Galactoside 3(4)-L-fucosyltransferase is an enzyme that in humans is encoded by the FUT3 gene. (wikipedia.org)
The mutations of fucosyltransferase genes α(1,2)-fucosyltransferase (FUT2 or Se) and α(1,3/1,4)- fucosyltransferase (FUT3 or Le), are responsible for the polymorphism of Lewis blood group phenotypes. (tmu.edu.tw)
The Lewis gene (FUT3) is linked to Se (FUT2) and H (FUT1), all located on chromosome 19. (keepnotes.com)
Secretor6
In secretor-fed infants, the relative abundance of the Bifidobacterium longum group was most strongly correlated with high percentages of the order Bifidobacteriale s. (biomedcentral.com)
Conversely, in non-secretor-fed infants, Bifidobacterium breve was positively correlated with Bifidobacteriale s, while the B. longum group was negatively correlated. (biomedcentral.com)
Known as the 'secretor' gene because of its role in the expression of ABO blood types in various secreted body fluids (tears, saliva, breast milk, and so on), this gene has well-known mutations that inactivate transferase activity which occur in most populations across the world, including in about 20% of the population of the United States [ 21 ]. (biomedcentral.com)
The synthesis of Lewis antigens depends on the interaction of the transferases produced by the Lewis and secretor genes. (keepnotes.com)
The Lewis and secretor transferases preferentially fucosylate type 1 chains, whereas the H gene (FUT1) preferentially fucosylates type 2 chains. (keepnotes.com)
o The Lewis fucosyltransferase (FuT 3) is more active than the secretor fucosyltransferase (FuT 2) in newborns, so more type 1 chains are available for conversion to Lea. (keepnotes.com)
Antigens11
Immunocytochemical analysis of the 3-D cultures also showed no detectable presence of histo-blood group antigens that participate in NV binding and host tropism. (cdc.gov)
FUT2 encodes an enzyme that produces histo-blood group antigens (HBGA) on the surface of epithelial cells and in mucosal secretions ( 21 , 22 ). (cdc.gov)
It is based on the premise that individuals have antigens on their red blood cells (RBCs) that correspond to the four main blood groups: A, B, O, and AB. (medscape.com)
Antibodies (isohemagglutinins) in an individual's plasma are directed against blood group antigens that their own RBCs lack (see Table 1, below). (medscape.com)
These are the different transferases necessary to produce the various ABO antigens (mainly glycolipoproteins) on blood components. (medscape.com)
this gene encodes for the transferases necessary to produce ABO antigens (mainly glycoproteins) that are affiliated with bodily fluids other than blood (eg, saliva). (medscape.com)
Development of Lewis antigens o Depending on the genes inherited, Lea and Leb glycoproteins will be present in the saliva of ewborns, but Lewis glycolipids are not detectable in the plasma until about 10 days after birth. (keepnotes.com)
o Lewis antigens will start to appear shortly after birth, with Lea developing first when the Le gene is present. (keepnotes.com)
Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (lookformedical.com)
FUT23
The methods used in this study are clinically applicable in population studies of the FUT2 gene polymorphism to explore relationships among different ethnic groups and correlations between phenotype and genotype. (tmu.edu.tw)
A major finding from human NV volunteer studies is that persons with strains containing 2 mutated alleles of the α(1,2) fucosyltransferase ( FUT2 ) gene were resistant to NV infection ( 16 - 20 ). (cdc.gov)
Among the genes that build HMGs in the mammary gland is the fucosyltransferase 2 (FUT2) gene, which catalyzes the transfer of fucose residues by an α1,2-linkage to glycans found in human milk. (biomedcentral.com)
Encodes an enzyme1
It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. (wikipedia.org)
Gene7
This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. (wikipedia.org)
Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. (wikipedia.org)
Isolation of a novel human alpha (1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group alpha (1,3/1,4)fucosyltransferase gene. (wikipedia.org)
The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X, an E-selectin ligand. (antibodypedia.com)
Mutations in this gene are a cause of fucosyltransferase-6 deficiency. (antibodypedia.com)
