CavityPolypsMucousRhinosinusitisAirway mucosaLavage fluidMucosalChronicRespiratorySymptomsSeptumIntranasalAlteration of the nasalEpithelial cellsTurbinatesMucusCavitiesTreatment of nasalMucociliary transportSeptalBiopsiesVivoAntibodiesStuffinessEpitheliumInferior turbinateHistochemicalLaryngeal cancerCancersFluidOlfactoryInflammationCytologicalOccurAdverse effectsImmunizationComparativeCRSsNPTissuesSprayEnzymesAbstractClinicalAirflowTherapiesNoseHumanOralStimulationConcentrationsPatientsParticipants
Cavity17
- The nasal mucosa lines the nasal cavity. (wikipedia.org)
- The mucosa, or mucous membrane, is a type of tissue that lines the nasal cavity. (medlineplus.gov)
- The enlarged nasal cavity resulting from turbinate resection was believed to increase nasal airflow and reduce the humidifying capabilities of the nasal mucosa, resulting in drying, crusting, and mucosal atrophy. (medscape.com)
- The objective of this research was to design and fabricate a nose-on-chip device and bi-directional airflow system that models flow within the nasal cavity to investigate how airflow induced mechanical stresses impact nasal secretion rates and cytoskeletal remodeling. (wright.edu)
- The keratin-filled cyst is distorting normal architecture, including that of the nasal cavity. (nih.gov)
- The nasal cavity is well-equipped with sticky mucus that traps pathogens and serves as an important site for immune cell surveillance and signaling. (earthnewsreport.com)
- A new study by researchers in the UNC School of Medicine, including Meghan Rebuli, PhD, Ilona Jaspers, PhD, and Kevin T. Cao, lead author, has found that SARS-CoV-2 mRNA vaccination induces an immune response in the mucosal lining of the nasal cavity, offering new insights into potential vaccine strategies in the future. (earthnewsreport.com)
- Intrigued by other research findings on mucosal immunity in the nasal cavity, Rebuli and colleagues wanted to know if antibody production induced by the mRNA vaccines resulted in antibody levels that promote neutralization of SARS-CoV-2 in the nasal cavities of vaccinated individuals. (earthnewsreport.com)
- But the study team went on to find that the vaccine-induced antibodies within the nasal cavity were able to better neutralize the virus compared to antibodies that were in the blood. (earthnewsreport.com)
- Is the Subject Area "Nasal cavity" applicable to this article? (plos.org)
- However, an emerging target for nasal drug product development is nose-to-brain delivery via a variety of pathways in the nasal cavity. (nih.gov)
- Most of the time, treatment of nasal cavity or paranasal sinus cancer is based on where it is and its stage (how far it has spread). (cancer.org)
- The staging of nasal cavity and paranasal sinus cancer is very complex. (cancer.org)
- At this time, staging systems have only created for the most common cancers - maxillary sinus and nasal cavity/ethmoid sinus cancers. (cancer.org)
- Treatment choices for less common cancers of the nasal cavity and paranasal sinuses are tailored to each patient depending on the tumor type, size, location, and the patient's general medical condition and wishes. (cancer.org)
- Because nasal cavity and paranasal sinus cancers are rare, they've been hard to study well. (cancer.org)
- Most experts agree that treatment in a clinical trial should be considered for any type or stage of nasal cavity and paranasal sinus cancer. (cancer.org)
Polyps8
- Metallothionein-3 (MT3) is an intracellular zinc chelator and previous data showed MT3 mRNA levels to be reduced in CRS patients with nasal polyps (CRSwNP). (hokudai.ac.jp)
- MT3 expression and tissue zinc fluorescence intensity were measured at different areas within the mucosa (surface epithelium and lamina propria) and compared between controls, CRSwNP and CRS without nasal polyps (CRSsNP) patients. (hokudai.ac.jp)
- sIgD levels and numbers of IgD + cells were significantly increased in uncinate tissue (UT) of patients with chronic rhinosinusitis without nasal polyps (CRSsNP) compared with that of control subjects (4-fold, P (bvsalud.org)
- 2. Plasminogen activators and tumor development in the human colon: activity levels in normal mucosa, adenomatous polyps, and adenocarcinomas. (nih.gov)
- 12. Plasminogen activators in human nasal polyps and mucosa. (nih.gov)
- Nasal polyps are benign tumors in the nasal mucosa. (bioprepwatch.com)
- Depending on the size of the tumor or the number of these polyps growing in the sinuses, nasal breathing can be severely restricted. (bioprepwatch.com)
