Mutations gene nuclear receptor subfamily 6 group a member 1. Medical search. Frequent questions

The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. (cancerindex.org)
It is unlike most orphan nuclear receptors in that it appears to lack an essential DNA-binding domain and instead acts as a transcriptional co-repressor. (nih.gov)

It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. (utsouthwestern.edu)

The classic diagnostic approach emphasizes obtaining these assessments before conducting genetic analyses (often limited to individual candidate genes) and is expensive, laborious, and time-consuming. (biomedcentral.com)
First, molecular events in T2DM pathogenesis have been examined directly by testing the role of sequence variants of specific candidate genes. (scialert.net)
The candidate gene approach focuses on the search for an association between T2DM and sequence variants in or near biologically defined candidate genes which have been chosen based on their known physiological function. (scialert.net)
We used a high density SNP array (600 K, Affymetrix) to estimate genomic heritability, perform genome-wide association analysis, and identify genomic regions and positional candidate genes (PCGs) associated with internal organ traits in an F2 chicken population. (biomedcentral.com)
Thus, the discovery of genomic regions and positional candidate genes (PCGs) for intestine length or weights and percentages of heart, liver, gizzard or lungs, is a first step for understanding their genetic architecture. (biomedcentral.com)
Our findings suggest that common coding variation in these candidate genes do not make a substantial contribution to breast cancer risk in the general population. (biomedcentral.com)
In this study, we employed a high-density single nucleotide polymorphism (SNP) chip to genotype 386 Nellore steers, a Bos indicus breed and, a Bayesian approach to identify genomic regions and putative candidate genes that could be involved with deposition and composition of IMF. (biomedcentral.com)

Earlier studies using a candidate gene approach, family linkage studies and gene expression profiling uncovered a number of T2DM genes, but the genetic basis of common T2DM remained unknown. (scialert.net)
No prior knowledge of gene or gene effects is necessary, but the genetic locus must have sufficient impact on the disease susceptibility to be detectable. (scialert.net)
The genetic component of T2DM comes from ethnic group differences in prevalence rates. (scialert.net)
Mutations in some genes cause rare forms of T2DM, giving additional support for the genetic roles in the aetiology of the disease. (scialert.net)
There are over 120 known genetic variants for neurological disorders in dogs alone ( 1 ), and with advances in molecular genetic technology and consistently decreasing costs, the list is continuing to expand at a rapid rate. (frontiersin.org)
This idea is supported by the discovery that many genetic mutations associated with PD appear to be associated in some way with mitochondrial dynamics or oxidative stress (e.g. (frontiersin.org)
I have always been fascinated by the process of genetic penetrance, how two people can carry the same mutation but only one of them may be affected. (stanford.edu)
In this study, we systematically screened the coding exons of steroid hormone receptor coactivator and corepressor genes in a multiethnic panel of women with breast cancer in an attempt to identify and catalogue potentially functional coding polymorphisms that may serve as genetic markers of breast cancer risk. (biomedcentral.com)
The genes present in these regions were identified and some can help explain the genetic basis of deposition and composition of fat in cattle. (biomedcentral.com)
The genomic regions and genes identified contribute to a better understanding of the genetic control of fatty acid deposition and can lead to DNA-based selection strategies to improve meat quality for human consumption. (biomedcentral.com)

Several skeletal dysplasias in specific dog breeds have been associated with mutations in members of the collagen gene family or its binding proteins ( 8 - 10 ), fibrilin related protein ( 11 ), as well as an altered sulfate transporter protein ( 12 ). (frontiersin.org)
Btk and Bmx (also named Etk) are members of the Tec subfamily of proteins, which are cytoplasmic (or nonreceptor) tyr kinases with similarity to Src kinases in that they contain Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. (umbc.edu)
It interacts with a variety of partners, from cytosolic proteins to nuclear transcription factors, suggesting a diversity of functions. (umbc.edu)
This domain occurred 417 times on human genes ( 954 proteins). (umbc.edu)
Cytoskeletal proteins such as dynamin (see IPR001401 ), Caenorhabditis elegans kinesin-like protein unc-104 (see IPR001752 ), spectrin beta-chain, syntrophin (2 PH domains) and S. cerevisiae nuclear migration protein NUM1. (embl.de)
1) Characterize novel families of oncoproteins (Pbx and Meis) that dimerize with and regulate the DNA binding properties of Hox proteins. (stanford.edu)
Our studies have demonstrated that several of the proteins encoded by cellular oncogenes function in fundamental aspects of gene regulation. (stanford.edu)
It binds and inactivates the 140 kDa subunit of RNA polymerase II, blocking all gene expression leading to proteins. (helmberg.at)
Subsequently, by using independent RNAi/ dominant negative forms, it was shown that Ecdysone Receptor (EcR) is essential for male fertility due to its requirement in the normal development of accessory glands in Drosophila: EcR depleted glands fail to make seminal proteins and have dying cells. (sdbonline.org)
Cellular response to estrogens is mediated through estrogen receptors (ERα and ERβ), which upon binding to ligand and DNA hormone response elements, recruit coactivator and corepressor proteins that regulate the expression of steroid hormone target genes. (biomedcentral.com)

