• Mitotic inhibitors are also used in cytogenetics (the study of chromosomes), where they stop cell division at a stage where chromosomes can be easily examined. (wikipedia.org)
  • Cytogenetics, the study of chromosomal material by analysis of G-Banded chromosomes, uses mitotic inhibitors extensively. (wikipedia.org)
  • Mechanistically, the CIP2A-TOPBP1 complex prematurely associates with DNA lesions within ruptured micronuclei during interphase, which poises pulverized chromosomes for clustering upon mitotic entry. (nature.com)
  • Mitotic clustering facilitates the reassembly of acentric fragments into rearranged chromosomes lacking the extensive DNA copy-number losses that are characteristic of canonical chromothripsis. (nature.com)
  • New findings from his lab published in the July 21 advance online issue of Nature demonstrate that the way the mitotic spindle-the machinery that separates chromosomes into daughter cells during cell division-aligns relative to the surface of the cell layer is essential for the maintenance of epithelial integrity. (stowers.org)
  • As division began, the mitotic spindle (which faithfully distributes chromosomes into each daughter cell) invariably oriented itself parallel to the apical surface of the epithelium. (stowers.org)
  • Conversely, 53BP1 nuclear bodies are partially suppressed by knocking down SMC2, a condensin subunit required for mechanical stability of mitotic chromosomes. (ku.dk)
  • Aurora B mislocalization on chromosomes utilizes the Haspin-H3T3P pathway and is a key factor for the mitotic delay. (ku.edu)
  • While interphase chromatin appears as thread-shaped structures, mitotic chromosomes appear as distinct rod-shaped structures. (differencebetween.com)
  • What are Mitotic Chromosomes? (differencebetween.com)
  • Mitotic chromosomes are distinct rod-shaped, highly condensed chromosomes that are present in the mitotic phase of cell division. (differencebetween.com)
  • Mitotic chromosomes are very distinct due to the shape and the amount of condensation. (differencebetween.com)
  • Mitotic chromosomes will undergo different biochemical changes under four sub-stages of mitosis. (differencebetween.com)
  • During the mitotic phase, mitotic chromosomes are attached to a structure known as the mitotic spindle. (differencebetween.com)
  • Mitotic chromosomes line up at the metaphase plate. (differencebetween.com)
  • Microtubules connect with the centrosomes of the lined up mitotic chromosomes. (differencebetween.com)
  • During anaphase, the mitotic chromosomes (sister chromosomes) split evenly. (differencebetween.com)
  • Interphase chromatin and mitotic chromosomes are types of chromosomes. (differencebetween.com)
  • Moreover, interphase chromatins are less condensed, while mitotic chromosomes are heavily condensed. (differencebetween.com)
  • The below infographic presents the differences between interphase chromatin and mitotic chromosomes in tabular form for side by side comparison. (differencebetween.com)
  • Mitotic chromosomes appear as distinct rod-shaped structures, and they are heavily condensed. (differencebetween.com)
  • Both interphase chromatin and mitotic chromosomes are essential for the cycle of cell division. (differencebetween.com)
  • So, this is the summary of the difference between interpahse chromatin and mitotic chromosomes. (differencebetween.com)
  • We have shown that in fixed mitotic chromosomes from female G. gerbillus cells the inactive X chromosome is distinctly less sensitive to DNAase I than the active X chromosome, as demonstrated by in situ nick translation. (huji.ac.il)
  • These results indicated that the specific chromatin conformation that renders potentially active genes sensitive to DNAase I is maintained in fixed mitotic chromosomes. (huji.ac.il)
  • Mitotic phases and chromosomes' structures were observed using root tips prepared with the squash method. (ptti.or.id)
  • The similarity of carbon nanotube s to microtubules suggests a potential to interact with cellular biomolecules, such as the mitotic spindle, as well as the motor proteins that separate the chromosomes during cell division. (cdc.gov)
  • Disruption of centrosomes and mitotic spindles would result in monopolar, tripolar, and quadrapolar divisions of chromosomes. (cdc.gov)
  • A mitotic inhibitor is a drug that inhibits mitosis, or cell division. (wikipedia.org)
  • Mitotic inhibitors are derived from natural substances such as plant alkaloids, and prevent cells from undergoing mitosis by disrupting microtubule polymerization, thus preventing cancerous growth. (wikipedia.org)