- Nasal polyps often cause headaches and a feeling of pressure in the middle of the face. (bioprepwatch.com)
Mucous6
- It is part of the respiratory mucosa, the mucous membrane lining the respiratory tract. (wikipedia.org)
- It is continuous with the skin through the nostrils, and with the mucous membrane of the nasal part of the pharynx through the choanae. (wikipedia.org)
- The mucous membrane is thickest, and most vascular, over the nasal conchae. (wikipedia.org)
- The mucous blanket serves to humidify and clean the inspired air and eliminate debris from the nasal airway. (medscape.com)
- Resistance is important in nasal function and turbulence optimizes inspiratory air contact with the mucous membrane. (medscape.com)
- Researchers also found that IgA concentrations in the blood samples and IgG concentrations in the nasal mucus samples were greater in Spikevax™ vaccinated individuals compared to Comirnaty® in both blood and nasal mucous samples. (earthnewsreport.com)
Rhinosinusitis3
- Objective: Recently, depleted tissue zinc levels were found in nasal mucosa from patients with chronic rhinosinusitis (CRS) in correlation with tissue eosinophilia, however, no clinical biomarkers for tissue zinc levels have been identified. (hokudai.ac.jp)
- Evidence for altered levels of IgD in the nasal airway mucosa of patients with chronic rhinosinusitis. (bvsalud.org)
- We assessed whether levels of sIgD and IgD + B cell counts are altered in nasal tissue from patients with chronic rhinosinusitis (CRS). (bvsalud.org)
Airway mucosa1
- Despite their frequent use in the treatment of chronic lung disease, the effect of antibiotics on the airway mucosa has not been defined. (nih.gov)
Lavage fluid4
- sIgD levels were measured by means of ELISA in nasal tissues , nasal lavage fluid , sera, and supernatants of dissociated nasal tissues . (bvsalud.org)
- Following the nasal stimulation with LTD4, the concentration of dye in the nasal lavage fluid rapidly increased. (researchgate.net)
- In OA-sensitized guinea pigs, the excretions of dye into nasal lavage fluid were recognized soon after the topical antigenic stimulation and continued for over 60 minutes. (researchgate.net)
- Currently, the evaluation of intranasal vaccine efficacy is based on the measurement of polyclonal antibody titers in nasal lavage fluid. (elifesciences.org)
Mucosal4
- CA enzymatic activity has been demonstrated in the human nasal mucosa using enzyme histochemical methods, but no systematic study of nasal mucosal CA isoenzyme gene expression has been published. (nih.gov)
- More commonly, the problem is mucosal hypertrophy causing impingement on the nasal valve, increased nasal resistance, and nasal obstruction. (medscape.com)
- As IgA demonstrated increased neutralization over IgG in the nose, this may suggest that to increase nasal mucosal levels of IgA and viral neutralization, future work on intranasal vaccines may benefit from targeting the S2 region. (earthnewsreport.com)
- The degrees of overall improvement, usefulness, improvement of nasal symptoms (sneezing, nasal discharge, nasal blockage) and improvement of rhinoscopical findings (mucosal swelling and nasal secretion) were found to be dose-dependent. (researchgate.net)
Chronic3
- Initial general examination should note "allergic shiners" or a facial appearance that may indicate signs of chronic nasal obstruction. (medscape.com)
- Oral mucosa - Hyperplasia, Cystic, Keratinizing in a male Harlan Sprague-Dawley rat from a chronic study. (nih.gov)
- Allergic rhinitis (AR) is a common chronic disease of nasal mucosa characterized by IgE-mediated allergic inflammation [ 1 ]. (biomedcentral.com)
Respiratory5
- The epithelium of the nasal mucosa is of two types - respiratory epithelium, and olfactory epithelium differing according to its functions. (wikipedia.org)
- The nasal respiratory mucosa plays a key role in conditioning the inhaled air and in regulating the immune response against foreign particles. (fupress.net)
- However, increased soluble IgD (sIgD) levels and increased IgD + IgM - B- cell populations have been described in the human upper respiratory mucosa . (bvsalud.org)
- Previous diagnostic criteria for acute bacterial sinusitis in children were acute upper respiratory tract infection (URI) with either nasal discharge and/or daytime cough for longer than 10 days or severe onset of fever, purulent nasal discharge, and other respiratory symptoms for 3 or more consecutive days. (medscape.com)
