• An aberrant miRNA expression could contribute to cancer development and progression [ 6 , 7 ] and could affect their target genes that are involved in many biological processes, such as cell differentiation, proliferation, apoptosis, metabolism, and development [ 8 ]. (hindawi.com)
  • γ-Glutamyl transferase (GGT) is a family of enzymes that was shown to control crucial redox-sensitive functions and to regulate the balance between proliferation and apoptosis. (stanford.edu)
  • We show here that expression of EBF3 resulted in cell cycle arrest and apoptosis. (aacrjournals.org)
  • Cells are also programmed for death at the genetic level as a response to DNA damages through the process of apoptosis. (bdbiosciences.com)
  • Cell division, proliferation, and apoptosis and death are integral parts of life. (bdbiosciences.com)
  • The balance of cell proliferation and apoptosis is important for both development and normal tissue homeostasis. (bdbiosciences.com)
  • Apoptosis is an organized process that signals cells to self-destruct for cell renewal or to control aberrant cell growth. (bdbiosciences.com)
  • As cells become damaged or are no longer needed, they undergo apoptosis or programmed cell death, a normal physiological process that occurs during embryonic development and tissue homeostasis. (bdbiosciences.com)
  • Apoptosis controls the orderly death of damaged cells, whereas necrosis occurs as a result of tissue damage, causing the loss of both damaged and surrounding cells. (bdbiosciences.com)
  • Methods for detecting apoptosis or dead cells (viability) by cell preparation type. (bdbiosciences.com)
  • However, some cell types do not display characteristic features of apoptosis. (bdbiosciences.com)
  • In those cases, multiple aspects of apoptosis might need to be analyzed to confirm the mechanism of cell death. (bdbiosciences.com)
  • p53 participates in relevant aspects of cell biology, including apoptosis and cell cycle control and must be strictly regulated to maintain normal tissue homeostasis. (molvis.org)
  • Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. (anticorps-enligne.fr)
  • Firstly, the overexpression of miRNA‑375 significantly suppressed cell proliferation, increased lactate dehydrogenase activity and induced apoptosis in HPV‑18(+) cervical cancer cells. (spandidos-publications.com)
  • It affects cell proliferation, differentiation and inhibits apoptosis, and its role in tumor development has received attention ( 9 ). (spandidos-publications.com)
  • Overexpression of IGF-1 in serum and tissue alters the growth of normal cells and causes uncontrolled proliferation, inhibits differentiation and reduces apoptosis, resulting in the incidence and development of malignant tumors ( 10 ). (spandidos-publications.com)
  • PL was described as an anticancer compound modulating apoptosis, ROS production, cell proliferation, migration and invasion, and showing selective cytotoxic effect on several cancer cell types including pancreatic, renal, prostate, and breast cancers. (oncotarget.com)
  • Interacting with various low risk hpv cause cancer proteins, E6 and E7 influence fundamental cellular functions like cell cycle regulation, telomere maintenance, susceptibility to apoptosis, intercellular adhesion and regulation of immune responses. (ghise-ioan.ro)
  • The various markers that enable assessment of the progression of preneoplastic lesions to spindle cell carcinoma include the p16 protein, which halts the cell cycle and induces apoptosis by pRb-mediated phosphorylation of cyclin-dependent kinase 4 (CDK4). (bvsalud.org)
  • Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. (bvsalud.org)
  • and cell differentiation ( SOX2 and TGFB3 ) as well as immunohistochemical assay for VEGFA, TP53, Bcl2, TGFB1, and Ki67 protein expression have been performed in 85 FFPE RCC tumor specimens. (hindawi.com)
  • It is involved in p53 pathways and is implicated in cell death/survival signaling, the cell cycle, and differentiation, thereby playing a regulatory role in carcinogenesis [ 12 ]. (hindawi.com)
  • 3) that were divided into two major clusters corresponding to the main phases observed during the preadipocyte culture: proliferation and differentiation. (biomedcentral.com)
  • Proliferation cluster comprised 1028 genes up-regulated from days 3 to 8 of culture meanwhile the differentiation cluster was characterized by 2140 induced genes from days 15 to 21. (biomedcentral.com)
  • Overall, our study demonstrates the coordinated expression of functionally related genes during proliferation and differentiation of rainbow trout adipocyte cells. (biomedcentral.com)
  • Therefore, growth of adipose tissue includes the hypertrophy of already existing adipocytes and the proliferation and differentiation of new ones from MSCs. (biomedcentral.com)
  • It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. (anticorps-enligne.fr)
  • Differentiation involves morphogenesis but also cell-appropriate organelle biogenesis programs. (biomedcentral.com)
  • Monocot leaves, where cell proliferation and differentiation are displayed along a linear developmental gradient, provide an ideally suited experimental system to study these processes. (biomedcentral.com)
  • Differentiation subsequently occurs in leaf primordia basipetally, resulting in a gradient of easily distinguishable cellular morphologies of distal differentiated cells towards the tip of the leaf, basal progenitor proliferating cells adjacent to the shoot apical meristem, and all possible intermediate stages in between. (biomedcentral.com)
  • It is not dissimilar to the gradient of proliferation and differentiation along developing roots [ 2 ] but, in contrast, it provides a unique opportunity to study chloroplast biogenesis and differentiation. (biomedcentral.com)
  • As activation of c-myc expression promotes cell proliferation and blocks differentiation, it may positively regulate cell growth. (wdv.com)
