chain and the ribosomal exit tunnel are critical. (cipsm.de)

Lipid Biosynthesis1

• The starting molecule for lipid biosynthesis is the fatty acid (FA) phosphatidylethanolamine or phosphatidylserine, which is converted to PI in two steps. (atthaiproperty.com)

Acid7

• Amino acid derivatives, like the peptide hormone vasopressin (ADH), can also enter cells and affect their function. (atthaiproperty.com)
• A zinc containing enzyme of the hydrolase class that catalyzes the removal of the N-terminal amino acid from most L-peptides, particularly those with N-terminal leucine residues but not those with N-terminal lysine or arginine residues. (lookformedical.com)
• An essential branched-chain aliphatic amino acid found in many proteins . (lookformedical.com)
• An unnatural amino acid that is used experimentally to study protein structure and function. (lookformedical.com)
• Arrand J.E. Preparation of nucleic acid probes. (microbiologyresearch.org)
• In Nucleic Acid Hybridisation. (microbiologyresearch.org)
• The underlying mechanism for rebalancing amino acid content for both o2 and RNAi is unclear, although it depends on reduced synthesis of the zein storage proteins and a compensatory increase in non-zein protein content [ 17 ]. (biomedcentral.com)

Subunit1

• Folding of proteins with WD-repeats: comparison of six members of the WD-repeat superfamily to the G protein beta subunit. (embl.de)

Translocation2

• A spiral rotation of the 3′ end of the A-site tRNA around a 2-fold axis of symmetry identified within the PTC suggests a unified ribosomal machinery for peptide-bond formation, A-to-P-site translocation, and entrance of nascent proteins into the exit tunnel. (cnr.it)
• Preexisting antivector immunity can severely compromise the ability of Salmonella enterica serovar Typhimurium live vaccines to induce protective CD8 T-cell frequencies after type III secretion system-mediated heterologous protein translocation in orally immunized mice. (cipsm.de)

Transcription4

• The heterochromatin-enriched HP1 proteins play a critical role in regulation of transcription. (cipsm.de)
• 8, 9] STAT3 is one of 7 human STAT (signal transducer and activator of transcription) proteins, which are critical second messengers for many cytokine, hormone, and growth factor receptors. (medscape.com)
• PHOSPHORYLATION of IRF-3 causes the protein to be translocated from the CYTOPLASM to CELL NUCLEUS where it binds DNA , and activates transcription. (lookformedical.com)
• WD-repeat proteins are a large family found in all eukaryotes and are implicated in a variety of functions ranging from signal transduction and transcription regulation to cell cycle control and apoptosis. (embl.de)

Mitochondria2

• Structure and function of cell and cytoplasmic constituents: Structure of nucleus, mitochondria, Golgi bodies, endoplasmic reticulum, lysosomes and ribosomes. (aadharinstitute.com)
• Aminoacylation is an early step required for the tRNA to be used in either the elongation or initiation phase of protein synthesis and is thus of central importance for protein synthesis in mitochondria. (ncsu.edu)

Molecules2

• Further modifications of peptide chains yield functional peptide and protein molecules. (nih.gov)
• Nucleic acids are the information-carrying molecules that determine inherited characteristics in all living organisms. (atthaiproperty.com)

Enzymes3

• protein_coding" "AAC74185","ptsG","Escherichia coli","fused glucose-specific PTS enzymes: IIB component/IIC component [Ensembl]. (ntu.edu.sg)
• In addition, nonribosomal peptide synthetases (NRPS) are also present in some organisms as enzymes that enable nonribosomal peptide synthesis. (itwreagents.com)
• Proteins can be enzymes and thus the catalysts of biology. (itwreagents.com)

Genetic3

• The translation of genetic information into proteins is a fundamental process of life. (ox.ac.uk)
• The biosynthesis of proteins on RIBOSOMES following an RNA template is termed translation ( TRANSLATION, GENETIC ). (nih.gov)
• They contain the genetic instructions that make proteins that are responsible for most of the processes in cells. (atthaiproperty.com)

Recombinant proteins1

• Expression of recombinant proteins using bacterial, animal and plant vectors. (aadharinstitute.com)

