• Tropical spastic paraparesis (TSP), is a medical condition that causes weakness, muscle spasms, and sensory disturbance by human T-lymphotropic virus resulting in paraparesis, weakness of the legs. (wikipedia.org)
  • Some of the signs of Tropical spastic paraparesis are: Leg instability Urinary dysfunction. (wikipedia.org)
  • In Tropical spastic paraparesis, HTLV-1 shows elevated cellular acquired immune response as well as high production of proinflammatory cytokines. (wikipedia.org)
  • Among the methods of diagnosing tropical spastic paraparesis are MRI (magnetic resonance imaging) and lumbar puncture (which may show lymphocytosis). (wikipedia.org)
  • A synthetic derivative, 17-alpha-ethinyltestosterone, can be used to treat Tropical spastic paraparesis, improvement in motor and bladder function was reported but not sustainable. (wikipedia.org)
  • Mogamulizumab, an anti-CCR4 IgG1 monoclonal antibody, is also being researched as a possible treatment for Tropical spastic paraparesis. (wikipedia.org)
  • The prognosis for Tropical spastic paraparesis indicates some improvement in a percentage of cases due to immunosuppressive treatment. (wikipedia.org)
  • For several decades, the term tropical spastic paraparesis was used to describe a chronic and progressive clinical syndrome that affected adults living in equatorial areas of the world. (wikipedia.org)
  • medical citation needed] Tropical myeloneuropathies are classified as two separate syndromes: tropical ataxic neuropathy (TAN) and tropical spastic paraparesis (TSP). (wikipedia.org)
  • They are placed together because they are found in tropical countries, although tropical spastic paraparesis has occurred in temperate countries (e.g. (wikipedia.org)
  • In order to better understand and manage HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP), a rare virus-induced neurodegenerative disease, we have established a registration system known as HAM-net to gather data from patients all over Japan. (biomedcentral.com)
  • Clinically, intellectual disability (ID), axial hypotonia and spastic paraparesis stood out in 4/4 and cerebellar symptoms in 2/4. (bvsalud.org)
  • A 29-year-old man was admitted on November 25, 2009, because of a progressive spastic paraparesis which had proceeded over the previous 2 months. (openventio.org)
  • Spastic paraparesis was observed. (openventio.org)
  • A 34-year-old white male was admitted to São Paulo University Hospital in Ribeirão Preto, for investigation of spastic paraparesis. (scielo.br)
  • Whereas all patients showed clinical signs of spastic paraparesis, MEPs were normal in 27% of patients and revealed a broad spectrum with axonal or demyelinating features in the others. (biomedcentral.com)
  • Diagnostic criteria for HSP included (i) spastic paraparesis or spastic tetraparesis with legs earlier and more severely affected than arms or (ii) spastic paraparesis as early and prominent sign of a neurodegenerative multisystem disease after exclusion of other causes. (biomedcentral.com)
  • To exclude secondary forms of spastic paraparesis standard diagnostic procedures covered MRI of head and spine, vitamin B12 and folic acid levels, very long chain fatty acids (VLCFA), neurometabolic screening (Krabbe disease, metachromatic leukodystrophy, GM1-gangliosidosis, GM2-gangliosidoses Tay Sachs and Sandhoff, Gaucher disease) and cerebrospinal fluid analysis. (biomedcentral.com)
  • The prevalence rates of the other less common neurological disorders were 62 for hemiparesis (15 of which were for cerebrovascular accidents), 20 for cerebral palsy, 16 for optic atrophy, 12 for perceptive deafness, 10 for tropical spastic paraparesis, 7 for Parkinson's disease and 5 for motor neuron disease, ataxia and chorea/athetosis. (nih.gov)
  • Bulbar signs, ataxia, palatal myoclonus, spastic paraparesis with hyperreflexia, and autonomic dysfunction are the most observed clinical manifestations. (biomedcentral.com)
  • This pedigree was also affected by familial spastic paraparesis, a rare neurodegenerative disorder of the central motor system characterized by progressive spasticity of the lower limbs. (alzforum.org)
  • Spastic paraparesis and AD co-occurred, but also appeared separately. (alzforum.org)
  • A rare genetic autosomal recessive spastic ataxia disease with characteristics of the onset in early childhood of spastic paraparesis, cerebellar ataxia, dysarthria and optic atrophy. (nih.gov)
  • HSMN with spastic paraparesis, or HSMN with optic atrophy) and/or patterns of inheritance (i.e. (neuroophthalmology.ca)
  • [ 4 ] HSP is also called familial spastic paraparesis and Strümpell-Lorrain syndrome. (medscape.com)
  • She has a spastic gait disturbance, mental retardation, and extrapyramidal symptoms. (medscape.com)
  • As many of you know, I was originally diagnosed with the upper motor neuron disorder, hereditary spastic paraplegia, but a change in symptoms, no family history, and ambiguous. (alsforums.com)
