Morphogenesis tissue adhesions. Medical search. Frequent questions

The scope of the conference ranges from embryonic induction and the gastrula organizer itself to its signaling systems, cell behavior during gastrulation, morphogenesis and pattern formation. (elsevier.com)
During embryonic morphogenesis, adhesion molecules are required for selective cell-cell interactions. (rupress.org)
Here, we uncovered a mechanism of progenitor cell allocation that stems from an incomplete process of epithelial delamination that allows progenitors to coordinate their movement with adjacent extra-embryonic tissues. (elifesciences.org)
Several embryonic tissues and organs originate from small sets of progenitor cells. (elifesciences.org)
Here, we examine this question during the early stages of morphogenesis of the embryonic laterality organ, the first organ to form during vertebrate development, using the zebrafish as a model organism. (elifesciences.org)
Ephrin/EphR signaling is important in neural development and plasticity, cell morphogenesis and proliferation, cell-fate determination, embryonic development, tissue patterning, and angiogenesis. (umbc.edu)
Organogenesis: Organogenesis is the process by which organs and organ systems develop from embryonic tissues. (microbiologynote.com)
The ectodermal dysplasias (EDs) comprise a large, heterogeneous group of inherited disorders that are defined by primary defects in the development of 2 or more tissues derived from embryonic ectoderm. (medscape.com)

There are four major superfamilies or groups of CAMs: the immunoglobulin super family of cell adhesion molecules (IgCAMs), Cadherins, Integrins, and the Superfamily of C-type of lectin-like domains proteins (CTLDs). (wikipedia.org)
Cadherins are transmembrane calcium-dependent cell adhesion proteins that mediate cellular adherens junction formation and tissue morphogenesis. (ibecbarcelona.eu)
The classical cadherins mediate homophilic calcium-dependent cell adhesion and are founding members of the large and diverse cadherin superfamily. (rupress.org)
Rabbit polyclonal to CDH2.Cadherins comprise a family of Ca2+-dependent adhesion molecules that function to mediatecell-cell binding critical to the maintenance of tissue structure and morphogenesis. (logic2010.org)
Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. (embl.de)
Cadherins are a group of transmembrane proteins that serve as the major adhesion molecules located within adherens junctions. (embl.de)
Cadherins form protein complexes with cytoplasmic proteins (catenins) that convert the specific, homophilic-binding capacity of the extracellular domain into stable cell adhesion. (embl.de)
The cadherins are glycosylated transmembrane proteins that form cell adhesion complexes in various tissues. (nebraska.edu)
Cadherins are glycosylated transmembrane proteins that were initially identified as Ca 2+ -dependent cell adhesion molecules. (nebraska.edu)
In the past several years, it has become clear that in addition to providing mechanical adhesion between cells, cadherins play integral roles in tissue morphogenesis and homeostasis. (nebraska.edu)
A CATENIN protein that plays a critical role in cell adhesion and tissue morphogenesis by regulating the surface stability of C-, E-, and N- CADHERINS. (bvsalud.org)

DEGs were also enriched in human papillomavirus infections, the focal adhesion pathway, PI3K-Akt signaling pathway, and among others. (hindawi.com)
Furthermore, we identified that phosphorylation of FAK and MOB1 is decreased in Rab40c knock-out cells, which may contribute to focal adhesion site regulation by Rab40c. (life-science-alliance.org)
Thus, we propose a model where Rab40c/CRL5 regulates ANKRD28 ubiquitylation and degradation, leading to a decrease in PP6 activity, which ultimately affects FAK and Hippo pathway signaling to alter focal adhesion dynamics. (life-science-alliance.org)
Transcripts found in unfertilized oocytes also encoded a large number of proteins implicated in cell adherence, tight junction and focal adhesion, suggesting high complexity in terms of structure and cellular interactions in embryos prior to midblastula transition (MBT). (biomedcentral.com)