Elongation2

• In addition, Met-tRNAMet must interact with elongation factor EF-Tumt and bind to the A-site of the ribosome during translational elongation. (ncsu.edu)
• The role of this modification in (hmtRNAMetCAU) for the decoding of AUA, as well as AUG, in both the peptidyl- and aminoacyl-sites of the ribosome in either chain initiation or chain elongation is still unknown. (ncsu.edu)

Lipids4

• or anabolic - the building up (synthesis) of compounds (such as proteins, carbohydrates, lipids, and nucleic acids). (wikipedia.org)
• Major site is a large protein that has an essential role in the synthesis of hormones, lipids, and nucleic acids. (atthaiproperty.com)
• Lipids are the building blocks of membranes that enclose all cellular compartments and provide an essential platform for protein recruitment. (atthaiproperty.com)
• Cells uphold a differential composition of lipids in the different organelle membranes, and transport mechanisms move lipids together with proteins into these compartments. (atthaiproperty.com)

Eukaryotic2

• We determined subnanometer-resolution cryo-electron microscopy structures of eukaryotic ribosome-Sec61 complexes. (cipsm.de)
• In many cases, they lack a number of the conserved or semi-conserved nucleotides that play important roles in creating the L-shaped tertiary structure of prokaryotic and eukaryotic cytoplasmic tRNAs (3Dirheimer G. Keith G. Dumas P. Westhof E. RajBhandary U. Soll D. tRNA: Structure, Biosynthesis and Function. (ncsu.edu)

Bacteria1

• Holmqvist, E. & Vogel, J. RNA-binding proteins in bacteria. (nature.com)

Mechanisms1

• However, the exact mechanisms by which it improves protein quality and creates a soft endosperm texture are unclear. (biomedcentral.com)

Sequences2

• IRF proteins bind specific DNA sequences such as interferon-stimulated response elements, interferon regulatory elements, and the interferon consensus sequence. (lookformedical.com)
• The specificity of the proteins is determined by the sequences outside the repeats themselves. (embl.de)

Structures2

• If WD proteins form structures similar to G beta, their hydrodynamic properties should be those of compact, globular proteins, and they should be resistant to cleavage by trypsin. (embl.de)
• Our working definition of folding was that the proteins from globular, trypsin-resistant structures because, except for G beta gamma, their functions are not known or cannot be assayed in reticulocyte lysates. (embl.de)

Transfer Rna1

• A transfer RNA which is specific for carrying leucine to sites on the ribosomes in preparation for protein synthesis. (lookformedical.com)

Escherichia4

• Here we demonstrate that PSRP1 is not a bona fide ribosomal protein, but rather a functional homologue of the Escherichia coli cold-shock protein pY. (cipsm.de)
• protein_coding" "AAC74323","adhE","Escherichia coli","fused acetaldehyde-CoA dehydrogenase/iron-dependent alcohol dehydrogenase/pyruvate-formate lyase deactivase [Ensembl]. (ntu.edu.sg)
• protein_coding" "AAC74850","yeaD","Escherichia coli","D-hexose-6-phosphate epimerase-like protein [Ensembl]. (ntu.edu.sg)
• protein_coding" "AAC74888","manY","Escherichia coli","mannose-specific enzyme IIC component of PTS [Ensembl]. (ntu.edu.sg)

Genes7

• They interact with receptor proteins that are already associated with specific regions of the cell's DNA and modify the activity of those genes. (atthaiproperty.com)
• At the end of rapid growth, a co-ordinated transient up-regulation of about 100 genes, including many for ribosomal proteins, was seen in the parent strain but not the Δ bldA mutant. (biomedcentral.com)
• Transcripts or proteins from a further 147 genes classified as bldA -influenced were mostly expressed late in culture in the wild-type, though others were significantly transcribed during exponential growth. (biomedcentral.com)
• Stat1 interacts with P53 TUMOR SUPPRESSOR PROTEIN and regulates expression of GENES involved in growth control and APOPTOSIS . (lookformedical.com)
• Genes are read in the course of the so-called expression, so that the right proteins are available at the right time in the living being. (itwreagents.com)
• In this study, we combined transcript profiling and proteomic analysis to better understand which genes and proteins are altered by opaque2 in the W64A inbred line. (biomedcentral.com)
• The mutant also had altered expression of a number of starch biosynthesis genes and this was associated with a more highly crystalline starch. (biomedcentral.com)

