Reactive Oxygen SpeciesNADPH OxidaseOxygenOxidative StressHydrogen PeroxideAntioxidantsFree Radical ScavengersOxidation-ReductionMitochondriaSuperoxidesSuperoxide DismutaseOxygen ConsumptionCatalaseAcetylcysteineOxidantsApoptosisNADH, NADPH OxidoreductasesOnium CompoundsGlutathioneCells, CulturedMembrane Potential, MitochondrialSignal TransductionLipid PeroxidationXanthine OxidaseNADPReactive Nitrogen SpeciesSinglet OxygenCyclic N-OxidesCell SurvivalAcetophenonesCell DeathEnzyme ActivationNitric OxideEnzyme InhibitorsHydroxyl RadicalFree RadicalsCell Line, TumorRespiratory BurstRats, Sprague-DawleyDose-Response Relationship, DrugGlutathione PeroxidaseDNA DamageCell LineRotenoneMice, Inbred C57BLNeutrophilsBlotting, Western1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium SaltLuminescent MeasurementsTime FactorsAscorbic AcidCytochromes cVitamin K 3XanthineMitochondrial ProteinsMice, KnockoutMitochondria, HeartAnoxiaOxygen Inhalation TherapyModels, BiologicalElectron Transportrac1 GTP-Binding ProteinEndothelium, VascularCaspase 3MetalloporphyrinsPeroxiredoxinsElectron Transport Complex ICell HypoxiaPhosphorylationParaquatRNA, MessengerSpin LabelsCaspasesDeoxyguanosineProtein CarbonylationRats, WistarUp-RegulationNF-kappa BNF-E2-Related Factor 2Cell RespirationMalondialdehydeOxidoreductasesDisease Models, Animalp38 Mitogen-Activated Protein KinasesDNA FragmentationCalciumtert-ButylhydroperoxideEndothelial CellsTioproninCytoprotectionRNA, Small InterferingGene Expression RegulationGlutathione DisulfideThioredoxinsGene Expression Regulation, EnzymologicUncoupling AgentsNADGlucoseThenoyltrifluoroacetoneReverse Transcriptase Polymerase Chain Reaction