The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. (cancerindex.org)
The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. (cancerindex.org)
The TAM receptor and ligand expression was evaluated in LMS cell lines and 358 sarcoma samples by either gene expression or immunohistochemistry. (nature.com)

The Ala isoform may lead to a less efficient stimulation of the PPAR-γ target genes and predisposes to lower levels of adipose tissue mass accumulation which in turn may be responsible for improved insulin sensitivity [ 7 ]. (biomedcentral.com)

Given the established role of estrogens in breast cancer, we hypothesized that coding variation in steroid receptor coactivator and corepressor genes may alter inter-individual response to estrogen and serve as markers of breast cancer risk. (biomedcentral.com)
Cataloging and testing of coding variants in coactivator and corepressor genes should continue and may serve as a valuable resource for investigations of other hormone-related phenotypes, such as inter-individual response to hormonal therapies used for cancer treatment and prevention. (biomedcentral.com)

The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. (utsouthwestern.edu)
MRP4 is an ATP-dependent, unidirectional efflux transporter belonging to the C subfamily of the ABC protein superfamily. (solvobiotech.com)

Variants in the SMCHD1 gene on chromosome 18, which encodes a protein known as structural maintenance of chromosomes flexible hinge domain containing 1, have been associated with FSHD2. (arkansasbluecross.com)

This study adds one novel NR5A1 variant to the pool of pathogenic variants and enriches the adolescents of information available about the mutation spectrum of this gene in Chinese population. (biomedcentral.com)
A total of 13,748 annotated sequence SNPs were in the 14 PCGs, including 156 SNPs in coding regions (124 synonymous, 26 non-synonymous, and 6 splice variants). (biomedcentral.com)
We sought genotype-phenotype correlations and undertook a comparative analysis with patients with PAH with BMPR2 (Bone Morphogenetic Protein Receptor type 2) causal variants (n = 162) or no identified variants in PAH-associated genes (n = 741) genotyped via the National Institute for Health Research BioResource-Rare Diseases. (stanford.edu)
Variants located in the T-BOX and nuclear localization domains were associated with earlier presentation (P = 0.005) and increased incidence of interstitial lung disease (P = 0.003). (stanford.edu)
We identified 45 coding variants with frequencies ≥ 1% in any one ethnic group (43 non-synonymous variants). (biomedcentral.com)
12 , 13 ] Polymorphic variants in these mediators of hormonal responsiveness could affect the functional activity of estrogen receptors following stimulation by endogenous or exogenous (i.e. (biomedcentral.com)
Alternatively spliced transcript variants encoding different isoforms have been found for this gene. (utsouthwestern.edu)

Radionetics Oncology Inc. has patented new melanocortin MC2 receptor ligands reported to be useful for the diagnosis and treatment of cancer. (bioworld.com)
The Wnt genes encode secreted glycoprotein ligands that regulate a wide range of developmental processes, including axis elongation and segmentation. (biomedcentral.com)
Furthermore, the Spätzle (Spz) family ligands for the Toll receptor are transcriptionally upregulated by activated JNK signalling in a non-cell-autonomous manner, providing a molecular mechanism for JNK-induced Toll pathway activation. (sdbonline.org)
The TAM receptors and their ligands are overexpressed or activated in multiple malignancies, including LMS. (nature.com)

Peroxisome proliferator-activated receptor gamma 2 ( PPAR-γ2 ) is a transcription factor with a key role in adipocyte differentiation, lipid storage and glucose homeostasis. (biomedcentral.com)
Some genes are thought to be involved in the development of T2DM and obesity amongst which, the peroxisome proliferator activated receptor gamma (PPAR-γ) gene. (biomedcentral.com)
Finally, we used siRNAs against the major transcription factors (TFs) predicted for these regions [peroxisome proliferator-activated receptor γ (PPARγ), Krüppel-Like Factor 4 (KLF4), and vitamin D receptor (VDR)] to assess EDN1 expression in cell culture and validate the binding sites. (stanford.edu)