Interaction1

• Identification of a peptide that disrupts hADA3-E6 interaction with implications in HPV induced cancer therapy. (du.ac.in)

Translation6

• An internal ribosome entry site, abbreviated IRES, is an RNA element that allows for translation initiation in a cap-independent manner, as part of the greater process of protein synthesis. (wikipedia.org)
• Cells may also use IRESs to increase translation of certain proteins during mitosis and programmed cell death. (wikipedia.org)
• The first reporter protein located in the first cistron is synthesized by the cap-dependent initiation, while translation initiation of the second protein is directed by the IRES element located in the intercistronic spacer between the two reporter protein coding regions. (wikipedia.org)
• Plastid-specific ribosomal proteins (PSRPs) have been proposed to play roles in the light-dependent regulation of chloroplast translation. (cipsm.de)
• Wu C, Roy B, He F, Yan K, Jacobson A. Poly(A)-Binding Protein Regulates the Efficiency of Translation Termination. (umassmed.edu)
• In protein biosynthesis in a cell, this reaction is catalyzed by ribosomes during translation. (itwreagents.com)

Regulation1

• Ribosome profiling in mouse hippocampus: plasticity-induced regulation and bidirectional control by TSC2 and FMRP. (umassmed.edu)

Glycobiology1

• Glycobiology in wider aspects includes the study of structure, function and biology of carbohydrates, biosynthesis related to sugars and saccharides. (biochemistryconferences.com)

Putative1

• Torc1 consists of either the Tor1 or the Tor2 kinase, a putative scaffold protein Kog1, Lst8, and Tco89 [4, 5]. (researchsquare.com)

Signal transduction1

• The changes in the proteome can sometimes occur very rapidly, for example through post-translational modifications such as the phosphorylation and dephosphorylation of proteins, which play a very important role in signal transduction. (itwreagents.com)

Functional2

• Functional recognition of the modified human tRNA(UUU)(Lys3) anticodon domain by HIV's nucleocapsid protein and a peptide mimic. (ncsu.edu)
• Functional interactions of proteins in human health and disease. (jhmi.edu)

Intracellular2

• Membrane structure and function: Structure of model membrane, Lipid bilayer and membrane protein, diffusion, osmosis, ion channels, Active transport membrane pumps, mechanism of solving and regulations of intracellular transport, Electrical properties of membrane. (aadharinstitute.com)
• The protease not only releases small peptides, such as the amyloid-β peptide, which drives Alzheimer's disease pathogenesis, but also intracellular domains, which can have critical functions in nuclear signaling. (cipsm.de)

Function4

• Many viral IRES (and cellular IRES) require additional proteins to mediate their function, known as IRES trans-acting factors (ITAFs). (wikipedia.org)
• The function of this protein is also dependent on other proteins. (atthaiproperty.com)
• Protein of unknown function (DUF520) [Interproscan]. (ntu.edu.sg)
• Proteins play a decisive role in our body's motor function and provide for the movement of the muscles in actin and myosin. (itwreagents.com)

Translational1

• but this includes many previously unknown effects at a variety of different levels, including post-translational changes in proteins and global cellular physiology. (biomedcentral.com)

Gene3

• The expression of the STE5 gene and its encoded scaffold protein Ste5, required for the sequential activation of the MAPKs of the pheromone pathway, is greatly reduced in the H2B R95A mutant. (researchsquare.com)
• The inhibition of Torc1 by rapamycin mimics nutrient starvation and causes an array of physiological changes that include global changes in gene expression, phosphorylation/dephosphorylation of various factors, decreased cell growth, degradation of proteins, and ultimately cell cycle arrest in the G 1 phase [4, 9-11]. (researchsquare.com)
• In contrast to the rather static genome, the proteome and also the transcriptome are dynamic and can therefore change in their qualitative and quantitative protein composition due to changing conditions (environmental factors, temperature, gene expression, drug administration, etc. (itwreagents.com)

