DisordersMultiple sclerosisUmbilical cordDebilitating neurodegenerative conditionStrokeRegenerationProgressive neurodegenerativeTherapeuticMuscular AtrophyCardiovascular diseaseTherapiesParkinson's DiseaseAlzheimer's DiseaseBrainIsolated from bone marrowInflammationNeuroprotectionDiabetesInfectiousIschemicMechanismsNerveLungsRegenerative medicineResearch centreDegenerative diseasesRetinal diseasesMesenchymal stemResearchersKnown as Lou Gehrig'AxonImmunePeripheralCerebralHuntington'sMitochondrialCervicalCongenitalTreatmentMarrow-derivedNeurological diseasesBovine spongiform encOxidativeNervousLimbEncephalopathyTissue
Disorders15
- According to clinicaltrials.gov, mesenchymal stem cells are being used in many therapeutic areas like bone diseases, cancer, heart diseases, diabetes, gastro intestinal diseases, immune rejection / autoimmunity, neurodegenerative disorders and many other therapeutic areas. (edu.in)
- Stem cell research in neurodegenerative disorders (ex: spinal cord injury) is still in developmental stage. (edu.in)
- Scientists are attempting to develop therapies that replace or rebuild spoiled cells with the tissues generated from stem cells and offer hope to people suffering from diabetes, cancer, spinal-cord injuries, cardiovascular disease, and many other disorders. (transparencymarketresearch.com)
- These transplants have treated blood disorders such as bone marrow failure, haematological malignancies, inherited blood disorders, immuno-deficiency syndromes and metabolic disorders. (cryosave.co.za)
- Blood Disorders, Bone Marrow Failure Syndrome, Immunodeficiencies and other diseases like Neuroblastoma and Solid Tumours. (cryosave.co.za)
- Part Four: Spine and Spinal Cord" includes chapters on congenital spinal anomalies, degenerative disk disease, spinal cord and spinal tumors, trauma, vascular disorders, and spinal infection/inflammation. (ajnr.org)
- This report describes the role of neuroprotection in acute disorders such as stroke and injuries of the nervous system as well as in chronic diseases such as neurodegenerative disorders because many of the underlying mechanisms of damage to neural tissues are similar in all these conditions and several products are used in more than one disorder. (researchandmarkets.com)
- In addition, pathophysiological roles for extracellular vesicles are beginning to be recognized in diseases including cancer, infectious diseases and neurodegenerative disorders, highlighting potential novel targets for therapeutic intervention. (nature.com)
- Dr. Robin Hsiung, an associate professor in the faculty of medicine and a staff neurologist at the UBC hospital clinic for Alzheimer's and related disorders, discussed their intriguing research on neurodegenerative diseases in an interview with The Ubyssey. (ubyssey.ca)
- Understanding epigenetic mechanisms (environmental influences other than genetics) of cell fate could lead to the deciphering of the molecular mechanisms of many diseases, including immunological disorders, anemia, leukemia, and many more. (weizmann-usa.org)
- Neurology is a branch of medical science that is concerned with disorders and diseases of the nervous system. (news-medical.net)
- Ganoderma lucidum has preventive and therapeutic effects on disease models such as Alzheimer's disease, Parkinson's disease, ischemic stroke, epilepsy and spinal cord injury through anti-inflammatory and antioxidant mechanisms, and can alleviate neurodegenerative disorders,and improve learning and memory abilities. (ganoherb.com)
- Myelopathy can be the result of primary intrinsic disorders of the spinal cord or from secondary conditions, which result in extrinsic compression of the spinal cord. (bvsalud.org)
- 2002) and also in neurodegenerative disorders such as Alzheimer's disease (McGeer & Rogers, 1992), HIV encephalopathy (Gendelman et al. (420magazine.com)
- Bovine spongiform encephalopathy (BSE), also known as mad cow disease, and variant Creutzfeldt-Jakob disease (CJD) are related disorders. (medscape.com)
Multiple sclerosis5
- Human umbilical cord blood cells have been used in a large number of trials for paraplegia, ataxia, multiple sclerosis, amyotrophic lateral sclerosis, cerebrovascular disease, multiple system atrophy, motor neuron disease, among other indications, without severe immunological response. (edu.in)
