Dicarbonyl/L-xylulose reductase, also known as carbonyl reductase II, is an enzyme that in human is encoded by the DCXR gene located on chromosome 17. (wikipedia.org)
The systematic name of this enzyme class is xylitol:NADP+ 2-oxidoreductase (L-xylulose-forming). (wikipedia.org)
Xylose2
These enzymes catalyze the sequential reduction of xylose to xylitoland oxidation of xylitol to xylulose[1].Although these strains could use xylose for growth and xylitol formation, ethanol production hasbeen rather poor. (vtt.fi)
An additionalimprovement in xylose to ethanol conversion came about by cloning and overexpressing theendogenous enzyme xylulokinase (XK), that phosphorylates xylulose to xylulose 5-phosphate. (vtt.fi)
1.101
In enzymology, an L-xylulose reductase (EC 1.1.1.10) is an enzyme that catalyzes the chemical reaction xylitol + NADP+ ⇌ {\displaystyle \rightleftharpoons } L-xylulose + NADPH + H+ Thus, the two substrates of this enzyme are xylitol and NADP+, whereas its 3 products are L-xylulose, NADPH, and H+. (wikipedia.org)
Enzyme3
Xylulose Xylitol (Note conversion of ketone to alcohol) This enzyme belongs to the superfamily of short-chain oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. (wikipedia.org)
Expression and molecular analysis of the Arabidopsis DXR gene encoding 1-deoxy-D-xylulose 5-phosphate reductoisomerase, the first committed enzyme of the 2-C-methyl-D-erythritol 4-phosphate pathway. (chinaagrisci.com)
Putrescine N -methyltransferase (PMT) was considered as the first rate-limiting upstream enzyme while tropinone reductase I (TRI) was an important branch-controlling enzyme involved in TA biosynthesis. (biomedcentral.com)
Ribose1
1. Ashwell, G. and Hickman, J. Enzymatic formation of xylulose 5-phosphate from ribose 5-phosphate in spleen. (qmul.ac.uk)
Characterization1
Ringer, K.L., McConkey, M.E., Davis, E.M., Rushing, G.W. and Croteau, R. Monoterpene double-bond reductases of the (-)-menthol biosynthetic pathway: isolation and characterization of cDNAs encoding (-)-isopiperitenone reductase and (+)-pulegone reductase of peppermint. (enzyme-database.org)
Enzymatic detection of γ -hydroxybutyrate using aldo-keto reductase 7A2. (bu.edu)
Phosphate2
The biosynthesis of pyridoxine has classically been studied in E. coli where the precursors 4-phosphohydroxy-L-threonine and 1-deoxy-D-xylulose-5-phosphate (DXP) are converted to pyridoxinephosphate by the action of the protein encoded by pdxJ. (ecmdb.ca)
3. Hurwitz, J. and Horecker, B.L. The purification of phosphoketopentoepimerase from Lactobacillus pentosus and the preparation of xylulose 5-phosphate. (qmul.ac.uk)
Biology1
Our research involves a combination of molecular biology, protein biochemistry, organic synthesis and structural studies and provides a strong training for students interested in understanding the organic chemistry of living systems and in pursuing careers in biotechnology, drug design or academia. (tamu.edu)
Exploring the roles of MVA pathway in cembranoid synthesis could contribute not only to the technical approach but also to the molecular mechanism for cembranoid biosynthesis. (bvsalud.org)
Mechanisms1
Therefore, there is a critical need to expand our understanding of the interaction between the microorganism and xenobiotics and various mechanisms of resistance presented by Mtb , identify new anti-TB chemical matter, expand our knowledge of microorganism and host interaction, and establish molecular targets for host-directed therapy. (nature.com)
Parasite1
For example, in the figure showing trypanothione reductase from the human protozoan parasite Trypanosoma cruzi, two molecules of an inhibitor called quinacrine mustard are bound in its active site. (pdgfrsignals.com)
Disease1
The insufficiency of L-xylulose reductase activity causes an inborn error of metabolism disease characterized by excessive urinary excretion of L-xylulose. (wikipedia.org)
Regulation1
Molecular features of phosphatase and tensin homolog (PTEN) regulation by C-terminal phosphorylation. (bu.edu)
In view of the molecular structure of celastrol, friedelin is subsequently converted to celastrol by multiple oxidations at the C-29, C-2, and C-24 positions, which are possibly mediated by specific cytochrome P450s (CYPs). (techscience.com)
The benzimidazole drugs share a common molecular structure, triclabendazole being the exception in having a chlorinated benzene ring but no carbamate group. (curezone.org)
Domain1
Both proteins contain a Cysteine-rich zinc finger domain that is highly specific to DnaJ-like molecular chaperons. (yokohama-cu.ac.jp)
Function1
This requires the function of a kinase encoded by pdxK and of the pyridoxal reductase Plr1. (ecmdb.ca)
Specific1
The specific cellular or molecular binding site relevant to the action of IAA and the auxin-mimicking herbicides has not been identified. (weedscience.com)