Mitosis variety of different cell types lamin type b. Medical search. Frequent questions

These complex structures allow nuclear lamins to perform their specialized functions in maintaining the shape of the nucleus as well as roles during mitosis and apoptosis. (wikipedia.org)
Apoptosis Programmed Cell Death (PCD). (agemed.org)
Signals to trigger apoptosis may come from within the cell or from outside, by stimulating suicide receptors in the cell's external membrane. (agemed.org)
Internal signals producing apoptosis depend on interactions of several proteins and may serve to protect the organism from cancer by killing cells that have pre-cancerous changes. (agemed.org)
Natural product anticancer agents enhance intracellular levels of ceramide, a sphingolipid that promotes cell apoptosis. (sphingolipidclub.com)

Lamins, also known as nuclear lamins are fibrous proteins in type V intermediate filaments, providing structural function and transcriptional regulation in the cell nucleus. (wikipedia.org)
Nuclear lamins interact with inner nuclear membrane proteins to form the nuclear lamina on the interior of the nuclear envelope. (wikipedia.org)
Lamin proteins are involved in the disassembling and reforming of the nuclear envelope during mitosis, the positioning of nuclear pores, and programmed cell death. (wikipedia.org)
Further investigations found evidence that supports that all IF proteins arose from a common lamin-like ancestor. (wikipedia.org)
however, the presence of lamins is not a requirement for simultaneously containing IF proteins. (wikipedia.org)
Furthermore, sequence comparisons between lamins and IF proteins support that an amino-acid sequence that is characteristic of lamins is found in early forms of IF proteins. (wikipedia.org)
Similar to other IF proteins, lamins self-assemble into more complex structures. (wikipedia.org)
The cellular phenomena associated with laminopathy invariably show disruption of nucleoskeleton of lamina due to deregulated expression, localization, function, and interaction of mutant lamin proteins. (bvsalud.org)
Impaired spatial and temporal tethering of lamin proteins to the lamina or nucleoplasmic aggregation of lamins are the primary molecular events that can trigger nuclear proteotoxicity by modulating differential protein-protein interactions, sequestering quality control proteins, and initiating a cascade of abnormal post-translational modifications. (bvsalud.org)
Here, we review nuclear proteostasis and its deregulation in the context of lamin proteins and laminopathies. (bvsalud.org)
The nuclear lamina is a complex network of nuclear lamins and lamin-associated nuclear membrane proteins, which scaffold the nucleus to maintain structural integrity. (bvsalud.org)
Rather, it is way that genes are utilized differently in each type of cell that determines which proteins will produce unique structures. (jonlieffmd.com)

During this time period, investigations of rat liver nuclei revealed that lamins have an architectural relationship with chromatin and nuclear pores. (wikipedia.org)
LINC complexes interact with lamins in the nucleus and with various cytoplasmic KASH effectors from the surface of nuclei. (ucdavis.edu)
These effectors regulate the cytoskeleton, leading to a variety of cellular outputs including pronuclear migration, nuclear migration through constricted spaces, nuclear anchorage, centrosome attachment to nuclei, meiotic chromosome movements, and DNA damage repair. (ucdavis.edu)
mitosis In cell biology, mitosis () is a part of the cell cycle in which replicated chromosomes are separated into two new nuclei. (theinfolist.com)

Lamins were first identified in the cell nucleus, using electron-microscopy. (wikipedia.org)
Epigenetic modifications and the architecture of chromatin in the nucleus, through the formation of specific regions of active as well as inactive chromatin, allow the coordinated regulation of the genes for each cell fate. (bvsalud.org)
cytoplasm In cell biology, the cytoplasm is all of the material within a eukaryotic cell, enclosed by the cell membrane, except for the cell nucleus. (theinfolist.com)
of a eukaryotic cell in that it is a gel-like substance found within a membrane, although the nucleoplasm only fills out the space in the nucleus and has its own unique functions. (theinfolist.com)
nucleolus The nucleolus (, plural: nucleoli ) is the largest structure in the nucleus of eukaryotic cells. (theinfolist.com)
Many important cell functions take place in the nucleus, more specifically in the nucleoplasm. (theinfolist.com)

Mutations in lamin genes can result in several genetic laminopathies, which may be life-threatening. (wikipedia.org)
Studies of lamins became more popular in the 1990s when it was discovered that mutations in the genes that code for lamins can be related to muscular dystrophies, cardiomyopathies, and neuropathies. (wikipedia.org)
Cells become cancerous by accumulating, stepwise, a series of several mutations that alter the function of genes important for cell growth. (agemed.org)
Humans have only 21,000 genes-the same as a worm-and they are identical in all of the different types of cells. (jonlieffmd.com)
The combinations of TFs and their target genes can sometimes control gene expression which may determine cell identity. (biomedcentral.com)