- NervGen is looking at the viability of utilizing this concept for multiple sclerosis, spinal cord injuries, and Alzheimer's treatment. (multiplesclerosis.net)
- This is true not only for acute brain trauma and hypoxic-ischemic brain damage following a stroke but also for chronic infection and neurodegenerative diseases, such as Alzheimer's disease, amyotrophic lateral sclerosis (ALS), Lewy body dementia, and leukoencephalopathies like multiple sclerosis (MS). In addition, local peritumoral inflammation plays a role in the clinical progression and malignancy of glioblastomas, the most aggressive primary brain tumors. (atlasantibodies.com)
- Stem cells harvested from a person's own bone marrow or blood, can safely slow progression of the most common form of the autoimmune disease, multiple sclerosis, or MS as it's usually known, finds research published online in the Journal of Neurology Neurosurgery & Psychiatry. (news-medical.net)
- Most (85%) patients with relapsing-remitting multiple sclerosis (RRMS) present with episodes of neurological dysfunction before transitioning to a secondary progressive multiple sclerosis (SPMS) phase of the disease years later. (medscape.com)
Umbilical cord9
- The stem cells can be derived from bone marrow, umbilical cord blood, placental, mesenchymal cells etc. (edu.in)
- Research has shown that umbilical cord blood is a trustworthy source of multipotent stem cells for regenerative medicine 2 . (cordforlife.com)
- Cord for Life ® is committed to advancing research into the potential for cord blood in regenerative medicine, beginning with clinical trials in the treatment of lower back pain arising from the Sacroiliac Joint (SIJ) using a biological therapeutic derived from umbilical cord blood. (cordforlife.com)
- Cord for Life ® collects umbilical cord blood, from which we extract and cryogenically store stem cells for potential future use. (cordforlife.com)
- ALTAMONTE SPRINGS, FL (October 2 9 , 2021 ) Cord for Life ® , a full-service cord blood bank with over 25 years of experience, today announced plans to conduct a clinical trial to treat lower back pain arising from the Sacroiliac Joint (SIJ) using a biological therapeutic derived from umbilical cord blood. (cordforlife.com)
- Recently, scientists have also recognized stem cells in the placenta and umbilical cord blood that can give rise to several types of blood cells. (transparencymarketresearch.com)
- There are currently over 80 approved therapies where umbilical cord blood stem cells can be used. (cryosave.co.za)
- Family-directed umbilical cord blood banking. (cryosave.co.za)
- Prevalence of medical conditions potentially amenable to cellular therapy among families privately storing umbilical cord blood. (cryosave.co.za)
Debilitating neurodegenerative condition1
- Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a debilitating neurodegenerative condition that attacks the nerve cells in the brain and spinal cord. (viezec.com)
Stroke2
- This is so because the central nervous system (CNS) which comprises the brain and the spinal cord doesn't have the ability to repair itself after major trauma as well as neurodegenerative diseases and stroke . (gilmorehealth.com)
- This makes them potentially capable to help in effectively combatting a variety of degenerative diseases and conditions such as spinal cord injury, stroke or heart attacks. (nhsjs.com)
Regeneration11
- These molecules have revolutionized the field of bioactive materials for regenerative medicine, with potential applications in bone and cartilage regeneration, angiogenesis for ischemia or peripheral artery disease, cancer therapy, novel therapies for neurodegenerative diseases, stem cell differentiation, spinal cord injury, diabetes, and many other areas. (wikipedia.org)
- According to Save the Cord Foundation, landmark trials are currently underway in regenerative medicine that are investigating treatments for brain injuries, juvenile diabetes, heart disease, and corneal regeneration 3 . (cordforlife.com)
- All stem cells are undifferentiated cells that exhibit unlimited self-renewal and can generate multiple cell lineages or more restricted progenitor populations that can contribute to tissue homeostasis by replenishing the cells or to tissue regeneration after injury. (biomedcentral.com)
- With this approach, the researchers were able to systematically examine the effects of axon injury location on degeneration and regeneration of the injured branch. (sciencedaily.com)
