• This study was aimed at determining the differential gene expression patterns of OBP genes in the developmental stages (larval, pupal, teneral) and differentially starved adults of Glossina brevipalpis (Newstead) collected from Shimba Hills National Park, Kenya. (bioone.org)
  • One-third of the 471 genes predicted to encode transcription factors are differentially expressed during sexual development of S. commune . (nature.com)
  • The two expression profile datasets were integrated and we found out coexpression of differentially expressed genes (DEGs) using bioinformatics methods. (hindawi.com)
  • With the development of the gene expression profile, comparisons of differentially expressed genes that participate in the regulation of pathophysiological conditions in pathological tissue and normal tissue were available and convenient, and mRNAs gene expression profiles have been carried out in many diseases including TAD [ 6 ]. (hindawi.com)
  • Then we downloaded another microarray dataset GSE52093 [ 9 ] and screened out the coexpression of differentially expressed genes (DEGs) between TAD patients and non-TAD patients. (hindawi.com)
  • The mHTT and wtHTT groups showed the highest number of differentially expressed genes compared to the BACHD mouse model. (lu.se)
  • In BACHD mice, few hypothalamic genes were differentially expressed compared to age-matched WT controls. (lu.se)
  • Two analyses were performed: the first involved CC of immature metaphase I (MI) and mature metaphase II (MII) oocytes where 359 genes were differentially expressed, and the second involved the two GnRH analogues where no differentially expressed genes were observed at the entire transcriptome level. (elsevierpure.com)
  • A further analysis of 359 differentially genes was performed, focusing on anti-Müllerian hormone receptor 2 (AMHR2), follicle stimulating hormone receptor (FSHR), vascular endothelial growth factor C (VEGFC) and serine protease inhibitor E2 (SERPINE2). (elsevierpure.com)
  • Among other differentially expressed genes we observed a marked number of new genes connected to cell adhesion and neurotransmitters such as dopamine, glycine and γ-Aminobutyric acid (GABA). (elsevierpure.com)
  • We analyse two comprehensive transcriptome datasets from human tissues and human-derived cell lines in terms of the expression profiles of the SLC and ABC families of membrane transporters. (biorxiv.org)
  • Transcriptome profiling reveals molecular players in early soybean - Sclerotinia sclerotiorum interaction. (usda.gov)
  • Smart-seq2 for sensitive full-length transcriptome profiling in single cells. (crossref.org)
  • In conclusion, we show that both wtHTT and mHTT overexpression change hypothalamic transcriptome profile, specifically mHTT, altering neuroendocrine circuits. (lu.se)
  • Transcriptional Profiling Shows that Gcn4p is a Master Regulator of Gene Expression During Amino Acid Starvation in Yeast. (jnu.ac.in)
  • Transcriptional profiling suggests that succinate formation is coupled to mitochondrial redox balancing, and more specifically, reductive TCA cycle activity. (dtu.dk)
  • In this study, we investigated whether hypothalamic HTT expression causes transcriptional changes. (lu.se)
  • Here, we used cell-based and in vivo Drosophila, Xenopus laevis, and mouse models to show that ZEB1, a G/C-centered E-box binding transcriptional repressor, imposes a temporary stage-dependent inhibition of muscle gene expression and differentiation via CtBP-mediated transcriptional repression. (wustl.edu)
  • Inhibition of muscle genes by ZEB1 occurs via transcriptional repression and involves recruitment of the CtBP corepressor. (wustl.edu)
  • On May 30, 2003, Ewan Birney of the European Bioinformatics Institute, who had organized the pool, announced the winner: Lee Rowen of the Institute for Systems Biology. (wikipedia.org)
  • The integrated advanced bioinformatics methods may provide a way to solve the disadvantages and identify the hub genes involved in TAD. (hindawi.com)
  • Traditional bioinformatics methods including gene ontology (GO) and pathways enrichment analyses of DEGs combined protein-protein interaction (PPI) network and cytohubber calculating software as well as Molecular Complex Detection (MCODE) analysis were used to analyze the key gene and pathway. (hindawi.com)
  • Using advanced sequencing technologies and a set of specialized bioinformatics tools, created by PhD student Raquel Garza, the researchers successfully detected the activity of LINE-1 elements and were able to dig into their functions and epigenetic profiles. (lu.se)
