• Both envelope proteins (E1 and E2) are highly glycosylated and important in cell entry. (wikipedia.org)
  • The thus replicated HCV genomic RNA is packaged by the Core protein and envelope proteins (E1 protein and E2 protein), which are structural proteins, so that new viral particles are formed. (justia.com)
  • HCV envelope proteins are considered to play a key role in the binding of HCV to cell surfaces. (justia.com)
  • Thus, research has been conducted for preparation of antibodies against envelope proteins in blood serum samples of HCV patients. (justia.com)
  • The large pre-protein is later cleaved by cellular and viral proteases into the 10 smaller proteins that allow viral replication within the host cell, or assemble into the mature viral particles. (wikipedia.org)
  • It prevents CD81 from latching onto its respective receptor on the virus. (wikipedia.org)
  • E1 serves as the fusogenic subunit and E2 acts as the receptor binding protein. (wikipedia.org)
  • First, HCV binds to a specific protein (virus receptor) on the cell surface and is incorporated by endocytosis into the host cell. (justia.com)
  • citation needed] The proteins of this virus are arranged along the genome in the following order: N terminal-core-envelope (E1)-E2-p7-nonstructural protein 2 (NS2)-NS3-NS4A-NS4B-NS5A-NS5B-C terminal. (wikipedia.org)
  • NS1 (p7) protein is dispensable for viral genome replication but plays a critical role in virus morphogenesis. (wikipedia.org)
  • The HCV genome encodes a precursor protein that is converted into 10 types of virus protein (i.e. (justia.com)
  • HVR1 helps E2 shield the virus from the immune system. (wikipedia.org)
  • After each virus protein has been generated by processing, the HCV genomic RNA is replicated by RNA polymerase, which is one of the generated virus proteins. (justia.com)
  • domain 3 (residues 175-191) is highly hydrophobic and acts as a signal sequence for E1 envelope protein. (wikipedia.org)