- The researchers found that injury to the main axon, before a branch point, resulted in regeneration in 89 percent of the cases. (sciencedaily.com)
- Regeneration occurred in the form of axon elongation, branching or both for at least five days after injury. (sciencedaily.com)
- Here we show through systematic epigenetic studies that the histone acetyltransferase p300/CBP-associated factor (PCAF) promotes acetylation of histone 3 Lys 9 at the promoters of established key regeneration-associated genes following a peripheral but not a central axonal injury. (nature.com)
- Finally, PCAF is necessary for conditioning-dependent axonal regeneration and also singularly promotes regeneration after spinal cord injury. (nature.com)
- Interestingly, the lack of regeneration of injured ascending sensory fibres in the spinal cord can be partially enhanced by an injury to the peripheral branch (conditioning lesion) of DRG neurones 7 . (nature.com)
- Finally, we established that PCAF is required for regeneration following a conditioning lesion and PCAF overexpression promotes axonal regeneration similar to that of a conditioning lesion after CNS injury in spinal ascending sensory fibres. (nature.com)
- Our results show the first evidence of immediate retrograde signalling leading to long-term epigenetic reprogramming of gene expression of select genes whose modulation leads to axonal regeneration in the hostile spinal environment. (nature.com)
Progressive neurodegenerative1
- Scientists studying Alzheimer's disease (AD) have identified thousands of genetic variants in the genome in the development of this progressive neurodegenerative disease. (news-medical.net)
Therapeutic2
- Here, we review recent progress in understanding extracellular vesicle biology and the role of extracellular vesicles in disease, discuss emerging therapeutic opportunities and consider the associated challenges. (nature.com)
- This is a new, yet very fundamental, understanding of neuron behavior -- one that will be important to keep in mind as new therapeutic approaches are proposed for spinal cord injuries, the researchers say. (sciencedaily.com)
Muscular Atrophy1
- Spinal muscular atrophy (SMA) is a neurodegenerative disease produced by low levels of Survival Motor Neuron (SMN) protein that affects alpha motoneurons in the spinal cord. (mdpi.com)
Cardiovascular disease4
- Lai, R. C., Chen, T. S. & Lim, S. K. Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease. (nature.com)
- For example, high blood pressure is a biomarker of potential cardiovascular disease. (michaeljfox.org)
- The Joint Public Health Impact of Family History of Diabetes and Cardiovascular Disease among Adults in the United States: A Population-Based Study. (cdc.gov)
- We estimated death rates for any cardiovascular disease (CVD, a composite of 6 CVD conditions) and 15 non-CVD comorbidities, and adjusted risks of death (hazard ratio [HR], 95% confidence interval [CI]) overall and by age group at CKD incidence. (cdc.gov)
Therapies7
- A review article says that there are many studies involving autologous therapies and some allogenic therapies, based on the recovery of mobilized bone marrow cells, including mesenchymal stem cells (MSCs) and adipose derived stem cells that also include the stromal or adherent cell type that has an MSC phenotype. (edu.in)
- Yet, in several countries, stem cells therapy is being used to treat spinal cord injury (SPI) although such therapies are not scientifically proved. (edu.in)
- The human umbilical cord is being increasingly recognized by the medical community for its potential in regenerative medicine and cellular therapies. (cordforlife.com)
- A comprehensive list of current treatable diseases and therapies can be found on Parents' Guide to Cord Blood . (cryosave.co.za)
- Pathomechanisms of diseases are described with steps at which neuroprotective therapies are directed. (researchandmarkets.com)
- They were amazed to find that none of the GRPs damaged the spinal cord or formed tumours, a worry with some stem cell therapies. (medindia.net)
- With models, researchers can study the mechanisms of a disease and test therapies. (michaeljfox.org)
Parkinson's Disease11
- A class of drugs used to treat mild to moderate dementia in Parkinson's disease. (michaeljfox.org)
