Among patients with HER2-positive early breast cancer who had residual invasive disease after completion of neoadjuvant therapy, the risk of recurrence of invasive breast cancer or death was 50% lower with adjuvant T-DM1 than with trastuzumab alone. (nih.gov)
Conversely, there are many arguments in favor of performing ND only for patients who have evidence of residual neck disease because of the very low probability of isolated neck recurrence following a complete response. (nih.gov)
Prognosis1
Patients who have residual invasive breast cancer after receiving neoadjuvant chemotherapy plus human epidermal growth factor receptor 2 (HER2)-targeted therapy have a worse prognosis than those who have no residual cancer. (nih.gov)
Primary neoplasms1
Thymic epithelial neoplasms or tumors, also known as thymoma and thymic carcinoma, are the most common primary neoplasms of the anterior mediastinum. (medscape.com)
Malignant5
Trichilemmal carcinomas (TCs) are rare, malignant, adnexal neoplasms that differentiate from the outer root sheath (ORS) of the hair follicle. (jcadonline.com)
Such clinical phenotypes can mimic infectious and autoimmune causes of meningoencephalitis.Objective: To ascertain whether CSF metagenomic next-generation sequencing (mNGS) can identify aneuploidy, a hallmark of malignant neoplasms, in difficult-to-diagnose cases of CNS malignant neoplasm.Design, Setting, and Participants: Two case-control studies were performed at the University of California, San Francisco (UCSF). (stanford.edu)
The first study used CSF specimens collected at the UCSF Clinical Laboratories between July 1, 2017, and December 31, 2019, and evaluated test performance in specimens from patients with a CNS malignant neoplasm (positive controls) or without (negative controls). (stanford.edu)
The second study evaluated patients who were enrolled in an ongoing prospective study between April 1, 2014, and July 31, 2019, with presentations that were suggestive of neuroinflammatory disease but who were ultimately diagnosed with a CNS malignant neoplasm. (stanford.edu)
The test performance study used 125 residual laboratory CSF specimens from 47 patients with a CNS malignant neoplasm and 56 patients with other neurological diseases. (stanford.edu)
Carcinoma1
The aim of this study was to compare the prognostic discrimination power of different histological regression grading systems: (i) the fibrosis/tumour ratio within the primary tumour (Mandard classification), (ii) the percentage of residual vital tumour cells (VTC) compared to the original primary tumour (Cologne Regression) and (iii) the ypT category, in patients with cT3 carcinoma of the oesophagus after neoadjuvant chemoradiation. (unige.ch)
Tumor8
Solid pseudopapillary tumor of the pancreas is considered a rare neoplasm, which predominately affects young African American women [ 1 ]. (hindawi.com)
The origins of the tumor remain unknown, and there are no identifiable risk factors which have been associated with the development of the neoplasm. (hindawi.com)
Even after successful resection of the tumor, attention needs to be paid to patients who subsequently become pregnant, secondary to any residual disease having a heightened sensitivity to increased levels of progesterone. (hindawi.com)
Solid pseudopapillary tumor of the pancreas is a rare neoplasm of the pancreas, predominately affecting the exocrine function of the pancreas. (hindawi.com)
The patient underwent radiation therapy with favorable regression of the residual tumor on subsequent imaging studies. (researchwithrutgers.com)
Influence of extent of resection of contrast enhanced tumor on progression-free survival and overall survival was analyzed, measured as relative extent of resection (EOR) and absolute residual tumor volume (RTV). (lu.se)
Results: Quantitative volumetric measurements, especially residual tumor volume of ≤1,6 mL, showed prognostic significance for longer progression-free and overall survival. (lu.se)
Flat tumors, termed en plaque, infiltrate the dura and grow as a thin carpet or sheet of tumor along the convexity dura, falx, or tentorium. (medscape.com)
Mucinous1
Thirteen individuals with FPC (6.1%) underwent surgical resection for a suspected PRL, but only four (1.9%) had high-risk lesions (ie, high-grade intraductal papillary mucinous neoplasms or grade 3 pancreatic intraepithelial neoplasms). (medscape.com)
Surgery4