Knockout of E-cadherin has been associated with non-viability and abnormal epithelial morphogenesis ( 4 ). (iiarjournals.org)
Loss of cadherin-mediated adhesion has been implicated in many different steps of tumor progression such as invasion and migration, and is strongly related to cell-cell detachment and metastasis. (ibecbarcelona.eu)
We determined the crystal structure of an E-cadherin extracellular fragment in complex with a peptidomimetic compound that partially inhibits cadherin homophilic adhesion. (ibecbarcelona.eu)
His current research interests include the functional and structural characterization of different members of the Cadherin family of cell adhesion proteins and of several different classes of enzymes for diagnostic (biosensors), therapeutic (structure-based drug design) and technological (protein and enzyme engineering) applications. (ibecbarcelona.eu)
In this paper, we demonstrate a novel mechanism of adhesion, mediated by a complex of Protocadherin-19 (Pcdh19) and N-cadherin (Ncad). (rupress.org)
A hallmark feature of EMT is the downregulation of E-cadherin, a cell-cell adhesion molecule localized on the surface of epithelial cells [ 17 ]. (biomedcentral.com)
Adherens junctions are specialized forms of cadherin-based adhesive contacts important for tissue organization in developing and adult organisms. (embl.de)
Solution structure of the epithelial cadherin domain responsible for selective cell adhesion. (embl.de)
Finally, we highlight recently described fundamental processes in tissue morphogenesis and argue where and how this alpha-catenin-dependent cadherin mechanotransduction may be involved. (knaw.nl)
While the functional roles of the cadherin-catenin cell adhesion complex have been extensively investigated in epithelial cells, it is now clear that components of the complex are well expressed in central neurons at different stages during development. (nebraska.edu)
In this review, we will provide a brief overview of the cadherin superfamily, describe cadherin family members expressed in central neurons, cadherin-catenin complexes in central neurons and then focus on role of the cadherin-catenin complex in dendrite morphogenesis and synapse morphogenesis, function and plasticity. (nebraska.edu)

Cell adhesion molecules (CAMs) are a subset of cell surface proteins that are involved in the binding of cells with other cells or with the extracellular matrix (ECM), in a process called cell adhesion. (wikipedia.org)
Many proteins in adhesion plaque such as integrin, cytoskeleton proteins, proteases, protein kinases, phosphatases take part in signal transferring by co-localizing with vinculin and talin [ 3 ]. (omicsonline.org)

The blood and lymphatic vascular systems are essential for the efficient transport of oxygen, nutrients, signaling molecules, and leukocytes to and from peripheral tissues, the removal of waste products, and the preservation of fluid homeostasis. (nature.com)

Jewell's research combines immunology and biomaterials to understand the interactions between synthetic materials and immune tissues, and to design more selective therapeutic vaccines for cancer and autoimmunity. (jhu.edu)

Genes related to systems development, osteogenesis and immune system were expressed at higher levels in UCB, whereas genes related to cell adhesion, morphogenesis, secretion, angiogenesis and neurogenesis were more expressed in UC cells. (escholarship.org)
This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. (utsouthwestern.edu)

Biomaterials have been used in medicine for decades to improve the functions of tissues and organs. (omicsonline.org)
Transcriptome profiling of the early stages in Atlantic cod revealed the presence of transcripts involved in patterning and development of tissues and organs long before activation of the zygotic genome. (biomedcentral.com)
During the following segmentation stage major events in the formation of tissues and organs take place. (biomedcentral.com)
Nobel Prize winner Alexis Carrel performed numerous experiments clearly showing that tissue explants, including connective tissue and heart tissue, could be cultured in vitro preserving their characteristics for prolonged periods of time [ 2 ] supporting the notion that entire organs could be cultured in vitro. (intechopen.com)
During embryo development, naïve cell lineages undergo concurrent processes of fate specification and morphogenesis as critical steps towards the generation of differentiated tissues and organs. (elifesciences.org)
It explores the intricate cellular and molecular events that orchestrate the formation of tissues, organs, and body structures, as well as the timing and coordination of these processes. (microbiologynote.com)
Stem Cells: Stem cells are undifferentiated cells that have the ability to differentiate into various cell types and contribute to the formation and repair of tissues and organs. (microbiologynote.com)
It involves studying how genes and their interactions regulate the various processes of development, including the formation of body axes, the specification of cell fates, and the patterning of tissues and organs. (microbiologynote.com)
These cells and tissues are organized into the three-dimensional shape of organs and the entire organism by morphogenetic movements. (xenbase.org)