- Aggregation of the protein alpha-synuclein is found in Lewy bodies, a pathological hallmark of Parkinson's disease. (michaeljfox.org)
- A genetic mutation in this protein is the basis for a rare inherited form of Parkinson's disease. (michaeljfox.org)
- A class of drugs often effective in reducing the tremor of Parkinson's disease. (michaeljfox.org)
- Some studies have linked oxidative damage to Parkinson's disease. (michaeljfox.org)
- A medicine used to treat Parkinson's disease. (michaeljfox.org)
- A movement disorder sometimes confused with Parkinson's disease that manifests in low, repetitive, involuntary, writhing movements of the arms, legs, hands, and neck that are often especially severe in the fingers and hands. (michaeljfox.org)
- Many of the symptoms of Parkinson's disease are brought on by loss of or damage to dopamine neurons in this region, which encompasses the striatum, the subthalamic nucleus, and the substantia nigra. (michaeljfox.org)
- No validated biomarker of Parkinson's disease currently exists. (michaeljfox.org)
- One of the cardinal clinical features of Parkinson's disease, the slowing down and loss of spontaneous and voluntary movement. (michaeljfox.org)
- Possible treatment for Alzheimer's disease and other neurodegenerative diseases ( Parkinson's disease , Huntington's disease , etc. (iptq.com)
Alzheimer's Disease5
- Alzheimer's disease (AD) is a brain disorder that causes progressive neurological atrophy and is the most common cause of dementia. (cisbio.jp)
- This protein is already known in connection with Alzheimer's disease and recent studies prove that CBD can lower levels of this protein and decrease its degenerative activity. (moya-cbd.co.uk)
- Now some researchers claim that inducing a mild autoimmune reaction could actually protect the central nervous system from a spectrum of neurodegenerative conditions, from glaucoma and spinal cord injury to Parkinson's and Alzheimer's disease. (weizmann-usa.org)
- A new tau PET radiotracer, 18F-SNFT-1, has been found to be more effective than existing tau PET radiotracers in identifying Alzheimer's disease in its earliest stages, according to research published in the September issue of The Journal of Nuclear Medicine. (news-medical.net)
- They can thus develop into brain, muscle, blood, skin, and other tissues and can, in theory, help with many health conditions involving organ dysfunction or failure, as well as cancer, injury, and may even address degenerative and otherwise incurable diseases such as Parkinson's and Alzheimer's disease. (nhsjs.com)
Brain24
- This 2-volume set is divided into 5 parts: Principles of MR Imaging (191 pages), Brain (892 pages), Skull Base (274 pages), Spine and Spinal Cord (373 pages), and Advanced Applications (150 pages). (ajnr.org)
- The last part of the book ("Part Five: Advanced Applications") deals with advanced applications with chapters on the fetal spine and brain, diffusion and diffusion tensor imaging, perfusion imaging, clinical functional MR imaging, psychiatric disease, MR spectroscopy, and contrast agents. (ajnr.org)
- These cells are capable of regenerating damaged brain and spinal cord tissue. (viezec.com)
- How does ALS damage the brain and spinal cord? (viezec.com)
- As the disease progresses, nerve cells in the brain and spinal cord die. (viezec.com)
- Parkinson s disease is a neurodegenerative disease caused by progressive dopamine brain cells loss. (medindia.net)
- Adult human axons in the brain and spinal cord are very limited in their ability to regenerate after injury -- a hurdle that many researchers are trying to overcome in the treatment of spinal cord injuries and neurodegenerative diseases of the brain. (sciencedaily.com)
- Genetic defects, birth defects, infections, cancerous tumours, bruises, and more - Although the brain and spinal cord are surrounded by strong membranes, wrapped inside bones of the skull and spine, and chemically isolated by the Blood-Brain Barrier (BBB), they are very sensitive if they are damaged. (moya-cbd.co.uk)
- Cerebral vascular diseases are associated with brain injuries, for example, autoimmune deficiencies are associated with damage caused to the body by its immune system. (moya-cbd.co.uk)