Contrary to the prevalent model, recruitment of the dMi-2 corepressor increases upon hormone addition to constrain gene activation through chromatin remodelling. (sdbonline.org)
This study identifies a non-canonical EcR-corepressor complex with the potential for a direct regulation of ATP-dependent nucleosome remodelling by a nuclear hormone receptor. (sdbonline.org)

This protein is a member of nuclear hormone receptor family of steroid hormone receptors. (wikipedia.org)

In the first group (pulmonary arterial hypertension [PAH]), the primary disorder affects the small pulmonary arterioles. (msdmanuals.com)

Notably, the separate overexpression of EcR-B1 or a transforming growth factor- β receptor Baboon , whose activation can upregulate the EcR-B1 expression, in MB neurons rescued the miR-34 -induced gamma axon pruning phenotype. (sdbonline.org)
The technique of GWAS exploits differences in allele frequencies of thousands of polymorphic markers available in unrelated individuals who possess different phenotypes (for example, deposition and composition of intramuscular fat), and leads to the identification of markers associated with a given phenotype [ 6 ]. (biomedcentral.com)

SWI/SNF‑related, matrix‑associated, actin‑dependent regulator of chromatin, subfamily a, member 4 (SMARCA4)‑deficient non‑small cell lung cancer (dNSCLC) is a rare malignant tumor that originates in the lungs. (spandidos-publications.com)
SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a, member 4 (SMARCA4)- deficient non-small cell lung cancer (SMARCA4-dNSCLC) is an uncommon yet notable malignancy originating within the lung. (spandidos-publications.com)
2) We have discovered a group of oncoproteins that are implicated in long-term maintenance of gene expression through their effects on the state of chromatin. (stanford.edu)
We are studying the role that normal chromatin structure plays in gene regulation in hematopoietic cells and how its disruption leads to altered development and cancer. (stanford.edu)
ELAC1 has been in the use and may as define as an RNase Z. In pyrophosphates subfamilies are transcribed from coupling tubules in the function by a two receptor chromatin that appears ultraviolet from protein threatening( reviewed in Popow et al. (evakoch.com)

Mutations in BMPR2 cause 75% of cases. (msdmanuals.com)

Here, we present evidence that the promoter regions of intellectual disability-associated genes are uniquely enriched in LTR sequences of the MER41 HERVs. (biorxiv.org)
Moreover, we have not found such a significant enrichment in the promoter regions of genes that associate with autism spectrum disorder (ASD) or schizophrenia. (biorxiv.org)
Of note, functionally-relevant differences between humans and chimpanzees are observed regarding the 3 main components of this pathway: i) the protein sequences of immunes TFs binding MER41 LTRs, ii) the insertion sites of MER41 LTRs in the promoter regions of ID-associated genes and iii) the protein sequences of the targeted ID-associated genes. (biorxiv.org)

In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. (cancerindex.org)

What pathways are this gene/protein implicaed in? (cancerindex.org)
Additional screens for MMTV provirus entry sites in tumors revealed several other upregulated genes that are associated with other gene development pathways such as INT2, INT3, and INT4 [4,5,6]. (chemdiv.com)
also, the 5' download volatility trading of the cytoplasm is involved actually by cationic end-product by the RNase proximity water cell, which has a direct RNA( RNA H1 in pathways) and at least 10 Fructose-6-phosphate nucleus( activated in Jarrous 2002, Xiao et al. (evakoch.com)
An orphan nuclear receptor that is implicated in regulation of steroidogenic pathways. (nih.gov)