  • This approach helped us to address these highly repetitive sequences, usually masked in standard bioinformatics pipelines, allowing us to accurately measure LINE-1 expression in each cell type found in our samples," explains Raquel Garza, co-first author of the study. (lu.se)
  • The Center for Translational Pediatric Research (CTPR) seeks to investigate how pediatric diseases develop from a systems biology and mechanistic approach, with the ultimate goal of identifying the intersections of disease and development, which will produce targets for therapeutic intervention and the development of new treatments. (archildrens.org)
  • Systems biology is an integrated approach examining all events within cells, tissues, and organisms that lead to a particular outcome. (archildrens.org)
  • By applying a systems biology approach to the study of pediatric diseases, the CTPR hopes to expand existing knowledge of pediatric disease development and contribute to new therapeutic targets. (archildrens.org)
  • The long-term goal of the CTPR is to build an innovative, multi-disciplinary pediatric research center that utilizes cutting-edge systems biology technologies and state-of-the-art translational research to study pediatric diseases. (archildrens.org)
  • The overall theme of the CTPR is to study how pediatric diseases develop from systems biology and mechanistic standpoints with the ultimate goal of identifying points in the intersection of disease and development which, in turn, will produce targets for intervention and the development of new treatments. (archildrens.org)
  • Accordingly, the group is positioned to work at the interface of systems biology, RNA biology and molecular neuroscience. (ed.ac.uk)
  • Mechanistic follow-up of key events is then carried out within hiPSC models using established molecular biology, functional genomics and systems biology methods in order to determine both their cause and consequence. (ed.ac.uk)
  • Our master's or doctorate program in forest molecular genetics and biotechnology focuses on researching functional genomics, ecological genetics, gene expression profiling at the whole-genome scale, and genetic improvement of trees for sustainable biofuel. (mtu.edu)
  • In addition, I am looking into the genome annotation and comparative genomics of Tembusu to identify genes selected when adapting to nutrient poor soils. (helsinki.fi)
  • Welcome to the fascinating world of molecular biology , where biologists study the intricate molecular mechanisms of biological molecules that determine our traits through genomics and mendelian genetics. (freescience.info)
  • To explore the concepts of genomics, molecular biologists employ cutting-edge techniques such as PCR (polymerase chain reaction), cloning, sequencing, and genetic engineering. (freescience.info)
  • In this article series on molecular biology, we will dive deeper into the captivating realm of genomics, where biologists study the genome and explore the fascinating world of Mendelian genetics. (freescience.info)
  • For instance, in cancer treatment, molecular biology techniques have led to breakthroughs in genomics and genetics such as personalized medicine. (freescience.info)
  • Thanks to molecular biology techniques like DNA sequencing and gene expression analysis, biologists have made significant strides in understanding genetics and genomics. (freescience.info)
  • The market expansion is fueled by several factors such as the rise in adoption of sequencing platforms in clinical diagnostics , growth in genomics & enzymology-based research, and increase in investments in R&D. In addition, the significance potential of molecular biology and advancement in precision medicine are further augmenting market growth. (grandviewresearch.com)
  • Hypothalamic expression of huntingtin causes distinct metabolic changes in Huntington's disease mice. (lu.se)
  • In the present study, we use mRNA microarray to acquire differential expression profiles in human TAD tissues and non-TAD tissues. (hindawi.com)
  • The top three single gene deletion strategies, Δmdh1 , Δoac1 , and Δdic1 , were tested using knock-out strains cultivated anaerobically on glucose, coupled with physiological and DNA microarray characterization. (dtu.dk)
  • In this study, we examine gene expression changes through microarray analysis in spheroid versus monolayer ovarian cancer cells treated with TGFβ to induce EMT. (usf.edu)