This important process includes changes that lead to the transient down-regulation of epithelial cell characteristics such as apical-basal polarization and organized cell-cell adhesion and the acquisition of a mesenchymal cellular phenotype, which is less adherent and more migratory ( 7 ). (iiarjournals.org)
Cell migration is a fundamental cellular function that is involved in many important biological processes, including embryological development, tissue formation, wound healing, and cancer metastasis. (life-science-alliance.org)
The Cellular Potts Model and Biophysical Properties of Cells, Tissues and Morphogenesis. (maa.org)
Thus, we reveal that incomplete delamination serves as a cellular platform for coordinated tissue movements during development. (elifesciences.org)

We found that tumors are rigid because they have a stiff stroma and elevated Rho-dependent cytoskeletal tension that drives focal adhesions, disrupts adherens junctions, perturbs tissue polarity, enhances growth, and hinders lumen formation. (ucsf.edu)

Our aim is to understand how the molecular components self-organize into meso-scale complexes that control processes as adhesion, polarization, signaling / sensing, which underlie morphogenesis of cells and tissues. (tu-dresden.de)
Understanding the underlying mechanisms of these fundamental processes can provide new approaches to tissue regeneration and therapy for diseases such as cancer. (nih.gov)
Dr. Yamada's group explores how coordination between the three-dimensional (3D) extracellular matrix of connective tissue or basement membranes, integrins, signal transduction, and cytoskeleton mediates or regulates key biological processes - cell adhesion, migration, matrix remodeling, tissue morphogenesis, and cancer cell invasion. (nih.gov)
Morphogenesis: Morphogenesis refers to the processes by which cells and tissues arrange themselves spatially to give rise to the three-dimensional structure of an organism. (microbiologynote.com)
Understanding developmental processes is crucial for elucidating the origins of birth defects, tissue regeneration, evolutionary changes, and disease mechanisms. (microbiologynote.com)

The protocadherins are the largest subgroup within this superfamily, yet their participation in calcium-dependent cell adhesion is uncertain. (rupress.org)

In this study, it was observed that the ion implantation stimulated the neural proliferation and the implantation of different ions on cell culture surfaces was essential to determine the effects of this technique on adhesion, proliferation, differentiation and apoptosis properties of cells in details. (omicsonline.org)
These early progenitor cells often travel long distances from their induction site to the site of terminal differentiation, making them vulnerable to environmental cues and movement of neighbouring tissues. (elifesciences.org)
Recent advances in live imaging and genetics of mammalian division, movement and cell differentiation leading to development which integrate observations of biochemical tissue formation [14 ]. (lu.se)

The adhesions between cultured cells and the material surface are called focal attachments or adhesion plaques. (omicsonline.org)
His main research areas are developmental biology, cell morphogenesis, adult stem cells and cardiac function analysis. (amrita.edu)
SPARC is produced by fibroblasts, capillary endothelial cells, platelets and macrophages, especially in areas of tissue morphogenesis and remodeling (3, 7). (rndsystems.com)
Dr. Yamada's research emphasizes the characterization of the dynamic movements of cells and their extracellular matrix as tissues are remodeled in 3D in real time. (nih.gov)
The biological systems studied include human primary cells migrating in 3D, human tumor cells and tissues, and mouse organ development (salivary glands, lungs, and kidneys). (nih.gov)
The levels of catalase (CAT) and glutathione (GSH) were measured in PC12 cells and Drosophila brain tissue. (sdbonline.org)
GSOs also mitigated the deleterious effects of GLU on the mitochondrial membrane potential and Cyt C release, thus alleviating mitochondrial dysfunction, and increased GSH levels and CAT activity in both cells and Drosophila brain tissue. (sdbonline.org)
Modelling Development of Complex Tissues using Individual Viscoelastic Cells. (maa.org)
Quantifying the mechanics and growth of cells and tissues in 3D using high resolution computational models. (crossref.org)
Mesenchymal stem cells (MSC) are multipotent cells which can be obtained from several adult and fetal tissues including human umbilical cord units. (escholarship.org)
Epithelial cells often leave their tissue context and ingress to form new cell types or acquire migratory ability to move to distant sites during development and tumor progression. (bvsalud.org)
During development, cells undergo changes in gene expression patterns, leading to the development of distinct cell types and tissues. (microbiologynote.com)
In addition, cell rearrangements and shape changes go along with modulation of the biomechanics properties of individual cells and tissues and an increased metabolic activity to generate the required energy. (xenbase.org)
of the most critical events which lead to tissue patterning involves mechanisms going beyond single cells. (lu.se)