  • Another protein, calgranulin A (Cal A), is involved in the regulation of several cell processes, including the cell cycle and cell differentiation. (bvsalud.org)
  • Cystatin A (Cys A), a cysteine protease inhibitor, is a precursor of proteins involves in keratinocyte keratinization, and is expressed during the late phase of differentiation of these cells. (bvsalud.org)
  • Its prominent properties are A lack of cell differentiation Local invasion of adjoining tissue Metastasis, which is spread to distant sites through. (msdmanuals.com)
  • Cell proliferation studies were performed by MTT assays and cell cycle analyses were performed by flow cytometry. (biomedcentral.com)
  • The proliferative ability of MCF-7 cells treated with lovastatin was reduced compared to normal, and further decreased in the presence of excess BRCA1, detected by methyl thiazolyl tetrazolium and flow cytometry techniques in vitro or by 5-bromodeoxyuridine incorporation in vivo. (nih.gov)
  • In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. (wikipedia.org)
  • This study aimed to evaluate the expression levels of miR-34a and 11 of its bioinformatically selected target genes and proteins to test their potential dysregulation in RCC. (hindawi.com)
  • Deletions of multiple GID subunits compromise cell proliferation, and this defect is accompanied by deregulation of critical cell cycle markers such as the retinoblastoma (Rb) tumor suppressor, phospho-Histone H3 and Cyclin A. We identify the negative regulator of pro-proliferative genes Hbp1 as a bonafide GID/CTLH proteolytic substrate. (elifesciences.org)
  • Loss of CK2α decreased two β-catenin-regulated genes that are involved in GBM-initiating cell growth, OCT4 and NANOG. (stanford.edu)
  • The expression of cyclin-dependent kinase inhibitors was profoundly affected with early activation and then repression of p21 cip1/waf1 and persistent activation of both p27 kip1 and p57 kip2 , whereas genes involved in cell survival and proliferation were suppressed. (aacrjournals.org)
  • p53 affects the transcription of many target genes and interacts with key cellular proteins. (molvis.org)
  • The proliferative arrest is mediated by transcriptional repression of genes essential for cell division by the retinoblastoma protein family. (biomedcentral.com)
  • Proliferation was characterized by enrichment in genes involved in basic cellular and metabolic processes (transcription, ribosome biogenesis, translation and protein folding), cellular remodelling and autophagy. (biomedcentral.com)
  • HPV-infected cells express some viral proteins encoded by genes called E6 and E7, and can inactivate p53 protein and the retinoblastoma-type pro-tein RBP involved in the regulation of proliferation and cell death. (pcmaster.ro)
  • The viral genome maintains itself as an episome in basal cells, where the viral genes are poorly expressed. (ghise-ioan.ro)
  • Retinoblastoma-like 1 (p107), also known as RBL1, is a protein that in humans is encoded by the RBL1 gene. (wikipedia.org)
  • The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. (wikipedia.org)
  • The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. (wikipedia.org)
  • Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 Large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. (wikipedia.org)
  • Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. (wikipedia.org)
  • This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. (fishersci.com)
  • It interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. (fishersci.com)
  • The purpose of this study was to investigate whether breast cancer susceptibility gene 1 (BRCA1) overexpression sensitizes mammary cancer cells to statins. (nih.gov)
  • Although the frequency of p16INK4a abnormalities is higher in tumor derived cell lines than in unselected primary tumors, significant subsets of clinical cases with aberrant p16INK4a gene have been reported among melanomas, gliomas, esophageal, pancreatic, lung, and urinary bladder carcinomas, and some types of leukemia. (neobiotechnologies.com)
  • This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. (utsouthwestern.edu)
  • The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. (anticorps-enligne.fr)
  • This allows us to generate the first biologically-informed gene expression map of this leaf, with the entire developmental gradient from meristematic to fully differentiated cells captured. (biomedcentral.com)
  • Inactivating mutations of the retinoblastoma gene (RB) are found in a wide variety of tumour cells. (wdv.com)
  • Oncotarget published " Piperlongumine promotes death of retinoblastoma cancer cells " which reported that while retinoblastoma initiation is triggered by the inactivation of both alleles of the retinoblastoma tumor suppressor gene in the developing retina, tumor progression requires additional epigenetic changes, retinoblastoma genomes being quite stable. (oncotarget.com)
  • A multi-step model for the progression of normal retina to retinoblastoma has been proposed, the first step being the inactivation of both alleles of the tumor suppressor gene RB1 in the developing retina. (oncotarget.com)
  • EZR transcript, encoding a cytoplasmic peripheral membrane protein, was used as a negative control and GAPDH was used as an internal control gene. (oncotarget.com)
  • This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. (thermofisher.com)
  • Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. (thermofisher.com)
  • Expression of p63 is almost exclusively restricted to epithelial cells, mutations in this gene are infrequent, and its expression is increased in a variety of solid tumors, particularly those of the head and neck area 12,13 . (bvsalud.org)
  • Structural and biochemical data revealed that binding of phosphorylated p27 (phosp27) to CDK4 altered the kinase adenosine triphosphate site to promote phosphorylation of the retinoblastoma tumor suppressor protein (Rb) and other substrates. (rcsb.org)