- Diseases of neuronal cell disability have few things in common and are a disorder in biochemical processes in neurons: problems with neural conduction, oxidative stress, activation of microglia [MG] cells (microglia are the local macrophages in the brain), and poor function of transferring vital proteins in the brain and cells of the central nervous system [CNS]. (moya-cbd.co.uk)
- Consequently, boosting the immune system via a vaccination may one day help to prevent aging of the brain and perhaps slow down disease progression in the cases of Alzheimer's and Parkinson's. (weizmann-usa.org)
- Neuroinflammation broadly defines the collective reactive immune response in the brain and spinal cord in response to injury and disease. (atlasantibodies.com)
- Neuroinflammatory processes are the key causative factors behind brain and spinal cord injury. (atlasantibodies.com)
- The microglia cells are multitasking and instrumental for maintaining the brain and spinal cord's essential regulatory and homeostatic functions. (atlasantibodies.com)
- Myelopathy is a clinical diagnosis with localization of the neurological findings to the spinal cord, rather than the brain or the peripheral nervous system, and then to a particular segment of the spinal cord. (bvsalud.org)
- The major cause of the problems we see from a brain injury are caused mainly from mitochondrial injury dysfunction. (johnathanedwardsmd.com)
- However, in ischemic heart (or brain) disease, ATP levels can be reduced, with supply not meeting demand. (johnathanedwardsmd.com)
- It is also widely available as an over-the-counter nutritional supplement which is has been shown to be beneficial in traumatic brain injury. (johnathanedwardsmd.com)
- During ischemic events (as in a brain injury) carnitine levels are depleted. (johnathanedwardsmd.com)
- Investigators used carnitine in a model of brain injury and found that carnitine likely provides neuroprotection by improving cerebral energy metabolism and, therefore, lessens the chance of cell death caused by metabolic failure. (johnathanedwardsmd.com)
- 1994), and traumatic brain injury (Dusart & Schwab, 1994). (420magazine.com)
- He found that insulin and glucose allowed him to get larger doses of toxic heavy metal drugs into the brain and spinal cord, kill all the syphilis spirochetes, and get the heavy metals back out without killing the patient. (iptq.com)
- 5] With the 2010 McDonald criteria revision[5] (see Table 1), it is possible to confirm the diagnosis of MS at initial presentation because the baseline MRI scan may be used to demonstrate DIS and DIT with respect to lesions of the brain and spinal cord. (medscape.com)
- Tissues such as brain, spinal cord, and small intestine, which may have a higher likelihood of containing the pathogenic agent of BSE, were removed during slaughter and sent for rendering (often to be used as nonruminant animal feed). (medscape.com)
Isolated from bone marrow1
- Mesenchymal stem cells (MSCs) are multipotent cells usually isolated from bone marrow, endometrium, adipose tissues, skin, and dental pulp. (techscience.com)
Inflammation2
- Although inflammation serves as a protective function in controlling infections and promoting tissue repair, it can also cause tissue damage and disease. (420magazine.com)
- Cervical muscle spasm causing torticollis can result from any injury or inflammation of the cervical muscles or cranial nerves from different disease processes. (medscape.com)
Neuroprotection1
- TREM2 is a mediator of neuroprotection and is associated with various neurodegenerative diseases. (cisbio.jp)
Diabetes5
- Type 2 diabetes, the most common form of the disease, develops when the body cannot adequately produce, or improperly uses, insulin, a hormone that regulates blood sugar levels. (weizmann-usa.org)
- People with type 2 diabetes are at an increased risk for many serious health problems, including heart disease, blindness, and kidney damage. (weizmann-usa.org)
- METHODS: We analyzed data from a representative sample of the US adult population including 29,440 participants from the National Health and Nutrition Examination Survey (2007-2018) and assessed self-reported first-degree family history of diabetes and CVD (premature heart disease before age of 50 years) as well as meeting criteria and/or having risk factors for CVD and diabetes. (cdc.gov)
- RESULTS: Participants with joint family history exhibit 6.5 greater odds for having both diseases and are diagnosed with diabetes 6.6 years earlier than participants without family history. (cdc.gov)