  • Therefore, the transcriptomic profile at different time points (days 3, 8, 15 and 21) along primary culture development of rainbow trout preadipocytes has been investigated using an Agilent trout oligo microarray. (biomedcentral.com)
  • Increased comparability between RNA-Seq and microarray data by utilization of gene sets. (uva.nl)
  • The BPRI has a Research Technician (RT) position available in the laboratories of Dr. Gabbiani and Dr. Zong in the Departments of Neuroscience and Molecular and Human Genetics at Baylor College of Medicine. (universityjobs.com)
  • The study of biological complexity is a new frontier that requires high-throughput molecular technology, high speed computer memory, new approaches to data analysis, and the integration of interdisciplinary skills. (intechopen.com)
  • Lee, J & Cho, Y 2021, ' Comparative gene expression profiling reveals the mechanisms of axon regeneration ', FEBS Journal , vol. 288, no. 16, pp. 4786-4797. (korea.ac.kr)
  • MicroRNA-guided prioritization of genome-wide association signals reveals the importance of microRNA-target gene networks for complex traits in cattle. (au.dk)
  • This study aims at integrating two gene expression profile datasets and verifying hub genes and pathways involved in TAD as well as exploring potential molecular mechanisms. (hindawi.com)
  • Molecular biology, a branch of science, has revolutionized the field of medicine by providing insights into the intricate mechanisms underlying diseases at a molecular level. (freescience.info)
  • To comprehend potential new mechanisms of immune regulation in endotoxemia, we examined macrophage mRNA expression by macroarray affected by LPS tolerance. (utmb.edu)
  • The need to understand the molecular mechanisms in species has made the PCR an indispensable tool for understanding the functioning of these biological systems. (intechopen.com)
  • Since it has been shown that injury-response signal transduction is mediated by gene expression changes, expression profiling is a useful tool to understand the molecular mechanisms of regeneration. (korea.ac.kr)
  • Thus, an experimental setup for the comparative analysis between regenerative and nonregenerative conditions is essential to identify ideal targets for the promotion of regeneration-associated genes and to understand the mechanisms of axon regeneration. (korea.ac.kr)
  • To understand the molecular mechanisms underlying the failure of parthenogenesis at early stages of development, we performed global gene expression profiling and functional analysis of parthenogenetic blastocysts in comparison with those of blastocysts from normally fertilized embryos. (prinsesmaximacentrum.nl)
  • Conclusions Unique gene expression profiles in muscle biopsies from patients with MSA-defined subtypes of myositis and IBM suggest that different pathological mechanisms underly muscle damage in each of these diseases. (johnshopkins.edu)
  • Determination of the molecular mechanisms underlying the toxicity induced by carbon nanotube s has merit in the prevention of the adverse health effects potentially resulting from their exposures. (cdc.gov)
  • Currently, a rat toxicity model was employed to investigate the molecular mechanisms underlying the lung toxicity induced by exposure to multi-walled carbon nanotube s (MWCNT). (cdc.gov)
  • After completing her undergraduate degree in Biology from the University of Massachusetts at Amherst, Dr. Kamendulis received her Ph.D. Toxicology from the University of New Mexico in 1994, where she studied mechanisms of hepatotoxicity, specifically focusing on the induction of apoptosis. (cdc.gov)
  • Her research focused on examining mechanisms by which environmental agents and therapeutic drugs elicit liver cancer, both in vivo and in vitro rodent models to examine the role of oxidative stress in modulating growth regulatory signaling networks and gene expression elicited by nongenotoxic carcinogens. (cdc.gov)
  • I was fascinated with topics such as the central dogma of molecular biology and protein synthesis, which are about the mechanisms of gene expression. (who.int)
  • These elements appear to influence the expression of both protein-coding genes and non-coding transcripts in the human brain through various mechanisms," says Raquel Garza. (lu.se)
  • Odorant binding proteins (OBPs) are involved in either olfactory or nonolfactory cue sensation depending on their spatial and temporal expression. (bioone.org)
