Ngal acute kidney injury. Medical search. Frequent questions

One of these biomarkers is Neutrophil Gelatinase-Associated Lipocalin (NGAL). (pediatrmedchir.org)
Shoaib M, Mahmud SN, Safdar M. Early diagnosis of acute kidney injury by urinary neutrophil gelatinase-associated lipocalin in adult critically ill patients. (pediatrmedchir.org)
Meta-analysis of the diagnostic value of serum, plasma and urine neutrophil gelatinase-associated lipocalin for the detection of acute kidney injury in patients with sepsis. (pediatrmedchir.org)
Neutrophil gelatinase-associated lipocalin (ngal) and kidney injury molecule 1 (kim1) in patients with diabetic nephropathy: A cross-sectional study and the effects of lisinopril. (pediatrmedchir.org)
Objective We aimed to investigate whether preoperative serum neutrophil gelatinase-associated lipocalin (sNGAL pre-op ) predicted postoperative acute kidney injury (AKI) during hospitalisation and 1-year cardiovascular and all-cause mortality following adult cardiac surgery. (bmj.com)
Background and aims To investigate the value of urinary neutrophil gelatinase associated lipocalin (NGAL) kidney injury molecular-1 (KIM-1) and interleukin-18 (IL-18) in the diagnosis of acute kidney injury (AKI) following childhood cardiopulmonary bypass (CPB). (bmj.com)
Several of these biomarkers include neutrophil gelatinase-associated lipocalin (NGAL), N-acetyl-B-D-glucosaminidase (NAG), Cystatin C, and kidney injury molecule-1 (KIM-1) which have been shown to be involved in tubular damage. (wikipedia.org)
The aim of this study was to establish reference intervals in healthy children for two novel urinary biomarkers of acute kidney injury, kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) using both Meso Scale Discovery and Luminex-based analytical approaches. (genomeweb.com)
β 2 -microglobulin (β 2 -MG) and N -acetyl-β-D-glucosaminidase (NAG) are the dominant biomarkers employed routinely in environmental toxicology research, while kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) are also emerging as effective markers to identify mycotoxin induced nephropathy. (frontiersin.org)
Urinary neutrophil gelatinase-associated lipocalin (NGAL), serum creatinine, urine protein, serum and urine catalytic iron, 25-hydroxyvitamin D3, 1,25-dihydroxyvitamin D3 and tissue lipid peroxidation were assayed. (alliedacademies.org)
This study aimed to explore the predictive value of neutrophil gelatinase-associated lipocalin (NGAL) and ß2 microglobulin (ß2-MG) in blood and urine amongst patients with acute pancreatitis (AP) and acute kidney injury (AKI). (bvsalud.org)
Neutrophil gelatinase-associated lipocalin (NGAL) is a secretory protein found in neutrophils, endothelial cells and in various organs of the gastrointestinal, respiratory, excretory and reproductive systems. (edu.pl)
Mishra J., Ma Q., Prada A., Mitsnefes M., Zahedi K., Yang J., Barasch J., Devarajan P. Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury. (edu.pl)
Chakraborty S., Kaur S., Guha S., Batra S.K. The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflammation and cancer. (edu.pl)
Buy Neutrophil Gelatinase Associated Lipocalin (NGAL) Detection Kit (Latex Enhanced Immunoturbidimetric Product on Nanjing Vazyme Biotech Co.,Ltd. (vazymemedical.com)
Neutrophil gelatinase associated lipocalin (NGAL) is an early and sensitive marker of acute kidney injury. (vazymemedical.com)
The Investigation Team led by Prof. Breithardt have assesed the potential benefit of bio-marker Neutrophil Gelatinase-Associated lipocalin (NGAL). (medicoinvestor.com)
Neutrophil gelatinase-associated lipocalin (NGAL) is a diagnostic marker for acute kidney injury (AKI). (biomedcentral.com)
Background and Aims: Neutrophil gelatinase-associated lipocalin (N-GAL) is an early biomarker of acute kidney injury (AKI) due to various etiologies. (ijccm.org)
Does Whole-Blood Neutrophil Gelatinase-Associated Lipocalin Stratify Acute Kidney Injury in Critically Ill Patients? (wustl.edu)
Neutrophil gelatinase-associated lipocalin (NGAL), a 25-kDa protein, is released from the secondary granules of neutrophils and is covalently bound to neutrophil gelatinase. (e-cep.org)
To compare the diagnostic values of cystatin C (CysC), β 2 -microglobulin (β 2 -MG), neutrophil gelatinase-associated lipocalin (NGAL) and retinol-binding protein (RBP) in acute kidney injury (AKI) in elderly patients with acute myocardial infarction (AMI). (c-jcm.com)
The search for early diagnostic methods revealed the Neutrophil gelatinase-associated lipocalin (NGAL) as a novel biomarker for detecting acute tubular injury (ATI). (fortuneonline.org)
On the other hand, the biomarker Neutrophil gelatinase-associated lipocalin (NGAL) can detect active tubular injury (ATI) from two hours after the start of the inducing event [1,2] which shows the precocity of NGAL in comparison to the traditional markers. (fortuneonline.org)
After 24h kidney function was measured via Inulin- and PAH-Clearance in re-anesthetized rats, and serum urea, creatinine (crea), cystatin C and Neutrophil gelatinase-associated lipocalin (NGAL) as well as histopathology were analysed. (uni-wuerzburg.de)