  • The Mitotic Counting algorithm was trained on over 100,000 individual mitosis and across seven scanner models. (news10.com)
  • We find that NF45 and NF90 play essential roles in mitosis, and transcriptome analysis reveals that they are necessary for the expression of a subset of mitotic mRNAs. (iric.ca)
  • To investigate how spindle-localized RNAs might influence mitosis, we comprehensively surveyed all messenger RNAs (mRNAs) that bound to microtubules during metaphase in both Xenopus laevis egg extracts and mitotic human cell extracts. (escholarship.org)
  • Mitotic count (mitosis per mm 2 ) was assessed on H&E sections, and Ki-67 expression was estimated by immunohistochemistry on standard sections. (biomedcentral.com)
  • The mitotic inducer nim1+ functions in a regulatory network of protein kinase homologs controlling the initiation of mitosis. (wikidata.org)
  • In a subsequent in-depth analysis of key mitotic regulatory complexes with the Aurora kinase B (AURKB) inhibitor Hesperadin and a new Polo-like kinase (PLK1) inhibitor, BI 4834, we determined the kinase dependency for 172 phosphorylation sites on 41 proteins. (nih.gov)
  • Browse our antibodies, ELISA kits and proteins related to mitotic G1-G1/S phases. (antibodies-online.com)
  • Gibson reasoned that the reported tumor-suppressive activity of these proteins might be linked to a role in keeping the mitotic spindle in line. (stowers.org)
  • Our group has identified DNA topoisomerase IIα (Topo IIα) as one of the important mitotic proteins for SUMOylation. (ku.edu)
  • EML4 and NUDC proteins are required for mitotic spindle formation, attachment of spindle microtubule ends to kinetochores, and alignment of mitotic chromosome at the metaphase plate. (reactome.org)
  • Mitotic spindles are three-dimensional molecular machines. (tu-dresden.de)
  • This approach allows us to reconstruct mitotic spindles in 3D with the resolution of about 2.3 nm. (tu-dresden.de)
  • Active mitotic translation occurs on X. laevis meiotic spindles, and a subset of microtubule-bound mRNAs (MT-mRNAs) associate with polyribosomes. (escholarship.org)
  • Mitotic inhibitors interfere with the assembly and disassembly of tubulin into microtubule polymers. (wikipedia.org)
  • Microtubules are essential to mitotic reproduction, so through the inactivation of the microtubule function of a cell, taxanes inhibit the cell's division. (wikipedia.org)
  • The maintenance of a single centromere per chromosome is critical for establishing bipolar microtubule attachments to the mitotic spindle and achieving high-fidelity genome segregation 17 . (nature.com)
  • Our results represent the first genome-wide survey of mRNAs localized to a specific cytoskeletal component and suggest that microtubule localization of specific mRNAs is likely to function in mitotic regulation and mRNA segregation during cell division. (escholarship.org)
  • Centromere-associated protein-E (CENP-E) is an essential mitotic kinesin that is required for efficient, stable microtubule capture at kinetochores. (rupress.org)
  • Although many MT-mRNAs associate with polyribosomes, we find that active translation is not required for mRNA localization to mitotic microtubules. (escholarship.org)
  • 2019) by serine/threonine kinases NEK6 and NEK7, leading to its dissociation from microtubules, which is necessary for the assembly of a dynamic mitotic spindle (Adib et al. (reactome.org)
  • Mitotic inhibitors are used in cancer treatment, because cancer cells are able to grow and eventually spread through the body (metastasize) through continuous mitotic division. (wikipedia.org)
  • In order to prepare a slide for cytogenetic study, a mitotic inhibitor is added to the cells being studied. (wikipedia.org)
  • Inactivation of CIP2A-TOPBP1 caused acentric fragments to disperse throughout the mitotic cytoplasm, stochastically partition into the nucleus of both daughter cells and aberrantly misaccumulate as cytoplasmic DNA. (nature.com)
  • 2017). My intention is to apply this approach now for a quantitative analysis of mitotic spindle structure in mammalian cells. (tu-dresden.de)
  • In other words, if you pointed a tiny camera in your gut toward dividing epithelial cells of its lining, you would "see" the mitotic spindle looking like a symmetrical web, exactly like it did in your high school biology textbook. (stowers.org)
  • Our results suggest that PIASy is an important E3 ligase that mediates mitotic SUMOylation in human cells. (ku.edu)