  • My current diagnosis is hereditary spastic paraplegia, but I have no family history of it and my symptoms don't really. (alsforums.com)
  • Patients with late-onset spastic paraplegia should be screened for underlying leukodystrophies, irrespective of the presence of additional complicating symptoms and neuroimaging abnormalities. (dovepress.com)
  • It is clinically imperative to suspect this disease in children with early-onset spastic paraparesis, especially in cases accompanied by baseline development delay or cognitive impairment and consanguinity. (pediatricneurosciences.com)
  • The clinical presentation is characterized by a combination of symptoms and signs, including lower back pain (LBP), radicular pain, lower extremities weakness, reduced deep tendon reflexes, saddle/perianal sensory deficits, bowel, bladder, and sexual dysfunction ( 2 ). (iiarjournals.org)
  • We present a series of 5 patients who experienced low back pain, progressive numbness, weakness and even paraparesis. (unboundmedicine.com)
  • The patient complained for the first time of symptoms of stiffness and weakness of legs. (openventio.org)
  • In the past, HSP was also classified as type I or type II, based on the patient's age at the onset of symptoms and on the amount of spasticity versus weakness. (medscape.com)
  • GBS diagnosis may be challenging in the early stages of the illness, particularly if reflexes are still intact if the weakness is not spread in the characteristic pattern (for instance, in patients with paraparesis). (drpoornimashah.com)
  • GBS can have variable presentations, including gait disturbance, pain, weakness, rapidly ascending symmetric flaccid muscle paralysis, areflexia with a distal predominance (involving lower motor neurons), sensory disturbance, and variable autonomic involvement, increased cerebrospinal fluid protein without pleocytosis [ 1 ]. (biomedcentral.com)
  • True muscle weakness is a primary symptom of a variety of skeletal muscle diseases, including muscular dystrophy and inflammatory myopathy. (rxharun.com)
  • A general term referring to a mild to moderate degree of muscular weakness, occasionally used as a synonym for PARALYSIS (severe or complete loss of motor function). (bvsalud.org)
  • Conclusions: In our series, KAND encephalopathy had a predominant neurodegenerative disorder phenotype with global developmental delay, gait delay, and progressive spasticity of the lower limbs, cerebellar atrophy, and/or involvement of the visual cortex, which in one case was associated with sensory-motor polyneuropathy. (bvsalud.org)
  • Mild or moderate loss of motor function accompanied by spasticity in the lower extremities. (nih.gov)
  • Approximately 15% of patients follow a primary progressive or progressive relapsing course from disease onset, usually characterized by symptoms of progressive myelopathy (gait instability, spasticity, bladder symptoms) and cognitive impairment. (medscape.com)
  • A 4-year-old boy firstborn to third-degree consanguineous parents of north Indian origin presented with progressive spasticity of lower limbs and regression of acquired motor milestones from 1 year of age. (pediatricneurosciences.com)
  • Troyer syndrome: a combination of central brain abnormality and motor neuron disease? (medlineplus.gov)
  • The patient was diagnosed with "suspect motor neuron disease" and was treated with IVIG cycles with slight initial improvement, but later lack of response and worsening of the clinical condition. (doctorsmedicalopinion.com)
  • MRI may be performed on the brain and spinal cord to check for abnormalities such as spinal cord degeneration and other potential causes of symptoms. (wikipedia.org)
  • Depending on its pathogenesis, spinal cord disease can manifest with variable impairment of motor , sensory, or autonomic function. (medscape.com)
  • The spinal nerves consist of the sensory nerve roots, which enter the spinal cord at each level, and the motor roots, which emerge from the cord at each level. (medscape.com)
  • Because symptoms of a spinal cord injury are not always immediately visible following an accident or traumatic event, it is critical to seek medical attention as soon as possible. (boettcherlawoffice.com)
  • Typical symptoms of relapses may be referable to demyelinating pathology involving the optic nerves (e.g. optic neuritis), brainstem (e.g. internuclear ophthalmoplegia) or spinal cord (e.g. partial myelitis), although non-specific symptoms referable to the cerebral hemispheres or other brain regions can also occur (Katz Sand and Lublin, 2013). (medscape.com)
  • Symptoms typically consist of a progressive myelopathy associated with increasing degrees of paralysis (e.g., quadriparesis/plegia, paraparesis/plegia). (surgicalneurologyint.com)
  • Other manifestations were urinary incontinence, sensory-motor polyneuropathy, and behavioral alteration. (bvsalud.org)