NGAL is a 25-kD protein of the lipocalin family. (medscape.com)
Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury. (edu.pl)
NGAL is also known as lipocalin-2. (aaltoscientific.com)

Conventional biomarkers for kidney function include serum creatinine (SCr), urine output (changes in which may precede biochemical changes), and urine microscopy. (medscape.com)
The tests are the ARCHITECT and ALINITY i Urine NGAL assays, BioPorto NGAL test and NephroCheck test. (nice.org.uk)
One test measures the diagnostic performance of a dipstick in urine for a novel biomarker, NGAL. (unc.edu)
Conclusion In this study, our results identify that possibly urine NGAL, KIM-1 and IL-18 are more significative than Scr for early detection. (bmj.com)
On a multivariate linear regression analysis, serum iron, urine catalytic iron and tissue lipid peroxidation independently and positively predicted urinary NGAL, an AKI biomarker. (alliedacademies.org)
Time course of plasma and urine NGAL, Cys-C, and sTREM-1 levels in non-AKI septic patients (A, C, E) and AKI septic patients (B, D, F) . For non-AKI septic patients, the time course of these markers in the plasma and urine was explored since their ICU admission. (biomedcentral.com)
The international Kidney Disease: Improving Global Outcomes (KDIGO) work group classified AKI in three stages of ascending severity [ 7 ], according to a quantitative increase in serum creatinine (SCr) or a decrease in urine output (UO). (biomedcentral.com)
Predictive Value of Serum NGAL and ß2 Microglobulin in Blood and Urine amongst Patients with Acute Pancreatitis and Acute Kidney Injury. (bvsalud.org)
The levels of serum NGAL and ß2-MG in blood and urine were compared in both groups. (bvsalud.org)
Logistic regression analysis was used to explore the influencing factors of AKI in patients with AP and the receiver operating characteristic (ROC) curve was used to evaluate the predictive efficacy of serum NGAL and ß2-MG in the blood and urine of patients with AKI and AP. (bvsalud.org)
The AKI group had higher serum NGAL and ß2-MG in blood and urine than the non-AKI group. (bvsalud.org)
Logistic regression analysis showed that the high levels of serum NGAL and ß2-MG in blood and urine were risk factors for AKI in patients with AP (p (bvsalud.org)
The increased levels of serum NGAL and ß2-MG in blood and urine have a warning significance for patients with AP and AKI and a certain predictive value. (bvsalud.org)
In addition, NGAL levels in blood and urine can also indicate the severity of kidney injury. (vazymemedical.com)
NGAL in both plasma and urine appears to be a marker that is very well suited for the early detection of AKI and could be instrumental in improving the diagnosis and prognosis of this condition. (aaltoscientific.com)
Other outcome measures included the rise in urine NGAL and serum cystatin from base line at 2 hours, as an early marker of acute kidney injury (AKI). (fortunejournals.com)
Changes in serum creatinine at 2 hours post-procedure did not correlate with changes in urine NGAL or serum Cystatin C. (fortunejournals.com)
With acute kidney problems it still suffers from the same stuff as urine output, most notably the lateness of its change. (doctorswriting.com)
Within the 72-hour period, the patients were exposed to high-dose furosemide (median dose, 560 mg IV) and had a median total urine output of nearly 8 L. Despite adequate diuresis, the investigators uncovered no changes in KIM-1, NGAL, and NAG from baseline and after 72 hours when cystatin C was used to calculate eGFR. (medscape.com)

