Molecular biology cell biological assay. Medical search. Frequent questions

HIV, Ebola, influenza, the coronavirus - they're all different viruses, but they share common features," said Zheng, a professor in the College of Osteopathic Medicine with the Department of Microbiology and Molecular Genetics . (msu.edu)
A Ph.D. degree in life or biology, genomics/genetics or a related discipline is required. (postdoc.com)
Scientific & Experimental Studies: Molecular biology, genetics, and cell biology are just a few of the scientific fields that heavily rely on assay kits. (healthbreaking.com)
This programme builds upon a first year core of anatomy and physiology, cell biology, microbiology, genetics, biochemistry and practical skill development. (mdx.ac.uk)
It will provide students with principles of genetics as well as a detailed understanding of the genetic processes that are operating at molecular, organism, population and species levels and that ultimately underlie adaptive change. (mdx.ac.uk)

Since the mammalian cells do not uptake the foreign DNA efficiently, the availability of effective methods for introducing genes into the cells is essential. (benthamscience.com)
Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries. (bcm.edu)
Because of their simplicity and versatility, and because of the absence of endogenous luciferase activity in most cell types, this test can be applied for testing a large variety of nanomaterial s for their pathogenic or carcinogenetic effects on a wide range of mammalian cells. (cdc.gov)
ADP/ATP Ratio Assay Kit provides a rapid method to measure ADP and ATP levels for the screening of apoptosis, necrosis and cell proliferation in mammalian cells. (biotrend-usa.com)

Sessions will cover the process of translating biological insight into tractable assays, efficient tool compounds and biologicals, and methods for generating attractive starting points for drug discovery programmes. (slas.org)
The anti‐proliferative activity of all newly synthesized compounds has been assessed against six human solid tumor cell lines. (researchgate.net)
Seven compounds show good activity against single cell line whereas, compounds having a pyridine scaffold showed significant anti‐proliferative activity. (researchgate.net)
All newly synthesized compounds were screened for anti‐proliferative activity against different human tumor cell lines. (researchgate.net)
The goal of the MLP is to screen compounds in the Small Molecule Repository in target-based and phenotypic assays to identify and subsequently optimize small molecule s as research probes. (nih.gov)
In biological samples like blood, urine, tissues, or cell cultures, allow researchers and medical practitioners to precisely measure and quantify the presence or concentration of these target compounds. (healthbreaking.com)
Her research interests are the chemical analysis and the biological assessment of edible and pharmaceutical plants and beekeeping products, as well as the isolation and identification of their bioactive compounds. (imgnpp.org)
Molecular aspects of monooxygenases and bioactivation of toxic compounds. (cdc.gov)
The IC50 values in the two cell lines were found to depend on the overall structure of the assayed compounds, although less in this subset of compounds compared to a previous investigation. (lu.se)

Studies using the frog Xenopus have made remarkable contributions to our understanding of fundamental processes such as cell cycle regulation, transcription, translation and many other topics. (cshl.edu)
Luciferase reporter assays represent a simple and sensitive experimental system in cell and molecular biology to study multiple biological processes. (muni.cz)
Taseen Gul, Henah Mehraj Balkhi, Ehtishamul Haq , " Evaluation of Cellular Processes by In Vitro Assays ", Bentham Science Publishers (2018). (benthamscience.com)
The introduction of cell culture techniques has helped a lot in understanding the physiological processes like cell signalling, neurobiology, cell proliferation, pathogenesis of diseases, apoptosis and even more. (benthamscience.com)
A good understanding of general biological processes and immunology is highly desirable. (postdoc.com)
Since intercellular communication seems to play a role in various biological processes, it might be important to conduct studies in co-culture systems, which at least mimic partially more physiological conditions, and enables this intercellular exchange to occur. (intechopen.com)
FGF-21 regulates thermogenesis in white and brown adipose tissue, and metabolic processes in cells of pancreatic origin (Kharitonenkov et al. (stemcell.com)
Assay kits make it easier to measure biomarkers, which are particular molecules or indications that represent healthy or unhealthy biological processes. (healthbreaking.com)
They enable researchers to examine particular biological processes, define cellular constituents, examine gene expression, quantify enzyme activity, and carry out other crucial tests. (healthbreaking.com)
In its current stage, these words are not written with the intent to be precise or complete, but to guide my own thoughts in the understanding - however superficial - of which are the general principles, opposite to specific molecular mechanisms, that drive biological processes and that are more likely to help us in the understanding of human physiology and pathological states. (quantitative-biology.org)
This lactone ring is a Michael acceptor that is known to affect biological processes such as cell proliferation, death/apoptosis, and cell migration, by interfering with nucleophilic sites in cell signalling pathways. (lu.se)