  • Both rapid progressors and very rapid progressors exhibited several statistically significant traits compared to the other patients: older when motor symptoms first manifested, older when first diagnosed, higher OMDS, higher HAQ-DI score, shorter gap between disease onset and diagnosis, and shorter disease duration from onset to present day. (biomedcentral.com)
  • Any one of these three signs and symptoms should suggest Ménière's disease or other labyrinthine disease as well as eighth nerve pathology. (checkorphan.org)
  • Charcot-Marie-Tooth disease, or hereditary sensory and motor neuropathy (HSMN), is a clinically and genetically heterogenous disorder affecting the peripheral motor and sensory nerves. (neuroophthalmology.ca)
  • Have a length of disease duration since PMS disease symptom onset =10 years if baseline EDSS =5.0 and =15 years if baseline EDSS >5.0. (who.int)
  • Infected patients may also have symptoms of autonomic dysfunction leading to constipation and, in some cases, sexual dysfunction. (medscape.com)
  • Hi all, I usually post in the PLS section since I've been diagnosed with a pure upper motor neuron disorder, but I wanted to post this here. (alsforums.com)
  • On neurological examination, cranial lumbar vertebral pain, hind limb cross-extensor reflex, delayed hindlimb postural reaction, upper motor neuron bladder dysfunction, and total absence of cutaneous trunci reflex were identified. (e-jvc.org)
  • The child seemed to have had relatively normal motor dexterity in all four limbs but abnormal tendon reflexes. (grin.com)
  • Similarly to Case 1, he had relatively normal motor dexterity in all four limbs, but had abnormal tendon reflexes. (grin.com)
  • 53-year-old male with lower motor neuropathy affecting all 4 limbs. (doctorsmedicalopinion.com)
  • Unlike the other two cases, he had bladder incontinence, difficulty speaking, and motor-dexterity problems. (grin.com)
  • Case report: Four patients are described, aged 1-13 years, with a median onset of symptoms of 5 months (IQR 0-11 months), which represents an approximate prevalence of 1 per 64,000 children under 14 years of age for our pediatric population. (bvsalud.org)
  • Electrophysiological abnormalities correlated with the severity of clinical symptoms. (biomedcentral.com)
  • Motor examination shows, on inspection, abnormalities of the calf and feet (shown below). (neuroophthalmology.ca)
  • NCS reveals demyelination symptoms in AIDP patients, such as delayed distal motor latency, decreased nerve conduction velocity, prolonged F-wave latency, increased temporal dispersion, and conduction block. (drpoornimashah.com)
  • The epidural levobupivacaine and morphine infusion were stopped, followed by motor block resolution. (jccm.ro)
  • Adrenomyeloneuropathy" (AMN) occurs in patients aged 21-37 years, and results in progressive neuropathy and paraparesis. (grin.com)
  • Voo I, et al: Hereditary motor and sensory neuropathy type VI with optic atrophy. (neuroophthalmology.ca)
  • Tonusin S, Malasao R, Mizuguchi M, et axonal motor neuropathy and mod- al. (cdc.gov)
  • Its rapid recognition in a patient with new-onset neurological symptoms and early treatment with hyperbaric oxygen therapy allows rapid clinical and imaging resolution and an improved prognosis. (jccm.ro)
  • Early signs and symptoms of these illnesses are nonspecific or mimic other illnesses, which can make diagnosis challenging. (cdc.gov)
  • People with Troyer syndrome can experience a variety of signs and symptoms. (medlineplus.gov)
  • The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition. (medlineplus.gov)
  • The reported pedigree contains seven affected individuals over three generations with symptoms typical of early onset AD, with onset ranging from 39 to 50 years of age. (alzforum.org)
  • Some mild symptoms of a concussion can include vision and hearing problems, headaches, and mild confusion. (augerlaw.com)
  • The initial symptoms may be limited to LBP and paresthesia, but the prolonged neuropathic damage may become irreversible, severely affecting patients' quality of life ( 8 ). (iiarjournals.org)
  • Serious neurological toxicity (including irreversible paraparesis and quadraparesis) has been reported in patients who received LEUSTATIN Injection by continuous infusion at high doses (4 to 9 times the recommended dose for Hairy Cell Leukemia). (nih.gov)
  • On average, these patients were 63.2 years old, had experienced their first symptoms at age 44.2, and were diagnosed at age 51.3. (biomedcentral.com)
  • Fifty-four of the patients were deemed "rapid progressors," defined as a patient who progressed from the onset of motor symptoms to at least OMDS 5 within two years, and 15 of those were "very rapid progressors," defined as those who reached at least OMDS 6. (biomedcentral.com)
  • Le présent article décrit les manifestations cliniques, le diagnostic et la prise en charge de la schistosomiase médullaire chez cinq patients admis dans les hôpitaux Shaab et Ibn Khaldoun de Khartoum entre 1997 et 2007. (who.int)