Chin'ombe N, Msengezi O, Matarira H. Microalbuminuria in patients with chronic kidney disease at Parirenyatwa Hospital in Zimbabwe. (pediatrmedchir.org)
Chronic Kidney Disease is an abnormal kidney function and/ or structure, present for a minimum period of 3 months. (randox.com)
Utilising patented Biochip Technology, the Randox Chronic Kidney Disease (CKD) arrays could improve patient risk stratification whilst monitoring the effectiveness of treatment. (randox.com)
Unlike chronic kidney failure that results from kidney damage that gets worse slowly, AKI can be reversed if it is found and treated quickly. (unc.edu)
We also know that repeated episodes of AKI lead to an increased risk of chronic kidney disease that is difficult to effectively manage, with usually no hope of getting a transplant. (unc.edu)
All patients who had a positive PCR test for SARS CoV-2 were included and patients with a history of chronic kidney disease, urinary symptoms, underlying urological disease or complications of Diabetes or hypertension were excluded. (asn-online.org)
The evaluation and treatment of SCD triggering factors and of underlying acute and chronic diseases will facilitate prevention and lower the risk of cardiac arrest. (jccm.ro)
We compared vital signs, PaO 2 /F I O 2 , serum C-reactive protein (CRP) levels, acute physiology and chronic health evaluation (APACHE) II score, sequential organ failure assessment (SOFA) score, and uNGAL levels between the sepsis group and the esophagectomy group. (biomedcentral.com)
Results: A total of 22 patients were assessed (77% male, age 52.8 years, Acute Physiology and Chronic Health Evaluation II [APACHE II] 17.3) in whom the most frequent site of cancer was the gastrointestinal tract. (ijccm.org)
However, it may not be possible to maintain this feature under critical conditions or in the case of pre-existing chronic kidney disease (CKD). (fortuneonline.org)
Another stalwart of kidney disease and an essential marker in the chronic kidney disease armoury. (doctorswriting.com)
The latest findings on the mechanisms of multiorgan damage in this disease, its clinical manifestations, diagnostic and therapeutic protocols, with special emphasis on acute and chronic complications of the heart, lungs and kidneys are presented. (karnef.org)
Harmonizing acute and chronic kidney disease definition and classification report of a kidney disease improving global outcomes KDIGO consensus conference[J]. Kidney Int 2021 100 3 516-526. (paperopen.com)
In that trial, patients with decompensated HF and chronic kidney disease were randomly assigned to receive either nesiritide vs placebo or dopamine vs placebo. (medscape.com)

NGAL has been tested in multiple studies of patients at risk of AKI due to sepsis, cardiac surgery or exposure to contrast media. (asn-online.org)
Purpose: To analyse the capacity of whole-blood NGAL (wbNGAL) to stratify AKI in critically ill patients with and without sepsis. (wustl.edu)
In sepsis HES should be avoided due to a higher risk for acute kidney injury (AKI). (uni-wuerzburg.de)
Therefore we conducted an animal study to evaluate the impact of 6% HES 130/0.4 on kidney integrity with sepsis or under healthy conditions Sepsis was induced by standardized Colon Ascendens Stent Peritonitis Volume therapy is a standard procedure in daily perioperative care, and there is an ongoing discussion about the benefits of colloid resuscitation with hydroxyethylstarch (HES). (uni-wuerzburg.de)
Therefore we conducted an animal study to evaluate the impact of 6% HES 130/0.4 on kidney integrity with sepsis or under healthy conditions Sepsis was induced by standardized Colon Ascendens Stent Peritonitis (sCASP). (uni-wuerzburg.de)
Timing of renal-replacement therapy in patients with acute kidney injury and sepsis[J]. N Engl J Med 2018 379 15 1431-1442. (paperopen.com)
YANG Hong-wei,NIU Wen-yan.Value of measuring uKIM IL-6 and T-cell subsets in sepsis patients with acute kidney injury[J].Journal of Tianjin Medical University,2018,24(05):145. (paperopen.com)

This guidance replaces the NICE medtech innovation briefing on NephroCheck test to help assess the risk of acute kidney injury in critically ill patients (MIB156). (nice.org.uk)
Predicting one-year mortality of critically ill patients with early acute kidney injury: data from the prospective multicenter FINNAKI study. (bmj.com)
Costs and outcomes of acute kidney injury in critically ill patients with cancer. (ijccm.org)
Conclusions: Whole-blood NGAL concentration at ICU admission was a good stratifier of AKI in critically ill patients. (wustl.edu)
Here's the low down on Acute Kidney Injury in the critically ill. (doctorswriting.com)

