Chemicals and DrugsPhenomena and Processes
NAD(P)H Dehydrogenase (Quinone)QuinonesNADPH OxidaseQuinone ReductasesNADH, NADPH OxidoreductasesNADPPQQ CofactorBenzoquinonesDicumarolOxidation-Reduction
Nicotinamide adenine dNADH or NADPHNQO1Pyrroloquinoline quinoneDehydrogenaseEnzymeCofactorsGlutathioneCatalyzesCovalently modifySemiquinoneSubstrate specificityReductasesLiverDistinctOrganicHumanPresenceOxidoreductaseInhibited NADPH-quinone rOxidaseReductase activityNadpCytochrome P-4RedoxGlutathione peroxidaseProteinReductionOxidationMetabolitesReactionAlcoholsRadicalActivation
Nicotinamide adenine d1
  • Other names in common use include reduced nicotinamide adenine dinucleotide phosphate (quinone), dehydrogenase, NADPH oxidase, and NADPH2 dehydrogenase (quinone). (wikipedia.org)
NADH or NADPH1
  • This enzyme belongs to the family of oxidoreductases, specifically those acting on NADH or NADPH with other acceptors. (wikipedia.org)
NQO12
  • Therefore, the present study has been designed to compare efficiency of human NAD(P)H:quinone oxidoreductase (NQO1) and phase II enzymes such as sulfotransferases (SULTs) and N,O-acetyltransferases (NATs) to activate AAI and AAII in vitro. (nel.edu)
  • These reductases often show broad and overlapping substrate specificities and some well-characterized members, e.g., carbonyl reductase (CBR1) or NADPH-quinone reductase (NQO1) have protective roles toward xenobiotic carbonyls and quinones because metabolic reduction leads to less toxic products, which can be further metabolized and excreted. (ox.ac.uk)
Pyrroloquinoline quinone1
  • Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). (lifescience-market.com)
Dehydrogenase1
  • In enzymology, a NADPH dehydrogenase (quinone) (EC 1.6.5.10) is an enzyme that catalyzes the chemical reaction NADPH + H+ + acceptor ⇌ {\displaystyle \rightleftharpoons } NADP+ + reduced acceptor The 3 substrates of this enzyme are NADPH, H+, and acceptor, whereas its two products are NADP+ and reduced acceptor. (wikipedia.org)
Enzyme3
  • The systematic name of this enzyme class is NADPH:(quinone-acceptor) oxidoreductase. (wikipedia.org)
  • Encodes NAD(P)H:quinone reductase which is an FMN binding protein that catalyzes the reduction of quinone substrates to hydroquinones.The enzyme activity was confirmed by in vitro assay. (or.jp)
  • An enzyme, called quinone reductase, takes electrons from NADPH, and donates them to vitamin K quinone, converting it into the reduced form which is called vitamin K hydroquinone. (osmosis.org)
Cofactors1
  • These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. (cancerindex.org)
Glutathione3
  • These antioxidant enzymes include glutathione S -transferase, or GST, NADPH:quinone oxidoreductase 1, thioredoxin and hemeoxygenase-1. (asbmb.org)
  • The role of several antioxidants in pain relief, by attenuating ROS generation and/or by activating the endogenous antioxidant system triggered by the nuclear factor erythroid-2 related factor 2 (Nrf2), heme oxygenase 1 (HO-1), NADPH quinone oxidoreductase 1, superoxide dismutase, glutathione peroxidase 1, and/or the catalase signaling pathway, has been demonstrated. (mdpi.com)
  • In liver of the mice, glutathione S-transferase and NADPH:quinone reductase activity increased with the doses of propolis or artepillin C, and an antioxidant-responsive element (ARE) was found to be activated for binding DNA. (propolisscience.org)
Catalyzes2
  • Catalyzes the one-electron reduction of certain quinones, with the orthoquinones 1,2-naphthoquinone and 9,10-phenanthrenequinone being the best substrates. (expasy.org)
  • Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. (joplink.net)
Covalently modify2
  • Phenytoin is metabolized by cytochrome P450 (P450) enzymes primarily to 5-( p -hydroxyphenyl-),5-phenylhydantoin (HPPH), which may be further metabolized to a catechol that spontaneously oxidizes to semiquinone and quinone species that covalently modify proteins. (aspetjournals.org)
  • Reactive carbonyls, formed during lipid peroxidation or food processing, and xenobiotic quinones are able to covalently modify DNA or amino acids. (ox.ac.uk)
Semiquinone1
  • The semiquinone free-radical product may be non-enzymically reduced to the hydroquinone or oxidized back to quinone in the presence of O2. (expasy.org)
Substrate specificity1