In order to diagnose infectious infections, autoimmune conditions, and hormonal abnormalities, enzyme-linked immunosorbent assay (ELISA) kits, for instance, are frequently used to look for the presence of particular antibodies or antigens. (healthbreaking.com)

Participation in scientific societies, such as Society for Medicinal Plant and Natural Product Research-GA, Hellenic Society of Biochemistry and Molecular Biology-HSBMB. (imgnpp.org)

The ligand-binding assay methodology quantified the concentration of the hormone in the test material by comparing the effects of the test sample to the results of varying amounts of known protein (ligand). (wikipedia.org)
Ligand binding assays provide a measure of the interactions that occur between two molecules, such as protein-bindings, as well as the degree of affinity (weak, strong, or no connection) for which the reactants bind together. (wikipedia.org)
The lab's efforts are mainly focused on the rational design, synthesis, and biological evaluation of drug-like small molecules that can modulate cellular signaling pathways with an emphasis on protein-protein interactions (PPIs) and target specificity. (usf.edu)
Four critical lab components include protein structure-based drug design, multiple-step synthesis, and molecular and cellular biology. (usf.edu)
We use a collection of innovative techniques, such as protein engineering, fluorescence and bioluminescence imaging, molecular and cell biology, and electrophysiology, to dissect signaling. (virginia.edu)
Manifold Bio is a biotech company pursuing a pipeline of protein therapeutics using novel molecular measurement technologies and library-guided protein engineering. (greenhouse.io)
The ideal candidate will have deep technical expertise in protein and/or molecular biology and a track record of designing and executing experiments. (greenhouse.io)
Moreover, C. albicans Hom6p affects expression of the cell wall protein Xog1p which is a major exoglucanase and is found to be involved in cell adhesion. (ncl.edu.tw)
We speculated that the defect of protein synthesis attenuated expression of other exoglucanases or glucan synthesis-related proteins, and then induced release of Xog1p to the cell wall. (ncl.edu.tw)
C. albicans Hom6p thus had an effect on cell survival and cell adhesion by maintaining protein synthesis and cell wall function. (ncl.edu.tw)
To test this hypothesis, we carried out ChIP assays treating the MCF-7/CD44 cells with formaldehyde (a protein-DNA crosslinker) as well as with DSG (a protein-protein crosslinker). (emerging-researchers.org)
We have concluded that the crosslinking process in the ChIP assay might be affecting the availability of the CD44-ICD epitope since in Proximity Ligation Assays (PLA) in which no crosslinkers are used, we were able to detect the hypothesized CD44-ICD/Runx2 protein-protein interaction in the same cell line using the same anti-CD44-ICD antibody. (emerging-researchers.org)
Aberrant chimeric RNA GOLM1-MAK10 encoding a secreted fusion protein as a molecular signature for human esophageal squamous cell carcinoma. (bcm.edu)
In cells, the majority of Sec61 is stably associated with a heterotetrameric membrane protein complex, the translocon-associated protein complex (TRAP), yet the mechanism by which TRAP assists in polypeptide translocation remains unknown. (lu.se)
The cryo-EM analysis also revealed a population of free V 1 bound to Oxidation Resistance 1 (Oxr1p), a poorly characterized protein that has been implicated in protecting cells from oxidative stress. (upstate.edu)
2017). In this dataset, we identified and characterized the Liver-Specific Protein 2 (LISP2) protein as an early molecular marker of liver stage development. (elifesciences.org)
Cells maintain protein homeostasis by regulating protein levels and destroying aberrant proteins by tagging them for destruction. (njbio.com)
For example, a protein that is essential for cancer cell replication may be identified and a ligand developed that may have good binding but may not be effective enough at modulating the function of the protein to reverse the disease state. (njbio.com)
However, although Michael acceptors are reactive, the Michael addition is reversible and it can be assumed that also other parts of the molecules will moderate the binding to and the release from any given nucleophilic site in a protein, and thereby moderate a specific biological activity. (lu.se)