  • Palbociclib instead primarily targeted monomeric CDK4 and CDK6 (CDK4/6) in breast tumor cells. (rcsb.org)
  • Additionally, the mRNA and protein expression of cyclin D1, cyclin-dependent kinase 4 (CDK4) and retinoblastoma protein (pRb), was further down-regulated under exposure to lovastatin in condition of BRCA1 overexpression, but the expression of p21WAF1/CIP1, a cyclin-dependent kinase inhibitor (CDKI), was further up-regulated, both in vitro and in vivo detected with quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot analysis. (nih.gov)
  • Our results suggest that BRCA1 overexpression sensitizes cancer cells to lovastatin via regulation of cyclin D1-CDK4-p21WAF1/CIP1 pathway, which will provide an innovative experimental framework to study control of breast cancer cell proliferation. (nih.gov)
  • Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. (neobiotechnologies.com)
  • Cyclin D1 and CDK4/6 are downstream of signaling pathways which lead to cellular proliferation. (shu.edu)
  • Virtually all mitogenic signals to the cell are processed through CDK4/6 - it is truly the central molecule that governs pRb phosphorylation status up through the R-point transition. (shu.edu)
  • In order to enter S phase, cells must sequentially activate CDK4/6 and CDK2. (shu.edu)
  • CDK4 is a member of the Ser/Thr protein kinase family. (thermofisher.com)
  • During cell growth and proliferation, ubiquitin plays an outsized role in promoting progression through the cell cycle. (intechopen.com)
  • Progression through the cell cycle is driven by the oscillating activity of Cyclin Dependent Kinases (CDKs). (intechopen.com)
  • A series of signal transduction events starting from the activation of cyclin-dependent kinase 2 (CDK2) to binding of E2F -target transcription to phosphorylation of Rb helps maintain cell-cycle progression. (bdbiosciences.com)
  • Transforming growth factor (3(TGF-P) is a crucial mediator of mammary epithelial morphogenesis and can negatively regulate cell cycle progression. (uwo.ca)
  • However, biological and molecular mechanisms linked to cancer development after mineral fibres exposure were not fully investigated.Methods: In the present study, mesothelial (MeT-5A) and human bronchoalveolar alveolar epithelial (A549) cell lines were incubated with rising concentrations of fluoro-edenite to evaluate the expression of retinoblastoma (Rb) protein, which has been demonstrated to play an important role in cell cycle control and tumour progression. (unict.it)
  • In vitro, palbociclib reduced cellular proliferation of estrogen receptor (ER)-positive breast cancer cell lines by blocking progression of the cell from G1 into S phase of the cell cycle. (shu.edu)
  • Rb blocks cell cycle progression in G1 by binding E2F transcription factors. (shu.edu)
  • ARF and p53 can block cell cycle progression via p21Cip1. (shu.edu)
  • Microinjection of Rb in G1 phase reversibly arrests cell-cycle progression. (wdv.com)
  • It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. (thermofisher.com)
  • Conclusion: p63, p16, MIB, Cal A, Cys A are markedly expressed and p16 is strongly suppressed in oral cavity tumors, which suggests that the latter protein may play a role in negative regulation of cell cycle progression. (bvsalud.org)
  • Immunohistochemical identification of molecular genetic events in the progression of preneoplastic lesions to spindle cell squamous-cell carcinoma enables early detection of lesions with the potential for malignant progression, thus permitting timely intervention 1,2 . (bvsalud.org)
  • Treatment of senescent cells with trichostatin A, a class I/II histone deacetylase inhibitor, also induced rapid and reversible decondensation of SAHFs. (biomedcentral.com)
  • The overexpression of miRNA‑375 significantly increased caspase‑3 and caspase‑9 activities, induced B‑cell lymphoma 2 (Bcl‑2)/Bcl‑2‑associated X protein, tumor protein 53 and cyclin‑dependent kinase inhibitor 1 protein expression and suppressed cyclin D1 and survivin protein expression in HPV‑18(+) cervical cancer cells. (spandidos-publications.com)
  • In addition, numerous important cellular proteins, such as B-cell lymphoma-2 homologous antagonist/killer, Myc proto-oncogene protein, cyclin-dependent kinase inhibitor 1B, DNA replication licensing factor MCM-7, retinoblastoma 1 and Annexin A1, are degenerated through the UBE3A-mediated ubiquitin proteasome pathway ( 7 ). (spandidos-publications.com)
  • Indeed, Hbp1 accumulates in cells lacking GID/CTLH activity, and Hbp1 physically interacts and is ubiquitinated in vitro by reconstituted GID/CTLH complexes. (elifesciences.org)
  • Association of PKC beta 2 isoform with retinoblastoma protein was discovered in retinal endothelial cells , and PKC beta 2 isoform increased retinoblastoma phosphorylation under basal and VEGF -stimulated conditions. (bvsalud.org)
  • [ 4 ] These specialized sensory cells are normally found in the basal epidermis of skin and parts of mucosal surfaces derived from the ectoderm. (medscape.com)
  • Within skin, Merkel cells have also been shown to cluster in the basal layers of the interfollicular epidermis in specialized epithelial structures called touch domes, where they are juxtaposed with epidermal keratinocytes. (medscape.com)
  • [ 6 ] As they are primarily postmitotic, Merkel cells putatively have low sensitivity to oncogenic stimuli, and they are found in the basal epidermis, whereas cutaneous neuroendocrine carcinomas arise in the dermis. (medscape.com)
  • Molecular characterization of this cell line revealed low expression levels and activity of Retinoblastoma protein and elevated basal levels of Erk1/2 activity and p70S6K expression and activity, which may be related to chemoresistance mechanisms. (biomedcentral.com)
  • The virus infects basal epithelial cells of stratified squamous epithelium. (ghise-ioan.ro)