  • NADPH-dependent reductase with broad substrate specificity. (joplink.net)
Reductases1
  • Carbonyl reductases: the complex relationships of mammalian carbonyl- and quinone-reducing enzymes and their role in physiology. (ox.ac.uk)
Liver1
  • Now, when vitamin K is absorbed from the digestive tract and travels to the liver, it's in its dietary form and it's called vitamin K quinone. (osmosis.org)
Distinct1
  • Carbonyl groups are reduced by an array of distinct NADPH-dependent enzymes, belonging to several oxidoreductase families. (ox.ac.uk)
Organic1
  • Although the mechanism of cardiovascular injury by PM is poorly understood, it has been shown that the particles are coated by a number of chemical compounds, including organic hydrocarbons (for example, polycyclic aromatic hydrocarbons and quinones), transition metals, sulfates and nitrates. (biomedcentral.com)
Human1
  • Recombinant human P450s were coexpressed with NADPH-cytochrome P450 reductase in Escherichia coli . (aspetjournals.org)
Presence1
  • Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. (lifescience-market.com)
Oxidoreductase14
  • The systematic name of this enzyme class is NADPH:(quinone-acceptor) oxidoreductase. (wikipedia.org)
  • NADPH quinone oxidoreductase 1 (NQO1) metabolizes the quinone structures contained in both amrubicin (AMR) and amrubicinol (AMR-OH). (nih.gov)
  • Comparison of activation of aristolochic acid I and II with NADPH:quinone oxidoreductase, sulphotransferases and N-acetyltranferases. (nel.edu)
  • Martinek V, Kubickova B, Arlt V, Frei E, Schmeiser H, Hudecek J, Stiborova M. Comparison of activation of aristolochic acid I and II with NADPH:quinone oxidoreductase, sulphotransferases and N-acetyltranferases. (nel.edu)
  • Alteration of pulmonary xenobiotic pathways was determined by monitoring the protein levels and activities of P-450 isozymes (CYP1A1 and CYP2B1), glutathioneS-transferase (GST), and NADPH:quinone oxidoreductase (QR). (cdc.gov)
  • Lack of association between NADPH quinone oxidoreductase 1 (NQO1) gene C609T polymorphism and lung cancer: a case-control study and a meta-analysis. (cdc.gov)
  • Association between NAD(P)H:quinone oxidoreductase 1 rs1800566 polymorphism and risk of bladder cancer. (cdc.gov)
  • NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism and lung cancer risk: a meta-analysis. (cdc.gov)
  • NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T gene polymorphism association with digestive tract cancer: a meta-analysis. (cdc.gov)
  • BLVRB, a cytoplasmic protein, is a broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and pyrroloquinoline quinone. (nih.gov)
  • However, using qPCR assessment the treatment concentrations used did not seem to indicate attenuation of the NADPH quinone oxidoreductase-1 (NQO1), a classical marker of ARE activation. (liberty.edu)
  • Alcohol dehydrogenase (ADH) contributes significantly to NADH-dependent C-nitroso reduction by cytosol relative to NAD(P)H: quinone oxidoreductase (NQOR). (lsu.edu)
  • The test system uses a transgenic HaCaT cell line which carries the luciferase reporter gene under control of an ARE-element (Antioxidative ResponseElement) from rat NADPH quinone oxidoreductase 1 gene. (amestest.cz)
  • It was just shown, in E. coli and Archaeoglobus fulgidus (and previously for some eukaryotic homologs) to act as fourth type of NAD(P)H:quinone oxidoreductase. (unl.edu)
Inhibited NADPH-quinone r1
  • 18. Emodin inhibited NADPH-quinone reductase competitively and induced cytotoxicity in rat primary hepatocytes. (nih.gov)
Oxidase4
  • Enzymatically derived oligophenols from apocynin can be effective inhibitors of human vascular NADPH oxidase (Nox). (rpi.edu)
  • A number of intracellular enzymes are known to create ROS/RNS, e.g., xanthine/xanthine oxidase, NADPH oxidase, cytochrome P450, nitric oxide synthases, prostaglandin synthases, and enzymes in the electron transport chain in mitochondria. (mingsheng88.org)
  • I will pursue three lines of research within the theme of oxidant stress-mediated effects on cell growth: NADPH oxidase 1, the glutathione peroxidase gene family, and the mechanism of action of anticancer quinones. (nih.gov)
  • First, we will be studying NADPH oxidase 1, a member of a recently discovered epithelial NADPH oxidase gene family that shares substantial homology with the NADPH oxidase of polymorphonuclear leukocytes. (nih.gov)