The foundations for which ligand binding assay have been built are a result of Karl Landsteiner, in 1945, and his work on immunization of animals through the production of antibodies for certain proteins. (wikipedia.org)
The course maintains stock mRNAs for targeting fluorescent proteins to specific structures for studying cell shape and cytoskeletal dynamics but students are encouraged to bring or suggest additional tools, including fluorescent biosensors, tension-sensors, etc. (cshl.edu)
Sino Biological, Inc. (SZSE: 301047) has recently deposited reagents for the Omicron variant, including recombinant proteins to Spike and Nucleocapsid, and antibody products to BEI Resources, a central repository for reagents to support infectious disease research. (the-scientist.com)
Lysine methylation marks manifest their biological effect via so-called 'readers' (or reading domains) which recognize and bind the methylation mark and directly alter the chromatin structure or act as a scaffold for other proteins, which induce biological responses. (europa.eu)
Under the terms of the agreement, Sino Biological will provide key bioreagents such as recombinant proteins, antibodies and detection kits for use in COVID-19 vaccine development underway at GeoVax. (gabio.org)
Sino Biological was the first to market with mammalian cell-made COVID-19 viral recombinant proteins and offers a full range of these and other bioreagents to complement and aid in COVID-19 vaccine development and has the world's largest selection of coronavirus research-grade products. (gabio.org)
In this respect, different routes of interactions were defined, such as direct cell-cell interactions or indirect cross talk, by release of soluble factors or vesicular particles containing proteins, RNAs and other molecules. (intechopen.com)
This company develops lipocalins, which are endogenous low-molecular-weight human proteins typically found in blood plasma and other body fluids. (genengnews.com)
RESULTS: The results of the study indicate that VBF presents anti-CRC effects and impacts cellular metabolic balance through its impact on cell cycle-regulating proteins, such as MTOR, CDK1, and TOP2A. (bvsalud.org)
Oxidant damage to cellular DNA, proteins (including the epigenome), and lipids can occur when reactive oxygen species escape cell antioxidant and repair mechanisms. (who.int)

I am an experienced scientific writer in the field of cell and developmental biology. (kolabtree.com)

RT-PCR is frequently combined with real time PCR (qPCR), which is widely used for the quantification of transcript levels in cells and tissues. (sigmaaldrich.com)
Existing methods for measuring transcript levels in single cells include RT-qPCR (1), single molecule counting using digital PCR (2) or hybridization probes (3, 4), and next generation sequencing (5). (justia.com)
Of these, single cell RT-qPCR provides combined advantages of sensitivity, specificity, and dynamic range, but is limited by low throughput, high reagent cost, and difficulties in accurately measuring low abundance transcripts (6). (justia.com)
Thus, many of the basic functionalities for microfluidic single cell gene expression analysis have been demonstrated in isolation, including cell manipulation and trapping (9, 10), RNA purification and cDNA synthesis (11-13), and microfluidic qPCR (14) following off-chip cell isolation cDNA synthesis and preamplification. (justia.com)
In particular, microfluidic qPCR devices (Biomark Dynamic Array, Fluidigm) have recently been applied to single cell studies (15, 16). (justia.com)
Although these systems provide a high-throughput qPCR readout, they do not address the front end sample preparation and require single cell isolation by FACS or micropipette followed by off-chip processing and pre-amplification of starting template prior to analysis. (justia.com)

In the few district hospitals that have appropriate laboratory facilities, the remaining CSF samples were stored after the latex agglutination assay or bacteriologic tests had been performed. (cdc.gov)
CETGA operates a state-of-the-art microbiology laboratory dedicated to microbiological diagnostics, employing a blend of biochemical and molecular techniques honed through years of research at the center, complemented by the incorporation of the latest advancements in the field. (cetga.org)
We thank Professor Ramanujan Hegde (MRC Laboratory of Molecular Biology, Cambridge, UK) for the kind gift of anti‐TRAPα antibody and Professor Peter Arvan (University of Michigan Medical School, Ann Arbor, MI, USA) for the kind gift of INS‐1 832/13 cells. (lu.se)
Assays are laboratory procedures created to identify, measure, or evaluate the presence or function of a certain chemical or biological component in a sample. (healthbreaking.com)
Applications for assay kits can be as varied as basic laboratory research to clinical disease diagnosis and monitoring. (healthbreaking.com)

Cell viability and cytotoxicity assays are used usually for screening of drugs and cytotoxicity tests of chemicals. (benthamscience.com)
Changes in the ADP/ATP ratio have been used to differentiate modes of cell death and viability. (biotrend-usa.com)
The prediction was verified by cell viability assay, EdU assay and flow cytometry. (bvsalud.org)

The proposal will apply an interdisciplinary approach in an international environment to maximize its chances of success: the biological role of reading domains will be evaluated with molecular biology (histone and chromatin pulldowns, ChIP-seq, confocal microscopy), biochemistry (Peptide arrays, mass spectrometry, methyltransferase activity assays) and biophysics techniques (fluorescence anisotropy, circular dichroism spectroscopy) as well as crystallography (solving the structure of reading domains). (europa.eu)
Support from the Swedish National Infrastructure for Biological Mass Spectrometry (BioMS) and the SciLifeLab, Integrated Structural Biology (ISB) platform, is gratefully acknowledged. (lu.se)

