• viral
  • Another strategy which is different from conventional vaccine is to induce the T cell arm of the immune response using viral vectors, adenoviral vectors that contain large parts of the hepatitis C virus genome itself, to induce a T cell immune response against hepatitis C.[citation needed] Most of the work to develop a T cell vaccine has been done against a particular genotype. (wikipedia.org)
  • Correlative analysis of the abundance of the different particle populations with infectivity, HCV RNA, and viral antigens suggests that infectious particles are likely to be present in the large ~60-nm HCV particle populations displaying a visible bilayer. (pubmedcentralcanada.ca)
  • The E1, E2, and core structural proteins are required for particle formation ( 5 , 6 ) but not for viral RNA replication or translation ( 7 , 40 ). (pubmedcentralcanada.ca)
  • The methods utilize one or more administrations of HCV protein compositions, followed by one or more administrations of a viral vector comprising a nucleic acid encoding a least one HCV epitope that is present in the first composition. (patentsencyclopedia.com)
  • andsubsequently administering at least once a second composition comprising a viral vector comprising a nucleic acid encoding said at least one epitope of said first composition, whereby the nucleic acid of said second composition is expressed in one or more cells of the subject and at least part of the protein of said first composition is produced. (patentsencyclopedia.com)
  • complement
  • To date, several host- and virus-related factors have been implicated in the progression to MCII, such as the virus-induced expansion of selected subsets of B-cell clones expressing discrete immunoglobulin variable (IgV) gene subfamilies, the involvement of complement factors and the specific role of some HCV proteins. (mdpi.com)
  • This immune complex-mediated vasculitis is characterized by a primary B-cell clonal proliferation accompanied by the deposition of immune complexes composed of complement factors, mono/oligoclonal IgMs with rheumatoid factor (RF) activity bound to oligo/polyclonal IgGs that, in the case of HCV infection, are mostly directed against HCV proteins [ 3 ]. (mdpi.com)
  • Being a major first line of immune defense, the complement system keeps a constant vigil against viruses. (frontiersin.org)
  • These include targeting the recognition molecules for the avoidance of detection, targeting key enzymes and complexes of the complement pathways like C3 convertases and C5b-9 formation - either by encoding complement regulators or by recruiting membrane-bound and soluble host complement regulators, cleaving complement proteins by encoding protease, and inhibiting the synthesis of complement proteins. (frontiersin.org)
  • cells
  • The detailed structure of E2 envelope glycoprotein, believed to be the key protein the virus uses to invade liver cells, was elucidated by scientists at The Scripps Research Institute (TSRI) in November 2013. (wikipedia.org)
  • Due to the relatively conserved binding region of E2 to the CD81 receptor on the liver cells, this discovery is expected to pave the way to design a HCV vaccine which will stimulate antibody response with neutralizing effects on broad range of virus strains. (wikipedia.org)
  • present
  • In particular, about 60% of HCV-infected patients present cold-precipitable (cryoprecipitable) and noncryoprecipitable immune complexes that could be associated with the clinical onset of type II mixed cryoglobulinemia (MCII) [ 2 ]. (mdpi.com)
  • virus
  • citation needed] Scientists can study the immune system's response to the virus in horses and study if vaccine candidates have any effect. (wikipedia.org)
  • In line, HBsAg preferentially bound to TLR9-triggered pDC demonstrating that once pDC are able to bind HBV/HBsAg, the virus exerts its immune regulatory effect. (jove.com)
  • contain
  • Negative-stain electron microscopy revealed that the particles were spherical (~40- to 75-nm diameter) and pleomorphic and that some of them contain HCV E2 protein and apolipoprotein E on their surfaces. (pubmedcentralcanada.ca)