• A knockout of the orthologous mouse gene is lethal prior to embryonic day 10.5. (nih.gov)
  • Knockout of the orthologous mouse gene indicates that the protein is necessary for normal cartilage development and aggrecan metabolism. (nih.gov)
  • Representative publication: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045950/pdf/main.pdf). (bu.edu)
  • Representative publication: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226329/) We also initiated an exciting collaborative project with biotech company investigating the targeted delivery of redox-controllable nanoparticles to cardiovascular system in vivo, which has been a great challenge for drug delivery and treatment for cardiovascular disease. (bu.edu)
  • https://pubmed.ncbi.nlm.nih.gov/37308051/?utm_source=no_user_agent&utm_medium=rs. (medworm.com)
  • Disponible en: https://doi.org/10.1016/B978-0-12-812537-3.00004-4. (sld.cu)
  • Disponible en: https://doi.org/10.1016/j.jaapos.2021.07.006. (sld.cu)
  • National Heart Lung and Blood Institute-R01HL137771, National Institute of Aging-R21AG058983, and National Institute of Alcohol Abuse and Alcoholism-R21AA026922) Animal models of atherosclerosis, vascular aging, and chronic binge drinking have been established, and conditional tissue specific transgenic and knockout mice strains are employed to decipher the in vivo role of thiol redox signaling in vascular dysfunction and development of atherosclerosis. (bu.edu)
  • The Cyagen Knockout Catalog Models repository provides a searchable listing of over 16k mouse strains in more than 20 research fields, including oncology, cardiology, and neurology. (cyagen.com)
  • You can quickly query the required genetically engineered global knockout (KO) mouse, conditional knockout (cKO/floxed) mouse and microRNA KO mouse strains by simply entering the gene name. (cyagen.com)
  • The IMSR is a searchable online database of mouse strains, stocks, and mutant ES cell lines available worldwide, including inbred, mutant, and genetically engineered strains. (re3data.org)
  • What that safe pace will turn out to be in humans is an open question, to be answered by experimentation, trials, and further studies, but the mouse data suggests it can be fairly rapid - just not all at once, immediately. (fightaging.org)
  • and the rat is considered several million years closer (in evolutionary terms) to humans than the mouse. (stemcellbattles.net)
  • We demonstrate the cross-species validity of the task by assessing performance parameters in adapted versions of the task for mice and Drosophila , and finally a virtual version in humans, and identify remarkable commonalities between vertebrate species' navigation of the maze. (springer.com)
  • So far, the expression pattern and the function of EZH2 have been broadly studied in humans [ 11 ] and mice [ 12 , 13 ]. (hindawi.com)
  • Monocytes are a heterogeneous cell population comprising of at least three subsets: classical monocytes (CMo, CD14 high CD16- in humans, Ly6C high TREML4- in mice), intermediate monocytes (IMo, CD14 high CD16+ in human, Ly6C+TREML4+in mice), and patrolling monocytes (PMo, CD14 dim CD16+ in human, Ly6C-TREML4+in mice). (bmj.com)
  • Observations in the SF1 knockout mouse and in humans indicate that mutations in SF1 result in congenital adrenal hypoplasia and hypogonadotropic hypogonadism as well. (medscape.com)
  • Homozygous ALDH2*2 knock-in (KI) mice on a C57BL/6J background and C57BL/6J mice were used for the animal experiments. (bvsalud.org)
  • The following Apod gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). (genscript.com)
  • Zhou Y, Wan X, Seidel K, Zhang M, Goodman JB, Seta F, Hamburg N, Han J. Aging and Hypercholesterolemia Differentially Affect the Unfolded Protein Response in the Vasculature of ApoE-/- Mice. (bu.edu)
  • Seidel K, Wan X, Zhang M, Zhou Y, Zang M, Han J. Alcohol Binge Drinking Selectively Stimulates Protein S-Glutathionylation in Aorta and Liver of ApoE-/- Mice. (bu.edu)
  • Compared to their littermates, miR-322 KO mice were susceptible to AngII-induced AAA, whereas the silencing of RUNX2 and the administration of exogenous miR-322 mimics ameliorated the AngII-induced AAA in ApoE KO mice. (bvsalud.org)
  • Genetic deficiency of apolipoprotein D in the mouse is associated with nonfasting hypertriglyceridemia and hyperinsulinemia. (genscript.com)
  • Stat 5a Knockout: Stat5a deficiency results in the loss of prolactin-dependent mammary gland development and lactogenesis. (nih.gov)
  • Surprizing, the effect of IFN-γ is greater in PMo deficiency mice, indicating the effect of IFN-IMo is not mediated through further differentiation into PMo. (bmj.com)
  • Was it different working with rats instead of mice? (stemcellbattles.net)
  • I had heard that the far smaller lab mice were more "bitey" than rats. (stemcellbattles.net)