Mechanical forces are increasingly recognized as central factors in the regulation of tissue morphogenesis and homeostasis. (knaw.nl)
They are critical in several cell activities, including tissue morphogenesis, homeostasis, cell migration and wound healing. (utah.edu)

Local 3D matrix microenvironment regulates cell migration through spatiotemporal dynamics of contractility-dependent adhesions. (nih.gov)
With nascent adhesion formation at the leading edge, the FAs at the cell rear need to be disassembled to promote rear end retraction and efficient cell migration. (life-science-alliance.org)
Cell Adhesion and Migration , 9 (3), 202-213. (nebraska.edu)

Adhesion by the Pcdh19-Ncad complex was unaffected by mutations that disrupt Ncad homophilic binding but was inhibited by a mutation in Pcdh19. (rupress.org)

Tumors are stiffer than normal tissue, and tumors have altered integrins. (ucsf.edu)
Because integrins are mechanotransducers that regulate cell fate, we asked whether tissue stiffness could promote malignant behavior by modulating integrins. (ucsf.edu)
Matrix stiffness perturbs epithelial morphogenesis by clustering integrins to enhance ERK activation and increase ROCK-generated contractility and focal adhesions. (ucsf.edu)
Thus, ERK and Rho constitute part of an integrated mechanoregulatory circuit linking matrix stiffness to cytoskeletal tension through integrins to regulate tissue phenotype. (ucsf.edu)

Fluctuations in actomyosin contraction are sensed by tension sensitive systems at the interface between actomyosin and cell adhesion complexes. (knaw.nl)

Basement membrane regulates fibronectin organization using sliding focal adhesions driven by a contractile winch. (nih.gov)
Btbd7 regulates epithelial cell dynamics and branching morphogenesis. (nih.gov)

They may play an important role in the sorting of different cell types during morphogenesis, histogenesis and regeneration. (embl.de)
They play a crucial role in development and are also important in adult organisms for tissue maintenance and regeneration. (microbiologynote.com)
Although some current treatment approaches offer high success rate in Endodontics, pulp regeneration may be an alternative to replace necrosed by healthy pulp tissue aiming at tooth revitalization 12 . (bvsalud.org)
Stem cell biology is an important study field to understand tissue regeneration and the implementation of regenerative medicine 11 . (bvsalud.org)

Cell-substrate adhesions are specialized regions of the plasma membrane that couple the cytoskeleton network to the extracellular environment. (utah.edu)

Most morphogenetic movements are coordinated mass cell movements, which require tight regulation of cell polarity, motility and adhesion to maintain tissue integrity during morphogenesis. (xenbase.org)
[ 8 ] Other classification systems categorize the ectodermal dysplasias based on defects in cell-cell communication and signaling, adhesion, transcription regulation, or development. (medscape.com)

They are also used as prosthesis and implants which are designed to substitute functions of a lacking organ or tissue. (omicsonline.org)

Newly formed nascent adhesions gradually grow and change their protein composition to mature into FAs. (life-science-alliance.org)
Hierarchical clustering based on protein-coding expression similarities grouped MSC according to their tissue location rather than original donor. (escholarship.org)
This protein is found in the brain and the retina, which is the specialized tissue at the back of the eye that detects light and color. (medlineplus.gov)

Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. (joplink.net)
A 3-D Deformable Ellipsoidal Cell Model with Cell Adhesion and Signaling. (maa.org)
We found that different α-Cat levels led to a differential activation of Hippo/Yorkie or JNK signaling causing tissue overgrowth or degeneration, respectively. (bvsalud.org)
α-Cat can modulate Yorkie-dependent tissue growth through recruitment of Ajuba, a negative regulator of Hippo signaling to AJs but also through a mechanism independent of Ajuba recruitment to AJs. (bvsalud.org)
We are studying different aspects of beta-catenin independent Wnt signaling in morphogenesis in Xenopus laevis. (xenbase.org)
In 2003, Lamartine reclassified the ectodermal dysplasias into the following 4 functional groups based on the underlying pathophysiologic defect: (1) cell-to-cell communication and signaling, (2) adhesion, (3) development, and (4) other. (medscape.com)

It also acts as a tumor suppressor that limits tissue growth. (bvsalud.org)