Evidence-based recommendations on tests to help assess risk of acute kidney injury for people being considered for critical care admission. (nice.org.uk)
Both hyperthermia and dehydration during physical work in the heat contribute to the risk of acute kidney injury. (cdc.gov)
Occupational heat stress increases the risk of acute kidney injury (AKI) and kidney disease. (cdc.gov)

Serum creatinine is reflective of glomerular filtration rate (GFR) under steady-state conditions but has less utility in the context of decreasing kidney function. (medscape.com)
In acute kidney injury (AKI), the serum creatinine level can take several hours or days to reach a new steady state and does not reflect the true decrease in GFR. (medscape.com)
Serum creatinine may not become elevated before substantial kidney function has been lost due to renal reserve. (medscape.com)
Serum creatinine measurement is not reliably indicative of underlying pathophysiology (ie, it does not allow differentiation of hemodynamically mediated changes in kidney function, such as prerenal azotemia from intrinsic renal failure or obstructive uropathy from structural kidney damage). (medscape.com)
Given the limitations of serum creatinine as a biomarker of kidney function, different urinary and serum proteins, molecules, and, most recently, microRNAs have been rigorously investigated over the past decade as possible biomarkers for kidney disease. (medscape.com)
The more intensive treatment consisted of an early warning system for a rise in the serum creatinine concentration, immediate consultation of a specialist, and the issuance of a patient kidney passport. (aerzteblatt.de)
Results Cisplatin challenged rats demonstrated kidney injury as shown by reduced creatinine clearance, increased of plasma BUN, plasma creatinine, and kidney MDA, decreased of kidney GSH levels, and kidney histopathology alterations. (thieme-connect.com)
In addition to commonly used diagnostic markers for nephrotoxicity including plasma creatinine, NAG, KIM-1 and NGAL can be used in pigs. (frontiersin.org)
Rats injected with iohexol showed elevated urinary NGAL (11.94±6.79 ng/mL), serum creatinine (2.92±0.91 mg/dL) and urinary protein levels (11.03±9.68 mg/mg creatinine) together with histological evidence of tubular injury and iron accumulation. (alliedacademies.org)
NGAL values were measured on admission and at six-hour intervals (until 48 hours after admission) , creatinine values were measured likewise up til 72 hours after admission. (medicoinvestor.com)
Still, other parameters (admission creatinine, GFR values, GFR-NGAL-entry classes or values) can predict the occurrence of renal damage. (medicoinvestor.com)
But - taking into account the intervals at which NGAL was measured, however, it is evident that that NGAL values increased significantly 12 hours before before creatinine levels rose" says Prof. Breithardt. (medicoinvestor.com)
AKI is difficult to diagnose since symptoms and elevated levels of markers of renal function (eg: creatinine) generally do not occur until the injury is quite advanced. (aaltoscientific.com)
Serial measurements of serum creatinine, serum cystatin and urinary NGAL were taken at baseline and 2, 24, 48- and 72-hours post-procedure. (fortunejournals.com)
The serum levels of CysC, β 2 -MG, NGAL, RBP and creatinine on day 1, and creatinine level on day 3 after admission were collected. (c-jcm.com)
Creatinine Bump: An Indication of AKI in Patients With Acute Heart Failure? (medscape.com)
Rather, the acute rise in creatinine during the treatment of decompensated HF is an innocuous change in concentration and not an indicator of true tubular damage. (medscape.com)
In each group, markers of tubular injury (KIM-1, NGAL, NAG) were evaluated to determine if true tubular damage (ie, AKI) was correlated with changes in eGFR (and, therefore, creatinine). (medscape.com)
Similarly, neither KIM-1 nor NGAL changed in the group in which eGFR was measured by serum creatinine (ie, those patients who experienced the creatinine bump). (medscape.com)
My fear is that this trial will lend support to those clinicians who want to ignore the creatinine bump as a true indicator of kidney damage. (medscape.com)
The creatinine bump and the concomitant debate between nephrologists and cardiologists have furthered our understanding of kidney injury in the face of heavy diuresis. (medscape.com)

Postoperative AKI within 72 hours was defined using the International Kidney Disease: Improving Global Outcomes classification. (bmj.com)
Conclusion In a cohort of high-risk adult patients undergoing cardiac surgery, there was an increase in postoperative AKI and 1-year mortality from the first to the third tertile of preoperative serum NGAL. (bmj.com)
Abelha FJ, Botelho M, Fernandes V, Barros H. Determinants of postoperative acute kidney injury. (ijccm.org)

Cystatin C is well recognised marker of kidney filtration dysfunction and injury. (randox.com)