  • A long-term collaboration with Dr. Austin Smith centered on an attempt to do with rats what had done with mice. (stemcellbattles.net)
  • In addition to the increased muscle protein degradation found during cancer growth, the presence of the tumor also induces an increased rate of DNA fragmentation in skeletal muscle in both rats and mice ( 8 ). (spandidos-publications.com)
  • We found that conditional loss of the de novo DNA methyltransferase Dnmt3a in mouse excitatory neurons altered expression of synapse-related genes, stunted synapse maturation, and impaired working memory and social interest. (elifesciences.org)
  • Los genes involucrados en el desarrollo del esmalte, así como los genes relacionados en la preferencia de los sabores dulces han sido asociados a la susceptibilidad de presentar caries dental. (sld.cu)
  • Entre los genes involucrados en el desarrollo del esmalte cuyos polimorfismos repercuten en dicha susceptibilidad, se encuentran AMEL, ENAM, AMBN, MMP TUFT1 y KLK4, y los genes asociados al gusto cuyos polimorfismos están asociados son TAS1R2 y TAS1R3. (sld.cu)
  • Previous study has showed that STE20/SPS1-related proline/alanine-rich kinase (SPAK) interferes with the intestinal barrier function in mice. (bvsalud.org)
  • A variety of (tissue-specific) Ndufs4 knockout mouse models were developed to study the Leigh syndrome pathomechanism and intervention testing. (nih.gov)
  • En: Pyeritz RE, Korf BR, Grody WW (Ed). Emery and Rimoin's Principles and Practice of Medical Genetics and Genomics [Internet]. (sld.cu)
  • As Cyagen Knockout Catalog Models repository has been growing, it is necessary to manually check whether the strain you need is in the recent resource bank construction plan. (cyagen.com)
  • Cyagen subdivides different mouse models into applied research fields and provides detailed information about the backgrounds and associated applications of the models to help simplify the model selection process. (cyagen.com)
  • PRMT5F/F ER day 4 NPCs and MEFs were treated with either 50nM 4-OHT or the equivalent volume of ethanol for 24 hours before splitting to induce PRMT5 knockout. (nih.gov)
  • To induce PRMT5 knockout, MEFs (passage 1) were grown to confluence in 15 cm-dishes. (nih.gov)
  • To determine how the pathogenesis of these viruses differs, we compared their ability to induce disease in mice and replicate and induce cell death in vitro. (cdc.gov)
  • Here, making use of a newly generated Pdgfd knockout mouse, we reveal a functionally important malignant cell heterogeneity modulated by PDGF-DD signaling in pancreatic neuroendocrine tumors (PanNET). (lu.se)
  • Elevated levels of this gene product have been observed in multiple tissues of Niemann-Pick disease mouse models, as well as in some tumors. (genscript.com)
  • Title: Cerebral Apolipoprotein-D Is Hypoglycosylated Compared to Peripheral Tissues and Is Variably Expressed in Mouse and Human Brain Regions. (genscript.com)
  • Due to compensatory genetic mechanisms, knockout status cannot be guaranteed and will have to be confirmed by the customer. (taconic.com)
  • Multiple different methods have been demonstrated to selectively kill senescent cells in mice, including the genetic engineering approach used a few years ago and the various senolytic drug candidates discovered more recently. (fightaging.org)
  • Functional annotation of a full-length mouse cDNA collection. (taconic.com)
  • We identified critical key factors and cytokines for our candidate cytokine activity by using gene-knockout mice and neutralization antibodies. (bmj.com)
  • In cardiac conditional Ezh2-knockout mice, cardiomyocyte proliferation was repressed, and the apoptosis process was induced [ 10 ]. (hindawi.com)
  • CHD6, a cellular repressor of influenza virus replication, is degraded in human alveolar epithelial cells and mice lungs during infection. (nih.gov)
  • We have developed a novel optical coherence tomography-based vascular imaging system enabling to real-time measure 3D angiography and hemodynamics of femoral artery of mouse models in vivo, which is noninvasive, label-free, contact-free, and high degree of automation in data acquisition and processing. (bu.edu)
  • Song W, Zhou L, Kot KL, Fan H, Han J, Yi J. Measurement of flow-mediated dilation of mouse femoral artery in vivo by optical coherence tomography. (bu.edu)
  • ALDH2*2 KI mice were susceptible to HS-induced ALI in vivo. (bvsalud.org)
  • We tested our candidate cytokine activity in vivo using multiple mice models. (bmj.com)
  • The knockout models are designed to be null alleles. (taconic.com)
  • Here, we review and discuss the role of complex I and NDUFS4 mutations in human mitochondrial disease, and review how the analysis of Ndufs4 knockout mouse models has generated new insights into the MC1ND1/Leigh syndrome pathomechanism and its therapeutic targeting. (nih.gov)