  • It unravels the secrets of genes, which are segments of genetic material, such as DNA, containing instructions for building proteins and controlling various cellular processes. (freescience.info)
  • By investigating nucleic acids like DNA and RNA, as well as proteins and other biomolecules, scientists gain insights into gene expression, protein synthesis, gene transfer, and more. (freescience.info)
  • By studying genes, proteins, and other molecules within cells, biologists can identify genetic mutations responsible for inherited disorders. (freescience.info)
  • Skeletal muscle development is orchestrated by the myogenic regulatory factor MyoD, whose activity is blocked in myoblasts by proteins preventing its nuclear translocation and/or binding to G/C-centered E-boxes in target genes. (wustl.edu)
  • Recent evidence indicates that muscle gene expression is also regulated at the cis level by differential affinity for DNA between MyoD and other E-box binding proteins during myogenesis. (wustl.edu)
  • Gene expression was quantified for five seminal fluid protein genes, and in four of these gene expression changed as males aged. (edu.au)
  • 0.05), and these candidate genes could be used as potential diagnostic biomarkers and therapeutic targets of TAD. (hindawi.com)
  • Different statistical methods with varying selection criteria resulted in identification of similar candidate genes. (cdc.gov)
  • Array data are intended to provide candidate genes for hypothesis generation and further experimentation. (cdc.gov)
  • Array studies provide candidate genes to identify common mechanistic pathways in the effector phase, as well as mechanistic pathways unique to individual allergens. (cdc.gov)
  • Proliferation was characterized by enrichment in genes involved in basic cellular and metabolic processes (transcription, ribosome biogenesis, translation and protein folding), cellular remodelling and autophagy. (biomedcentral.com)
  • For example, gene therapy offers promising solutions by delivering functional genes or gene-editing tools directly into affected cells. (freescience.info)
  • A functional group of genes related to cell death regulation was identified. (utmb.edu)
  • Such functional data are essential for understanding of how sequence variation in genes and regulatory elements determine phenotypic diversity. (au.dk)
  • Using such probes, one can obtain a fingerprint of the gene expression activity in a macroscopic sample. (lu.se)
  • Continued studies focused on genes showing minimal changes in the TMA-induced model but with clear up-regulation in the ovalbumin model. (cdc.gov)
  • I was intrigued to learn more about the regulation of gene expression (protein synthesis) and how this is altered in disease conditions. (who.int)
  • After my master's degree, I was sure I wanted to pursue research as a career, and while selecting my PhD research topic I came across the field of epigenetics, which is the branch of molecular biology that deals with gene regulation. (who.int)
  • These differences were found in genes involved in cell cycle regulation, apoptosis, cell signaling, metastasis, and myeloid differentiation. (medscape.com)
  • Methods in Molecular Biology. (wikipedia.org)
  • The main emphasis is on supervised machine learning methods for classification and prediction of tumor gene expression profiles. (lu.se)
  • Furthermore, methods to rank the genes according to their importance for the classification are explored. (lu.se)
  • Molecular Immunology , 47 (16), 2587-2593. (utmb.edu)
  • Toxicity and global gene expression profiles were determined in the rat lungs, 16-hours following the last exposure. (cdc.gov)
  • Particularly in cancer research, where data are obtained by microarrays, identifying "biomarker" genes can potentially improve diagnostic accuracy for applying individual therapeutic or preventive treatments [ 1 , 2 ]. (biomedcentral.com)
  • Our discovery of critical genes and molecular events presents interesting avenues for mechanistic studies and biomarker development for early diagnosis in low-resource settings. (who.int)
  • Intracellular amastigote protocols need further refinement, but we describe a first generation tool for high-throughput comparative molecular characterization of patients' isolates, based on the changing expression profiles of promastigotes during in vitro differentiation. (cambridge.org)