- It also affects the mucosa of the upper respiratory tract and produces skin lesions (Ryan et al. (newworldencyclopedia.org)
Symptoms6
- It is further suggested that pre-seasonal prophylactic administration of INCS suppresses both basal and pollen-induced upregulation of H1R gene expression in the nasal mucosa of patients with pollinosis, leading to prevention of the exacerbation of nasal symptoms during peak pollen season. (tokushima-u.ac.jp)
- Nasal symptoms of sneezing and stuffiness decreased significantly for flunisolide treated patients during treatment. (researchgate.net)
- A third criterion added to the updated guideline is URI with worsening symptoms such as nasal discharge, cough, and fever after initial improvement. (medscape.com)
- NASONEX ® Nasal Spray 50 mcg is indicated for the treatment of the nasal symptoms of seasonal allergic and perennial allergic rhinitis, in adults and pediatric patients 2 years of age and older. (nih.gov)
- Nasal symptoms increase the risk of snoring and snoring increases the risk of nasal symptoms. (uib.no)
- Although it is not life-threatening, AR can deteriorate the quality of life because of the clinical symptoms including sneezing, rhinorrhea, itching and nasal congestion. (biomedcentral.com)
Septum3
- It is also thick over the nasal septum where increased numbers of goblet cells produce a greater amount of nasal mucus. (wikipedia.org)
- The nasal valve is formed medially by the septum and laterally by the caudal edge of the upper lateral cartilage and it accounts for approximately 50% of total upper airway resistance. (medscape.com)
- The erectile tissue of the nasal septum and inferior turbinate can impinge on the nasal valve and increase resistance. (medscape.com)
Intranasal5
- To compare nasal symptomatology and function and local concentrations of estradiol (E2), estradiol receptor (ERalpha), vasoactive intestinal peptide (VIP), substance P (SP) and neuropeptide Y (NPY) in nasal biopsies of 20 postmenopausal women complaining of paradoxical nasal stuffiness before and after treatment with intranasal or transdermal E2. (nih.gov)
- Both intranasal and transdermal HT improve nasal symptomatology and nasal mucosa appearance and reduce mean mucociliary transport time. (nih.gov)
- A strain of S. gordonii expressing on its surface a model vaccine antigen fused to the ovalbumin (OVA) peptide from position 323 to 339 was constructed and used to study the OVA-specific T-cell activation in nasal mucosa-associated lymphoid tissue (NALT), lymph nodes, and spleens of mice immunized by the intranasal route. (unisi.it)
- The purpose of this study is to examine the effect of intranasal corticosteroid (INCS) administration on histamine H1 receptor (H1R) gene expression in the nasal mucosa of healthy participants and the effects of dexamethasone on basal and histamine-induced H1R mRNA expression, and histamine-induced phosphorylation of extracellular signal-regulated kinase (ERK) in HeLa cells. (tokushima-u.ac.jp)
- To understand the precise contribution and molecular nature of multimeric secretory IgAs induced by intranasal vaccines, we developed 99 monoclonal IgAs from nasal mucosa and 114 monoclonal IgAs or IgGs from nonmucosal tissues of mice that were intranasally immunized with the SARS-CoV-2 spike protein. (elifesciences.org)
Alteration of the nasal1
- Nasal obstruction after rhinoplasty can result from alteration of the nasal valve or nasal vault narrowing as a result of osteotomies. (medscape.com)
Epithelial cells1
- In this study, we examined the correlation between MT3 expression and zinc levels in nasal mucosa and primary human nasal epithelial cells (HNECs) to investigate whether MT3 could be a clinical biomarker for tissue zinc levels. (hokudai.ac.jp)
Turbinates1
- A cyclic alteration of constriction and dilation of the inferior turbinates, known as the nasal cycle, occurs approximately every 2-7 hours. (medscape.com)
Mucus1
- This research hypothesizes that the airflow induced shear stresses on the nasal mucosa will influence mucus production and the cytoskeleton of the cells. (wright.edu)
Cavities1
- It is very thin in the meatuses on the floor of the nasal cavities, and in the various sinuses. (wikipedia.org)
Treatment of nasal1
- Flunisolide nasal spray 0.025% in the prophylactic treatment of nasal polyposis after polypectomy. (researchgate.net)
Mucociliary transport1