Cell" for elucidating the intricate mechanisms. (benthamscience.com)
Leading experts in disease biology will present new strategies for identifying, investigating and validating challenging target mechanisms in case studies. (slas.org)
Thus, it is crucial to improve analytical methods of investigation of co-cultured cells, to study their interactions and so to understand biology of leukemia in order to understand molecular mechanisms and offer novel therapeutic strategies. (intechopen.com)
Her research focuses on deciphering molecular mechanisms that drive obesity disease and using this information to develop targeted therapeutic strategies. (imgnpp.org)
What we call a living cell requires the preservation of its own identity for long enough to give birth to life as we recognize it-a living organism must exhibits mechanisms to ensure its own integrity over time: the integrity of its boundary and the integrity of an active internal chemical system. (quantitative-biology.org)
MATERIALS AND METHODS: An integrative approach combining biological network analysis, molecular docking and multi-dose metabolomics was used to predict the effects and mechanisms of VBF in CRC treatment. (bvsalud.org)
establish mechanisms of action by studying the effects of the same chemicals in experimental animals and on human cells in vitro, allowing for a better prediction of human carcinogenicity and assessment of carcinogenic mechanisms. (who.int)

In addition, we show that the LuminoCell is suitable to be used in cytotoxicity assays as well as for monitoring periodic circadian gene expression. (muni.cz)
In this investigation, the cytotoxicity of 20 α-methylene-γ-lactones towards normal breast epithelial MCF-10A cells as well as breast cancer JIMT-1 cells is compared, by determining the inhibitory concentration 50 (IC50) from dose response curves. (lu.se)

Sino Biological will also obtain exclusive rights to research-use-only (RUO) reagents developed jointly by the companies. (gabio.org)
We look forward to further expansion of our relationship with Sino Biological, including our agreement related to research-use-only (RUO) reagents. (gabio.org)
We at Sino Biological are honored to be the exclusive provider of COVID-19-related research reagents to assist their vaccine development efforts. (gabio.org)
Reagents and instruments for immunology, cell biology and molecular biology. (biotrend-usa.com)

Genetic Luciferase Reporter System or Reporter gene assay has become an invaluable tool in studies of gene expression. (cdc.gov)

Pure compound 1 was shown to have in vitro cytotoxic activity against several human cancer cell lines in both traditional cell culture and zone inhibition bioassays. (henryford.com)
Polymerase chain reaction (PCR) is a powerful core molecular biology technique that is an efficient and rapid in vitro method for enzymatic amplification of specific DNA or RNA sequences from various sources. (sigmaaldrich.com)
The candidate is expected to be an innovative scientist with knowledge and experience in molecular biology, cell culture, in vitro functional assays and genomic editing. (postdoc.com)
Experience in cell culture including the in vitro propagation, manipulation and characterization of lymphocytes. (postdoc.com)
The ability to make these in vitro molecular measurements, or "fingerprints," marks a new advance in molecular diagnostics that could ultimately help physicians predict patient prognosis and guide personalized treatment. (nanowerk.com)

Our goal is for each student to design a set of experiments focusing on their gene or biological interest. (cshl.edu)
Inevitably, there are fundamental and applied questions, such as those relating to transcriptional control of stem cell differentiation, intrinsic noise in gene expression, and the origins of disease, that may only be addressed at the single cell level. (justia.com)
For example, single cell analysis allows for the direct measurement of gene expression kinetics, or for the unambiguous identification of co-regulated genes, even in the presence of de-synchronization and heterogeneity that could obscure population-averaged measurements. (justia.com)

Molecular biology, immunology, biochemistry, and clinical diagnostics are just a few of the scientific disciplines that frequently use assay kits. (healthbreaking.com)

The incumbent will provide the technical skills required to perform neurocognitive testing of rodents, histological studies, and molecular techniques for biochemical and molecular analysis.Preference will be given to a highly organized candidate with prior experience in bio-medical research. (employdiversity.com)

A ligand binding assay (LBA) is an assay, or an analytic procedure, which relies on the binding of ligand molecules to receptors, antibodies or other macromolecules. (wikipedia.org)
For example, lower molecular weight and more potent forms of antibodies are being evaluated for topical delivery, including an anti-interleukin-13 Fab for the treatment of asthma and a highly potent nanobody to treat infection with the respiratory syncytial virus. (genengnews.com)

The department of pathology of the City of Hope Medical center is recruiting a postdoctoral fellow to work with a group of researchers in lymphoma genomics and biology. (postdoc.com)

we also demonstrate that Hom6p can localize at cell wall by western blot. (ncl.edu.tw)

Perspective applications of synthetic biology for algal bioproducts optimization. (bcm.edu)
Experience in biomaterial synthesis and handling with one or more expertise in bioscaffold construction, nanoparticle synthesis and optimization, cellular/islet biology as well as cellular encapsulation techniques. (stanford.edu)

The power of Xenopus can be leveraged when live-cell fluorescence imaging is combined with microsurgery, grafting, and dissociated cell culture. (cshl.edu)