  • To understand the development of adiposity, it is crucial to identify the genes which expression is associated with adipogenic differentiation. (biomedcentral.com)
  • Proliferation cluster comprised 1028 genes up-regulated from days 3 to 8 of culture meanwhile the differentiation cluster was characterized by 2140 induced genes from days 15 to 21. (biomedcentral.com)
  • On the other hand, the terminal differentiation phase was enriched with genes involved in energy production, lipid and carbohydrate metabolism. (biomedcentral.com)
  • Overall, our study demonstrates the coordinated expression of functionally related genes during proliferation and differentiation of rainbow trout adipocyte cells. (biomedcentral.com)
  • MyoD binds to G/C-centered E-boxes, enriched in muscle differentiation genes, in myotubes but not in myoblasts. (wustl.edu)
  • We found that, contrary to MyoD, ZEB1 binds to G/C-centered E-boxes in muscle differentiation genes at the myoblast stage but not in myotubes. (wustl.edu)
  • Its knockdown results in precocious expression of muscle differentiation genes and acceleration of myotube formation. (wustl.edu)
  • Lastly, we show that the pattern of gene expression associated with muscle differentiation is accelerated in ZEB1 -/- mouse embryos. (wustl.edu)
  • A diverse range of wet and dry-lab techniques are used to achieve this, whilst the translational research is principled upon core concepts of basic mammalian RNA biology. (ed.ac.uk)
  • Mammalian parthenogenesis could not survive but aborted during mid-gestation, presumably because of lack of paternal gene expression. (prinsesmaximacentrum.nl)
  • I am interested in the evolutionary biology and especially how genes and genomes evolve. (helsinki.fi)
  • Their research in evolutionary biology and cell biology contributes to advancements in medicine, agriculture, and biotechnology by unlocking the mysteries of biological molecules and developing new therapies. (freescience.info)
  • This work provided insight into the evolutionary biology of the species as well as discovered the regulatory genomic landscapes and transcribed coding and non-coding loci associated with specific physiological and developmental stages. (au.dk)
  • Filipe Pereira, professor of molecular medicine at Lund University, is awarded this year's Fernström prize for young, exceptionally promising, and successful researchers. (lu.se)
  • Today, he is a professor of molecular medicine at Lund University, and in recent years, his research successes and prestigious research grants have followed one another. (lu.se)
  • When we looked at our data, we noticed a pattern of stress-induced changes in gene activity, especially in cells exposed to higher temperatures during isolation," explains David Bryder, Professor of Molecular Hematology at Lund University, and research group leader at Lund Stem Cell Center. (lu.se)
  • No differential expression in CC between the two GnRH analogues supports the findings of clinical studies where no significant difference in live birth rates between both GnRH analogues has been proven. (elsevierpure.com)
  • A 2010 study comparing gene expression of cells expressing CD207 (a marker of Langerhans cells) in LCH lesions with epidermal CD207+ control cells identified differential expression of more than 2000 genes between these 2 subsets. (medscape.com)
  • He completed post-doctoral training at the Human and Molecular Genetics Department at Baylor College of Medicine, then joined the faculty of the Department of Genetics and Medical Genetics at the University of Wisconsin in 1997. (nuskin.com)
  • Despite recent advances in the understanding of the molecular biology controlling energy homeostasis and large efforts to uncover the genetic underpinnings of obesity in human populations, the exact molecular cause of weight gain in the majority of people remains unknown. (rti.org)
  • By subscribing to the notion that the brain plays a critical role in the control of energy homeostasis and ultimately the genesis of obesity, we acknowledge that the greatest challenge following the identification of the genetic make up of obese individuals will be to understand how these molecular defects work in combination to alter the neurophysiology of those regions of the brain that control energy balance. (rti.org)
  • Molecular biology techniques, such as DNA sequencing and genotyping, have facilitated the identification of genetic variations that impact drug metabolism and efficacy. (freescience.info)