- Reduction of blood flow, deteriorated sense of smell and taste, changes in mucociliary transport and nasal flora are the other alterations [ 6 , 7 ]. (hindawi.com)
Septal2
Biopsies2
- Nasal biopsies and evaluation of local concentrations of E2, ERalpha NPY were performed in groups A and B before and after 6 months of HT and in group C. (nih.gov)
- Nasal mucosa biopsies from 7 patients (mean age 42+10) affected with inferior turbinate hypertrophy were taken before operation and 4 months after surgery and compared with 2 unaffected controls of the same age. (fupress.net)
Vivo2
- The in vivo model of nasal microvascular leakage was used for the nasal allergic challenge in ovalbumin (OA)-sensitized guinea pigs, or nasal stimulation with leukotriene D4 (LTD4) in non-sensitized animals. (researchgate.net)
- Effects of Benzalkonium Chloride on Innate Immunity Physiology of the Human Nasal Mucosa In Vivo. (uib.no)
Antibodies1
- While the presence of antibodies in the nasal mucosa is promising, the detection alone did not confirm the function of the antibodies or neutralization of the virus. (earthnewsreport.com)
Stuffiness1
- HT improves nasal function and symptomatology in postmenopausal women with paradoxical nasal stuffiness, modulating nasal mucosa function through an action on cholinergic, adrenergic, and sensory peptides. (nih.gov)
Epithelium1
- Squamous cysts and periodontal pockets tend to be unilocular structures lined by a fairly thin, benign-appearing squamous epithelium and do not appear to be arising from a hyperplastic gingival mucosa. (nih.gov)
Inferior turbinate6
- For local anaesthesia 2% lidocaine HCl, 0.125% epinefrine solution (Jetokain, Adeka) injected into the mucosa of the inferior turbinate. (hindawi.com)
- Beekhuis concluded that nasal obstruction postrhinoplasty resulted primarily from inferior turbinate hypertrophy. (medscape.com)
- 1] Changes in nasal airflow as a result of rhinoplasty may unmask inferior turbinate hypertrophy and obstruction that were not clinically significant or evident preoperatively. (medscape.com)
- The anterior tip of the inferior turbinate is found in the nasal valve region, and hypertrophy of this structure can cause exponential increases in airway resistance. (medscape.com)
- The nasal valve is the region of the nasal airway extending from the caudal end of the upper lateral cartilages and including the anterior end of the inferior turbinate. (medscape.com)
- Because the cross-sectional area of the nasal valve is small, minor changes in inferior turbinate congestion can have marked effects on resistance. (medscape.com)
Histochemical1
- Biotransformation enzymes in the rodent nasal mucosa: the value of a histochemical approach. (nih.gov)
Laryngeal cancer2
- In laryngeal cancer patients histopathologic changes occur in nasal mucosa eventuate due to the cessation of air current stimulation, however there was no relation between progression of the histopathologic findings and the duration of cessation. (hindawi.com)
- Results of recent studies in animals indicate an increased incidence of laryngeal cancer in hamsters and nasal cancer in rats following exposure to acetaldehyde. (cdc.gov)
Cancers2
Fluid1
- To conduct their study, researchers collected blood and nasal epithelial lining fluid samples from healthy human volunteers. (earthnewsreport.com)
Olfactory2
- Such strong chemical irritants can damage the sensitive cells in our olfactory mucosa so badly that they die and cannot regenerate. (bioprepwatch.com)
- If the olfactory mucosa is chronically irritated by these substances, there is a risk of loss of nasal sense. (bioprepwatch.com)
Inflammation1
- Nasal indices of eosinophilic and exudative inflammation in bakery-workers. (uib.no)
Cytological4
- The absence of a physiological air flow stimulus after total laryngectomy leads to clinical, cytological, and histological changes of the nasal mucosa. (hindawi.com)
- Cytological evaluation of the nasal mucosa in neonates exposed to tobacco smoke during fetal life. (nel.edu)
- The objective of this study is to assess the cytological picture of the nasal mucosa of neonates born to mothers who are activ. (nel.edu)
- Krol M, Tupieka-Kolodziejska A, Tarchalska-Krynska B, Florek E, Wilczynski J, Borszewska-Kornacka M, Bokiniec R. Cytological evaluation of the nasal mucosa in neonates exposed to tobacco smoke during fetal life. (nel.edu)
Occur3
- Some of these lesions occur in isolation, whereas others occur in association with diffuse hyperplastic lesions of the mucosa. (nih.gov)
