• regulate
  • Upon completion of this activity, the participant should have a better understanding of the lipid and protein phosphatases that regulate the PI3K pathway and their potential application as biomarkers to improve patient stratification, prediction of therapeutic responses, and disease outcomes in patients with cancer. (aacrjournals.org)
  • Genes that code for proteins that regulate cell growth, such as NF1 and TP53, are referred to as tumor suppressor genes. (wikipedia.org)
  • His Calgary laboratory has thrived over the years with a recent focus on the hormone-like roles of proteinases that regulate the innate immune response by activating proteinase-activated receptors (PARs). (apcari.ca)
  • PI3K
  • Here, we discuss how therapy using PI3K pathway inhibitors could benefit from information on specific phosphatases, which naturally antagonize the kinase targets. (aacrjournals.org)
  • receptors
  • Evidence for multiple signaling states for the G-protein-coupled receptors will be reviewed and is derived from many different pharmacological behaviors: efficacy, kinetics, protean agonism, differential desensitization and internalization, inverse agonism, and fusion chimeras. (aspetjournals.org)
  • In recent years, our understanding of how drugs bind and subsequently activate receptors is becoming more complex with many different types of conformations resulting from the binding of various ligands or even the same ligand. (aspetjournals.org)
  • This chapter will review these activational paradigms in the G-protein-coupled receptors (GPCRs 1 ) and provide a review of the prevailing theory that receptors can adopt multiple signaling states. (aspetjournals.org)
  • It is estimated that over 5% of the human genome encode for these receptors and represents one of the biggest family of ancestrally related proteins. (aspetjournals.org)
  • The receptors bind a ligand on the extracellular side and following activation by the drug, causes conformational changes that cause the intracellular loops to bind and activate the heterotrimeric G-protein. (aspetjournals.org)
  • Hollenberg MD . Mentors And The Butterfly Effect: Triggers For Discovering Signalling by Proteinases via Proteinase-Activated Receptors (PARs) And More. (apcari.ca)
  • ERK1
  • Active Motif also offers our FACE™ In-cell Western Phospho ELISAs for quantifying and comparing the phosphorylated and total amounts of ERK1/2 , JNK and p38 proteins. (activemotif.com)
  • nuclear
  • When nuclear or whole-cell extract is added, activated transcription factor of interest binds the oligonucleotide at its consensus binding site and is quantified using the included antibody, which is specific for the bound, active form of the transcription factor being studied. (activemotif.com)
  • Activated nuclear extract is added to each well and the transcription factor of interest binds specifically to this bound oligonucleotide. (activemotif.com)