  • Thoracic aortic dissection (TAD) is a catastrophic disease worldwide, but the pathogenic genes and pathways are largely unclear. (hindawi.com)
  • Thus, in the current study we provide evidence for the selective reprogramming of the gene expression of cell death pathways during LPS tolerance and link these changes to protection from cell death and enhanced survival rates. (utmb.edu)
  • Moreover, during this phase an enrichment in genes involved in the formation of the lipid droplets was evidenced as well as the activation of the thyroid-receptor/retinoic X receptor (TR/RXR) and the peroxisome proliferator activated receptors (PPARs) signalling pathways. (biomedcentral.com)
  • Since route of allergen exposure can influence mechanistic pathways, mice were sensitized by identical routes with a high molecular weight occupational allergen ovalbumin and a low molecular weight occupational allergen trimellitic anhydride (TMA). (cdc.gov)
  • Two of these genes, arginase 1 and eotaxin 1 are the focus of continuing investigations in mouse models of asthma regarding differences in mechanistic pathways depending on the allergen. (cdc.gov)
  • In particular, with some exceptions such as olfactory receptors and genes involved in keratin production, transporter genes are significantly more heterogeneously expressed than are most non-transporter genes. (biorxiv.org)
  • these often differ significantly from the 'housekeeping' genes commonly used for normalisation in transcriptomics and qPCR studies. (biorxiv.org)
  • A comprehensive characterisation of phaeochromocytoma and paraganglioma tumours through histone protein profiling, DNA methylation and transcriptomic analysis genome wide. (kcl.ac.uk)
  • I am delighted about our recent publication related to the ESCC project, where we identified crucial tumour-specific molecular (DNA methylation) events and proposed a novel early detection marker panel. (who.int)
  • These results were published in the article "Genome-wide DNA methylation profiling of esophageal squamous cell carcinoma from global high-incidence regions identifies crucial genes and potential cancer markers" in the journal Cancer Research . (who.int)
  • The Gini index (coefficient) characterises inequalities of distributions, and is used in a novel way to describe the distribution of the expression of each transporter among the different tissues and cell lines. (biorxiv.org)
  • Similar trends hold true for the expression profiles of transporters in different cell lines, suggesting that cell lines exhibit largely similar transport behaviour to that of tissues. (biorxiv.org)
  • PCBP1 is both reasonably highly expressed and has a low Gini coefficient in both tissues and cell lines, and is an excellent novel housekeeping gene. (biorxiv.org)
  • Given that the basic genome of a differentiated organism is constant between cells (and we here ignore epigenomics), what mainly discriminates one cell type from another is its expression profile. (biorxiv.org)
  • 12 Department of Neurosurgery and Center for Stem Cell & Regenerative Medicine, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Texas. (aacrjournals.org)
  • Adipogenesis has been extensively studied in mammals [ 7 ] and several cell and animal models have been successfully used to describe the chronology of the molecular events governing this process. (biomedcentral.com)
  • Since genes are composed of a given alphabet (A, T, C, G) with fixed pairing properties A-T and C-G, probes can be constructed that attract gene transcripts extracted from cell tissues and cultures. (lu.se)
  • Journal of molecular cell biology , 2 (6), 333-44. (prinsesmaximacentrum.nl)
  • Trends in Cell Biology, 2021. (bu.edu)
  • Molecular Cell, 2020. (bu.edu)
  • 2023 the Department of Biochemistry & Cell Biology ventured. (bu.edu)
  • The Department of Biochemistry and Cell Biology at the Boston University Chobanian. (bu.edu)
  • Anna Konturek-Ciesla, a researcher at Lund Stem Cell Center and the lead author of the study explains, "In our research, which focuses on hematopoiesis, or blood cell formation, many studies have attempted to analyze the changes associated with aging in blood stem cells using gene expression profiling. (lu.se)
  • As of 2018[update] there is continuing debate amongst scientists about the total number of genes in the human genome, with most estimates ranging from 19,000 and 22,000. (wikipedia.org)
  • 1. UMPIRE - UMPIRE provides tools to simulate realistic biological expression data. (r-project.org)