  • Schematic low risk hpv cause cancer of the HPV double-stranded circular DNA genome Journal of Virology Nov HPV integration into the host genome and Papillomavirus life low risk hpv cause cancer To establish infection, the virus must infect basal epithelial cells of stratified squamous epithelium, that are long lived or have stem cell-like properties. (ghise-ioan.ro)
  • Once inside the host cell, HPV DNA replicates as the basal cells differentiate and progress to the surface of the epithelium. (ghise-ioan.ro)
  • We also verified that inhibition of CK2α decreased the activity of a well-known GBM-initiating cell regulator, β-catenin. (stanford.edu)
  • The p27 protein is a canonical negative regulator of cell proliferation and acts primarily by inhibiting cyclin-dependent kinases (CDKs). (rcsb.org)
  • p53 E3 ubiquitin protein ligase homolog (Mdm2) is an important negative regulator of p53. (molvis.org)
  • Results: Intriguingly, these results show that Rb expression was unchanged, while the level of the phosphorylated protein increased significantly in a dose-dependent manner, suggesting an involvement of this regulator protein in the pathogenesis of the lung diseases induced by mineral fibres. (unict.it)
  • Angela Brooks is developing computational and experimental approaches to determine which mutations in cancer cells are functionally important. (ucsc.edu)
  • HGUE-C-1 cells did not show microsatellite instability and did not harbour mutations in KRAS , BRAF , PI3KCA or TP53 . (biomedcentral.com)
  • Here we show a novel function for Retinoblastoma family member, p107 in controlling stem cell expansion in the mammalian brain. (rupress.org)
  • Adult p107-null mice had elevated numbers of proliferating progenitor cells in their lateral ventricles. (rupress.org)
  • In vitro neurosphere assays revealed striking increases in the number of neurosphere forming cells from p107 −/− brains that exhibited enhanced capacity for self-renewal. (rupress.org)
  • The accumulation of both Cyclin and CKI proteins is tightly regulated at the level of transcription. (intechopen.com)
  • In addition, Cyclin and CKI proteins are controlled at the level of their destruction. (intechopen.com)
  • The cell cycle is a tightly regulated process that is controlled by the conserved cyclin-dependent kinase (CDK)-cyclin protein complex 1 . (nature.com)
  • Lundberg, A. S. & Weinberg, R. A. Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. (nature.com)
  • TGF-P has been shown to inhibit cyclin dependent kinase activity, which leads to activation of the retinoblastoma protein (pRB) and growth arrest. (uwo.ca)
  • Replacement of wild-type RB can suppress the tumorigenicity of some of these cells, suggesting that the RB protein (Rb) may negatively regulate cell growth. (wdv.com)
  • Even as the nature of the exact cell in which Merkel cell carcinoma oncogenesis occurs is controversial, there is strong support for the notion that Merkel cell carcinoma results from of one of two distinct pathways. (medscape.com)
  • Numerous E3 ubiquitin ligases, which facilitate the ubiquitination of specific substrates, have been shown to control G1/S. In this chapter, we will discuss components in the ubiquitin proteasome system that are implicated in G1/S control, how these enzymes are interconnected, gaps in our current knowledge, and the potential role of these pathways in the cancer cycle and disease proliferation. (intechopen.com)
  • Cellular proteostasis involves the coordinated and compensatory action of pathways that control biogenesis, folding, trafficking and breakdown of proteins allowing the cell to adapt to physiological or pathological environmental changes. (elifesciences.org)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • [ 5 , 6 ] Furthermore, experiments have demonstrated that epidermal progenitors in the touch domes are capable of producing Merkel cell lines and that epithelial progenitor populations in adults have the capacity to give rise to both neuroendocrine and squamous lineages. (medscape.com)
  • Expression of p16INK4a (p16 positive) is highly correlated with human papilloma virus (HPV) infection in head and neck squamous cell carcinomas (HNSCC). (neobiotechnologies.com)
  • Human cervical squamous cell carcinoma. (neobiotechnologies.com)
  • In addition to papilloma tongue treatment and alcohol abuse, certain hpv on tongue treatment have been associated with squamous cell carcinoma SCC papilloma tongue treatment the head and neck, causing alterations in DNA. (pcmaster.ro)
  • Moldovan Andreea - Centrul de Diagnostic si Tratament Oncologic Human papillomavirus infection poster Citate duplicat In addition to tobacco and alcohol abuse, certain viruses have been associated with squamous cell carcinoma SCC of the head and neck, causing alterations papilloma in poodles DNA. (info-tecuci.ro)
  • Hpv virus vaccine age limit Hpv human papillomavirus age HPV vaccination: Risk factors, sexual history shouldn't guide decisions about it sucuri fresh detoxifiere In addition to tobacco and alcohol abuse, certain viruses have been associated with squamous cell carcinoma SCC of the head and neck, causing alterations in DNA. (granturieuropene.ro)
  • Hpv treatment singapore Wart pox virus Human papillomavirus 52 positive squamous cell carcinoma of the conjunctiva Meniu de navigare Hpv virus causing tongue cancer, In addition to tobacco and alcohol abuse, certain viruses have been associated with squamous cell carcinoma SCC of non hpv tongue cancer head and neck, causing alterations in DNA. (mediafilmcenter.ro)
  • Methods: fifteen histological specimens of spindle cell squamous cell carcinoma of the lower lip were obtained from the Department of Oral Pathology, Bahia Federal University. (bvsalud.org)
  • Other markers, such as retinoblastoma and p53, may be related with early steps of carcinogenesis in oral cavity squamous cell carcinoma. (bvsalud.org)
  • Cancer Lett, 300:215-224.doi:10.1016/j. squamous cell carcinoma in north-eastern Iran. (who.int)
