• Differential control of mincle-dependent cord factor recognition and macrophage responses by the transcription factors C/EBPβ and HIF1α. (mpg.de)
  • DiPT activates Mincle, a macrophage activating receptor that also recognizes mycobacterial cord factor (6,6'-trehalose dimycolate). (ox.ac.uk)
  • CLECSF8 is a predominantly monocyte/macrophage and neutrophil expressed receptor, showing significant interdependence with Mincle, but not Dectin-2. (biomedcentral.com)
  • TDM binds to the receptor Mincle and activates macrophage C-type lectin, thereby inducing the Syk-Card9-Bcl1-Malt1 signaling pathway and a strong Th1/Th17 immune response in vivo . (bioglyco.com)
  • Now, the identification of the monocyte-inducible C-type lectin (Mincle) as an essential receptor for TDM provides new insight into the formation of the characteristic granulomas in tuberculosis and an avenue for rational adjuvant design. (silverchair.com)
  • The C-type lectin receptor Mincle binds to Streptococcus pneumoniae but plays a limited tole in the anti-pneumococcal innate immune response. (mpg.de)
  • The murine C-type lectin receptor Mincle: Functional characterization, ligand specificity, and its role in inflammation. (mpg.de)
  • Mincle is a C-type lectin receptor that has emerged as an important player in innate immunity. (invivogen.com)
  • C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia. (invivogen.com)
  • Mincle is a member of the C-type lectin receptor (CLR) family. (invivogen.com)
  • Upon ligand recognition, Mincle interacts with the Fc receptor common γ-chain (FcRγ), which triggers intracellular signaling through Syk leading to CARD9-dependent NF-κB activation. (invivogen.com)
  • Mincle is an ITAM-coupled activating receptor that senses damaged cells. (invivogen.com)
  • CLEC4E, also known as Mincle, is a transmembrane C-type lectin that functions as an activating innate immune receptor on monocytes, macrophages, and immature dendritic cells. (bio-techne.com)
  • Mincle, a C-type lectin on innate immune cells, was identified as a receptor for TDM and its analogs. (bioglyco.com)
  • Mincle also binds trehalose-6,6-dibehenate (TDB) which is a synthetic analog of TDM. (invivogen.com)
  • Human CLEC4E binds to mycobacterial glycolipids including the immune adjuvant TDM (cord factor), its synthetic analog TDB, and GroMM. (bio-techne.com)
  • Exogenous ligands for Mincle include fungal α-mannose, and the mycobacterial glycolipid, trehalose-6'6'-dimycolate (TDM), also known as cord factor the immunostimulatory component of Mycobacterium tuberculosis [3]. (invivogen.com)
  • Therefore, this sparked scientists' interest in developing synthetic Mincle ligands as novel adjuvants. (bioglyco.com)
  • Anti-mMincle-IgG (clone 6G5) is a monoclonal rat IgG2b antibody specific for murine Mincle (mMincle). (invivogen.com)
  • Interestingly, surface expression of CLECSF8 in a murine fibroblast cell line was greatly enhanced by co-transfection of Mincle, but not Dectin-2. (biomedcentral.com)
  • Much research effort has focused on the mycobacterial glycolipid trehalose-6,6'-dimycolate (TDM), a potent immunostimulant that is also known as cord factor. (silverchair.com)
  • Contribution of MINCLE-SYK signaling to activation of primary human APCs by mycobacterial cord factor and the novel adjuvant TDB. (mpg.de)
  • T-cell adjuvant properties of mycobacterial cord factor TDM have been well characterized. (bioglyco.com)
  • Osteogenic Potential of the Transcription Factor c-MYB. (biossantibodies.com)
  • The pH-responsive PacC transcription factor of Aspergillus fumigatus governs epithelial entry and tissue invasion during pulmonary aspergillosis. (chiba-u.ac.jp)
  • Intriguingly, Mincle expression mirrored CLECSF8 expression in our in vitro stimulation experiments. (biomedcentral.com)
  • Mincle-binding DNA aptamer demonstrates therapeutic potential in a model of inflammatory bowel disease. (invivogen.com)
  • A major mycobacterial virulence factor, trehalose-6',6-dimycolate, is recognised by the macrophage-inducible C-type lectin, Mincle, which leads to the activation of the Syk-Card9 signalling pathway in macrophages. (nih.gov)
  • 1. Contribution of MINCLE-SYK Signaling to Activation of Primary Human APCs by Mycobacterial Cord Factor and the Novel Adjuvant TDB. (nih.gov)
  • 3. The mycobacterial cord factor adjuvant analogue trehalose-6,6'-dibehenate (TDB) activates the Nlrp3 inflammasome. (nih.gov)
  • 4. Cutting edge: Mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analog trehalose-dibehenate. (nih.gov)
  • 9. C-type lectin MCL is an FcRγ-coupled receptor that mediates the adjuvanticity of mycobacterial cord factor. (nih.gov)
  • 10. Neutrophils Promote Mycobacterial Trehalose Dimycolate-Induced Lung Inflammation via the Mincle Pathway. (nih.gov)
  • 14. Macrophage Phosphoproteome Analysis Reveals MINCLE-dependent and -independent Mycobacterial Cord Factor Signaling. (nih.gov)
  • 15. Mycobacterial Cord Factor Reprograms the Macrophage Response to IFN-γ towards Enhanced Inflammation yet Impaired Antigen Presentation and Expression of GBP1. (nih.gov)
  • Like Mincle, Clec4d recognizes mycobacterial cord factor, trehalose dimycolate, and we recently demonstrated its key role in anti-mycobacterial immunity in mouse and man. (elsevierpure.com)
  • 7. C-type lectin receptor dectin-3 mediates trehalose 6,6'-dimycolate (TDM)-induced Mincle expression through CARD9/Bcl10/MALT1-dependent nuclear factor (NF)-κB activation. (nih.gov)
  • 11. The Mincle ligand trehalose dibehenate differentially modulates M1-like and M2-like macrophage phenotype and function via Syk signaling. (nih.gov)
  • 12. Trehalose diester glycolipids are superior to the monoesters in binding to Mincle, activation of macrophages in vitro and adjuvant activity in vivo. (nih.gov)
  • 5. Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRgamma-Syk-Card9-dependent innate immune activation. (nih.gov)
  • The conceptual distinction then is between signal 2 adjuvants that can provide signal 2 directly by acting as ligands for specific receptors, and signal 1 activators that provide it indirectly as a result of releasing endogenous factors (Figure 2). (medscape.com)
  • In addition, we provide evidence that Clec4d and Mincle, but not Dectin-2, are interdependently coregulated during inflammation and infection. (elsevierpure.com)