Current research is being performed to develop treatment methods for the aforementioned laminopathies and to investigate the role lamins play in the aging process. (wikipedia.org)

Expressed in differentiated cells, A-type lamins originate from the LMNA gene. (wikipedia.org)
However, since all cells of the human body originate from this single-celled ancestor (except germ and immune cells), they have the same primary DNA sequence. (activemotif.com.cn)

A-type lamins are characterized by a neutral isoelectric point, and they are typically displayed during later stages of embryonic development. (wikipedia.org)
During embryonic development, stem cells undergo the differentiation process so that they can specialize for different functions within the organism. (bvsalud.org)
The use of hASCs for therapeutic applications has grown substantially in the last years, because the use of stem cells from adult tissues circumvent some ethical issues associated with the application of embryonic stem cells, and because of their accessibility via isolation from lipoaspirates, a disposable byproduct of cosmetic surgery. (biomedcentral.com)

Lamins of higher level organisms, such as vertebrates, continue to assemble into paracrystalline arrays. (wikipedia.org)
As a result of aging, older organisms become increasingly vulnerable to a variety of age-related diseases and conditions, culminating in death. (agemed.org)
qPCR Primer Sets for a variety of gene targets and model organisms. (activemotif.com)
Organisms usually contain large numbers of sphingolipid subspecies (for a pathway based compilation, see www.sphingomap.org) and knowledge about the types and amounts is imperative because they influence membrane structure, interactions with the extracellular matrix and neighboring cells, vesicular traffic and the formation of specialized structures such as phagosomes and autophagosomes, as well as participate in intracellular and extracellular signaling. (sphingolipidclub.com)
Most people now agree that epigenetics is the study of heritable differences in genetic expression passed down through successive generations of cells or organisms, without any change in the primary DNA sequence. (activemotif.com.cn)

DNA strands are wound on spools of histone protein molecules and then molded into a variety of structures. (jonlieffmd.com)
For each type of process, specific large protein molecules aid the formation of 3D structures. (jonlieffmd.com)

The FFPE ChIP assay comes in two modules, the Chromatin Preparation Kit (for which there are two options, depending on sample quality) and the ChIP-IT ® FFPE II Kit (to perform the ChIP-based enrichment), to allow flexibility dependent on type and amount of starting material. (activemotif.com)

We sought to identify PKA phosphorylation sites in PLIN5 and assess their functional relevance in cultured cells and the livers of mice. (uci.edu)
It really is today generally accepted which the livers of mice and human beings contain types of innate immune system cells [11]C[13]. (enmd-2076.com)

Invited Perspective in The Journal of Cell Biology . (ucdavis.edu)
organelle In cell biology, an organelle is a specialized subunit, usually within a cell, that has a specific function. (theinfolist.com)
The complexity of the sphingolipidome is hard to imagine, but one hopes that, when partnered with other systems biology approaches, the causes and consequences of the complexity will explain how these intriguing compounds are involved in almost every aspect of cell behavior and the malfunctions of many diseases. (sphingolipidclub.com)

Transcriptional regulation plays a crucial role in the cell identity maintenance of cancer cells and cancer-associated cells. (biomedcentral.com)
Understanding how transcriptional programs control different cell states and cell types in the cancer ecosystem will provide opportunities for therapeutic benefits in cancer. (biomedcentral.com)
Recently, single-cell RNA sequencing (scRNA-seq) has been used to assess transcriptional similarities and differences within a population of cells in cancer. (biomedcentral.com)

It wasn't until 1986 that an analysis of lamin cDNA clones across a variety of species supported that lamins belong to the intermediate filament (IF) protein family. (wikipedia.org)

Cell viability and differentiation capacity toward the mesenchymal lineages were assessed, along with immunophenotype. (biomedcentral.com)
During the process, known as cellular differentiation, the zygote develops into pluripotent stem cells which can give rise to all of the different organs in the body. (activemotif.com.cn)
This picture is a metaphor for the decisions that need to be made in the development and differentiation of a cell. (activemotif.com.cn)

Later in 1978, immunolabeling techniques revealed that lamins are localized at the nuclear envelope under the inner nuclear membrane. (wikipedia.org)

All of these variations alter the triggering of genetic networks in different ways for different cells and specific responses. (jonlieffmd.com)

Cancer is a complex ecosystem that comprises many different cell types including malignant cells, immune cells, and stromal cells. (biomedcentral.com)
Jacks and colleagues analyzed the single-cell epigenome in a mouse model and found changes in epigenomic states from normal cells to different states of malignant cells with cancer progression, which was controlled by key transcription factors [ 5 ]. (biomedcentral.com)
Next, we identified the regulons that were associated with different states of malignant cells. (biomedcentral.com)