Effective cell−cell adhesion modulators may represent potential anti-angiogenic drugs or pharmaceutical excipients to improve drug delivery across biological barriers. (ibecbarcelona.eu)
The main effect of ephrin/EphR interaction is cell-cell repulsion or adhesion. (umbc.edu)

Chii Jou Chan investigates how tissue mechanics and fluid pressure regulate mammalian development, with a special focus on folliculogenesis and oocyte quality control. (rupress.org)
Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression. (ucsf.edu)

Contractile, EGF-transformed epithelia with elevated ERK and Rho activity could be phenotypically reverted to tissues lacking focal adhesions if Rho-generated contractility or ERK activity was decreased. (ucsf.edu)

Patterned cell and matrix dynamics in branching morphogenesis. (nih.gov)
In this study, we developed a multiscale model of adhesions formation based on coupling Molecular Dynamics, coarse-graining techniques and Brownian Dynamics approaches in order to study mechanisms of adhesion reinforcement. (utah.edu)

Unfortunately, the biophysical and conformational mechanisms by which adhesions reinforce in response to stress are not fully understood. (utah.edu)
These results provide important insights into the biophysical principles and mechanisms of adhesion mechanosensing, with functional consequences on both cell and tissue physiology. (utah.edu)

Although Pcdh19 alone is only weakly adhesive, the Pcdh19-Ncad complex exhibited robust adhesion in bead aggregation assays, and Pcdh19 appeared to play the dominant role. (rupress.org)

Proteína CATENINA que desempeña un papel fundamental en la adhesión celular y la morfogénesis de los tejidos mediante la regulación de la estabilidad de la superficie de las CADHERINAS C, E y N. (bvsalud.org)

Central elements of cell-substrate adhesions are transmembrane receptors, that form physical links between cell cytoskeleton and external binding partners. (utah.edu)

Recent studies have revealed the importance of long noncoding RNAs (lncRNAs) as tissue-specific regulators of gene expression. (nature.com)
These molecular differences verified in tissue-specific MSC gene expression may reflect functional activities influenced by distinct niches and should be considered when developing clinical protocols involving MSC from different sources. (escholarship.org)
During the development of a complex multicellular organism from a single fertilized oocyte cell types and tissues are specified by differential gene expression patterns. (xenbase.org)

The basis of regenerative medicine is the use of tissue regenerative therapies 14 . (bvsalud.org)

Jewell will discuss new degradable polymer depots that could improve the selectivity of therapies for autoimmune diseases such as multiple sclerosis and diabetes by locally reprogramming the function of lymph nodes - tissues that coordinate immune function. (jhu.edu)

May play a role in cell fate determination and tissue morphogenesis. (joplink.net)

They affirm that tissue engineering is "an interdisciplinary field that applies the engineering and medical science principles target to the development of biological substitutes to restore, maintain, or improve the tissue function" 13 . (bvsalud.org)

Here, we took advantage of the tension landscape in the Drosophila embryo to define three different states of α-Catenin mechanosensing in support of cell adhesion. (bvsalud.org)

CAMs are crucial components in maintaining tissue structure and function. (wikipedia.org)
Individual M region domains make complex contributions to cell adhesion through their impact on interaction partner recruitment, and redundancies with the function of Canoe. (bvsalud.org)
Tissue engineering goal is to restore some of lost tissue function through natural or synthetic reconstruction in laboratory. (bvsalud.org)

Anatomy20

Organisms6

Diseases1

Chemicals and Drugs33

Analytical, Diagnostic and Therapeutic Techniques and Equipment8

Phenomena and Processes27

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science3

Embryonic8

Cadherins11

Focal adhesion4

Cadherin11

Proteins2

Molecules1

Selective1

Angiogenesis2

Organs9

Cellular4

Adherens junctions1

Processes5

Calcium-dependent cell adhesion1

Differentiation3

Cells14

Homeostasis2

Migration3

Homophilic1

Integrins4

Complexes1

Regulates2

Regeneration4

Plasma membrane1

Regulation2

Lacking organ1

Protein3

Signaling6

Tumor1

Cell-cell2

Regulate2

Contractile1

Dynamics2

Mechanisms2

Adhesive1

Fundamental1

Cytoskeleton1

Gene expression3

Regenerative Medicine1

Immune1

Role1

Development1

Drosophila1

Function3