The company's lead product is designed to protect patients from procedure-induced acute kidney injury (AKI) which may result from cardiac surgery and heart cath procedures, and may also be present in ICU patients. (renalguard.com)

Subclinical Acute Kidney Injury (AKI) describes patients who did not fulfill the classical criteria for AKI diagnosis but showed elevated levels of new biomarkers reflecting tubular injury. (pediatrmedchir.org)
Roy JP, Devarajan P. Acute kidney injury: Diagnosis and management. (pediatrmedchir.org)
Diagnosis of CKD at early stages will allow earlier intervention for the treatment of kidney disease, and the prevention of further kidney damage. (randox.com)
Nevertheless, there are deficits in terms of diagnosis and acute treatment. (aerzteblatt.de)
New diagnostic tests could offer a quicker diagnosis for impaired kidney function, not only for people in Africa but in other places with limited resources, as well as in disaster zones. (unc.edu)
UNC's division of nephrology is focused on a research portfolio of clinical, translational and basic kidney research, and this includes early diagnosis. (unc.edu)
Working with Dr. Anthony Charles , leader of the UNC Malawi Surgery Initiative and associate professor of surgery acute care, Bjornstad is investigating the viability of two novel diagnostic dipstick tests that she hopes will enable a quicker diagnosis in limited resource settings. (unc.edu)
Early diagnosis of acute kidney injury (AKI) is a major challenge in the intensive care unit (ICU). (biomedcentral.com)
Denker B, Robles-Osorio ML, Sabath E. Recent advances in diagnosis and treatment of acute kidney injury in patients with cancer. (ijccm.org)

Results The incidence of AKI was 34%, including 15 cases with Risk stage AKI, 4 cases with Injury stage AKI, 3 cases with Failure stage AKI, 1 cases with Loss stage AKI. (bmj.com)
Incidence and outcomes in acute kidney injury: a comprehensive population-based study. (bmj.com)
Incidence of acute kidney injury in cancer patients: A Danish population-based cohort study. (ijccm.org)

Urinary NGAL (uNGAL) is secreted predominantly by the injured epithelial cells of the kidney. (e-cep.org)
In veterinary medicine, few studies related to changes in serum NGAL (sNGAL) and urinary NGAL (uNGAL) in patients with cancer or other equally severe conditions [8]. (fortuneonline.org)

EGF regulates renal cell proliferation, fibrosis and inflammation and is produced in response to renal injury. (randox.com)
CRP is an acute phase reactant involved in inflammation. (randox.com)
Objective In addition to oxidative stress, inflammation and apoptosis have an important role in the pathogenesis of cisplatin-induced kidney damage. (thieme-connect.com)
This study aimed to investigate the molecular mechanisms of protective effects of curcumin against cisplatin-induced kidney inflammation and apoptosis in rats. (thieme-connect.com)
Over the last few decades, it has been studied that the mechanisms of cisplatin-induced kidney damage are complex and involved numerous cellular and molecular processes including inflammation, apoptosis, accumulation of cisplatin in renal tubular cells via renal drug transporters, Ctr1 and OCT2, and involvement of mitogen-activated protein kinases (MAPK) pathways [ 3 ] [ 4 ]. (thieme-connect.com)
In particular, extracellular-regulated kinase (ERK) 1/2, one of the MAPK pathway is considered as an important mediator of signal transduction processes, namely cell survival, cell division, gene expression, and cell metabolism that plays role in injury, death, and inflammation of kidney tubular cells due to cisplatin administration [ 5 ]. (thieme-connect.com)
NGAL expression is highly induced not only in kidney injury but also in bacterial infection, inflammation, and cancer. (biomedcentral.com)

Additionally, the differential findings between IGFBP7 (preferentially secreted in proximal tubules) and TIMP-2 (distal tubules) suggest the proximal tubules as the location of potential renal injury. (cdc.gov)
The biomarker panel employed in this study suggests the proximal tubules as the location of potential renal injury. (cdc.gov)

Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. (pediatrmedchir.org)
At a consensus conference of the Acute Dialysis Quality Initiative (ADQI), the CRS was classified into five subtypes primarily based upon the organ that initiated the insult as well as the acuity of disease. (wikipedia.org)

The aim of this study is to investigate the role of urinary NGAL and microalbuminuria as non-invasive biomarkers in the detection of subclinical AKI. (pediatrmedchir.org)
Acute kidney injury: prevention, detection and management. (bmj.com)
Recently, research has found several biomarkers that can be used for early detection of acute kidney injury before serious loss of organ function may occur. (wikipedia.org)
An estimated 1 in 5 hospital admissions in the UK is associated with acute kidney injury 1 , providing a clear illustration of the need for novel, rapid detection methods. (randox.com)
Thus, confirming the study's hypothesis, NGAL proved helpful for the early detection of silent events of attacks on renal tubular integrity. (fortuneonline.org)