DEC-205 (CD205), a member of the macrophage mannose receptor protein family, is the prototypic endocytic receptor of dendritic cells, whose ligands include phosphorothioated cytosine-guanosine (CpG) oligonucleotides, a motif often seen in bacterial or viral DNA. (uci.edu)

Lamins are present in all animals but are not found in microorganisms, plants or fungi. (wikipedia.org)
He discovered mitosis in plants. (theinfolist.com)

Four wild-type (drug-sensitive) human breast cancer cell lines (MCF-7, T47D,MDA-MB-231, MDA-MB-435) were used to evaluate the influence of acute and chronic exposure to ceramide and ceramide metabolites on MDR1 mRNA,P-gp, and resistance to chemotherapeutic agents. (sphingolipidclub.com)
72 hours) to C8- ceramide (5 μg/ml culture medium), a cell-permeable analog of ceramide, enhanced MDR1 mRNA levels by 3- and 5-fold in T47D and inMDA-MB-435 cells, respectively, but did not affect MCF-7 cells.D-erythro-sphingosine exposure (5 μg/ml, 72 hr) increased MDR1 mRNA levels in MDA-MB-435 cells by 3.5-fold. (sphingolipidclub.com)
Acute exposure ofMCF-7 and MDA-MB-231 cells to C8-glucosylceramide (10 μg/ml culture medium), a cell-permeable analog of glucosylceramide, increased MDR1 mRNA levels by 2- and 4-fold, respectively. (sphingolipidclub.com)

Cancer A clonal growth (cells all descended from one ancestral cell) that undergo continuing mitotic divisions and are not inhibited in their growth when they come in contact with neighboring cells (contact inhibition). (agemed.org)
MARV assembles and buds from the host cell plasma where MARV matrix protein (mVP40) dimers associate with anionic lipids at the plasma membrane inner leaflet and undergo a dynamic and extensive self-oligomerization into the structural matrix layer. (uci.edu)

These data are the first evidence that chronic exposure to ceramide and its metabolites enhances expression of the MDR phenotype in cancer cells. (sphingolipidclub.com)

Human adipose tissue-derived stem cells (hASCs) are attractive cells for therapeutic applications and are currently being evaluated in multiple clinical trials. (biomedcentral.com)

The Compact disc11b+ Kupffer cells portrayed intracellular TNF and surface area Fas-ligand (FasL). (enmd-2076.com)

A previous post noted that there are thousands of different types of neurons and each has different expression of the gene networks. (jonlieffmd.com)
Expression of phosphorylation-defective PLIN5 S155A in Plin5 null cells resulted in decreased rates of lipolysis and triglyceride-derived fatty acid oxidation. (uci.edu)
Re-expression of PLIN5 S155A in the liver of Plin5 liver-specific null mice reduced lipolysis compared with wild-type PLIN5 re-expression, but was not associated with other changes in hepatic lipid metabolism. (uci.edu)
Beyond this protective role, Mrr can inflict chromosomal DNA damage that elicits the SOS response in the host cell upon heterologous expression of specific methyltransferases such as M.HhaII, or after exposure to high pressure (HP). (uci.edu)
This complete characterization of hASCs cultivated in pooled allogeneic human serum, a suitable xeno-free approach, shows that pooled allogeneic human serum provides a high proliferation rate, which can be attributed for the first time to C-MYC protein expression, and showed cell stability for safe clinical applications in compliance with good manufacturing practice. (biomedcentral.com)
In the present study we examined the relationship between ceramide, ceramide metabolites and expression of the MDR1 gene in human breast cancer cell lines. (sphingolipidclub.com)
Exposure of cells to either octanoic acid (C8:0), a C8-ceramide hydrolysis product, or oleic acid (C18:1) did not affect MDR1 expression. (sphingolipidclub.com)

Mrr from Escherichia coli K12 is a type IV restriction endonuclease whose role is to recognize and cleave foreign methylated DNA. (uci.edu)
The CD11b+ Kupffer cells producing TNF and FasL play a pivotal role in CCl4-induced acute hepatic injury thus. (enmd-2076.com)

In today's study, we looked into the immunological function of Kupffer cells/macrophages in CCl4-induced hepatitis in mice. (enmd-2076.com)
The adoptive transfer and cytotoxic assay against principal cultured hepatocytes verified the function of Compact disc11b+ Kupffer cells in CCl4-induced hepatitis. (enmd-2076.com)

from Latin or , meaning ''kernel'' or ''seed'') is a membrane-bound organelle found in eukaryotic cells. (theinfolist.com)

A CaaX motif is found within the unique residues in prelamin A. Due to the presence of the CaaX motif, prelamin A undergoes a series of posttranslational modifications to become mature lamin A. These steps include farnesylation of the carboxyl-terminal cysteine, endoproteolytic release of the terminal amino acids, carboxymethalation of the accessible farnesylcysteine, and removal of the final fifteen residues by a zinc metalloprotease. (wikipedia.org)