Human derived T lymphocytes engineered to express chimeric antigen receptors, which are expanded in vitro culture and then infused into patients exerting robust cytotoxicity after tumor antigen recognition and subsequent activation. (biomedcentral.com)
Nussе and Varmus identified components of the Wnt/β-catenin pathway in 1982 in a study of oncogenic breast tumor viral diseases (MMTV) [1]. (chemdiv.com)
CTLs) that produce cytokines and cytotoxic enzymes (perforin, granzyme B) that eliminate pathogens or target cells (including pathogen-infected host cells and tumor cells) and can develop into memory T cells ( Figure 1 ) [ 12 ] . (encyclopedia.pub)
The tumor suppressor p53, encoded by the TP53 gene and known as "the guardian of the genome", performs a variety of functions in cancer prevention. (encyclopedia.pub)
The methylation specific polymerase chain reaction in conjunction with sequencing verification was used to establish the methylation patterns of the 14 genes in the liver tissues of four healthy liver donors, as well as tumor and the paired non-cancerous tissues of 30 HCC patients. (wjgnet.com)
Both glutathione S-transferase pi ( GSTpi ) (80%, 24/30 in tumor and 56.7%, 17/30 in the paired non-cancerous tissues) and cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7) ( CFTR ) (77%, 23/30 in tumor and 50%, 15/30 in the paired non-cancerous tissues) genes were prevalently hypermethylated in HCC as well as their neighboring non-cancerous tissues. (wjgnet.com)

Seven deleterious SNPs were identified in TNFSF11 , NR4A2 or ITGB4 genes. (biomedcentral.com)

Stimulation of a diverse array of cell surface receptors, including antigen engagement of the B-cell receptor (BCR), leads to PH-mediated membrane translocation of Btk and subsequent phosphorylation by Src kinase and activation. (umbc.edu)
Mutations in Brutons tyrosine kinase (Btk) within its PH domain cause X-linked agammaglobulinaemia (XLA) in patients. (embl.de)
other specificity is tiny gene activity and distribution browser through the kinase of the R-RasGAP complex ileal to suitable or through the functionality of RhoA. (evakoch.com)
Both receptors belong to the TAM (TYRO3, AXL and MER - MER proto-oncogene, tyrosine kinase) receptor tyrosine kinase family, which emerged as new potential targets in many oncological diseases, from leukaemia to solid tumours ( Graham et al, 2014 ). (nature.com)

Thus, the detection of genomic regions and/or potentially causative mutations associated with internal organ weight traits may provide important information to poultry breeding programs, facilitating selection of chickens with proportional development of internal organs, improved feed efficiency and reduced susceptibility to metabolic disorders. (biomedcentral.com)
natural genomic receptor exhibits Rho and its fifth rRNA growth. (evakoch.com)

COUP-TF1 (COUP Transcription Factor 1) also known as NR2F1 (Nuclear Receptor subfamily 2, group F, member 1) is a protein that in humans is encoded by the NR2F1 gene. (wikipedia.org)
Nuclear receptor subfamily 5 group A member 1 ( NR5A1, also known as SF-1 , AD4BP and FTZF1 ) is a key transcription factor that determines gonadal development and regulates coordinates endocrine functions [ 9 ]. (biomedcentral.com)
The Ki‑67 positivity index was 75%, and the thyroid transcription factor‑1, NapsinA, p40, nuclear protein in testis, CD34, Sal‑like protein 4, SRY‑box transcription factor 2 and synaptophysin were negative. (spandidos-publications.com)
It has also been demonstrated that STAT1 (Signal Transducer And Activator Of Transcription 1), a transcription factor (TF) crucially involved in the IFNγ pathway, binds consensus sequences that, in humans, are located with a high frequency in the LTRs (Long Terminal Repeats) of the MER41 family of primate-specific HERVs (Human Endogenous Retrovirus). (biorxiv.org)

GXD's primary emphasis is on endogenous gene expression during development. (jax.org)
Enzymatic assay of endogenous glutamate release Confluent U 87MG cells plated on glass cover slips were lodged in the one x 1 cm cuvette containing Ringers remedy supplemented with glutamate deshydrogenase and 1 mM NADP inside a Hitachi 2000 computerized spectrofluorimeter at 37 C under stirring. (cox-inhibitors.com)

PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. (umbc.edu)
Two such genes in Drosophila encode the enzymes dopa decarboxylase (Ddc) and tyrosine hydroxylase (ple) . (sdbonline.org)
Tyrosine protein kinases belonging to the Btk/Itk/Tec subfamily. (embl.de)

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)
Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly. (cancerindex.org)

Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. (cancerindex.org)
According to the bimodal switch model, steroid hormone receptors recruit corepressors in the absence of hormone and coactivators in its presence. (sdbonline.org)

16(1): 57, 2023 Mar 21. (bvsalud.org)
In accordance with the publishing schedule , BioWorld Science was not published on Wednesday, Dec. 6, 2023, and will not be published on Friday, Dec. 8, 2023. (bioworld.com)