With the emergence of COVID-19 disease, it is necessary to be able to prevent and treat acute kidney injury on time, in order to reduce the morbidity and mortality of these patients. (asn-online.org)
Acute kidney injury (AKI) causes significant morbidity and mortality. (alliedacademies.org)
Abstract Background: Septic patients with acute kidney injury (AKI) are associated with increased morbidity and mortality compared to septic patients without AKI. (criticalcareshock.com)

2022 United States Renal Data System (USRDS) annual data report: epidemiology of kidney disease in the United States. (bmj.com)

Biomarkers of kidney function can be used to estimate the severity and nature of kidney injury. (medscape.com)
External validation for acute kidney injury severity scores: a multicenter retrospective study in 14 Japanese ICUs. (bmj.com)

The factors regulating NGAL expression are proinflammatory cytokines, and plasma NGAL levels have been increased in septic shock. (biomedcentral.com)
Septic acute kidney injury: Molecular mechanisms and the importance of stratification and targeting therapy. (ijccm.org)
PENG Yan,XU Hua,WANG Bing,et al.Prognostic value of serum NGAL combined with lactic acid and APACHE score in patients with septic shock complicated with acute kidney injury[J].Journal of Tianjin Medical University,2021,27(05):365. (paperopen.com)

FABP1 binds long-chain fatty acids, contributing to reducing oxidative stress in the kidneys. (randox.com)

Analysis of urinary NGAL and microalbuminuria in 91 subjects [30 pediatric intensive care unit (PICU) patients, 31 diabetic patients and 30 healthy controls] recruited from Cairo University Pediatric Hospital was done. (pediatrmedchir.org)
Background: In patients with acute kidney injury (AKI), specialized treatment initiated in response to an early-warning system may be beneficial compared with routine treatment. (aerzteblatt.de)
Many patients with kidney disease are not aware of their risk, most often because there are no early symptoms. (unc.edu)
Methods 67 patients accepted CPB assigned to acute kidney injury group (group AKI) ornon-acute kidney injury group (group non-AKI). (bmj.com)
Acute kidney injury and mortality in hospitalized patients. (bmj.com)
Epidemiology and outcomes of acute renal failure in hospitalized patients: a national survey. (bmj.com)
It was previously believed that low cardiac output in heart failure patients results in decreased blood flow to the kidneys which can lead to progressive deterioration of kidney function. (wikipedia.org)
Elevated intra-abdominal pressures resulting from ascites and abdominal wall edema may be associated with worsening kidney functions in heart failure patients. (wikipedia.org)
In fact, the prevalence of cisplatin-induced kidney damage was 34% after fourth cycles and 52% after six cycles of cisplatin chemotherapy in adult cancer patients treated with cisplatin at a dose of ≥60 mg/m 2 at Dharmais National Cancer Hospital, Jakarta, Indonesia [ 6 ]. (thieme-connect.com)
ASN urges the Biden-Harris Administration to evacuate kidney patients, provides humanitarian resources via the Emergency Partnership. (asn-online.org)
His presentation carried the stunning title: New Biomarkers improve the prediction of acute renal damage significantly in patients who suffer from heart failure (HF). (medicoinvestor.com)
Approximately 20 to 40 percent of all patients who are hospitalized due to acute Heart Failure (HF) suffer an acute kidney injury in the hospital. (medicoinvestor.com)
The study included 87 patients with acute HF. (medicoinvestor.com)
All patients admitted complained of shortness of breath (NYHA III / IV), - they showed radiological signs of acute Heart attacks, and had a BNP value exceeding 500pg/ml. (medicoinvestor.com)
In total 20 percent of the patients suffered acute kidney damage during the first three days. (medicoinvestor.com)
In a similar study with 330 patients with dyspnea (2 / 3 HF patients) neopterin, another promising biomarkers was meaured, Also in this case occurrence of acute renal damage was predicted in advance. (medicoinvestor.com)
On the other hand, N-GAL is also elevated in patients with acute inflammatory conditions and in several solid neoplasms. (ijccm.org)
Development and validation of an acute kidney injury risk index for patients undergoing general surgery: Results from a national data set. (ijccm.org)
Methods: Whole-blood NGAL was measured with a point-of-care device at admission and 48 hours later in patients admitted to a general ICU. (wustl.edu)
Canine patients needing surgical intervention are at risk of developing acute kidney injury, whose clinical manifestation it's late. (fortuneonline.org)
Assuming that surgical patients may be under many simultaneous risk factors, it is plausible to consider that they may develop kidney damage. (fortuneonline.org)
The issue of the impact of Covid-19 on specific populations, such as patients with diabetes and those on dialysis, as well as those with a kidney transplant, was also addressed. (karnef.org)
This trial is an interesting effort to debunk the belief that AKI occurs when patients with acute HF are heavily diuresed. (medscape.com)