This process gets rid of unneeded cells and is particularly important for "sculpting" tissue and organ structure during development of the embryo (or larval metamorphosis in insects), but may occur at any time even in adult cells when a tissue needs to be remodeled. (agemed.org)

Lamins have elastic and mechanosensitive properties, and can alter gene regulation in a feedback response to mechanical cues. (wikipedia.org)
This regulation is different in each type of cell. (jonlieffmd.com)

Clearly, laminopathic cells exhibit moderate to high nuclear proteotoxicity, raising the question of whether an imbalance in nuclear proteostasis is involved in laminopathic diseases, particularly in diseases of early aging such as HGPS and laminopathy-associated premature aging. (bvsalud.org)
Cells were resuspended and pelleted in development moderate. (bms-911543.com)

As a result, these liver organ immune system cells, including B cells and their cytokines, mainly become innate immune effectors against tumors and infections simply by their T helper-1 immune response in the liver organ. (enmd-2076.com)

The mechanisms that control how the two parental pronuclei fuse in the first mitosis of the embryo are poorly understood. (ucdavis.edu)

The structure of lamins is composed of three units that are common among intermediate filaments: a central α-helical rod domain containing heptad repeats surrounded by globular N and C-terminal domains. (wikipedia.org)
Lamins have a unique structure of the heptad repeats that is continuous in nature and contains an additional six heptads. (wikipedia.org)
Unlike lamin C, Lamin A is generated in a precursor form called prelamin A. Prelamin A and lamin C differ in structure only at the carboxyl-terminus. (wikipedia.org)
The DEC-205 monomer forms a compact structure comprising two intercalated rings of C-type lectin-like domains, where the N-terminal cysteine-rich and fibronectin domains reside at the central intersection. (uci.edu)

Cancer cells often spread (or metastasize ) throughout the body by way of the bloodstream or lymphatic vessels to form tumors in new locations beyond the primary site of origin. (agemed.org)

We first constructed the regulatory networks from single-cell RNA sequencing data in human lung adenocarcinoma (LUAD). (biomedcentral.com)
Up until now, the underlying gene regulatory networks (GRNs) at the single cell resolution for human LUAD remain unclear. (biomedcentral.com)
Our own bodies start out as a single cell zygote which eventually develops into an embryo and then a fully grown human with about 10 trillion cells . (activemotif.com.cn)

We next introduce LPRI (Lung Cancer Prognostic Regulon Index), a precision oncology framework to identify new biomarkers associated with prognosis by leveraging the single cell regulon atlas and bulk RNA sequencing or microarray datasets. (biomedcentral.com)
Isolated cells and bits of Descemets membrane from an individual cornea had been plated in a single well of 6-well or 12-well cells tradition plates pre-coated with FNC Layer Blend (US Biological, Salem, MA) for quarter-hour at space temperatures. (bms-911543.com)

It really is popular that liver organ HGFB NK cells and NKT cells potently generate IFN- in response to IL-12 and/or LPS [11]C[13]. (enmd-2076.com)

Lamins are divided into two major categories: A- and B-types. (wikipedia.org)

A previous post described the way cells edit the DNA to make multiple different messenger RNAs out of the same code fragment. (jonlieffmd.com)

Oddly enough, the serum MCP-1 Metoclopramide HCl level elevated and peaked at six h after c-lipo pretreatment quickly, suggesting which the MCP-1 made by c-lipo-phagocytized Compact disc68+ Kupffer cells Metoclopramide HCl may recruit Compact disc11b+ macrophages in the periphery and bone tissue marrow. (enmd-2076.com)
Fetal bovine serum is the supplement most widely used for cell culture, but it has disadvantages and it is not safe for cell therapy due to the risks of pathogen transmission and immune reaction. (biomedcentral.com)

These designer material architectures exhibit outstanding stability and superoleophobicity in high salt solution, which can be used to repel and manipulate a variety of oils. (regenerativemedicine.net)

Anatomy31

Organisms10

Diseases5

Chemicals and Drugs40

Analytical, Diagnostic and Therapeutic Techniques and Equipment16

Phenomena and Processes49

Disciplines and Occupations1

Information Science3

Apoptosis5

Proteins12

Nuclei4

Nucleus6

Genes5

Laminopathies1

Originate2

Embryonic3

Organisms5

Structures2

Chromatin1

Livers of mice2

Biology3

Transcriptional3

Species1

Differentiation3

Nuclear envelope1

Genetic1

Malignant3

Protein family1

Plants2

MRNA3

Undergo2

Phenotype1

Stem cells1

Intracellular1

Expression7

Role2

Function2

Membrane-bound1

Found1

Adult1

Regulation2

Moderate2

Effectors1

Mechanisms1

Structure4

Primary1

Human3

Single2

Response1

Major1

Code1

Serum2

High1