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KCNQ1 Potassium ChannelKCNQ Potassium ChannelsKCNQ3 Potassium ChannelKCNQ2 Potassium ChannelCalcium ChannelsPotassium Channels, Voltage-GatedPotassium ChannelsIon ChannelsCalcium Channel BlockersPotassiumPotassium Channels, Inwardly RectifyingPotassium Channel BlockersIon Channel GatingCalcium Channels, L-TypeCalcium Channels, N-TypeShaker Superfamily of Potassium ChannelsSodiumMembrane PotentialsCalcium Channels, T-TypePotassium Channels, Calcium-ActivatedKv1.3 Potassium ChannelElectrophysiologyKv1.2 Potassium ChannelPatch-Clamp TechniquesEther-A-Go-Go Potassium ChannelsKv1.1 Potassium ChannelCalcium Channel AgonistsChloride ChannelsKATP ChannelsShaw Potassium ChannelsLarge-Conductance Calcium-Activated Potassium ChannelsElectric ConductivityKv1.5 Potassium ChannelCalcium SignalingKv1.4 Potassium ChannelShab Potassium ChannelsOocytesXenopus laevisSodium Channel BlockersCalciumShal Potassium ChannelsCalcium Channels, P-TypeKineticsSmall-Conductance Calcium-Activated Potassium ChannelsCalcium Channels, Q-TypeBariumTetraethylammoniumDihydropyridinesAction PotentialsNifedipineG Protein-Coupled Inwardly-Rectifying Potassium ChannelsNeuronsXenopusCalcium Channels, R-TypeMolecular Sequence DataDelayed Rectifier Potassium ChannelsPotassium Channels, Tandem Pore DomainAmino Acid SequenceGlyburideDose-Response Relationship, DrugCells, CulturedRats, Sprague-DawleyPhenylenediaminesTRPC Cation ChannelsCyclic Nucleotide-Gated Cation Channelsomega-Conotoxin GVIAEpithelial Sodium ChannelsScorpion VenomsAdenosine TriphosphateIntermediate-Conductance Calcium-Activated Potassium ChannelsCell MembraneCell LineProtein SubunitsLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsIon Transportomega-ConotoxinsSodium ChannelsTime FactorsVerapamilDiltiazemTRPV Cation ChannelsMutation4-AminopyridineCharybdotoxinElectric StimulationProtein Structure, TertiaryAcid Sensing Ion ChannelsTetraethylammonium CompoundsTRPM Cation ChannelsModels, BiologicalTetrodotoxinMyocardiumIsradipineRats, WistarGuinea PigsCalcium, DietarySulfonylurea ReceptorsMibefradilCromakalimRabbits

ProteinsSubfamilySelectiveSeizuresNeuronsMechanismsMarkersIncreaseActionFoundNormalCells

Proteins2

• Some of these loci have been identified further as specific mutations in the KCNQ2 and KCNQ3 M-type potassium channel proteins. (medscape.com)
• The calcium acts as an intracellular messenger by activating calcium-responsive proteins. (lookformedical.com)

Subfamily2

• Voltage-gated K + channels of the Kv3 subfamily have unusual electrophysiological properties, including activation at very depolarized voltages (positive to −10 mV) and very fast deactivation rates, suggesting special roles in neuronal excitability. (jneurosci.org)
• Voltage-gated potassium (Kv) channels in the KCNQ (Kv7) subfamily are highly influential in the nervous system, muscle and epithelia. (bvsalud.org)

Selective5

• Although evidence points to a key role in high-frequency firing, a definitive understanding of the function of these channels has been hampered by a lack of selective pharmacological tools. (jneurosci.org)
• A class of drugs that act by selective inhibition of calcium influx through cellular membranes. (lookformedical.com)
• Gated, ion-selective glycoproteins that traverse membranes. (lookformedical.com)
• Therefore, tissue-selective calcium agonists have the potential to combat cardiac failure and endocrinological disorders. (lookformedical.com)
• Gating is thought to involve conformational changes of the ion channel which alters selective permeability. (lookformedical.com)

Seizures1

• Given the severity of the impairment to the M-type potassium channel, that these seizures are difficult to treat is not surprising, because no currently used antiepileptic medications are known to increase the efficiency of the potassium channel. (medscape.com)

Neurons2

• In the brain, Kv3 channels are prominently expressed in select neuronal populations, which include fast-spiking (FS) GABAergic interneurons of the neocortex, hippocampus, and caudate, as well as other high-frequency firing neurons. (jneurosci.org)
• CALCIUM CHANNELS located in the neurons of the brain. (lookformedical.com)

Mechanisms1

• Signal transduction mechanisms whereby calcium mobilization (from outside the cell or from intracellular storage pools) to the cytoplasm is triggered by external stimuli. (lookformedical.com)

Markers1

• Dihydropyridine-based calcium antagonists are used as markers for these binding sites. (lookformedical.com)

Increase1

• Agents that increase calcium influx into calcium channels of excitable tissues. (lookformedical.com)

Action3

• Moreover, we reveal that, in male and female rats, this action depends on M-like potassium conductance. (jneurosci.org)
• A potent vasodilator agent with calcium antagonistic action. (lookformedical.com)
• Blockade of potassium channels prolongs the duration of ACTION POTENTIALS. (lookformedical.com)

Found1

• Long-lasting voltage-gated CALCIUM CHANNELS found in both excitable and nonexcitable tissue. (lookformedical.com)

Normal1

• The potassium current was reduced in the channel expressed by the mutated gene to 5% of that in the channel expressed by the normal gene. (medscape.com)

Cells2

• The largest group of neocortical inhibitory interneurons (∼50%) consists of cells that contain the calcium-binding protein parvalbumin (PV). (jneurosci.org)
• CALCIUM CHANNELS located within the PURKINJE CELLS of the cerebellum. (lookformedical.com)