It will introduce the nature of functional relationships between organisms and their environment and thus provide a framework to support future learning of concepts related to functional biology. (mdx.ac.uk)
1 We can accelerate and add value to your TPD program with our synthetic chemistry, linker design, BioNMR, bioconjugation and functional assay capabilities. (njbio.com)

Methods in Molecular Biology, 540:335 (2009). (bcm.edu)
The present chapter outlines the importance of modern, multiparameter flow cytometry methods, which allow to analyze interactions between different types of cells within the leukemia microenvironment. (intechopen.com)
Nanoparticle s in biology and medicine: methods and protocols, methods in molecular biology. (cdc.gov)
Methods for cell capture and preparation are also provided that include flowing cells through a chamber, funneling the cells towards a cell trap, capturing a predefined number of the cells within the trap, interrupting the flow of cells, flowing a wash solution through the chamber to remove contaminants from the chamber, and sealing the predefined number of cells in the chamber. (justia.com)
In particular, the invention relates to microfluidic devices and their uses and methods for assaying cells. (justia.com)
Similarly, single cell methods are vital in stem cell research and cancer biology, where isolated populations of primary cells are heterogeneous due to limitations in purification protocols, and it is often a minority cell population that is the most relevant. (justia.com)

regulating the differentiation, proliferation, maintenance and sculpturing organs and tissues, functioning of immune system and the elimination of defective harmful cells. (benthamscience.com)
FGF-21 does not induce proliferation in immortalized cell lines, unlike other FGFs (Kharitonenkov & Shanafelt). (stemcell.com)
A) The biological activity of Mouse Recombinant FGF-21 was tested by its ability to promote the proliferation of NIH-3T3 cells in the presence of 1.25 μg/mL mouse Klotho and 10 μg/mL heparin. (stemcell.com)
Cell proliferation was measured using a fluorometric assay method. (stemcell.com)
The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. (stemcell.com)
Cell proliferation: effects of cytokines, growth factor, nutrients. (biotrend-usa.com)
1. Test gives markedly elevated ATP levels with no significant increase in ADP levels in comparison to control cells=proliferation. (biotrend-usa.com)
The results of the multi-dose metabolomics analysis suggest a dose-dependent reduction of metabolites related to DNA synthesis after VBF treatment, while the EdU and flow cytometry results indicate that VBF inhibits cell proliferation and arrests the cell cycle at the S and G2/M phases. (bvsalud.org)

The services encompass a wide range of specialized expertise and resources, including medicinal chemistry, biology, pharmacology, toxicology, drug metabolism and pharmacokinetics (DMPK), and clinical trial management. (gminsights.com)
Bio-Rad Laboratories, Inc. offers products for life science research, clinical diagnostics, informatics/sadler, process separation and food/animal/nvironmental testing. (biosciregister.com)
For example, his team developed less dangerous versions of the virus along with lab-grown cells for these "pseudo-viruses" to infect while preserving the biochemistry of real, clinical infections. (msu.edu)
Chapter Six focuses on the latest advances in the development of the telomerase assays and the authors further discuss the application potentiality of the assays for clinical samples. (novapublishers.com)
High-throughput single cell measurement technologies are therefore of interest and have broad applications in clinical and research settings. (justia.com)
As scientists learn more about the molecular basis of cancer, the development of new tools capable of multiple, inexpensive biomarker measurements on small samples of clinical tissue will become essential to the success of genetically informed and personalized cancer therapies. (nanowerk.com)
Led by Tseng and Thomas Graeber, an assistant professor of molecular and medical pharmacology, both of whom are researchers at the Crump Institute for Molecular Imaging at the David Geffen School of Medicine at UCLA and the California NanoSystems Institute (CNSI) at UCLA, the team analyzed a panel of 19 human brain tumor biopsies to show the clinical application of the MIC platform to solid tumors. (nanowerk.com)
Mature schizonts release merozoites that infect red blood cells (RBCs) and lead to the onset of clinical symptoms associated with malaria. (elifesciences.org)

The comprehensive roles of VBF in CRC through systems biology and metabolomics approaches have been rarely investigated. (bvsalud.org)
This proposed workflow integrating molecular docking, multi-dose metabolomics, and biological validation, which contented EdU assay, cell cycle assay, provides a valuable framework for future similar studies. (bvsalud.org)

There are numerous types of ligand binding assays, both radioactive and non-radioactive. (wikipedia.org)
As such, ligand binding assays are a superset of radiobinding assays, which are the conceptual inverse of radioimmunoassays (RIA). (wikipedia.org)
Some newer types are called "mix-and-measure" assays because they do not require separation of bound from unbound ligand. (wikipedia.org)
Ligand binding assays are used primarily in pharmacology for various demands. (wikipedia.org)
Historically, ligand binding assay techniques were used extensively to quantify hormone or hormone receptor concentrations in plasma or in tissue. (wikipedia.org)
The first successful ligand binding assay was reported in 1960 by Rosalyn Sussman Yalow and Solomon Berson. (wikipedia.org)
As a direct result of these monumental findings, researchers have continued the advancement of ligand binding assays in many facets in the fields of biology, chemistry, and the like. (wikipedia.org)