  • We show that depletion of SMD components increases the binding of mitotic mRNAs to the NF45-NF90 complex and rescues cells from mitotic defects. (iric.ca)
  • Mitotic cells lacking hMDC1 exhibit markedly reduced levels of APC/C activity characterized by reduced levels of Cdc20, and a failure of Cdc20 to bind the APC/C and CREB-binding protein. (ox.ac.uk)
  • The antibody may be used as biomarker for mitotic cells. (fsu.edu)
  • In support of a role for hMDC1 in controlling mitotic progression, depletion of hMDC1 by small interfering RNA results in a metaphase arrest that appears to be independent of both BubR1-dependent signaling pathways and ATM/ATR activation. (ox.ac.uk)
  • SUMOylated Topo IIα C-terminus (CTD) interacts with Haspin kinase and recruits chromosome passenger complex (CPC) to the mitotic centromeres. (ku.edu)
  • It also directly binds to BubR1, a kinetochore-associated kinase implicated in the mitotic checkpoint, the major cell cycle control pathway in which unattached kinetochores prevent anaphase onset. (rupress.org)
  • Thus, CENP-E is required for enhancing recruitment of its binding partner BubR1 to each unattached kinetochore and for stimulating BubR1 kinase activity, implicating it as an essential amplifier of a basal mitotic checkpoint signal. (rupress.org)
  • Examples of mitotic inhibitors frequently used in the treatment of cancer include paclitaxel, docetaxel, vinblastine, vincristine, and vinorelbine.Colchicine and griseofulvin are mitotic inhibitors used in the treatment of gout and toenail fungus, respectively. (wikipedia.org)
  • Wikimedia Commons has media related to Mitotic inhibitors. (wikipedia.org)
  • High doses of mitotic inhibitors can cause nerve damage. (healthline.com)
  • Numerical simulations reproduce the main features of wild-type mitotic cycles: patterns of protein accumulation and degradation, lengthening of later cycles, and arrest in interphase 14. (vt.edu)
  • The model is consistent with mutations that introduce subtle changes in the number of mitotic cycles before interphase arrest. (vt.edu)
  • The key difference between interphase chromatin and mitotic chromosome is the structural appearance of the chromatin when observed under the microscope. (differencebetween.com)
  • At the end of the interphase, the cell becomes ready to process into the mitotic stage. (differencebetween.com)
  • Mitotic Spindle Apparatus" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
  • This graph shows the total number of publications written about "Mitotic Spindle Apparatus" by people in this website by year, and whether "Mitotic Spindle Apparatus" was a major or minor topic of these publications. (wakehealth.edu)
  • Below are the most recent publications written about "Mitotic Spindle Apparatus" by people in Profiles. (wakehealth.edu)
  • Most, if not all, of the mitotic processes are regulated by a set of mitotic protein kinases that control protein activity by phosphorylation. (nih.gov)
  • Although many mitotic phosphorylation events have been identified in proteome-scale mass spectrometry studies, information on how these phosphorylation sites are distributed within mitotic protein complexes and which kinases generate these phosphorylation sites is largely lacking. (nih.gov)
  • We used systematic protein-affinity purification combined with mass spectrometry to identify 1818 phosphorylation sites in more than 100 mitotic protein complexes. (nih.gov)
  • The mitotic reorganization of the Golgi is accompanied by a temporary block in Golgi functioning, as protein transport in and out of the Golgi stops. (biologists.com)
  • The aim of the present study was to evaluate the prognostic impact of mitotic count, Ki-67 expression and novel proliferation markers phosphohistone H3 (PHH3), minichromosome maintenance protein 4 (MCM4) and mitosin, and to compare the results with histopathological variables. (biomedcentral.com)
  • Mediator of DNA damage checkpoint 1 (MDC1) regulates mitotic progression. (ox.ac.uk)
  • Chromosomal ultrastructure and ribonucleoproteins (RNP) at mitotic metaphase in garlic (Allium sativum L. ) were studied. (jipb.net)
  • A: Spermatogonial mitotic prometaphase. (cdc.gov)
  • D: Mitotic prometaphase in male specimen from Andean Bolivia. (cdc.gov)
  • Using Xenopus egg extracts (XEEs) we have shown that disruption of mitotic SUMOylation causes chromosome segregation defects. (ku.edu)
  • This was recently achieved for the mitotic spindle in the early C. elegans embryo (Redemann et al. (tu-dresden.de)