  • The powerful database offers you a more convenient experience by streamlining the process of identifying KO mouse models and ordering them for research. (cyagen.com)
  • Title: Identification of apolipoprotein D as a cardioprotective gene using a mouse model of lethal atherosclerotic coronary artery disease. (genscript.com)
  • We assessed the reproductive and maternal profile of global IRAP knock out mice. (monash.edu)
  • Given the expression of IRAP in areas of the brain associated with oxytocin modulated maternal behavior, we also investigated whether the IRAP global knockout mice had improved maternal responses. (monash.edu)
  • In a 2021 study , researchers tested curcumin's effects on mice. (healthline.com)
  • GRe significantly attenuated Bay k-8644-induced convulsive behaviors and hippocampal oxidative stress in mice. (medworm.com)
  • For most lines, the mouse ES cells used in generating the model are of the 129S5 strain. (taconic.com)
  • Phosphatidylserine Ameliorates Neurodegenerative Symptoms and Enhances Axonal Transport in a Mouse Model of Familial Dysautonomia. (genscript.com)
  • We demonstrate DBD in a mouse model that harbors hepatic-specific insulin receptor substrate 1 and 2 deletions (double knockout [DKO]), which develops type 2 diabetes. (harvard.edu)
  • However, western blot analysis of pregnant mouse serum, failed to detect IRAP, a result which was confirmed by fluorimetric IRAP enzyme assay. (monash.edu)
  • In the case of senolytic drugs this is enough for old mice to display lasting health benefits after even a single treatment. (fightaging.org)
  • Mouse Embryonic Fibroblasts (MEFs). (nih.gov)
  • EZH2, a methyltransferase catalyzing H3K27me3, has been abundantly studied in human and mouse embryonic development. (hindawi.com)
  • Therefore the absence of IRAP from the circulation in mice, and other species during pregnancy, is due to the inability of a secretase to cleave placental IRAP to produce a soluble form of the enzyme. (monash.edu)
  • They found that it could help alleviate the symptoms in the mice test subjects, which is promising for potential human application. (healthline.com)
  • In conclusion, the physiological significance of circulating IRAP during human pregnancy cannot be addressed by investigations on mice. (monash.edu)
  • Many human diseases cannot be mimicked in the mouse - but might be in the rat. (stemcellbattles.net)
  • TRPV4 knockout mice at age 8 weeks exhibited normal, but those at 24 weeks revealed significantly higher thresholds by auditory brainstem response. (nih.gov)
  • The auditory threshold shift was significantly larger in the TRPV4 knockout than in the TRPV4+/+ mice 1 week after the acoustic overexposure of 128dB SPL. (nih.gov)
  • The lung homogenates of mice pretreated with Alda-1 exhibited significantly elevated ALDH2 activity and decreased ROS accumulation after WBH. (bvsalud.org)
  • Excess expression of DAX1 in the male mouse results in reversal of phenotypic sex. (medscape.com)
  • Transcriptome analysis of mouse stem cells and early embryos. (nih.gov)
  • However, only one transcript has been validated in pigs, with several other transcript variants of EZH2 from digital computational analysis in NCBI that have not been empirically validated. (hindawi.com)
  • A minimum of four (4) mutant mice, heterozygous for the selected mutation on a mixed 129S5;B6 background. (taconic.com)
  • Stat5a null mice developed normally, and were indistinguishable from hemizygous and wild-type littermates in size, weight and fertility. (nih.gov)
  • This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. (cancerindex.org)
  • Title: Apolipoprotein D modulates amyloid pathology in APP/PS1 Alzheimer's disease mice. (genscript.com)
  • Senescent cell clearance treatments could be made much more efficient than the prototypes demonstrated so far in mice. (fightaging.org)
  • To investigate the role of TRPV4 in the cochlea, the hearing thresholds and effects of acoustic overexposure on the cochlea were examined in TRPV4 knockout mice. (nih.gov)
  • Enhanced antinociceptive effects of morphine in histamine H2 receptor gene knockout mice. (hypothes.is)
  • We have previously shown that antinociceptive effects of morphine are enhanced in histamine H1 receptor gene knockout mice. (hypothes.is)
  • GRe treatment did not have additional effects on PKCδ gene knockout-mediated neuroprotection, suggesting that PKCδ is a molecular target of GRe. (medworm.com)
  • Title: Immunohistochemical distribution of somatostatin and somatostatin receptor subtypes (SSTR1-5) in hypothalamus of ApoD knockout mice brain. (genscript.com)
  • Description: RNA profiling data sets generated by the Mouse ENCODE project. (nih.gov)