  • Molecular biology , a field studied by biologists, focuses on the study of biological molecules and their interactions at the molecular level. (freescience.info)
  • The limitations and possibilities associated with expression profiling in intracellular amastigotes and promastigotes were assessed through a series of comparative experiments in which technical and biological parameters were scrutinized. (cambridge.org)
  • On the biological level, we demonstrate that gene expression levels fluctuate during in vitro development of both intracellular amastigotes and promastigotes. (cambridge.org)
  • We chose to use expression-curves rather than single, specific, time-point measurements to capture this biological variation. (cambridge.org)
  • Gene Set Enrichment Analysis (GSEA) with leading-edge analysis showed that suppressed sterol- and cholesterol metabolism were shared between hypothalamic wtHTT and mHTT overexpression. (lu.se)
  • Molecular Metabolism. (lu.se)
  • 3 Faculty of Biology, Medicine and Health, The University of Manchester M13 9PL, UK. (biorxiv.org)
  • Molecular biology, a branch of science that combines biology and chemistry, is crucial for advancements in medicine, biotechnology, agriculture, and our understanding of evolution and biodiversity. (freescience.info)
  • In contrast, the ubiquitous expression of full-length mHTT in the BACHD hypothalamus moderately affects the transcriptomic profile. (lu.se)
  • Machine learning algorithms were trained on transcriptomic data and recursive feature elimination was used to determine which genes were most useful for classifying muscle biopsies into each type and MSA-defined subtype of myositis. (johnshopkins.edu)
  • Dr. Prolla's work currently focuses on the use of gene expression profiling, lifespan studies, and histopathology. (nuskin.com)
  • Current research in my laboratory is concerned with understanding the molecular genetics of extraordinary long lifespan and aging. (au.dk)
  • The role of a soybean 14-3-3 gene (Glyma05g29080) on white mold resistance and nodulation investigations using CRISPR-Cas9 editing and RNA silencing. (usda.gov)
  • Safeguarding CRISPR-Cas9 gene drives in yeast. (cdc.gov)
  • So necessary understanding of the molecular mechanism may provide new insights into therapeutic targets for TAD. (hindawi.com)
  • Insights into the Molecular Evolution of Dengue virus Type 4 in Puerto Rico over Two Decades of Emergence. (cdc.gov)
  • His laboratory focuses on understanding the molecular mechanism by which the klotho protein suppresses aging. (nuskin.com)
  • Examples of high molecular environmental factors are known to influence the development weight occupational allergens include proteases used in the and expression of asthma, and a vast array of triggers of asthma detergent industry, laboratory animal allergens, and ovalbumin have been identified. (cdc.gov)
  • Hence, there is a pressing need to understand the molecular mechanism involved in stress response and legumes adaptation. (researchgate.net)
  • Molecular Plant-Microbe Interactions. (usda.gov)
  • By unraveling the complex interactions between genes and their regulatory elements, researchers can identify disease-causing mutations more accurately. (freescience.info)
  • The molecular interactions of genes and gene products underlie fundamental questions of biology. (lu.se)
  • Clinical, immunological and molecular characteristics of 37 Iranian patients with X-linked agammaglobulinemia. (lu.se)
  • By May 23, 2000, 228 bets had been placed, with the average number of predicted genes among them being 62,598. (wikipedia.org)
  • Four novel and three recurrent mutations of the BTK gene and pathogenic effects of putative splice mutations. (lu.se)
  • Exploring crime scene science, toxicology, chemistry, and molecular biology, this degree is designed to be one of the most modern and relevant of its kind. (bournemouth.ac.uk)
  • While the molecular players involved in the first phase are currently emerging, regulatory compon. (researchgate.net)
  • Axon regeneration is regulated by injury-responsive genes induced in both neurons and their surrounding non-neuronal cells. (korea.ac.kr)
  • More even lucky to join Mike Blower's lab at MGH in 2016, learning and growing as a scientist using Xenopus and human cells to understand how gene expression is regulated as cells transit through mitosis. (bu.edu)
  • The aim of our study was to improve the understanding of gene expression profile of cumulus cells (CC) in terms of ovarian stimulation protocol and oocyte maturity. (elsevierpure.com)
