• The association of t(15,17) with the M3 subtype of acute myeloid leukemia (acute promyelocytic leukemia) is one example. (medscape.com)
  • In Section III, Dr. Martin Tallman describes the evaluation and management of patients with acute promyelocytic leukemia, a notable example of therapeutic progress in a molecularly defined entity of leukemia. (ashpublications.org)
  • and myeloid cells are seen in stem cell leukemia/lymphoma (SCLL), which is also known as 8p11 myeloproliferative syndrome (EMS). (medscape.com)
  • Stem cell leukemia/lymphoma (SCLL), which is also known as the 8p11 myeloproliferative syndrome (EMS), is characterized in its typical form by the occurrence, either simultaneously or sequentially, of a bcr/abl-negative myeloproliferative disorder and a lymphoma, usually a precursor T-cell lymphoblastic lymphoma. (medscape.com)
  • As with chronic myelogenous leukemia (CML) , the myeloproliferative aspect of SCLL has a chronic phase that transforms into a myeloblastic phase, typically within 1 year of diagnosis. (medscape.com)
  • [ 1 , 2 , 3 ] Owing to the variety of hematologic malignancies or proliferative disorders that may be associated with leukemia cutis, terms such as myeloid or lymphoid leukemia cutis have been used to further classify the leukemic cells. (medscape.com)
  • Leukemia cutis has been described in patients with myeloid and lymphoid types of leukemias. (medscape.com)
  • The presence of the characteristic chromosomal translocation always involving the fibroblast growth factor receptor 1 ( FGFR1 ) gene at chromosome 8p11 in both the myeloid and lymphoid malignancies suggests bilineage differentiation from an affected pluripotent stem cell. (medscape.com)
  • A diagnosis of leukemia cutis in the setting of acute leukemia generally portends a poor prognosis and strongly correlates with additional sites of extramedullary involvement. (medscape.com)
  • NFATC1 expression causes FLT3 ITD -induced transcriptome changes, which are associated with HSC transformation, quizartinib resistance, and a poor prognosis in AML. (biomedcentral.com)
  • Myeloid-related precursor neoplasms derive from precursor cells that have at least one form of myeloid differentiation. (medscape.com)
  • We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)
  • Be it for development, differentiation, stemness, or sex chromosome dosage compensation, stable, cell specific regulation of gene expression is essential for normal function ( 1 ). (aacrjournals.org)
  • The subtype of leukemia is determined by the hematopoietic lineage of neoplastic cells and the stage at which maturational arrest occurs. (medscape.com)
  • Some antecedents are specific to a leukemia subtype, such as the association of acute T-cell leukemia-lymphoma (ATL) with human T-lymphotropic virus type I (HTLV-1). (medscape.com)
  • Accurate diagnosis has tremendous prognostic significance and may establish a diagnosis in cases in which leukemia cutis is the harbinger of a systemic leukemic process. (medscape.com)
  • Class II mutations cause defects in myeloid cell differentiation. (medscape.com)
  • In fact, the requirements, under which CHIP mutations become myeloid driver mutations, cooperate with other genetic or epigenetic changes to eventually cause AML, are not well understood. (biomedcentral.com)
  • Acute leukemias induced by MLL chimeric oncoproteins are among the subset of cancers distinguished by a paradoxical dependence on GSK-3 kinase activity for sustained proliferation. (stanford.edu)
  • Leukemia cutis usually occurs in the setting of a previously diagnosed systemic leukemia or lymphoproliferative disorder/myelodysplastic syndrome. (medscape.com)
  • Two nucleoside inhibitors of DNA methylation, azacitidine and decitabine, are now standard of care for the treatment of the myelodysplastic syndrome, a deadly form of leukemia. (aacrjournals.org)
  • Accumulation of genetic defects in hematopoietic precursors leads to impaired cellular differentiation, increased proliferative potential, unregulated proliferation, and defective apoptosis. (medscape.com)
  • ALK is one of the receptor tyrosine kinase (RTK) family of enzymes, which have significant roles in the proliferation and differentiation of cells. (lab-ally.com)
  • Genetic alterations predisposing to leukemia may be congenital or acquired. (medscape.com)
  • Similarly, some genetic or chromosomal abnormalities are found in specific leukemia subtypes. (medscape.com)
  • In addition to these basic issues concerning leukemia pathogenesis, we are devising new diagnostic procedures for detecting and monitoring leukemia patients based on molecular genetic abnormalities in the malignant cells. (stanford.edu)
  • The term acute myeloid leukemia (AML) collectively refers to a mixture of distinct diseases that differ with regard to their pathogenetic evolution, genetic abnormalities, clinical features, response to therapy, and prognosis. (ashpublications.org)
  • Leukemia cutis is defined by migration of leukemic cells to the skin. (medscape.com)
  • World Health Organization differentiation markers and criteria for AMLs defined by differentiation. (medscape.com)
  • Leukemia cutis is the infiltration of neoplastic leukocytes or their precursors into the epidermis, the dermis, or the subcutis, resulting in clinically identifiable cutaneous lesions. (medscape.com)
  • Aberrant expression of a third marker such as Thy-1/CD90 negativity, expression of CLL-1 and IL-3R (CD123), intermediate levels of aldehyde dehydrogenase and co-expression of common chromosomal translocation may be used to distinguish from normal hematopoietic stem cells. (ghrnet.org)
  • Our research focuses on developmental pathways that regulate hematopoietic cell growth and differentiation and are disrupted in the course of neoplastic transformation, particularly in leukemias and lymphomas. (stanford.edu)
  • This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. (stanford.edu)
  • Indeed, early cancer research focused on the fact that neoplastic cells have aberrant gene expression and differentiation states, pointing to shared mechanisms between normal development and cancer ( 2 ). (aacrjournals.org)
  • In the setting of chronic leukemia, cutaneous involvement can indicate blast transformation. (medscape.com)
  • In large cell lymphoma and leukemia cells involvement of body fluid this concept becomes less challenging. (cytojournal.com)
  • Large cell lymphoma and leukemia cells tend to have large size nuclei, less mature chromatin, and visible nucleoli with and without cytoplasmic vacuoles. (cytojournal.com)
  • Leukaemia stem cells (LSC) are identified by high CD34 and negative CD38 expression. (ghrnet.org)
  • Taking advantage of the diverse γδ TCR repertoire or other ligand-receptor interactions, γδ T cells can recognize a broad spectrum of tumor-associated antigens (TAAs) in a major histocompatibility complex (MHC)-independent manner, thereby activating downstream pleiotropic effects. (explorationpub.com)
  • 3) We are defining the properties of cancer stem cells that initiate and sustain the unique disease features of acute leukemias through the use of various adoptive animal models. (stanford.edu)
  • A type of clonal malignancy characterized by excess accumulation of lymphoblasts that phenotypically resemble the early stages of normal B-cell differentiation. (lab-ally.com)
  • Acute myeloid leukemia (AML) patients with a high allelic burden of an internal tandem duplication ( ITD )-mutated FMS - like Tyrosine Kinase - 3 ( FLT3 ) have a dismal outcome. (biomedcentral.com)
  • We also retrospectively analyzed the overall survival of AML patients with different NFATC1 expression status. (biomedcentral.com)
  • In patients, primary or acquired resistance to chemotherapy is associated with the expression of P-gp. (ashpublications.org)
  • We generated a triple transgenic mouse model, in which tamoxifen-inducible Cre-recombinase targets expression of a constitutively nuclear transcription factor NFATC1 to FLT3 ITD positive HSC. (biomedcentral.com)
  • Leukemia cutis is a broad term used to describe any cutaneous presentation of leukemia. (medscape.com)