Modifications3

• Anticodon domain modifications contribute order to tRNA for ribosome-mediated codon binding. (ncsu.edu)
• The accuracy and efficiency with which tRNA decodes genomic information into proteins require posttranscriptional modifications in or adjacent to the anticodon. (ncsu.edu)
• To increase the level of sample complexity, untargeted identification of several RNA modifications from 70S ribosome was achieved by the Nucleos'ID search following CE-MS/MS analysis. (cnrs.fr)

Pathways1

• During iron starvation, HapX represses iron-consuming pathways, including heme biosynthesis and respiration, to spare iron and activates synthesis of ribotoxin AspF1 and siderophores, the latter partly by ensuring supply of the precursor, ornithine. (frontiersin.org)

Structural1

• Other proteins have structural or mechanical functions, such as those that form the cytoskeleton, a system of scaffolding that maintains the cell shape. (wikipedia.org)

Acyl2

• Enoyl-(Acyl carrier protein) reductase [Interproscan]. (ntu.edu.sg)
• Lipoate protein ligase B primarily recognizes the C8-phosphopantetheine arm of its donor substrate and weakly binds the acyl carrier protein. (du.ac.in)

Expression1

• Hatzis P, Kyrmizi I, Talianidis I. (2006) Mitogen-activated protein kinase-mediated disruption of enhancer-promoter communication inhibits hepatocyte nuclear factor 4alpha expression. (forth.gr)

Affinity1

• We employed conditional translating ribosome affinity purification (TRAP) followed by RNA sequencing (TRAP-seq) for transcriptome profiling of DA neurons in transgenic Drosophila lines expressing human PARIS wild type (WT) or mutant (C571A). (nature.com)

Structure9

• Major Recent Advances Covered Range From The Draft Sequence Of The Human Genome To Elucidation Of The High-resolution Structure Of The Ribosome. (bookabout.io)
• Glykos NM, Papanikolau Y, Vlassi M, Kotsifaki D, Cesareni G, Kokkinidis M. (2006) Loopless rop: structure and dynamics of an engineered homotetrameric variant of the repressor of primer protein. (forth.gr)
• This is referred to as the primary structure of proteins . (lookformedical.com)
• Structure and types of nucleic acids. (aadharinstitute.com)
• The basic protein model used was a minimalist Gō model using the native structure to determine attractive energies in the protein chain. (researcher.life)
• WD40 repeats usually assume a 7-8 bladed beta-propeller fold, but proteins have been found with 4 to 16 repeated units, which also form a circularised beta-propeller structure. (embl.de)
• The crystal structure of one WD-repeat protein (G beta) has now been solved (Wall et al. (embl.de)
• It is very likely that all WD-repeat proteins form a similar structure. (embl.de)
• However, the only studied example of a WD-repeat protein, G beta, synthesized in vitro in a rabbit reticulocyte lysate, is unable to fold into a native structure without its partner protein G gamma. (embl.de)

Mesh1

• Protein Biosynthesis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)

Transcriptional1

• 2006) Senseless physically interacts with proneural proteins and functions as a transcriptional co-activator. (forth.gr)

Chemical1

• Most naturally occurring proteins and peptides from plants are considered safer than chemical drugs. (edu.in)

Membrane1

• The trimeric Sec61/SecY complex is a protein-conducting channel (PCC) for secretory and membrane proteins. (cipsm.de)

Bond formation1

• The PTC tolerates various orientations of puromycin derivatives and its flexibility allows the conformational rearrangements required for peptide-bond formation. (cnr.it)

Comprises2

• More precisely defined, the proteome comprises the totality of all proteins present in a cell or a living organism under defined conditions and at a defined time. (itwreagents.com)
• The family of WD-repeat proteins comprises over 30 different proteins that share a highly conserved repeating motif [Neer, E. J., Schmidt, C. J., Nambudripad, R., & Smith, T. F. (1994) Nature 371, 297-300]. (embl.de)