  • Consequently, H1.2 influences transcriptional repression and cell cycle control. (ox.ac.uk)
  • The advanced pathological grade was associated with strong TGFB1, VEGFA, and Ki67 protein expression and absent Tp53 staining. (hindawi.com)
  • Levels of retinoblastoma protein (Rb), Ki67, and Bcl-2 were measured, reflecting cellular proliferation and death. (atsjournals.org)
  • Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization. (bvsalud.org)
  • Activation of protein kinase C (PKC) enhances the angiogenic process and is involved in the signaling of vascular endothelial growth factor ( VEGF ). (bvsalud.org)
  • Here we demonstrate that p38 MAPK gamma (p38γ) acts as a CDK-like kinase and thus cooperates with CDKs, regulating entry into the cell cycle. (nature.com)
  • The protein interaction landscape of the human CMGC kinase group. (nature.com)
  • Previously the Li lab has identified an interesting protein, known as casein kinase 2, which plays an integral role in adult brain tumor growth. (stanford.edu)
  • My goal is to expand on this initial finding and determine if casein kinase 2 could be a therapeutically relevant drug target in adult brain tumors and whether this protein plays a role in pediatric brain tumors. (stanford.edu)
  • Silencing of the EBF3 locus was observed in brain, colorectal, breast, liver, and bone tumor cell lines and its reactivation was achieved on treatment with 5-aza-2′-deoxycytidine and trichostatin A in a significant portion of these tumor cells. (aacrjournals.org)
  • It is well established that statins display potent anticancer activity in several types of proliferating tumor cells. (nih.gov)
  • This categorization is based on microscopic position of the tumor cells. (niagarafallshypnosiscenter.com)
  • Previous studies have identified that UBE3A exhibits abnormal expression in numerous tumor cells, including prostate, cervical and breast cancer ( 6 , 7 ). (spandidos-publications.com)
  • Our studies demonstrate that the CK2 subunit, CK2α, is overexpressed in and has an important role in regulating brain tumor-initiating cells (BTIC) in GBM. (stanford.edu)
  • An "in vitro"study on lung cells exposed to fluoro-edenite fibres. (unict.it)
  • In vitro treatment of ER-positive breast cancer cell lines with the combination of palbociclib and antiestrogens leads to increased cell senescence, which was sustained for up to 6 days following drug removal. (shu.edu)
  • We have previously shown that fish primary preadipocytes differentiate into mature adipocytes in vitro and that these cells represent a very helpful model system to study adipose tissue development in fish [ 5 , 6 ]. (biomedcentral.com)
  • The c-myc protein is localized in the nucleus and can physically associate with RB protein in vitro, hence c-myc may functionally antagonize RB function. (wdv.com)
  • Recent work has shown that these proteins are also involved in hormonal regulation of breast cancer cells. (ucsc.edu)
  • Negative growth regulation generally occurs during the G0/G1 phase of the cell cycle, yet the redundancy and complexity among components of this regulatory network have made it difficult to discern how negative growth cues protect cells from aberrant proliferation. (uwo.ca)
  • Variable DNA compaction observed during senescence is explained in part by cell-type specific regulation of H4 deacetylation and HMGA1/2 expression. (biomedcentral.com)
  • Cancer research at UC Santa Cruz includes faculty in a wide range of departments, including Applied Math and Statistics, Biomolecular Engineering, Chemistry and Biochemistry, Electrical Engineering, Microbiology and Environmental Toxicology, and Molecular, Cell, and Developmental Biology. (ucsc.edu)
  • Adipogenesis has been extensively studied in mammals [ 7 ] and several cell and animal models have been successfully used to describe the chronology of the molecular events governing this process. (biomedcentral.com)
  • RegIIIβ and RegIIIγ are antimicrobial peptides expressed in intestinal epithelial cells. (shengsci.com)
  • HPV promotes latency and consequently does not cause a disease phenotype following initial infection by an immune evasion response reaction, featuring binding to epithelial cells and integrating into the host genome, resulting in the proliferation of epidermal cells containing the viral genome and neovascularization ( 3 ). (spandidos-publications.com)
  • SIRT2, an NAD-dependent class III histone deacetylase, contributes to H4-K16Ac deacetylation and DNA compaction in human fibroblast cell lines that assemble striking senescence-associated heterochromatin foci (SAHFs). (biomedcentral.com)
  • The potential functional consequences of PKC beta-induced retinoblastoma phosphorylation could include enhanced E2 promoter binding factor transcriptional activity and increased VEGF -induced endothelial cell proliferation. (bvsalud.org)
  • In this study we investigated how RELA impacts the beta cell transcriptional landscape and provides network control over glucoregulation. (researchgate.net)
  • In mammals, X chromosome dosage compensation involves heterochromatization and transcriptional silencing of one of two copies of the X chromosome in female cells. (biomedcentral.com)
  • 11. Amsel, A. & Roussel, J. Motivational properties of ences in post-transcriptional processes spark interest in the development of frustration: I. Effect on a running response of the (protein redistribution, degradation), pharmacotherapies that selectively reg- addition of frustration to the motivational com- plex. (lu.se)
  • In order to understand the development of adiposity, it is crucial to identify the factors and mechanisms that regulate the recruitment of mesenchymal stem cells (MSCs) of the vascular stromal fraction of the adipose tissue and its transformation into lipid-filled adipocytes. (biomedcentral.com)