- This wide presence of high-risk family history and its simplicity of ascertainment suggests that clinical and public health efforts should collect and act on joint family history of CVD and diabetes to improve population efforts in the prevention and early detection of these common chronic diseases. (cdc.gov)
Infectious1
- The relevant infectious disease has been identified as coronavirus disease-2019 (COVID-19) by World Health Organization and declared as a global pandemic. (bvsalud.org)
Ischemic1
- Ischemic optic neuropathies are prevalent diseases and important cases of vision loss. (scientificarchives.com)
Mechanisms2
- This work aimed to explore the underlying mechanisms and focused on the changes in spinal cord. (biomedcentral.com)
- In experimental animals, high-dose HD intoxication was found to cause demyelination in PNS and spinal cords and has been used to study the mechanisms of HD neurotoxicity and evaluate the therapeutical potential of various reagents for demyelinating conditions [ 9 ]. (biomedcentral.com)
Nerve4
- The study is developing an innovative treatment for nerve and neurodegenerative diseases. (multiplesclerosis.net)
- Team at NeuroRestore introduces a groundbreaking gene therapy that has effectively promoted nerve regrowth and reconnection, post spinal cord injury. (medindia.net)
- Neurodegenerative diseases of the nervous system are debilitative and incurable medical conditions that lead to neurodegeneration and/or death of nerve cells. (moya-cbd.co.uk)
- Optic neuritis refers to an inflammatory injury of the optic nerve and represents a common afferent visual pathway manifestation of MS. Less often, homonymous visual field defects caused by retrogeniculate lesions are encountered. (medscape.com)
Lungs1
- Diseases of the lungs can cause problems in any part of this complex system of the human body. (usapeptides.info)
Regenerative medicine5
- Prior to the advent of regenerative medicine and cellular expansion, cord blood treatments typically required the entire unit to help rebuild the blood and immune system. (cordforlife.com)
- In support of this emerging potential for utilization of stem cells in regenerative medicine, Cord for Life ® now offers the option of storing cord blood in a 5-compartment cryo-bag. (cordforlife.com)
- Although we offer the option to store cord blood in a two-chamber cryo-bag, we recommend the five-chamber bag to anyone who wants to keep their options open for using cord blood in regenerative medicine applications as they become available. (cordforlife.com)
- Cord for Life ® 's 5-chamber cryo-bag offers maximum flexibility for storing cord blood stem cells - whether you need the entire unit for one of the 80+ FDA treatments or a portion of the unit for regenerative medicine. (cordforlife.com)
- There are other, less controversial alternatives to embryonic stem cells, such as adult, fetal, cord blood, and induced pluripotent stem cells, but they have other biological restrictions that make them less promising for use in regenerative medicine at this time. (nhsjs.com)
Research centre2
- ICORD is a world leading health research centre focused on spinal cord injury. (ubc.ca)
- The Yuel Family Physical Activity Research Centre is studying how exercise impacts quality of life for those with spinal cord injury, while providing a space for community building and knowledge sharing. (ubyssey.ca)
Degenerative diseases1
- Mitochondrial biology, stress signaling and aging-related degenerative diseases. (upstate.edu)
Retinal diseases1
- This paper reviews recent advances and potential sources of stem cells for cell therapy in retinal diseases. (biomedcentral.com)
Mesenchymal stem1
- Demyelinating conditions are difficult to treat and stem cell therapy using bone marrow mesenchymal stem cells (BMSCs) is a promising novel strategy. (biomedcentral.com)
Researchers8
- From the lab-based cellular level of understanding injury to rehabilitation and recovery, our researchers are dedicated to the development and translation of more effective strategies to promote prevention, functional recovery, and improved quality of life after spinal cord injury. (ubc.ca)
- In the after-math of the bombings of Hiroshima and Nagasaki in 1945, researchers discovered that bone marrow (BM) transplanted into irradiated mice produced hematopoiesis [ 1 ]. (biomedcentral.com)
