• Dicarbonyl/L-xylulose reductase, also known as carbonyl reductase II, is an enzyme that in human is encoded by the DCXR gene located on chromosome 17. (wikipedia.org)
  • This gene provides instructions for making a protein called dicarbonyl and L-xylulose reductase (DCXR), which plays multiple roles in the body. (encyclopedia.pub)
  • Lee SK, Son le T, Choi HJ, Ahnn J. Dicarbonyl/l-xylulose reductase (DCXR): Themultifunctional pentosuria enzyme. (encyclopedia.pub)
  • A deficiency is responsible for pentosuria. (wikipedia.org)
  • On the nature of L-xylulose reductase deficiency in essentialpentosuria. (encyclopedia.pub)
  • In enzymology, an L-xylulose reductase (EC 1.1.1.10) is an enzyme that catalyzes the chemical reaction xylitol + NADP+ ⇌ {\displaystyle \rightleftharpoons } L-xylulose + NADPH + H+ Thus, the two substrates of this enzyme are xylitol and NADP+, whereas its 3 products are L-xylulose, NADPH, and H+. (wikipedia.org)
  • Xylulose Xylitol (Note conversion of ketone to alcohol) This enzyme belongs to the superfamily of short-chain oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. (wikipedia.org)
  • The systematic name of this enzyme class is xylitol:NADP+ 2-oxidoreductase (L-xylulose-forming). (wikipedia.org)
  • One of its functions is to perform a chemical reaction that converts a sugar called L-xylulose to a molecule called xylitol. (encyclopedia.pub)
  • Without this protein, L-xylulose is not converted to xylitol, and the excess sugar is released in the urine. (encyclopedia.pub)
  • The insufficiency of L-xylulose reductase activity causes an inborn error of metabolism disease characterized by excessive urinary excretion of L-xylulose. (wikipedia.org)
  • While essential pentosuria is caused by genetic mutations, some people develop a non-inherited form of pentosuria if they eat excessive amounts of fruits high in L-xylulose or another pentose called L-arabinose. (encyclopedia.pub)
  • Yin, N. Essential Pentosuria. (encyclopedia.pub)
  • Essential Pentosuria" Encyclopedia , https://encyclopedia.pub/entry/5561 (accessed December 11, 2023). (encyclopedia.pub)
  • Essential pentosuria is a condition characterized by high levels of a sugar called L-xylulose in urine. (encyclopedia.pub)
  • Essential pentosuria occurs almost exclusively in individuals with Ashkenazi Jewish ancestry. (encyclopedia.pub)
  • Essential pentosuria is caused by mutations in the DCXR gene. (encyclopedia.pub)
  • The condition is so named because L-xylulose is a type of sugar called a pentose. (encyclopedia.pub)