  • However, the regulatory mechanisms of HPV infection and consequent immune escape reaction, persistent infection and cell proliferation and the regulatory mechanisms of vascular proliferation are poorly understood and require additional investigation ( 4 ). (spandidos-publications.com)
  • Moreover, in adults, Merkel cells undergo slow turnover and are replaced by cells originating from epidermal stem cells, not through the proliferation of differentiated Merkel cells. (medscape.com)
  • Other suggested cells of origin include the neural crest‒derived cell of amine precursor uptake and decarboxylation (APUD) system, dermal fibroblasts, pre or pro B cells, residual epidermal stem cells, and epithelial, non-Merkel cell progenitors. (medscape.com)
  • Microtrauma of the suprabasal epidermal cells enables the virus to infect the cell within the low risk hpv cause cancer layer. (ghise-ioan.ro)
  • In the differentiated keratinocytes of the suprabasal layers of the epithelium, the virus switches to a rolling-circle mode of DNA replication, amplifies its DNA to high copy number, synthesizes capsid proteins, and causes viral assembly to occur 3. (ghise-ioan.ro)
  • Decreased H4-K16Ac was observed in both replicative and oncogene-induced senescence of these cells. (biomedcentral.com)
  • UBE3A is associated with cervical cancer and may combine with the E6 proto-oncogene encoded by HPV16 within cervical cancer cells to form the E6/E6-AP protein complex through the ubiquitin proteasome pathway ( 4 ). (spandidos-publications.com)
  • The p63 protein, a homologue of p53, may be associated with tumor formation in the epithelial tissue, acting as an oncogene 11,12 . (bvsalud.org)
  • The activity of CDKs is controlled by their binding to coactivator subunits termed Cyclins, as well as by CDK inhibitory proteins termed CKIs. (intechopen.com)
  • These kinases are expressed throughout the cell cycle, but are only activated upon complex formation with their corresponding cyclins. (shu.edu)
  • PL effectively inhibited cell growth, impacted the cell cycle by decreasing the level of cyclins and CDK1 and increasing CDKN1A and triggered a caspase-3 independent cell death process in which reactive oxygen species production is a major player. (oncotarget.com)
  • Ribosome-inactivating proteins (RIPs) are N-glycosidases (EC3.2.2.22) that universally inactivate the ribosome, thereby inhibiting protein biosynthesis. (shengsci.com)
  • High-risk E6 and E7 bind to p53 and pRb and inactivate their functions with dysregulation of the cell cycle. (ghise-ioan.ro)
  • [ 2 ] As neuroendocrine carcinomas were thought to be of neural crest origin, in 1978 Tang and Toker proposed that this carcinoma might be derived from Merkel cells. (medscape.com)
  • Feng et al established in 2008 that approximately 80% of Merkel cell carcinomas in the Northern hemisphere occur after genomic integration by a ubiquitous skin commensal virus, Merkel cell polyoma virus (MCPyV). (medscape.com)
  • Background Renal cell carcinomas (CCR) account for 90% of renal tumors. (irjs.info)
  • AZD6738 biological activity RCC, renal cell carcinomas strong class="kwd-title" Keywords: Gallblader tumor, Renal cell carcinomas, Latente metastasis, Case report 1. (irjs.info)
  • Background Renal cell carcinomas (CCR) account for 1%C3% of all malignant visceral neoplasms and 90% of renal tumors. (irjs.info)
  • The N-terminal phosphorylation of RB by p38 bypasses its inactivation by CDKs and prevents proliferation in cancer cells. (nature.com)
  • Fig. 1: p38γ phosphorylates Rb and promotes liver proliferation after PHx. (nature.com)
  • Any alteration in this system consequences in uncontrolled division and proliferation of cells that finally leads to a mass known as a tumor.Tumors may be benign or malignant. (niagarafallshypnosiscenter.com)
  • Malignant tumor, on the other manus, turn sharply and occupy other organic structure tissues, that allows tumor cell entry into the circulatory system and so to other parts of the organic structure. (niagarafallshypnosiscenter.com)
  • Oral Oncol, Retinoblastoma-independent antiproliferative activity socioeconomic status: a cross-sectional study. (who.int)
  • With the advent of improved immunohistochemical profiling, the tumor was reclassified as Merkel cell carcinoma because shared epithelial and neuroendocrine markers, along with ultrastructural features suggestive of neural crest origin, were observed in both the constituent tumor cell and the physiologic Merkel cell of the skin. (medscape.com)
  • Merkel cells were thought to be of neural crest origin because they are excitable cells that secrete neuropeptides and stain positively for neuroendocrine markers. (medscape.com)
  • We discovered that loss of CK2α activity reduced the sphere-forming capacity of BTIC and decreased numerous GBM stem cell markers, including CD133, CD90, CD49f and A2B5. (stanford.edu)
  • The mitogenic action of VEGF , a potent hypoxia -induced angiogenic factor , was increased by 2-fold in retinal endothelial cells by the overexpression of PKC beta 1 or beta 2 isoforms and inhibited significantly by the overexpression of a dominant-negative PKC beta 2 isoform but not by the expression of PKC alpha, delta , and zeta isoforms . (bvsalud.org)
  • Exogenous expression of GGT7 resulted in a 2- to 3-fold reduction in proliferation and anchorage-independent growth under minimal growth conditions (1% serum). (stanford.edu)
  • Decreasing GGT7 expression using either short interfering RNA or short hairpin RNA consistently increased proliferation 1.5- to 2-fold. (stanford.edu)
  • In addition, intracranial injections of U87-MG cells with reduced GGT7 expression increased tumor growth in mice approximately 2-fold, and decreased mouse survival. (stanford.edu)
  • BMP-2 stimulated the expression of Sox9, Col2a1, and Aggrecan mRNAs in free-body and synovial cells and that of Runx2, Col1a1, and Osteocalcin mRNAs in the synovial [corrected] cells only. (shengsci.com)
  • Noggin suppressed the expression of Sox9, Col2a1, Aggrecan, and Runx2 mRNAs in both the free-body and synovial cells. (shengsci.com)