  • Specifically, a variety of other cellular populations have been identified that possess phenotypic characteristics similar to Langerhans cells, including expression of CD207 and Birbeck granules. (medscape.com)
  • 10] Interestingly, this analysis found no differences in expression of proliferation markers between these subsets of CD207+ cells, consistent with the hypothesis that LCH may be a disease of abnormal cellular accumulation. (medscape.com)
  • Studying gene expression is essential for understanding how cells function and respond to different stimuli. (lu.se)
  • Today, performing gene expression analysis on young and aged hematopoietic stem cells is a common practice, used to understand the changes associated with aging. (lu.se)
  • Despite this wealth of knowledge, Anna Konturek-Ciesla noted that there is still no consensus about the molecular profile of aged hematopoietic stem cells. (lu.se)
  • Suspecting that experimental procedures used during gene expression analysis might be influencing the results, they examined how stress-related genes behaved in cells collected under different conditions. (lu.se)
  • Parthenogenetic blastocysts exhibited changes in the expression of 749 genes, of which 214 had lower expression and 535 showed higher expressions than fertilized embryos using a minimal 1.8-fold change as a cutoff. (prinsesmaximacentrum.nl)
  • Five OBP genes, GbrOBP2 , GbrOBP6 , GbrOBP7 , GbrOBP8 , and GbrOBP13 , were selected for quantitative PCR expression analysis as representatives of the three OBP classes in Glossina spp. (bioone.org)
  • In what follows we limit ourselves to the analysis of gene expression measurements obtained using microarrays with small spots of DNA fixed to glass slides. (lu.se)
  • Typically when data are presented, the fluor- escent intensity from the tissue is pseudo-colored red and the intensity from the reference green, and the logarithmic ratio of background corrected red and green intensities for each gene (spot) is subject to analysis (see Fig. 1 ). (lu.se)
  • Meta-analysis of genome-wide association studies for cattle stature identifies common genes that regulate body size in mammals. (au.dk)
  • In both these projects, I am coordinating the collaborations for project administration, which involves obtaining ethical clearances for project execution, collecting biospecimens and data, experimentation and molecular analysis, preparing manuscripts, and writing grant applications to support these projects. (who.int)
  • Microarrays are one such tool that allows for the study of expression of thousands of genes simultaneously. (lu.se)
  • Identify key genes in root development of poplar trees. (mtu.edu)
  • To identify research strategies for the study of human obesity that complement positional cloning, we have developed a concept that we will refer to as neuroimagenomics (NIG), consisting of an iterative experimental approach combining neuroimaging and gene expres-sion profiling of the human brain. (rti.org)
  • Micro- array data from the ovalbumin and TMA model of asthma were also compared to previous data using Aspergillus as allergen to identify putative asthma `signature genes', i.e. genes up-regulated with all 3 allergens. (cdc.gov)
  • The gene ontology and pathway enrichment of DEGs were performed by DAVID and Kyoto Encyclopedia of Genes and Genomes online analyses, respectively. (hindawi.com)
  • As the sequencing and gene annotation projects of entire genomes of many species are headed towards completion (see, e.g. [13] ), massive mapping efforts in biology are now focused on how the genes interact. (lu.se)
  • Furthermore, Formalin-fixed, paraffin-embedded (FFPE) samples play a crucial role in determining the molecular correlates of carcinogenesis. (grandviewresearch.com)
  • Gene expression profiling is increasingly used in the field of infectious diseases for characterization of host, pathogen and the nature of their interaction. (cambridge.org)
  • The purpose of this study was to develop a robust, standardized method for comparative expression profiling and molecular characterization of Leishmania donovani clinical isolates. (cambridge.org)
  • Stochastic models of gene transcription with upstream drives: exact solution and sample path characterization. (crossref.org)
  • Characterization of novel Bruton's tyrosine kinase gene mutations in Central European patients with agammaglobulinemia. (lu.se)