SYSZKO J. Acute kidney injury its definition and treatment in adults guidelines and reality[J]. Pol Arch Intern Med 2020 130 12 1074-1080. (paperopen.com)
Controversies in acute kidney injury conclusions from a kidney disease improving global outcomes KDIGO conference[J]. Kidney Int 2020 98 2 294-309. (paperopen.com)

A June report from the American Society of Nephrology identifies kidney disease as a hidden 'epidemic' that affects more than 850 million people worldwide-double the number of diabetics (422 million) and more than 20 times the number of people with cancer (42 million) or HIV/Aids (36.7 million). (unc.edu)

Erica Bjornstad, MD, MPH, a third-year pediatric nephrology fellow, is studying the epidemiology of acute kidney injury (AKI) in Malawi. (unc.edu)
Last December, Erica Bjornstad, MD, MPH, a third-year pediatric nephrology fellow, received a funding award from the International Society of Nephrology to study the epidemiology of acute kidney injury (AKI) in a Malawian trauma cohort. (unc.edu)

Apoptotic pathways in ischemic acute renal failure. (bmj.com)
hence, NGAL is considered to be a novel urinary biomarker for ischemic injury. (medscape.com)
The increase in serum concentration of NGAL after surgical repair of AAA mainly results from a greater inflow of this cytokine into the systemic circulation from vascular areas of the lower part of body, which is ischemic due to the aortic clamp. (edu.pl)
Non-steroidal anti-inflammatory drugs (NSAIDs), even at therapeutic doses, can cause ischemic kidney injury [11]. (fortuneonline.org)

However, unlike markers of heart damage or stress such as troponin, creatine kinase, natriuretic peptides, reliable markers for acute kidney injury are lacking. (wikipedia.org)
Is NGAL the Troponin of the kidney? (medicoinvestor.com)

Kidney disease: improving global outcomes (KDIGO) Acute Kidney Injury Work Group. (bmj.com)

TANG Yuan,WANG Wei,SONG Yu.Risk factors of acute kidney injury after cardiac valve operation[J].Journal of Tianjin Medical University,2021,27(05):247. (paperopen.com)

Global epidemiology and outcomes of acute kidney injury[J].Nat Rev Nephrol 2018 14 10 607-625. (paperopen.com)

Ventricular septal rupture is a potentially fatal complication of acute myocardial infarction. (jccm.ro)

We are national leaders in the research field of bladder dysfunction and urinary symptoms that follow nervous system injury or disease. (medstarhealth.org)
If we can prevent kidney disease upstream, then we can potentially prevent the downstream effects, as well as the need for dialysis and transplants. (unc.edu)
Hospitalization discharge diagnoses for kidney disease: United States, 1980-2005. (bmj.com)
Several kidney biomarkers are used successfully in drug development, however cost-efficient, and reliable kidney biomarkers are urgently needed for monitoring farm animals for early signs of kidney disease. (frontiersin.org)
Plasma galectin-3 (Gal-3) is associated with organ fibrosis, but whether urinary Gal-3 is a potential biomarker of kidney disease progression has never been explored. (mdpi.com)
Onconephrology: The latest frontier in the war against kidney disease. (ijccm.org)

MIP-1 alpha plays a roles in inflammatory responses at sites of injury or infection. (randox.com)
Other cardiorenal connectors include renin-angiotensin-system activation, nitric oxide/reactive oxygen species imbalance, inflammatory factors and abnormal activation of the sympathetic nervous system, which can cause structural and functional abnormalities in both heart and/or the kidney. (wikipedia.org)
Conclusions These data indicate that curcumin has nephroprotective properties against cisplatin-induced kidney damage in rats and this effect is associated with its anti-inflammatory and anti-apoptosis profiles, in addition to its antioxidant. (thieme-connect.com)
However, the molecular mechanisms behind the anti-inflammatory and anti-apoptotic effects of curcumin in the cisplatin-induced kidney damage have not been explored. (thieme-connect.com)
Therefore, in this study, we aimed to investigate the possible molecular mechanisms of anti-inflammatory and anti-apoptotic effects of curcumin in cisplatin-induced kidney damage. (thieme-connect.com)
NGAL, involved in inflammatory processes in cells, is regarded to be the early indicator of renal dysfunction. (edu.pl)