- Experiments conducted on rat models of ALS, also called Lou Gehrig's disease, have shown that transplanting a new line of stem cell-like cells reduces neuron loss, and extends life, Johns Hopkins researchers have revealed. (medindia.net)
- During the study, the researchers had transplanted about 900,000 glial restricted precursors overall to specific sites in the cervical spinal cord of each model rat in early stages of disease. (medindia.net)
- Researchers at University of California, San Diego School of Medicine report a previously unappreciated phenomenon in which the location of injury to a neuron's communication wire in the spinal cord -- the axon -- determines whether the neuron simply stabilizes or attempts to regenerate. (sciencedaily.com)
- All this led the researchers in the direction of testing the potential of cannabidiol treatment of these diseases. (moya-cbd.co.uk)
- In post-mortem examinations carried out on the brains of people who died as a result of diseases such as Alzheimer's, Parkinson's, and Huntington's, the researchers found an imbalance in the endocannabinoid system. (moya-cbd.co.uk)
- In a new study in mice, a team of researchers from UCLA, the Swiss Federal Institute of Technology, and Harvard University have uncovered a crucial component for restoring functional activity after spinal cord injury. (news-medical.net)
Known as Lou Gehrig'1
- Three new studies at the University of Michigan Health System seek to help people with the terminal illness known as Lou Gehrig's disease live and breathe more comfortably. (medindia.net)
Axon3
- A previously unappreciated phenomenon has been reported in which the location of injury to a neuron's communication wire in the spinal cord -- the axon -- determines whether the neuron simply stabilizes or attempts to regenerate. (sciencedaily.com)
- While the body of a neuron is small, its axon can extend far up or down the spinal cord, which is about one and half feet long in humans. (sciencedaily.com)
- The injury locations they compared were just before an axon's major branch point (where a single axon branches into two) and just after it. (sciencedaily.com)
Immune3
- It is important to note that not all people who receive a bone marrow transplant will benefit from stem cell treatment - it is only likely to be effective if the donor has a high level of immune system diversity (which includes many different types of lymphocytes). (viezec.com)
- It is most effective in increasing growth hormone levels, lean muscle mass, improving bone strength, burning fat and boosting immune function. (usapeptides.info)
- It also takes just living in a context of famine, whether chosen or enforced, to notice the effects of starvation on people, from lethargy and fatigue to wasted muscles, brittle bones and immune system suppression, crowned with irritability, depression, cognitive impairment and overall diminished social affect. (starshipnivan.com)
Peripheral2
- Axonal regenerative failure is a major cause of neurological impairment following central nervous system (CNS) but not peripheral nervous system (PNS) injury. (nature.com)
- The regenerative response initiated following axonal injury in the peripheral nervous system (PNS) versus the central nervous system (CNS) leads to differential growth capacities and repair. (nature.com)
Cerebral1
- People with a higher cumulative estrogen exposure throughout their life may have a lower risk of cerebral small vessel disease, according to a new study published in the September 27, 2023, online issue of Neurology, the medical journal of the American Academy of Neurology. (news-medical.net)
Huntington's1
- An analogous experience of prediction for knowledge's sake is presymptomatic testing for Huntington's disease (HD), for which despite having broad availability, only between 4% and 24% of eligible persons elect to have testing. (bmj.com)
Mitochondrial3
- Mitochondrial injury leads to oxidative stress and subsequent apoptosis (cell death) and decreased cellular energy production. (johnathanedwardsmd.com)
- The topic of mitochondrial dysfunction after TBI is hugely complex and requires treatment that specifically addresses the secondary injury. (johnathanedwardsmd.com)
- Carnitine ameliorated mitochondrial dysfunction after spinal cord injury. (johnathanedwardsmd.com)
Cervical2