  • Further, it inhibited Osteocalcin expression in the synovial cells. (shengsci.com)
  • Introduction: In this study we addressed the expression of Rb and pRb protein in human lung epithelial A549 and MeT-5A cell cultures treated with three concentrations of fluoro-edenite fibres to gain insights into the biomolecular mechanisms underlying the interaction between these environmental particulates/fibres and human respiratory epithelium. (unict.it)
  • Several other proteins, including kinases, play an important role in generation of rhythmic expression [ 7 ]. (aging-us.com)
  • Treatment of breast cancer cell lines with the combination of palbociclib and antiestrogens leads to decreased retinoblastoma protein (Rb) phosphorylation resulting in reduced E2F expression and signaling and increased growth arrest compared to treatment with each drug alone. (shu.edu)
  • Differential Expression of Multiple Disease-Related Protein Groups Induced by Valproic Acid in Human SH-SY5Y Neuroblastoma Cells. (anticorps-enligne.fr)
  • The overexpression of miRNA‑375 significantly suppressed the levels of protein expression of ubiquitin‑protein ligase E3A (UBE3A) and Insulin‑like growth factor‑1 receptor (IGF‑1R) in HPV‑18(+) cervical cancer cells. (spandidos-publications.com)
  • Inhibition of CKα using siRNA or small-molecule inhibitors (TBBz, CX-4945) reduced cell growth, decreased tumor size, and increased survival rates in GBM xenograft mouse models. (stanford.edu)
  • Although the survival rate of patients with retinoblastoma is extremely high in developed countries, left untreated advanced tumors limit eye preservation and expose patients to risks of metastasis and death. (oncotarget.com)
  • Pack LR, Daigh LH, Meyer T. Putting the brakes on the cell cycle: mechanisms of cellular growth arrest. (bdbiosciences.com)
  • Cellular senescence is a stress response of mammalian cells leading to a durable arrest of cell proliferation that has been implicated in tumor suppression, wound healing, and aging. (biomedcentral.com)
  • Abrogation by c-myc of G1 phase arrest induced by RB protein but not by p53. (wdv.com)
  • Our results demonstrate that tumor growth, peritoneal dissemination and peritoneum or organ metastasis implanted MKN45 cells were significantly decreased in shAhR and Biseugenol-treated mice and that endoplasmic reticulum (ER) stress was caused. (oncotarget.com)
  • The lethality of mdm2 −/− mice before implantation makes it impossible to analyze Mdm2 interaction with p53 in vivo at specific times of development, at postnatal/adult stages, or in specific cell types. (molvis.org)
  • MCF-7 cells, which have only one wild-type BRCA1 allele, were transfected with pcDNA3-beta-HA-hsBRCA1 plasmids via liposomes to reconstitute BRCA1 overexpression human breast cancer cell line, and tumoral xenografts with BRCA1 overexpression were subsequently established in BALB/c nude mice. (nih.gov)
  • although it is derived from cells of the renal tubular epithelium, it has several histological subtypes which differ in their clinical outcome and biological features. (hindawi.com)
  • Here, we show that amyloid fibrils of Aβ1-40 peptide can effectively initiate amyloid formation in different globular proteins and metabolites, converti. (shengsci.com)
  • We tested the hypothesis that the lunasin peptide is the active component in soy protein responsible for lowering LDL cholesterol . (wealththrunutrition.com)
  • Primordium cells, in contrast to stem cells, are already specified, have entered a period of maximal proliferation, but for a limited number of times, and can thus be considered the plant equivalent of progenitor cells in animal organs. (biomedcentral.com)
  • The mechanisms by which cells control their growth and size are poorly understood and represent a fundamental unsolved problem in cell biology. (ucsc.edu)
  • Doug Kellogg's lab is working to elucidate these mechanisms, using biochemistry, genetics, and mathematical modeling to understand signaling networks that are required for control of cell size and cell growth. (ucsc.edu)
  • Initial studies showed that two GBM cell lines (U87-MG and U138) transduced with CK2α had enhanced proliferation and anchorage-independent growth. (stanford.edu)
  • During the first stage called G1, cells monitor their environment and, when the requisite signals are received, the cells synthesize RNA and proteins to induce growth. (bdbiosciences.com)
  • Cell proliferation is an increase in the number of cells as a result of growth and division. (bdbiosciences.com)
  • Cells were cultured in Dulbecco's modified Eagle medium containing 10% foetal bovine serum (Gibco), 2 mM glutamine (Gibco), 10,000 IU/ml penicillin/streptomycin (Gibco) and 100 ng/ml nerve growth factor on poly-L-lysine- and laminin-coated dishes and used the day after preparation. (biomedcentral.com)
  • Estrogen is a mitogenic growth factor - disrupting the production or effective signaling of estrogen deprives cells of signals to divide. (shu.edu)
  • Initial exponential tumor growth is followed by a plateau phase when cell death nearly equals the rate of formation of daughter cells. (msdmanuals.com)
  • Experiments suggest that the abilities to invade, migrate, and successfully implant and stimulate new blood vessel growth are all important properties of the cells that cause metastases, which are likely a subpopulation of the primary cancer. (msdmanuals.com)
  • Camilla Forsberg studies how the different types of blood cells develop from hematopoietic stem cells in the bone marrow. (ucsc.edu)
  • Kim uses stem cells and mouse models of cancer to examine how lncRNAs are involved in epigenetic reprogramming. (ucsc.edu)
  • To determine the importance of CK2α in GBM stem cell maintenance, we reduced CK2α activity in primary GBM samples and tumor spheres derived from GBM patients. (stanford.edu)