A great proportion of 46,XY is caused by mutations in key transcription factors required for sex differentiation and androgen biosynthesis or action [ 2 ]. (biomedcentral.com)
Immature SP thymocytes undergo further differentiation to generate either MHC Class II restricted CD4 SP helper or MHC Class I restricted CD8 SP cytotoxic lineage cells [ 1 ] . (encyclopedia.pub)

These mutations account for 30% of all missense mutations in the TP53 gene. (encyclopedia.pub)

Unlike Src kinases, most Tec subfamily members (except Rlk) also contain an N-terminal pleckstrin homology (PH) domain, which binds the products of PI3K and allows membrane recruitment and activation. (umbc.edu)
Ser/Thr protein kinases such as the Akt/Rac family, the beta-adrenergic receptor kinases, the mu isoform of PKC and the trypanosomal NrkA family. (embl.de)

The subsequent targeting specific disease‐causing genes, comprising 360 endocrine disease-causing genes, was employed for molecular diagnosis. (biomedcentral.com)

This study examined the roles of hormone-dependent transcription factors (Nuclear Receptors), in accessory gland development, function and male fertility of a genetically tractable insect model, Drosophila melanogaster. (sdbonline.org)
First, an RNAi screen was carried out involving 19 hormone receptors, individually and specifically, in a male reproductive tissue (accessory gland) for their requirement in Drosophila male fertility. (sdbonline.org)
Simultaneous work in the field of developmental biology and work with Drosophila has established the INT1 gene is a homologue of the Drosophila segment polarity gene [2]. (chemdiv.com)

Type 2 Diabetes Mellitus (T2DM) is a complex heterogeneous group of metabolic condition characterized by elevated levels of serum glucose, caused mainly by impairment in both insulin action and insulin secretion. (scialert.net)
Insulin Receptor Substrate 1 (IRS-1). (embl.de)
In a cross-sectional study of 48 AD patients without diabetes, 20 cognitively normal diabetic patients, 16 patients with frontotemporal dementia, and 84 cognitively normal controls, researchers found that dysfunctionally phosphorylated insulin receptor substrate-1 (IRS-1), a neuronal protein, is detectable in blood using exosome-based technology and may be able to predict AD up to 10 years before the appearance of symptoms. (medscape.com)

The aim of this study was to investigate the association of Pro12Ala polymorphism in the PPAR-γ2 gene with susceptibility to obesity or T2DM in a Cameroonian population. (biomedcentral.com)
PPAR-γ2 Pro12Ala gene polymorphism may not be associated with obesity and T2DM. (biomedcentral.com)
Children with Down syndrome: association of Bcl-I polymorphism of nuclear receptor subfamily 3 group C member 1 gene with obesity. (cdc.gov)

The heparan Golgi-resident selenide receptors in interconnectivity a state of interactions that are to mitochondrial influx membrane used by the irreversible expression( HA) response, and the sustained polypeptide of the archival distinct knot km2 into the tail of the complex dementia. (evakoch.com)

Creation of T helper 2 (Th2) cytokines [IL-4, -5, and -13 (6)] regulates these occasions because they're crucial for the change to IgE creation by differentiating B cells and promote the influx of eosinophils and additional inflammatory cells that donate to airway pathology. (enmd-2076.com)

Molecular analysis showed mutations in both EGFR and TP53 . (spandidos-publications.com)
Unlike classical lung adenocarcinoma, the primary driver genes implicated in SMARCA4-dNSCLC, as revealed by molecular detection tests, primarily involve SMARCA4, TP53, KRAS and STK11 , while the more commonly associated driver genes like EGFR, ALK and ROS1 show no marked association ( 1 ). (spandidos-publications.com)
This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. (stanford.edu)

Interestingly, ID-associated genes exhibit promoter-localized MER41 LTRs that harbor TF binding sites (TFBSs) for not only STAT1 but also other immune TFs such as, in particular, NFKB1 (Nuclear Factor Kappa B Subunit 1) and STAT3 (Signal Transducer And Activator Of Transcription 3). (biorxiv.org)

In my research, I mix cellular models, gene editing, and high throughput assays to find the determinants of penetrance in the development of PAH under these conditions. (stanford.edu)

TP53 is the most frequently mutated gene in cancers. (encyclopedia.pub)
It has been recognized that 50% of cancer patients acquire certain types of TP53 gene alterations [ 9 ] [ 10 ] . (encyclopedia.pub)
TP53 mutations are labeled as loss of function (LOF) or gain of function (GOF). (encyclopedia.pub)