Management of acute kidney injury: core curriculum 2018. (bmj.com)
10] MOORE P K HSU R K LIU K D. Management of acute kidney injury core curriculum 2018[J]. Am J Kidney Dis 2018 72 1 136-148. (paperopen.com)

While the physiological role of NGAL is not fully understood, it is thought to play a role in the response to bacterial infection by sequestering iron and thus making it less available to invading pathogens. (aaltoscientific.com)
The kidneys have an intrinsic physiological mechanism of protection and regulation of renal blood flow, mediated by eicosanoid derivatives, the prostacyclin [6]. (fortuneonline.org)
Bellomo R, Kellum JA, Ronco C: Defining acute renal failure: physiological principles. (doctorswriting.com)

The results showed a significant increase in urinary NGAL in 11 of 17 dogs, 48 hours after surgery, while traditional markers showed no significant change, and no related clinical signs were observed. (fortuneonline.org)
Investigators measured a number of markers of kidney function and found that renal function did not improve with either treatment. (medscape.com)

Even though various treatment strategies namely saline hydration and diuresis have been suggested for prevention of cisplatin-induced kidney damage, but its prevalence is still high. (thieme-connect.com)
The success of a biomarker-guided therapy for the prevention of kidney damage questions are currently studied - and results are eagerly awaited. (medicoinvestor.com)

KDIGO clinical practice guideline for acute kidney injury. (bmj.com)
KDOQI US commentary on the 2012 KDIGO clinical practice guideline for acute kidney injury. (bmj.com)
Review the essentials of nephrology and explore the latest clinical updates with the Kidney Self-Assessment Program (KSAP). (asn-online.org)
Clinical Kidney Journal. (doctorswriting.com)

Acute kidney injury (AKI), which initially affects the renal tubules, is characterized by rapid deterioration of renal function caused by nephrotoxic substances or renal ischemia. (fortuneonline.org)

Urinary NGAL may be a potential biomarker to detect subclinical AKI before actual functional renal damage leading to early intervention and reduction of mortality. (pediatrmedchir.org)

The receiver operating characteristics (ROC) curve was used to evaluate the diagnostic value of CysC, β 2 -MG, NGAL, RBP in AKI, and the correlation between serum levels of each indicator and eGFR was analyzed. (c-jcm.com)

Our study revealed that urinary NGAL was significantly higher in the PICU group followed by the diabetic group and lowest in the controls group (p=0.022). (pediatrmedchir.org)
The serum concentration of NGAL in the samples obtained from the peripheral vein significantly increased after the surgery. (edu.pl)
Just before removal of the aortic clamp, a significantly higher concentration of NGAL was found in the serum obtained from the inferior vena cava compared to the renal vein. (edu.pl)

The Kidney Week 2023 mobile app features interactive maps, complete program, personalized scheduler, social media integration, and m. (asn-online.org)
View the abstracts accepted for Kidney Week 2023, the world's premier nephrology meeting. (asn-online.org)

In a 2004 report from the National Heart, Lung and Blood Institute, CRS was defined as a condition where treatment of congestive heart failure is limited by decline in kidney function. (wikipedia.org)

Anatomy8

Organisms5

Diseases51

Chemicals and Drugs26

Analytical, Diagnostic and Therapeutic Techniques and Equipment45

Phenomena and Processes14

Disciplines and Occupations2

Technology, Industry, Agriculture1

Information Science6

Health Care28

Gelatinase-associated lipocalin25

Lipocalin3

Urine19

Chronic14

Sepsis7

Critically ill5

Risk of acute kidney3

Creatinine21

Postoperative3

Marker1

Cardiac surgery1

Diagnosis9

Incidence3

UNGAL2

Inflammation7

Renal injury2

Dialysis Quality Initiative2

Detection5

Morbidity and morta3

20221

Severity2

Septic3

Oxidative stress1

Patients23

20202

American Society of Nephrology1

Pediatric2

Ischemic4

Troponin2

Global Outcomes1

20211

Nephrol1

Myocardial infarction1

Disease6

Inflammatory6

20182

Physiological3

Markers2

Prevention2

Clinical4

Nephrotoxic1

Potential biomarker1

Diagnostic1

Significantly3

20232

Heart failure1