• enzymes
  • This is useful for control of cellular signaling because the di-phosphorylated phosphoinositide PIP2 is only phosphorylated by the family of enzymes, PI 3-kinases (phosphoinositide 3-kinase or PI3-K), and only upon receipt of chemical messengers which tell the cell to begin the growth process. (wikipedia.org)
  • gene
  • Neurofibromas arise from nonmyelinating-type Schwann cells that exhibit biallelic inactivation of the NF1 gene that codes for the protein neurofibromin. (wikipedia.org)
  • This gene codes for neurofibromin which is a large 220-250 KDa cytoplasmic protein that is composed of 2,818 amino acids with three alternatively spliced exons (9a, 23a and 48a) in the encoding gene. (wikipedia.org)
  • Mutations in this gene have been associated with the Proteus syndrome. (cancerindex.org)
  • What does this gene/protein do? (cancerindex.org)
  • In the first study, the effect of heat stress on prolactin-signaling gene expression and protein abundance and immune status of Holstein calves expressing either the slick hair gene or normal hair coats was evaluated. (ufl.edu)
  • regulate
  • Genes that code for proteins that regulate cell growth, such as NF1 and TP53, are referred to as tumor suppressor genes. (wikipedia.org)
  • His Calgary laboratory has thrived over the years with a recent focus on the hormone-like roles of proteinases that regulate the innate immune response by activating proteinase-activated receptors (PARs). (apcari.ca)
  • activation
  • The receptors bind a ligand on the extracellular side and following activation by the drug, causes conformational changes that cause the intracellular loops to bind and activate the heterotrimeric G-protein. (aspetjournals.org)
  • It was shown that the activation occurs through phosphatidylinositol 3-kinase. (cancerindex.org)
  • Zinc induces MHC protein dimerisation required for MAM binding, MHC-induced cell-cell adhesion, and efficient T cell activation 13, 14 . (bjmp.org)
  • immune
  • Furthermore, the effect of heat stress and photoperiod on immune status was evaluated to investigate the role of PRL signaling and effects on protein expression. (ufl.edu)