Section F, Structural biology communications. (lu.se)

The research, which appears in the Aug. 1 issue of the journal Cancer Research , represents the teamwork of 35 co-authors from UCLA's Jonsson Comprehensive Cancer Center with expertise in surgery, pathology, cancer biology, bioinformatics and diagnostic devices. (nanowerk.com)

If you do not know it, the title is an obvious reference to the famous Schrodinger's assay that motivated many physicists to create the branch of science that is Biophysics. (quantitative-biology.org)

The techniques used for maintenance, preservation and authentication of cell lines are also included. (benthamscience.com)
The polymerase chain reaction is one of the most widely used techniques in molecular biology. (sigmaaldrich.com)
The molecular biology techniques developed in recent years stand as pivotal tools for pathogen identification, offering advancements in time and cost efficiency, as well as result reliability. (cetga.org)
The researchers also developed new bioinformatics - computational and statistical techniques and algorithms - that allowed them to process and analyze the data gleaned from the MIC platform's single-cell measurements. (nanowerk.com)
The successful candidate will join a team of researchers who investigate new CAR T-cell therapies for the treatment of glioblastoma in mouse models with multi-modality imaging techniques. (stanford.edu)
Students will also be introduced to core theory and experimental techniques used to investigate physiology, growth and death of cells. (mdx.ac.uk)
At NJ Bio, we offer both sophisticated BioNMR services and standard NMR techniques that can help determine the natural conformation of the TPD at physiological conditions. (njbio.com)

Sino Biological is an international biological reagent supplier and service provider. (the-scientist.com)
Sino Biological is dedicated to virology and infectious disease research. (the-scientist.com)
Sino Biological assumes no obligation to update these forward-looking statements and do not intend to do so. (the-scientist.com)
ATLANTA, GA, April 30, 2020 - GeoVax Labs, Inc. (OTC: GOVX), a biotechnology company developing human vaccines and immunotherapies against infectious diseases and cancer, announced today that Beijing- and Philadelphia-based Sino Biological, Inc. will be its exclusive supplier of SARS-Cov-2 (COVID-19) bioreagent research products. (gabio.org)
Commenting on the exclusive partnership, David A. Dodd, GeoVax Chairman & CEO stated, "We are delighted to establish this collaboration with Sino Biological related to our COVID-19 vaccine development program. (gabio.org)
Sino Biological is recognized as the research reagent industry leader in developing and providing COVID-19 bioreagent research products, as well as a leader throughout the bioreagent research industry. (gabio.org)
commented Rob Burgess, Ph.D., Chief Business Officer for Sino Biological. (gabio.org)

Approaches covered will include microinjection and molecular manipulations such as CRISPR/Cas9 knockouts, antisense morpholino-based depletions, transgenics, and mRNA overexpression. (cshl.edu)
In this chapter, we will provide general overview of various technical approaches for detecting apoptotic cells. (benthamscience.com)
To make sense of the data, we had to develop some new bioinformatics approaches that would preserve the power of single-cell analysis but allow for comparison between patients. (nanowerk.com)
Finally, we will invite speakers to talk about aspects of personalized or stratified medicine based on systems biology approaches for better care and future drug development. (lu.se)

The LuminoCell costs $40, requires less than 1 h to assemble, and it is capable of performing real-time sensitive detection of both magnitude and duration of the activity of major signalling pathways in cell cultures, including receptor tyrosine kinases (EGF and FGF), WNT/β-catenin, and NF-κB. (muni.cz)
The second is the application of new tools to designing selective PPI inhibitors for clinically highly relevant signaling pathways and characterizing the biological activities of new inhibitors using biochemical and cell-based assays. (usf.edu)
Researchers at UCLA have now developed a microfluidic image cytometry (MIC) platform that can measure cell-signaling pathways in brain tumor samples at the single-cell level. (nanowerk.com)
CONCLUSIONS: These findings suggest that VBF disrupts purine and pyrimidine pathways in CRC cancer cells, leading to cell cycle arrest. (bvsalud.org)

The MIC is essentially a cancer diagnostic chip that can generate single-cell 'molecular fingerprints' for a small quantity of pathology samples, including brain tumor tissues," said Dr. Hsian-Rong Tseng, a UCLA associate professor of molecular and medical pharmacology and one of the leaders of the research. (nanowerk.com)
Molecular and medical pharmacology graduate researcher Michael Masterman-Smith approached the project as a translational cancer biologist. (nanowerk.com)