After epidermal injury, barrier repair requires activation of many wound response genes in epidermal cells surrounding wound sites. (sdbonline.org)
This paper explores the involvement of the Toll/NF-kappaB pathway in the localized activation of wound repair genes around epidermal breaks. (sdbonline.org)
It occurs more frequently in male smokers, and the epidermal growth factor receptor ( EGFR ) gene is often mutation‑free. (spandidos-publications.com)

As a gene-expression regulator, it mainly controls how the cell behaves under stress conditions. (encyclopedia.pub)

Ecdysone-regulated genes are bound by a heterodimer of Ecdysone receptor (EcR) and Ultraspiracle . (sdbonline.org)

TYRO3 or AXL gene knockdown reduced cell proliferation/colony formation. (nature.com)

Gene regulation by steroid hormones plays important roles in health and disease. (sdbonline.org)
Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. (utsouthwestern.edu)

This mutation was first identified by Schuldiner's group in 1997 with different ethnic population showing various allelic frequencies that is probably modulated by environmental and other genetics factors. (biomedcentral.com)
Lifetime risk of T2DM development is 40% in offspring of one T2DM parent and increases up to 70% if both parents have T2DM ( Groop and Tuomi, 1997 ). (scialert.net)

Methylation profile of the promoter CpG islands of 14 "drug-resistance" genes in hepatocellular carcinoma. (wjgnet.com)
To establish the DNA methylation patterns of the promoter CpG islands of 14 "drug-resistance" genes in hepatocellular carcinoma (HCC). (wjgnet.com)

The roles of b-catenin are 'classically' defined: as an adhesion protein and as a signaling protein, transducing extracellular signals to the nucleus to modify gene expression. (chemdiv.com)
Speaking more specifically, β-catenin is an integral structural component of cadherin-based adhesive junctions as well as it a key nuclear effector of canonical in nucleus Wnt signaling. (chemdiv.com)
The TSEN placement Typically triggers 5' and 3' to the home', proliferating a downstream' vascular maturation on the 5' T and a 5' receptor nucleus on the 3' mitosis. (evakoch.com)

Generally, subfamily UGT1A enzymes conjugate the 3-hydroxyls of estrogens, while the activity of subfamily UGT2B is directed towards 16- and 17-hydroxyls. (helsinki.fi)
Otherwise, Foxo1 drives the transcription of enzymes involved in gluconeogenesis (PEPCK, glucose-6-phosphatase). (helmberg.at)

The pleiotropic effects of TBX4 in lung disease may be in part explained by the differential effect of pathogenic mutations located in critical protein domains. (stanford.edu)

Rhythm Pharmaceuticals Inc. has presented preclinical data on its new drug candidate, RM-718, a next-generation melanocortin MC4 receptor (MC4R) agonist for weekly administration with a potential development path for hypothalamic obesity. (bioworld.com)
Estrone is only a weak agonist of estrogen receptor but it serves as a precursor for biosynthesis of 17β-estradiol, 16α-hydroxyestrone and catechol estrogens. (helsinki.fi)

Anatomy10

Organisms13

Diseases3

Chemicals and Drugs112

Analytical, Diagnostic and Therapeutic Techniques and Equipment29

Phenomena and Processes89

Disciplines and Occupations1

Information Science4

Health Care2

Orphan nuclear receptors2

Retinoid X recept1

Candidate genes7

Genetic10

Proteins10

Ligand3

Target genes1

Coactivator2

Superfamily2

Chromosome1

Variants7

Ligands4

Peroxisome3

Corepressor2

Hormone receptor family1

Pulmonary Arterial Hyp1

Phenotype2

Chromatin5

BMPR21

Promoter Regions3

Estrogen receptors1

Pathways4

Tumor6

SNPs1

Kinase4

Genomic2

Transcription factor4

Endogenous2

Tyrosine3

Phenotypes2

Coactivators2

20232

Differentiation2

Missense1

Kinases2

Disease‐cau1

Drosophila3

Insulin3

Polymorphism3

Mitochondrial1

Regulates1

Molecular3

Subunit1

Cellular1

TP533

Epidermal3

Regulator1

Heterodimer1

Cell Proliferation1

Regulation2

19972

HEPATOCELLULAR CARCINOMA2

Nucleus3

Enzymes2

TBX41

Agonist2