- The study suggested parts of the cervical spinal cord that control the diaphragm muscles, which are largely responsible for breathing, might reap the most benefit from such a therapy. (medindia.net)
- This targeted cell delivery to the cervical spinal cord is a promising strategy to slow that loss of motor neurons in ALS. (medindia.net)
Congenital1
- Retinal dystrophies - retinitis pigmentosa (RP) (Figure 1 ), Stargardt disease, Best disease, Leber congenital amaurosis, and so on - all evolve with early loss of photoreceptors and subsequent loss of RGC. (biomedcentral.com)
Treatment10
- Stem cell technology is being used in treating many diseases those formerly have no treatment, but most of them are in elementary stage. (edu.in)
- In a recent interview given by Prof. Alan Mackay-Sim, Director of National Centre for Adult Stem Cell Research in Australia, he has explained Phase I clinical trials in exploring the use of stem cells for spinal cord injury treatment. (edu.in)
- If you are eligible for treatment with stem cells, your doctor will typically begin by using a bone marrow transplant to collect your bone marrow cells. (viezec.com)
- The information should not be used for either diagnosis or treatment or both for any health related problem or disease. (medindia.net)
- With so many lung diseases the need for treatment is high on the list in research laboratories. (usapeptides.info)
- Progress in different areas of basic research, new animal models, and the generation of specific antibody markers to target essential proteins help find and improve the treatment of patients with neuroimmunological diseases. (atlasantibodies.com)
- Autologous hematopoietic stem cell transplantation, or aHSCT for short, is usually used to treat blood cancers, and involves harvesting stem cells from the person's own bone marrow or blood followed by chemotherapy and antibody treatment. (news-medical.net)
- Demyelination and remyelination of the spinal cord before and after BMSC treatment were examined microscopically. (biomedcentral.com)
- One of the promising features of IPT is its reported effectiveness in treatment of numerous nervous system diseases. (iptq.com)
- Treatments include supportive measures and chemotherapy or local treatment with surgery or radiation therapy as indicated by the extent of disease. (msdmanuals.com)
Marrow-derived1
- Experimental and human studies with intravitreal bone marrow-derived stem cells have begun. (biomedcentral.com)
Neurological diseases1
- The event, called excitotoxicity, also occurs in other neurological diseases. (medindia.net)
Bovine spongiform enc2
- Is it possible that IPT might be able to reverse the protein conformation changes of prion diseases such as bovine spongiform encephalopathy and Creutzfeldt-Jakob disease? (iptq.com)
- Incidence of bovine spongiform encephalopathy (BSE) and variant Creutzfeldt-Jakob disease (CJD) in Great Britain. (medscape.com)
Oxidative1
- Ganoderma lucidum may have protective effects against non-alcoholic liver disease as well as alcoholic liver disease through anti-oxidative stress and anti-inflammatory effects. (ganoherb.com)
Nervous3
- The injury can also begin with another system in the body that has relationships with the nervous system. (moya-cbd.co.uk)
- unlike some natural regenerating appendages and organs, the central nervous system has evolved to be so specialized that it lacks the ability of regrowth in response to injury. (gilmorehealth.com)
- MS is an inflammatory and neurodegenerative disorder of the central nervous system (CNS) that causes progressive neurological disability over time. (medscape.com)
Limb1
- Dr. Nicholas Maragakis, an associate professor of neurology at Johns Hopkins who led the research team, says that the new work supports the hypothesis that artificially outnumbering unhealthy cells with healthy ones in targeted parts of the spinal cord preserves limb strength and breathing and can increase survival. (medindia.net)
Encephalopathy1
- Other TSEs include scrapie (a disease of sheep), feline spongiform encephalopathy, transmissible mink encephalopathy, and chronic wasting disease of deer and elk. (medscape.com)
Tissue1
- Dr Tamara Jamaspishvili is a research pathologist, translational research scientist focusing on developing, evaluating, validating, and applying tissue-based prognostic and predictive biomarkers and models for improved disease prognostication and management of cancer patients. (upstate.edu)