Bone marrow & Lymphoid tissues Brain Breast and female reproductive system Connective & Soft tissue Endocrine tissues Eye Gastrointestinal tract Kidney & Urinary bladder Liver & Gallbladder Lymphoid Male reproductive system Muscle tissues Myeloid Pancreas Proximal digestive tract Respiratory system Skin * nTPM: Normalized TPM levels represent consensus gene expression calculated using two data sets. (antibodypedia.com)
Enzyme2
DNA samples were studied by polymerase chain reaction and then by a restriction enzyme digestion method to distinguish wild-type and six known mutations. (tmu.edu.tw)
Alpha-2-L-fucosyltransferase is the enzyme responsible for adding fructose to the primary galactose of the oligosaccharide chain. (medscape.com)
Precursor1
HBGA are complex carbohydrates distinguished by different monosaccharides added to a precursor oligosaccharide by fucosyltransferase enzymes ( 2 3, 24 ). (cdc.gov)
Genes2
Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. (wikipedia.org)
Genome-wide comparison between healthy nonsmokers (n = 60) grouped as "high MUC5AC expressors" vs "low MUC5AC expressors" identified 528 genes significantly up-regulated and 15 genes significantly down-regulated in the high vs low expressors. (biomedcentral.com)
Specificity1
These antibodies have been verified by Relative expression to confirm specificity to Blood Group Lewis A. Find the Blood Group Lewis A antibody that fits your needs. (thermofisher.com)
Histo-blood2
The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. (wikipedia.org)
BACKGROUND: The human Lewis histo-blood group system belongs to a family of structurally related oligosaccharides. (tmu.edu.tw)
Tissues1
Extracellular vesicle DNA from human melanoma tissues contains cancer-specific mutations. (gu.se)
Phenotype2
They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. (wikipedia.org)
o As a result, cord blood and RBCs from newborn infants phenotype as Le(a -b-). o Some can be shown to be weakly Le(a+) when tested with a potent anti-Lea or with methods more sensitive than direct agglutination. (keepnotes.com)
Fucose1
L-Fucose, is a dietary sugar that has been showed to effectively ameliorate central nervous system injuries, but its potential for ameliorating ENS damage and the involvement of ENPCs in this process remains uncertain. (bvsalud.org)
Antibodies4
Antibodies that detect Blood Group Lewis A can be used in several scientific applications, including Immunohistochemistry, Immunocytochemistry, Flow Cytometry, ELISA and SDS-PAGE. (thermofisher.com)
These antibodies target Blood Group Lewis A in Human, Mouse samples. (thermofisher.com)
Our Blood Group Lewis A monoclonal and polyclonal antibodies are developed in Mouse and Rabbit. (thermofisher.com)
These individuals are known as Bombay and are able to receive only Bombay type blood, because they make antibodies to not only type A, B, or AB donor RBCs but also to type O donor red cells (anti-H), causing hemolysis of the transfused donor RBCs. (medscape.com)
In the human gastroduodenal junction where NV has been shown to bind HBGA type 1 (Lewis b [Le b ]), is found exclusively on epithelial surfaces, whereas HBGA type 2 is primarily found at the glandular level ( 19 , 24 - 26 ). (cdc.gov)
ABO grouping is a test performed to determine an individual's blood type. (medscape.com)
Type O blood is the most frequent, and type B and AB are the least frequent (see Table 2, below). (medscape.com)
A type and cross needs to be completed before blood is issued to prevent ABO incompatibility. (medscape.com)
Gastrointestinal1
BACKGROUND: Diabetes can lead to extensive damage to the enteric nervous system (ENS), causing gastrointestinal motility disorders. (bvsalud.org)
Development1
The lack of an efficient cell culture system in which to study NoV infections has hindered development of antiviral drugs to control or limit NoV outbreaks ( 5 ). (cdc.gov)
Found1
We found that VE was similar by age group, presence of underlying health conditions, and pregnancy status on the test date, as well as among immunocompromised participants. (cdc.gov)
Donor1
ABO testing is performed to prevent an adverse transfusion reaction that could be caused by ABO incompatibility between the blood of a patient (recipient) and that of a donor. (medscape.com)
Production1
These two groups are both involved in the production of short-chain fatty acids and lactate, which alter the pH of the environment, modulate the microbiota, and have other systemic properties [ 19 ]. (biomedcentral.com)