Gene Knockdown TechniquesRNA InterferenceRNA, Small InterferingPoint MutationMutation, MissenseMutationZebrafishLentivirusZebrafish ProteinsFrameshift MutationCell Line, TumorMorpholinosGene SilencingBase SequenceGerm-Line MutationCell LineEmbryo, NonmammalianMolecular Sequence DataGenetic VectorsAnimals, Genetically ModifiedTransfectionSignal TransductionOligonucleotides, AntisenseRNA, MessengerPedigreeGreen Fluorescent ProteinsGene Expression Regulation, DevelopmentalGene Expression RegulationGenetic TechniquesCell ProliferationCells, CulturedReverse Transcriptase Polymerase Chain ReactionDoxycyclinePhenotypeGene TargetingMutation RateTranscription FactorsApoptosisExonsPromoter Regions, GeneticAmino Acid SubstitutionHeterozygoteBlotting, WesternHeLa CellsRNA, Double-StrandedPolymerase Chain ReactionDown-RegulationGene ExpressionDNA Mutational AnalysisAllelesAmino Acid SequencePhosphorylationCell MovementTransgenesMutagenesis, Site-DirectedPolymorphism, Single-Stranded ConformationalCell DifferentiationLarvaModels, BiologicalProtein-Serine-Threonine KinasesMice, TransgenicMice, Inbred C57BLCell SurvivalCodon, NonsenseMice, KnockoutGenotypeHomozygoteMutagenesisSequence Analysis, DNAProtein BindingProtein Structure, TertiaryDNA PrimersDisease Models, AnimalGenes, RecessiveDNA-Binding ProteinsMembrane ProteinsSequence DeletionGenes, DominantNuclear ProteinsNeuronsGenetic TestingBinding SitesTime FactorsHEK293 CellsSuppression, GeneticEscherichia coliSequence Homology, Amino AcidTranscription, GeneticModels, MolecularChromosome MappingGene DeletionFlow CytometryCarrier ProteinsCodonMutant ProteinsGenetic Complementation TestCloning, MolecularSequence AlignmentGenes, p53Gene Expression Regulation, Neoplastic