We conducted a phase 3, open-label trial involving patients with HER2-positive early breast cancer who were found to have residual invasive disease in the breast or axilla at surgery after receiving neoadjuvant therapy containing a taxane (with or without anthracycline) and trastuzumab. (nih.gov)
As planned surgery will only benefit patients with residual disease in the neck alone, there is a high rate of unnecessary ND with its associated morbidity. (nih.gov)
She was followed up in surgery clinic and underwent a CT of the abdomen and pelvis one year later which did not demonstrate any evidence of residual or metastatic disease. (hindawi.com)
There was no evidence of residual disease at the time of surgery. (hindawi.com)
Neoadjuvant2
Assessment of Residual Cancer Burden and Event-Free Survival in Neoadjuvant Treatment for High-risk Breast Cancer: An Analysis of Data From the I-SPY2 Randomized Clinical Trial. (providence.org)
IMPORTANCE: Residual cancer burden (RCB) distributions may improve the interpretation of efficacy in neoadjuvant breast cancer trials. (providence.org)
Pediatric1
No significant associations were found with upper or lower respiratory infections, otitis media, any infectious diseases, neoplasms, sensory disorders, urgent and inpatient health services use, pediatric complex chronic conditions, or mortality. (bmj.com)
Disease3
however, increased attention was paid to the patient during her pregnancy secondary to elevated hormonal levels of progesterone, which any residual disease would have a heightened sensitivity to. (hindawi.com)
It has a non-debatable contribution to the diagnosis of hematolymphoid neoplasm as well as in minimal residual disease. (ijpmonline.org)
MAIN OUTCOMES AND MEASURES: Residual cancer burden (pathological measure of residual disease) and event-free survival (EFS). (providence.org)
Survival1
Assessment of Residual Cancer Burden and Event-Free Survival in Neoadj" by W Fraser Symmans, Christina Yau et al. (providence.org)
Detection1
Detection of Neoplasms by Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid. (stanford.edu)
Asthma1
Residual confounding may explain the small associations observed with increased asthma and reduced gastrointestinal infections. (bmj.com)
Pathology1
Pathology confirmed the lesion to be solid pseudopapillary neoplasm of the pancreas with clear margins (Figures 3 and 4 ). (hindawi.com)
Central nervou1
Importance: Cerebrospinal fluid (CSF) cytologic testing and flow cytometry are insensitive for diagnosing neoplasms of the central nervous system (CNS). (stanford.edu)
Margins1
Tangential shave biopsy of the lesion was performed and the histopathologic report revealed an adnexal neoplasm with trichilemmal differentiation, desmoplastic component, and atypia with margins involved (Figures 2A, 2B, 3A, and 3B). (jcadonline.com)
Minimal residua1
The utilization of ctDNA to detect minimal residual disease is currently being employed across the continuum of cancer care. (houstonmethodist.org)
The indication for hysterectomy was residual histological finding at conization pathology in 30 women and patients' request in 53 women. (medscape.com)
Residual disease was found in 42 hysterectomy specimens: in 16 of 30 with residual histological finding and in 26 of the 53 patients' request. (medscape.com)
Primary2
Thymic epithelial neoplasms or tumors, also known as thymoma and thymic carcinoma, are the most common primary neoplasms of the anterior mediastinum. (medscape.com)
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site. (bvsalud.org)
Imaging1
Somatostatin receptor (SSR) imaging offers an opportunity to identify receptor-expressing neuroendocrine neoplasms (NENs) ( 2 , 3 ). (snmjournals.org)
Leukemia1
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare acute leukemia sub-type that often first presents with skin manifestations. (dermatologytimes.com)
Patients1
In 29 first-line patients who received the optimal dose of [tagraxofusp] in the pivotal trial (12 mcg/kg/day), the overall response rate was 90%, with a 72% rate of complete response (CR) plus complete response with minimal residual skin abnormality (CRc). (dermatologytimes.com)
Role1
This article provides a guide to the performance and interpretation of 68 Ga-DOTATATE PET/CT and describes its role in the diagnostic algorithm of neuroendocrine neoplasms and its overall utility in their management. (snmjournals.org)