  • We set out for an electrophysiological characterisation of motor and sensory tracts in patients with HSP. (biomedcentral.com)
  • To analyse the spread of long fibre tract affection in HSP and to explore potential effects of different pathomechanisms in distinct genotypes we studied motor and sensory involvement of the central and peripheral nervous system by clinical and electrophysiological means in a representative cohort of HSP patients. (biomedcentral.com)
  • The purpose of this study is to evaluate the safety and efficacy of zilganersen (ION373) in improving or stabilizing gross motor function across the full range of affected domains in patients with AxD. (stanford.edu)
  • The clinical presentation is often nonspecific with symptoms including headache Headache The symptom of pain in the cranial region. (lecturio.com)
  • Often, the diagnosis process is based on symptoms and one's risk of exposure to the virus. (wikipedia.org)
  • Early diagnosis and timely intervention are critical to prevent symptom progression and, when feasible, promote neurological recovery ( 3 , 4 ). (iiarjournals.org)
  • Thoracolumbar spinal magnetic resonance imaging (MRI), neurophysiologic studies such as motor evoked potential (MEP) or somatosensory evoked potential (SSEP), and dynamic thoracolumbar lateral radiography were performed, and a final diagnosis of lower thoracic degenerative spondylolisthesis was made. (unboundmedicine.com)
  • Diagnosis should be made properly, especially because symptoms/signs cannot be explained purely on the basis of the available images. (unboundmedicine.com)
  • Whereas HSP is primarily considered as an upper motoneuron disorder, our data suggest a more widespread affection of motor and sensory tracts in the central and peripheral nervous system as a common finding in HSP. (biomedcentral.com)
  • At his last clinical evaluation, 9 months after hospitalization, the patient's motor skills had clearly improved. (cdc.gov)
  • Additionally, Case 3 is different from the other two cases in that the symptoms arose much later in the patient's life. (grin.com)
  • The patient's symptoms temporarily improved and then worsened again. (e-jvc.org)
  • The area postrema syndrome consists of uncontrollable vomiting, brain stem lesions, and weight loss symptoms and has been reported in association with inherited white matter disorders such as AxD [ 4 ]. (biomedcentral.com)
  • However, with the use of thoracolumbar orthosis, his symptoms/signs stabilized, although partial lower leg myelopathy was present. (unboundmedicine.com)
  • Exacerbations alternate with remissions, when partial or full recovery occurs or symptoms are stable. (msdmanuals.com)
  • The patient recalled a tick bite after a walk in a forest in his neighborhood 2 weeks before symptom onset. (cdc.gov)
  • The patient went through a severe motor polyradiculitis and was using a wheelchair at discharge. (cdc.gov)
  • Here, we report clinical improvement of an AxD type II patient who presented area posterma-like symptoms. (biomedcentral.com)
  • However, their symptoms continued to progress, even after conservative treatments or lumbar surgeries. (unboundmedicine.com)
  • They presented with symptoms and signs due to cord compression at the lower thoracic and lumbar vertebrae. (who.int)
  • Introducción: La encefalopatía KIF1A-associated-neurological-disorder (KAND) es un grupo de patologías neurodegenerativas progresivas de diversa gravedad ocasionadas por mutaciones en el gen KIF1A (kinesin family member 1A) situado en el cromosoma 2q37.3. (bvsalud.org)
  • To summarize the clinical aspects of X-ALD, this disorder does not have one set of symptoms, but rather a unique set for each of its phenotypes. (grin.com)
  • However, one must note that these are not perfectly discrete forms of the disorder, as symptoms can differ from case to case. (grin.com)
  • The mode of inheritance cannot be used to predict the severity of the disorder, however, because symptoms can vary greatly within each type. (medscape.com)
  • L2-S2 provide motor control to lower extremities and related muscles. (medscape.com)
  • Case 2 presented with more severe symptoms. (grin.com)
  • A 10-year-old neutered male Siberian Husky presented with paraparesis and severe lethargy. (e-jvc.org)
  • A 10-year-old neutered male Siberian Husky dog presented to the Veterinary Medical Teaching Hospital of Chungnam National University with severe lethargy and two months of paraparesis. (e-jvc.org)
  • Preceding nonspecific infection or triggering factors like trauma, surgery, or vaccination, are frequently associated with GBS, usually a few days to weeks before neurological symptoms. (biomedcentral.com)
  • Also typical of the hereditary sensory and motor neuropathies is the predominance of motor symptoms over sensory, despite electrophysiological evidence of both motor and sensory involvement. (neuroophthalmology.ca)
  • instead sensory and motor amplitudes are markedly reduced in a symmetric and length dependent fashion. (neuroophthalmology.ca)