Reductase activity2
  • Super anion radical and H2O2 decreased cytochrome-P-450 content and NADPH-cytochrome-P-450- reductase activity in a concentration dependent manner, and SOD eliminated this effect, while catalase produced a slight reversal of the effects on cytochrome-P-450, but had no effect on the decrease in NADPH-cytochrome-P-450-reductase. (cdc.gov)
  • Sulforaphane and broccoli sprout extract potently induce quinone reductase activity in cultured prostate cells, and this induction appears to be mediated by increased transcription of the NQO-1 gene. (brocon.co)
Nadp1
  • Then the electron of photosystem II is transferred by photosystem I and the electron of the photosystem I is used with H+ and NADP to form NADPH. (answers.com)
Cytochrome P-41
  • Oxidative reactions are mostly carried out by a group of monooxygenases in the liver, called as cytochrome P-450 , NADPH, cytochrome P-450 reductase and molecular O2. (slideshare.net)
Redox5
  • Aerobic cytochrome P450 reductase-mediated redox cycling of 35.50 microM DESQ, 0.35 microM EQ, or 3.55 microM 3,4EQ increased the reduction of succinoylated cytochrome c, a measure of superoxide radical formation, by 19-20% over control values (24.5+/-0.3 microM) in the absence of estrogen quinone substrate. (nih.gov)
  • the roles of CYP2E1, the redox cycling of quinone metabolites, glutathione oxidation, and oxidative stress in the unique radiomimetic, hematopoietic toxicity of benzene are discussed. (nih.gov)
  • In the presence of transition metals or redox cycling compounds (including quinones), reactive oxygen species such as superoxide can be converted to the more reactive hydroxy radicals. (mingsheng88.org)
  • We report that RrpA is a positive regulator of mdaB, encoding a flavin-dependent quinone reductase that contributes to the protection from redox stress mediated by structurally diverse quinones, while RrpB negatively regulates the expression of cj1555c (renamed nfrA for NADPH-flavin reductase A), encoding a flavin reductase. (lshtm.ac.uk)
  • Quinones and flavins are redox cycling agents secreted by a wide range of cell types that can form damaging superoxide by one-electron reactions. (lshtm.ac.uk)
Glutathione peroxidase1
  • Tetrahydrocurcumin is believed to be superior to curcumin for induction of glutathione peroxidase, glutathione-S-transferase, NADPH: quinone reductase, and quenching of free radicals. (feelny.net)
Protein1
Reduction3
  • NQO1's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. (thermofisher.com)
  • NADPH-dependent pNSP reduction by liver cytosol of ADH+ animals is mostly dicumarol-sensitive which implicates NQOR as the major NADPH-dependent activity. (lsu.edu)
  • Nitroreductases (NTRs) catalyze the reduction of a wide range of nitro-compounds and quinones using NAD(P)H. Although the physiological functions of these enzymes remain obscure, a tentative function of resistance to reactive oxygen species (ROS) via the detoxification of menadione has been proposed. (olmdiagnostics.com)
Oxidation1
  • The current understanding of the molecular etiology of breast cancer hypothesizes biotransformation of E2 and E1 within the breast tissue to catechols and subsequent oxidation to genotoxic quinones resulting in DNA damage via formation of estrogen-DNA adducts or via formation of reactive oxygen species resulting in oxidative stress (Yager 2015 ). (springer.com)
Metabolites1
  • LC/MS/MS analysis of incubations containing chlorpromazine or thioridazine in the presence of NADPH and glutathione (GSH) revealed the formation of GSH conjugates derived from the addition of the sulfydryl nucleophile to monohydroxy metabolites of chlorpromazine and thioridazine, respectively. (nih.gov)
Reaction1
  • 4H+ + 4e- + O2 The electrons from water pass through photosystem II to reduce quinone molecules, which shuttle the electrons to the next step of the photosynthetic reaction chain. (answers.com)
Alcohols1
Radical1
  • The ratio of dihydrodiols and quinones to phenols was increased more than two times after exposure to super oxide radical. (cdc.gov)
Activation1
  • In one study, the presence of cumene hydroperoxide accelerated the activation of cytochrome P450scc and inhibited NADPH-dependent lipid peroxidation. (nih.gov)