  • 2015). It is possible that other mitotic kinases, besides NEK6 and NEK7, also phosphorylate EML4. (reactome.org)
  • Furthermore, the piceatannol-suppressed mitotic clonal expansion was accompanied by reduced activation of the insulin-signaling pathway. (oregonstate.edu)
  • The Hec1/Nek2 Mitotic Pathway Inhibitor II, INH6, also referenced under CAS 1001753-24-7, controls the biological activity of Hec1/Nek2 Mitotic Pathway. (emdmillipore.com)
  • 2019). At mitotic entry, EML4 undergoes phosphorylation (Pollmann et al. (reactome.org)
  • This study was conducted to determine the significance of Ki‑67 expression in oral potential malignant and malignant lesions (MLs) as well as correlation of mitotic index (MI) with MIB‑1 labeling index (LI) in these lesions. (who.int)
  • Griseofulvin, derived from a species of Penicillium is an mitotic inhibitor that is used as an antifungal drug. (wikipedia.org)
  • Mitotic Checkpoint Regulators Control Insulin Signaling and Metabolic Homeostasis. (bvsalud.org)
  • Yet asexuality - production of progeny through proliferation of mitotic cell-lineages - is found in over one half of all eukaryotic phyla, and is likely to contribute to adaptive changes, as suggested by recent evidence from both animals and plants. (edu.au)
  • Mutation in CTD SUMOylation sites has abrogated the mitotic delay. (ku.edu)
  • In vitro and in vivo studies have suggested many deleterious effects of carbon nanotube exposure including granulomatous inflammation, release of cytosolic enzymes, pulmonary fibrosis, reactive oxygen damage, cellular atypia, DNA fragmentation, mutation and errors in chromosome number as well as mitotic spindle disruption. (cdc.gov)
  • Increased mitotic count and elevated Ki-67 expression were strongly associated with increased tumor thickness, presence of ulceration and tumor necrosis. (biomedcentral.com)
  • High expression of PHH3 and MCM4 was correlated with high mitotic count, elevated Ki-67 expression and tumor ulceration, and increased PHH3 frequencies were associated with tumor thickness and presence of tumor necrosis. (biomedcentral.com)
  • Piceatannol, natural polyphenolic stilbene, inhibits adipogenesis via modulation of mitotic clonal expansion and insulin receptor-dependent insulin signaling in early phase of differentiation. (oregonstate.edu)
  • This study was aimed to observe the mitotic phases and chromosome structures of I. suffruticosa. (ptti.or.id)
  • Ki-67 was a stronger and more robust prognostic indicator than mitotic count in this series of nodular melanoma. (biomedcentral.com)
  • A method for using the antibody in accordance with the invention comprises contacting a cell with the antibody and detecting antibody bound to the cell as an indicator of the cell being in the mitotic state. (fsu.edu)
  • Symbiodinium density was similar among sites yet their mitotic index increased in anemones under elevated p CO 2 . (nature.com)
  • 2019). EML4, through its WD40 repeats, interacts with NUDC and recruits it to the kinetochores of the mitotic spindle (Chen et al. (reactome.org)
  • Bifurcation analysis of the differential equations reveals the dependence of mitotic oscillations on cycle number, and how this dependence is altered by mutations. (vt.edu)
  • The book the mitotic exit network and experience of the study: The driven cases of Howard Gardner. (dailystrip.de)
  • Furthermore, high mitotic count and elevated Ki-67 expression were also associated with Clark's level of invasion and presence of vascular invasion. (biomedcentral.com)
  • Univariate analyses showed a worse outcome in cases with elevated Ki-67 expression and high mitotic count, whereas PHH3, MCM4 and mitosin were not significant. (biomedcentral.com)
  • Note 1:** Physician statement of mitotic count for a uveal melanoma can be used to code this data item when no other information is available. (cancer.gov)
  • Note 2:** The mitotic count, the number of mitoses per 40 high-power fields (HPF), reflects the potential aggressiveness or prognosis of uveal melanomas. (cancer.gov)
  • This data item presumes the denominator of 40 HPF, so just the numerator (the mitotic count) is coded here. (cancer.gov)
  • For other schemas in which mitotic count is collected, the denominator may vary. (cancer.gov)
  • Note 4:** Record mitotic count to the nearest tenth as documented in the pathology report. (cancer.gov)
  • For ***example,*** a mitotic count of 6/40 HPF would be coded 6.0. (cancer.gov)
  • cdc25+ functions as an inducer in the mitotic control of fission yeast. (wikidata.org)