Dr. Ji's research is Medicinal Chemistry and Chemical Biology. (usf.edu)
Graduate students in the Ji lab expect to receive training in rational drug design, synthetic organic chemistry, medicinal chemistry, chemical biology, and molecular and cell biology. (usf.edu)
Biological Chemistry, 388:779-86 (2007). (bcm.edu)

Landsteiner's work demonstrated that immunoassay technology allowed researchers to analyze at the molecular level. (wikipedia.org)
Through the development of RIA technology, researchers have been able to move beyond the use of radioactivity, and instead, use liquid- and solid-phase, competitive, and immunoradiometric assays. (wikipedia.org)
In order to get the intricate biology of living organisms, the researchers started using the basic unit of life i.e. (benthamscience.com)
Microscale technology platforms are finding wide application in biological assays in which careful manipulation and measurement of limited sample amounts are required, and the new MIC platform is capable of making molecular measurements on small tumor samples provided by tumor resection and biopsy using as few as 1,000 to 3,000 cells, according to the researchers. (nanowerk.com)

In the following chapter, we will discuss the basics of cell culture including the equipments, chemicals and different types of materials required for cell culture. (benthamscience.com)
Chapter Two discusses the G-quadruplexes and i-motifs as scaffolds for molecular engineering of DNA aptamers. (novapublishers.com)

Although there was no particular selectivity between the cell lines tested for samoamide A, the most potent activity was observed against H460 human non-small-cell lung cancer cells (IC50 = 1.1 μM). (henryford.com)
Here, we introduce LuminoCell-an open-source platform for the construction of an affordable, sensitive, and portable luminometer capable of real-time monitoring in-cell luciferase activity. (muni.cz)
Xog1p level increased on the cell wall, however, the overall exoglucanase activity reduced in the hom6hom6 mutant. (ncl.edu.tw)
The transcriptional activity of Zcf29p was induced after menadione treatment, revealed by one-hybrid assay. (ncl.edu.tw)
Compound 5 showed high antiproliferative activity against several human tumor cell lines. (researchgate.net)
Cancer cells, including leukemia cells, reside in a complex microenvironment, which influences biology and activity of the cells. (intechopen.com)
Preclinical studies support the use of HCQ for anti-cancer therapy, especially in combination with conventional anti-cancer treatments since they sensitize tumor cells to drugs, potentiating the therapeutic activity. (bvsalud.org)
FIP1L1/PDGFR point mutations often camouflage assays of TK activity, but do not necessarily affect imatinib effectiveness. (medscape.com)

Therefore, CERMES decided to include the PCR assay in the national framework of the routine surveillance system of the MOH in November 2002 to be ready when the next meningitis season began in January. (cdc.gov)

The SLAS Europe 2021 Digital Conference and Exhibition Programme will feature four important tracks focused on emerging biology, technology, discovery and careers in business and technology. (slas.org)
NJ Bio has a variety of tools, expertise and skills at its disposal to accelerate TPD discovery. (njbio.com)

You will be equipped to carry out individual research projects, for example, for your own final year research project that is supervised by one of our academics with expertise in ecological, molecular, microbiological or bioinformatics research. (mdx.ac.uk)
You will specialise by selecting modules from a variety of disciplines related to themes in molecular biology, biotechnology, bioinformatics, ecology and biodiversity. (mdx.ac.uk)
If omics-based assays were applied with appropriate study designs, thorough validation of the markers, and careful interpretation of study results then a bioinformatics database could be built of the human response to different chemical exposures and associated chronic diseases. (who.int)

However, the application of these assays is often limited by the costs of conventional luminometer instruments and the versatility of their use in different experimental conditions. (muni.cz)

Why choose Biological Sciences BSc at Middlesex? (mdx.ac.uk)
Throughout your degree you will gain biological and transferable skills necessary for a career in the Biological Sciences. (mdx.ac.uk)
What will you study on the Biological Sciences BSc? (mdx.ac.uk)
In the biological sciences the suffix -omics is used to refer to the study of large sets of biological molecules. (who.int)

Gel electrophoresis provides a convenient assay to detect splicing and to locate the spliced regions. (brainkart.com)

