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Motor NeuronsRotenoneAmyotrophic Lateral SclerosisSpinal CordSuperoxide DismutaseNeuronsMotor Neuron DiseaseNanodiamondsNeurons, AfferentAxonsSurvival of Motor Neuron 1 ProteinMotor CortexSurvival of Motor Neuron 2 ProteinEvoked Potentials, MotorNerve Tissue ProteinsUncoupling AgentsMotor ActivityMuscular Atrophy, SpinalCells, CulturedCell DeathMice, TransgenicDisease Models, AnimalSMN Complex ProteinsRats, Sprague-DawleyImmunohistochemistryAnimals, NewbornElectron Transport Complex IAction PotentialsMutationNerve DegenerationMolecular Motor ProteinsElectric StimulationSynapsesNeuromuscular DiseasesGanglia, InvertebrateSignal TransductionDopaminergic NeuronsAntimycin AElectrophysiologyApoptosisCell LineInterneuronsSynaptic TransmissionDopamineBrainMovementCholinergic NeuronsMembrane PotentialsAplysiaTime FactorsElectromyographyParkinsonian DisordersAnterior Horn CellsNeuromuscular JunctionDendritesSensory Receptor CellsPatch-Clamp TechniquesCerebral CortexBulbar Palsy, ProgressiveGanglia, SpinalNeural InhibitionGABAergic NeuronsModels, NeurologicalMesencephalonCell SurvivalHippocampusFacial NerveMice, Inbred C57BLMotor Skills DisordersAnimals, Genetically ModifiedCell CountOligomycinsgamma-Aminobutyric AcidBehavior, AnimalBrain StemParkinson Disease, SecondaryGlutamic AcidAxonal TransportRats, WistarParkinson DiseaseNeuropeptidesReactive Oxygen SpeciesNADH DehydrogenaseAstrocytesNeural ConductionCholine O-AcetyltransferaseMuscle, SkeletalGreen Fluorescent ProteinsSubstantia NigraGangliaGrasshoppersNeurons, EfferentNerve NetNeurofilament ProteinsLocomotionNeurogenesisCell DifferentiationCentral Nervous SystemReaction TimeGene Expression Regulation, Developmental
MesenchymalProliferationMSCsInteractionsCentral
Mesenchymal2
  • In recent years, conditioned medium (CM) obtained from the culture of mesenchymal stromal/stem cells (MSCs) has been shown to effectively promote tissue repair and modulate the immune response in vitro and in different animal models, with potential for application in regenerative medicine. (bvsalud.org)
  • Exosomes involved in neurodegenerative diseases are generated from manifold sources, such as human mesenchymal stem cells (MSCs), immunity cells, and microglia [ 9 , 11 - 14 ], and exosomes derived from different sources with different cargos seem to have a different impact on neurodegenerative diseases [ 15 ]. (hindawi.com)
Proliferation4
  • The aim of this study was to evaluate in vitro cell adhesion and proliferation of CS films synthesized from SKC shell wastes functionalized with RGD peptides. (bvsalud.org)
  • In contrast, a cyclic RGD peptide showed similar adhesion to control peptide (RDG), but the highest cell proliferation was after 48 h of culture. (bvsalud.org)
  • This study shows that functionalization of SKC-CS films with linear or cyclic RGD peptides are useful to improve effects on cell adhesion or cell proliferation. (bvsalud.org)
  • In vitro preconditioning strategies can increase the viability, proliferation, and paracrine properties of MSCs and therefore improve the therapeutic potential of the cells and their derived products. (bvsalud.org)
MSCs1
  • Using CM offers multiple advantages over the implantation of MSCs themselves: 1) simpler storage, transport, and preservation requirements, 2) avoidance of the inherent risks of cell transplantation, and 3) potential application as a ready-to-go biologic product. (bvsalud.org)
Interactions2
  • This seems to be due to the properties of venom enzymes and peptides for their natural stability as injectable solutes, their effectiveness in reaching targeted tissues, and their ability to synergize their actions by enhancing cell-cell interactions. (mdpi.com)
  • ß-catenin is a central mediator of both, Wnt signaling activity and cell-cell interactions. (bvsalud.org)
Central1
  • Following the release, exosomes will transfer to specific targets such as immune cells or the central nervous system (CNS) to exert pleiotropic effects [ 8 , 9 ]. (hindawi.com)