Type III contains the proteins vimentin, desmin, peripherin and glial fibrillary acidic protein (GFAP). (wikipedia.org)
Plasma glial fibrillary acidic protein is raised in progranulin-associated frontotemporal dementia. (genfi.org)
Neurodegenerative diseases2
These new assays will further support biomarker research in the field of neurodegenerative diseases, an important mission for Fujirebio. (fujirebio.com)
More recently, it has been demonstrated that mitochondrial dynamics likely plays a key role in AD and PD as proteins that regulate mitochondrial fission and fusion are altered in some neurodegenerative diseases [ 3 , 8 ]. (biomedcentral.com)
Albumin1
We determined BBB integrity by measuring cerebrospinal fluid (CSF)/plasma albumin ratios in archived CSF samples prior to and after initiation of ART in longitudinally-followed neuroasymptomatic HIV-1-infected individuals and patients with HAD. (biomedcentral.com)
Cytokines2
Deterioration of the BBB is most likely multifactorial, with contributing factors including secretion of pro-inflammatory cytokines and viral proteins from infected cells, as well as direct invasion of the cells of the neurovascular unit especially pericytes and perivascular macrophages by HIV [ 2 ]. (biomedcentral.com)
The purpose of this study is to determine how the genetic code of cells, particularly cells of the innate immune system, changes during early osteoarthritis progression and how those values correlate to levels of inflammatory biomarkers, called cytokines, in joint fluid. (grayson-jockeyclub.org)
Structural1
Structural models generally assume eight tetramers (32 neurofilament polypeptides) in a filament cross-section, but measurements of linear mass density suggest that this can vary. (wikipedia.org)
Viral1
HIV infection in the CNS can be detected and monitored by cerebrospinal fluid (CSF) viral load measurements. (medscape.com)
Axonal1
These sites almost all contain the peptide lysine-serine-proline (KSP), and phosphorylation is normally found on axonal and not dendritic neurofilaments. (wikipedia.org)
Neuronal1
Neuronal pentraxin 2: a synapse-derived CSF biomarker in genetic frontotemporal dementia. (genfi.org)
Axons1
In the adult nervous system neurofilaments in small unmyelinated axons contain more peripherin and less NF-H whereas neurofilaments in large myelinated axons contain more NF-H and less peripherin. (wikipedia.org)
Plasma3
These CLEIA (chemiluminescent enzyme immunoassay) assays allow for the quantitative measurement of the E4 isoform of the apolipoprotein E (ApoE4), specifically, and for all isoforms of the same protein (Pan-ApoE), respectively, in human plasma within just 35 minutes. (fujirebio.com)
In this regard, ApoE as a protein biomarker can be used in research to determine its value alone or as part of a panel of plasma biomarkers 2 . (fujirebio.com)
To improve our understanding of PSAP and PGRN in PD, we analyzed these proteins in SNc, cerebrospinal fluid (CSF), plasma, and leucocytes from PD patients and matched controls. (nature.com)
Nerve2
The five neurofilament proteins can co-assemble in different combinations in different nerve cell types and at different stages of development. (wikipedia.org)
The precise composition of neurofilaments in any given nerve cell depends on the relative expression levels of the neurofilament proteins in the cell at that time. (wikipedia.org)
Levels2
Molecular testing remains the gold standard for APOE genotyping, however quantification of the ApoE proteins using immunoassays could provide another piece of information, related to the expression levels of the proteins coded in the genes. (fujirebio.com)
Elevated or rising protein levels on serial lumbar punctures and 10 or fewer mononuclear cells/mm 3 strongly support the diagnosis. (medscape.com)
Clinical2
The GENFI investigators have now published a number of papers on clinical, cognitive, imaging, and fluid biomarker measures in genetic FTD. (genfi.org)
They will allow researchers and clinical research professionals across the world to further investigate the clinical utility of the ApoE protein quantification in Alzheimer's disease and related disorders on the LUMIPULSE G platform. (fujirebio.com)
Light chain3
Neurofilament light chain: a biomarker for genetic frontotemporal dementia. (genfi.org)
Serum neurofilament light chain in genetic frontotemporal dementia: a longitudinal, multicentre cohort study. (genfi.org)
We also analyzed HIV RNA in blood and CSF, IgG Index, CSF WBC counts, and CSF concentrations of β2-micoglobulin, neopterin, and neurofilament light chain protein (NfL). (biomedcentral.com)
Cell2
We decellularized the metastatic lung sections, measured the micromechanics of the tumor ECM, and stained the sections for ECM proteins, proliferation, and cell death markers. (ibecbarcelona.eu)
This work will integrate new technologies including single cell RNA sequencing and multiplex biomarker analysis towards this goal. (grayson-jockeyclub.org)
Normal1
4 5 Rise in cerebrospinal fluid (CSF) protein level with normal CSF cellularity, also known as 'albumino-cytological dissociation', is characteristic of GBS, and present in over 90% of patients 2 weeks postonset. (bmj.com)
Study2
Downregulation of exosomal miR-204-5p and miR-632 as a biomarker for FTD: a GENFI study. (genfi.org)
One Sentence Summary: This study will assess efficacy of recombinant equine lubricin (rEqLub) in mitigating equine joint disease and identify gene and protein pathways affected by rEqLub in equine joints. (grayson-jockeyclub.org)
Patients1
Le contenu de ce site web est en partie réservé aux professionnels de santé qui sont directement impliqués dans la fourniture de services de soins de santé aux patients. (fujirebio.com)
Association1
The type III intermediate filament subunit, vimentin, is expressed in developing neurons and a few very unusual neurons in the adult in association with type IV proteins, such as the horizontal neurons of the retina. (wikipedia.org)
Amyloid1
All recognized mutations for AD are associated with increased deposition of amyloid-beta (Abeta), a peptide fragment comprising 39-43 amino acids that derive from the catabolism of the amyloid precursor protein (APP) molecule. (medscape.com)
Measurements2
Structural models generally assume eight tetramers (32 neurofilament polypeptides) in a filament cross-section, but measurements of linear mass density suggest that this can vary. (wikipedia.org)
HIV infection in the CNS can be detected and monitored by cerebrospinal fluid (CSF) viral load measurements. (medscape.com)
Discovery3
2016 Discovery of a more accurate biomarker for infulenza immunity. (nih.gov)
2015 Discovery of a more sensitive biomarker to predict relapse in patients with diffuse large B-cell lymphoma. (nih.gov)
One of the most explored areas of research in ALS is the discovery and validation of biomarkers that can be applied to clinical practice and incorporated into the development of innovative therapies. (mdpi.com)
Light2
Another CSF biomarker for neuroaxonal injury is neurofilament light (NFL) protein. (biomedcentral.com)
2020 Two studies demonstrated that a blood test of neurofilament light chain can accurately identify all stages - mild, moderate, and severe - of a traumatic brain injury. (nih.gov)