- The observations of work practices, including the use of personal protective equipment, the presence of characteristic orange chromate stains on workers' skin and the results of spot tests in the work area suggest that much of the nasal and cutaneous pathology that have occurred and continue to occur within this plant probably result from direct contact with the hexavalent chromate ion rather than through airborne exposure. (cdc.gov)
- If such changes occur, discontinue NASONEX Nasal Spray slowly. (nih.gov)
Adverse effects1
- Monitor patients periodically for signs of adverse effects on the nasal mucosa. (nih.gov)
Immunization1
- Our investigation is the first to demonstrate the function of nasal IgAs at the monoclonal level, showing that nasal immunization can provide effective immunity against SARS-CoV-2 by inducing multimeric secretory IgAs at the target site of virus infection. (elifesciences.org)
Comparative1
- The efficacy, safety and optimal dose of TL-102, a powder mixture of beclomethasone dipropionate (BDP) and hydroxypropylcellulose (HCP) were studied in 250 patients with perennial nasal allergy in an intergroup comparative double-blind manner. (researchgate.net)
CRSsNP1
- sIgD levels and IgD +CD19+CD38bright plasmablast counts were increased in nasal tissue of patients with CRSsNP. (bvsalud.org)
Tissues1
- The nonmucosal IgAs exhibited shared origins and both common and unique somatic mutations with the related nasal IgA clones, indicating that the antigen-specific plasma cells in the nonmucosal tissues originated from B cells stimulated at the nasal mucosa. (elifesciences.org)
Spray1
- Monitor growth routinely in pediatric patients receiving NASONEX Nasal Spray. (nih.gov)
Enzymes1
- 16. Plasminogen activator content of human colon tumors and normal mucosae: separation of enzymes and partial purification. (nih.gov)
Abstract1
- abstract = "Background: The regulation of nasal mucosa blood fow (NMBF) is afected by multiple factors, such as the autonomic nervous system, medications, temperature, humidity, endocrine, even emotional stress and vision. (tmu.edu.tw)
Clinical1
- Conclusions: MT3 expression reflects intramucosal zinc levels in both nasal mucosa and HNECs indicating MT3 could be used as a clinical biomarker for monitoring intracellular zinc levels in the nasal mucosa. (hokudai.ac.jp)
Airflow2
- As airflow enters this constricted segment, it accelerates and the pressure drops (per Bernoulli principle), which can result in nasal valve collapse if the upper lateral cartilages are anatomically weak. (medscape.com)
- A major determinant of resistance to airflow is the radius of the nasal vault. (medscape.com)
Therapies2
- Adjunctive therapies such as nasal saline irrigation are recommended. (medscape.com)
- Nasal high flow confers benefits that conventional oxygen therapies cannot. (fphcare.com)
Nose4
- In this paper we aimed to determine the long term histopathological changes in nasal mucosa in total laryngectomized patients breathing through tracheastoma instead of the nose. (hindawi.com)
- However, currently available nasal PBPK models do not include pathways for nose-to-brain drug delivery. (nih.gov)
- The purpose of this funding opportunity is to fund the development of a nasal PBPK model that includes at least one pathway for nose-to-brain drug delivery and links with a full body PBPK model that includes, at least, a brain compartment. (nih.gov)
- Nose-to-brain drug delivery is an emerging application for nasal drug products. (nih.gov)
Human2
Oral2
- Generally, a connection can be seen between the cystic structure and the overlying gingival oral mucosa, suggesting the cystic keratinizing hyperplasia may have arisen from squamous hyperplasia. (nih.gov)
- Oral administration of ONO-1078 (pranlukast) (3-30 mg/kg) significantly inhibited the LTD4-induced nasal microvascular leakage. (researchgate.net)
Stimulation1
- To determine the long-term histopathologic changes in nasal mucosa and the relationship between progression of the histopathologic changes and the duration without air current stimulation. (hindawi.com)
Concentrations1
- IgA and IgG concentrations were greater in the post-vaccinated group in comparison to the pre-vaccinated group in both blood and nasal samples. (earthnewsreport.com)
Patients1
- Avoid use in patients with recent nasal ulcers, nasal surgery, or nasal trauma. (nih.gov)
Participants1
- Levels of H1R mRNA in the nasal mucosa of healthy participants receiving INCS was significantly decreased. (tokushima-u.ac.jp)