  • Leaf primordia form at the flanks of the stem cell population in the shoot apical meristem. (biomedcentral.com)
  • A subpopulation of cells within a cancer has the properties of stem cells. (msdmanuals.com)
  • A hallmark of proteome balance is the ubiquitin-proteasome system (UPS) that degrades roughly 80% of multi-ubiquitinated proteins ( Collins and Goldberg, 2017 ). (elifesciences.org)
  • The strong antiproliferative activity of p53 may have detrimental effects in normal cells if it is activated inappropriately. (molvis.org)
  • This skin cancer has been called by several other names, including primary small-cell carcinoma of the skin, APUDoma, primary undifferentiated carcinoma of the skin, and the Toker tumor. (medscape.com)
  • Notably, the G1/S boundary represents a major barrier to cell proliferation and is universally dysfunctional in cancer cells, allowing for the unbridled proliferation observed in malignancy. (intechopen.com)
  • Cells show extraordinary diversity in size and shape, and cancer cells often have abnormal sizes and shapes. (ucsc.edu)
  • Using cell culture techniques, we isolated clonal populations from primary cultures of ascitic effusion derived from a colon cancer patient and after several passages an established cell line, HGUE-C-1, was obtained. (biomedcentral.com)
  • We have established a new cell line from ascitic efussion of a colon cancer patient who did not respond to 5-fluorouracil or irinotecan. (biomedcentral.com)
  • Then, the inhibitory activity of lovastatin on cancer cells and tumoral xenografts, and the underlying mechanism involving in cell-cycle regulatory proteins were analyzed. (nih.gov)
  • The left bronchial tube contains no eparterial subdivision.Cancer of the lung arises from aberrances in organic structure 's cell. (niagarafallshypnosiscenter.com)
  • Deacetylation of H4-K16Ac during senescence may explain reported decreases in this mark during mammalian aging and in cancer cells. (biomedcentral.com)
  • Anti-estrogen therapy involves blocking the production, binding, or signaling of estrogen in cancer cells. (shu.edu)
  • Papilloma in poodles Throat Cancer and the Human Papilloma Virus risk of cervical cancer after hpv vaccination Virus del papiloma humano en la boca como se contagia abdominal cancer treatment options, papilloma znaczenie viermii intestinali simptome. (info-tecuci.ro)
  • Ginecologie MGVI LR Înțelesul "papiloma" în dicționarul Spaniolă - Virus del papiloma humano en mujeres que es Papilloma in poodles Warts or Papillomas - Symptoms and Treatments oxiuri in vis Human papillomavirus rash description papilloma of head and neck, paraziti u stolici slike pancreatic cancer quality of life. (info-tecuci.ro)
  • FDA OKs HPV vaccine to age 45 operazione papilloma virus uomo Urothelial cell papilloma enterobius vermicularis human papillomavirus vaccine age, hpv related throat cancer caracteristicas de un papiloma humano. (granturieuropene.ro)
  • Human papillomavirus vaccine age - hhh Cervical Cancer Oral Sex Hpv human papillomavirus age - Human papillomavirus hpv human papillomavirus age vaccine age Medicamente vierme pentru lista de oameni Human papillomavirus vaccine for older adults, Human papillomavirus vaccine for older adults Mayo Clinic Minute: HPV Vaccine Prevents Cancer virus del papiloma humano tratamientos Colorectal cancer cauzele cancerului de plamani, stade 3 papillomavirus precancerous cervical cells without hpv. (granturieuropene.ro)
  • Clear Cell (CC) RCC is the most common type of renal cancer, accounting for 75% of all primary kidney tumours [1]. (irjs.info)
  • To conclude, it was identified that the probable anti‑CA mechanism of miRNA‑375 modulates HPV through the UBE3A and IGF‑1R pathway in cervical cancer cells. (spandidos-publications.com)
  • It is designed to treat micrometastatic disease (or breast cancer cells that have escaped the breast and regional lymph nodes but which have not yet had an established identifiable metastasis). (medscape.com)
  • Many factors are involved in causing and permitting the unregulated proliferation of cells that occurs in cancer. (msdmanuals.com)
  • Overview of Cancer Cancer is an unregulated proliferation of cells. (msdmanuals.com)
  • Cancer cells, particularly those arising from the bone marrow or lymphatic system, may have a short generation time, and there usually are a smaller percentage of cells in G0 (resting phase). (msdmanuals.com)
  • A cancer may release cells into the circulation at a very early stage of development. (msdmanuals.com)
  • Circulating cancer cells are present in many patients with advanced cancer and even in some with localized disease. (msdmanuals.com)
  • Although most circulating cancer cells die, an occasional cell may penetrate into tissues, generating a metastasis at a distant site. (msdmanuals.com)
  • Cancer cells often present neoantigens on their cell surface that can be detected as "non-self" by the immune system, resulting in an attack by the immune system. (msdmanuals.com)
  • E7 from human papil omavirus type 16 cooperate to cancer: the European prospective investigation into doi:10.1093/carcin/bgp321 PMID:20047954 target the PDZ protein Na/H exchange regulatory cancer and nutrition study. (who.int)
  • 99:209 -215.doi:10.1007/s11060 - 010 - 0129 -5 cell carcinoma-a population-based study in with and without cervical cancer in Tbilisi, Georgia. (who.int)
  • Renal cell carcinoma (RCC) accounts for approximately 3% of human malignancies, and its incidence appears to be increasing globally [ 1 ]. (hindawi.com)
  • In various human cancers, pRB suppresses cellular proliferation and is inactivated. (utsouthwestern.edu)
  • In this report, the authors analyzed the pro-death effect of piperlongumine, a natural compound isolated from Piper longum L., on two human retinoblastoma cell lines, WERI-Rb and Y79. (oncotarget.com)
  • Both non-neoplastic meningothelial cells and meningiomas possess mixed features of epithelial and mesenchymal cells. (medscape.com)