• These studies have mostly been performed by biologically synthesizing batroxobin from Bothrops moojeni cDNA, and analyzing this product and using homology models based on other proteases, such as thrombin and trypsin, among others. (wikipedia.org)
  • An autologous or commercial tissue adhesive containing FIBRINOGEN and THROMBIN . (nih.gov)
  • The commercial product is a two component system from human plasma that contains more than fibrinogen and thrombin. (nih.gov)
  • We evaluated the differences in the levels of fibrinogen, activated factor VII (FVIIa), thrombin-antithrombin complex (TAT), and soluble fibrin monomer complex (SFMC) during surgery between these two groups. (biomedcentral.com)
  • This complex may then generate thrombin massively during CPB despite full heparinization because of the limited thrombin-inhibiting effect and the subsequent soluble fibrin formation of heparin with antithrombin on the extrinsic coagulation pathway. (biomedcentral.com)
  • In this study, we analyzed and compared some molecular markers of coagulation activation {e.g., thrombin-antithrombin complex (TAT), soluble fibrin monomer complex (SFMC), FVIIa} during CPB between patients undergoing aortic replacement surgery and those with valve surgery. (biomedcentral.com)
  • Pechik I,Madrazo J, Mosesson MW, Hernandez I, Gilliland GL, Medved L. Crystal structure of the complex between thrombin and the central "E" region of fibrin. (ukrbiochemjournal.org)
  • Two small peptide chains removed from the N-terminal segment of the beta chains of fibrinogen by the action of thrombin. (bvsalud.org)
  • Fibrin \u0026 fibrinogen degradation products(FDP) and fibrin monomer test (FM test) were useful for diagnosis of DIC. (nii.ac.jp)
  • Owing to the parallel activation of the fibrinolytic system to maintain proper balance between coagulation and fibrinolysis, plasmin, the end product of the fibrinolytic system, cleaves insoluble fibrin polymers, resulting in the production of fibrin degradation products (FDPs). (medscape.com)
  • Batroxobin obtained from certain subspecies exhibits the hemostatic efficacy, whereas the protein obtained from other subspecies exhibits the cleavage of fibrinogen. (wikipedia.org)
  • Some of the forms have hemostatic efficacy as main effect, where the other forms have degradation of fibrinogen as main effect. (wikipedia.org)
  • Consequently, if these individuals develop thrombosis, they present with increased fibrin degradation products but undetectable plasma D-dimer levels. (medscape.com)
  • Medved L, Weisel JW, Fibrinogen and Factor XIII Subcommittee of Scientific Standardization Committee of International Society on Thrombosis and Haemostasis. (ukrbiochemjournal.org)
  • Notable features of the A chain are the N-terminal peptide (fibrinopeptide A (FPA, 1-16)), factor XIIIa crosslinking sites and 2 phosphorylation sites. (cellsystems.eu)
  • The primary fibrin polymerization pocket: three-dimensional structure of a 30-kDa C-terminal gamma chain fragment complexed with the peptide Gly-Pro-Arg-Pro. (ukrbiochemjournal.org)
  • Since there is constant minimal physiologic fibrin formation and degradation in vivo, healthy individuals have a minimal D-dimer level. (medscape.com)
  • Controlled plasmin degradation at these sites converts Fbg into fragment D and fragment E. The individual fragments are isolated by salt fractionation, gel filtration and ion exchange chromatography. (cellsystems.eu)
  • The first component contains highly concentrated fibrinogen, FACTOR VIII , fibronectin, and traces of other plasma proteins. (nih.gov)
  • Crystal structures of fragment D from human fibrinogen and its crosslinked counterpart from fibrin. (ukrbiochemjournal.org)
  • Madrazo J, Brown JH, Litvinovich S, Dominguez R, Yakovlev S, Medved L, Cohen C. Crystal structure of the central region of bovine fibrinogen (E5 fragment) at 1.4-A resolution. (ukrbiochemjournal.org)
  • Burton RA, Tsurupa G, Medved L, Tjandra N. Identification of an ordered compact structure within the recombinant bovine fibrinogen alphaC-domain fragment by NMR. (ukrbiochemjournal.org)
  • Among fibrinogen domains, two BβN-domains are formed by the N-terminal portions of its two Bβ chains including- amino acid residues Bβ1-64. (ukrbiochemjournal.org)
  • Medved LV, Gorkun OV, Privalov PL. Structural organization of C-terminal parts of fibrinogen A alpha-chains. (ukrbiochemjournal.org)
  • Medved' LV, Litvinovich SV, Privalov PL. Domain organization of the terminal parts in the fibrinogen molecule. (ukrbiochemjournal.org)
  • Gorlatov S, Medved L. Interaction of fibrin(ogen) with the endothelial cell receptor VE-cadherin: mapping of the receptor-binding site in the NH2-terminal portions of the fibrin beta chains. (ukrbiochemjournal.org)
  • Fibrinogen is a polyfunctional plasma protein involved in various physiological and pathological processes through the interaction of its multiple domains with different ligands and cell receptors. (ukrbiochemjournal.org)
  • Removal of fibrinopeptides B (amino acid residues Bβ1-14) from these domains upon fibrinogen to fibrin conversion results in the exposure of multiple binding sites in fibrin βN-domains (residues β15-64). (ukrbiochemjournal.org)
  • These sites provide interaction of the βN-domains with different proteins and cells and their participation in various processes including fibrin assembly, fibrin-dependent angiogenesis, and fibrin-dependent leukocyte transmigration and thereby inflammation. (ukrbiochemjournal.org)
  • The objective of this review is to summarize the current view of the structure and function of these domains in fibrinogen and fibrin and their role in the above-mentioned processes. (ukrbiochemjournal.org)
  • Domains in the fibrinogen molecule. (ukrbiochemjournal.org)
  • The time required for the appearance of FIBRIN strands following the mixing of PLASMA with phospholipid platelet substitute (e.g., crude cephalins, soybean phosphatides). (lookformedical.com)
  • Mixing of the two components promotes BLOOD CLOTTING and the formation and cross-linking of fibrin. (nih.gov)
  • The fragments are supplied lyophilized for storage at -20°C. Highly purified research grade fibrinogen (>95% clottable) is prepared by a combination of conventional and affinity techniques. (cellsystems.eu)
  • Malabarin is not lethal when injected i.p. or i.m. but causes extensive hemorrhage and degradation of muscle tissue within 24 hours. (uni-mysore.ac.in)