Also, complexity associated with drug research and development, with intricate biological targets and technologies necessitates the access to specialized expertise. (gminsights.com)
Molecular Depot LLC specialize in the development of research tools and biochemicals. (biosciregister.com)
MiraiBio designs & develops instruments and software for biological research. (biosciregister.com)
The session on super-resolution microscopy will explore its emergence from basic research applications towards exciting new applications in industrial scale screening of biological events at unparalleled sub-cellular scales. (slas.org)
This book provides current research on G-quadruplex structures, their formation and role in biology. (novapublishers.com)
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. (biotrend-usa.com)
Find or custom design the right target-specific assays and panels to research your biological targets of interest. (qiagen.com)
qBiomarker Somatic Mutation PCR Arrays are translational research tools that allow rapid and accurate profiling of the somatic mutation status for important genes related to a biological pathway or disease. (qiagen.com)
Accordingly, a goal of microfluidics research has been the development of integrated technology for scalable analysis of transcription in single cells. (justia.com)
We are excited about the possibility of using this method to investigate responses of individual tumors to potential therapeutics, as well as to enhance our knowledge about how they become resistant to therapies," said Dr. Harley Kornblum, a physician-scientist who studies brain tumor biology and is a member of both UCLA's Intellectual and Developmental Disabilities Research Center and the Johnson Cancer Center cell biology program area. (nanowerk.com)

An assay kit is a set of chemicals and supplies used to carry out a particular analytical operation known as an assay. (healthbreaking.com)
Assay kits are frequently used for diagnostic, investigative, and analytical reasons in a variety of medical and scientific domains. (healthbreaking.com)

Molecular epidemiology of G12 rotavirus strains during eight consecutive epidemic seasons in the Basque Country (North of Spain), 2010-2018. (cdc.gov)

A Postdoctoral Fellowship position is available in the Daldrup-Link lab ( http://daldrup-link-lab.stanford.edu/ ) in the Molecular Imaging Program at Stanford (MIPS) for a postdoctoral fellow with expertise in molecular biology and molecular imaging . (stanford.edu)

Our results advance our understanding of PI3K biology and pave the way for the development of specific inhibitors of class II PI3K function with wide applications in biomedicine. (nature.com)
Phosphoinositide 3-kinases (PI3Ks) are a family of lipid-modifying enzymes that phosphorylate the 3′-OH group of inositol phospholipids and play key roles in physiology ranging from cell growth and metabolism to organismal development. (nature.com)
Xenopus is remarkable for studying development and disease, including birth defects, cancer, and stem cell biology. (cshl.edu)

In previous courses, we have guided students in the ablation of a wide variety of genes and helped them design suitable assays for their biological interests. (cshl.edu)

Assay design is also highly variable and can make the difference between PCR success and failure and also contributes to the reproducibility and sensitivity of an assay. (sigmaaldrich.com)
Microfluidic systems provide numerous advantages for single cell analysis: economies of scale, parallelization and automation, and increased sensitivity and precision that comes from small volume reactions. (justia.com)

Assay kits frequently include standardized protocols and pre-measured chemicals, which streamline the experimental procedure and provide repeatable and accurate findings. (healthbreaking.com)

Timothy E. Allen teaches and mentors students in the areas of computational modeling of complex biological systems, molecular and cell biology assays, and medical device design. (virginia.edu)
Importantly, the proposed experimental setups can be easily transformed to study different cell types and different biological systems. (intechopen.com)
It follows that nanoparticle s may also express distinct bioactivity and unique interactions with biological systems. (cdc.gov)
The Molecular Imaging Program at Stanford (MIPS) was established to bring together scientists and physicians who share a common interest in developing and using state-of-the-art imaging technology and developing molecular imaging assays for studying intact biological systems. (stanford.edu)
In this assay, I describe reflections on biological systems and the nature of life. (quantitative-biology.org)

Stem Cell Rep. 5, 954-962 (2015). (nature.com)
Experience in stem cell and islet biology is highly desirable. (stanford.edu)

Anatomy23

Organisms12

Diseases2

Chemicals and Drugs35

Analytical, Diagnostic and Therapeutic Techniques and Equipment45

Phenomena and Processes55

Disciplines and Occupations28

Anthropology, Education, Sociology and Social Phenomena4

Technology, Industry, Agriculture4

Humanities5

Information Science28

Health Care9

Genetics5

Mammalian cells4

Compounds9

Processes11

ELISA1

Biochemistry and Molecular Biology1

Protein19

Proteins10

Developmental Biology1

QPCR6

Laboratory5

Viability3

Mass spectrometry2

Mechanisms7

Cytotoxicity2

Reagents4

Reporter1

Vitro5

Gene3

Immunology1

Biochemical and molecular1

Antibodies2

Genomics1

Western blot1

Optimization2

Fluorescence1

Functional2

Methods6

Proliferation8

Clinical8

Metabolomics2

Ligand7

Structural1

Cancer biology1

Biophysics1

Techniques7

Sino Biological7

Approaches4

Pathways4

Pharmacology2

Chemistry3

Researchers4

Chapter2

Activity8

Framework1

Discovery2

Bioinformatics3

Luminometer1

Sciences4

Electrophoresis1

Research10

Analytical2

Epidemiology1

Postdoctoral Fellow1

Development3

Suitable1

Sensitivity2

Procedure1

Systems5

Stem cell2