Midazolam drug combinations. Medical search. Frequent questions

Medicines used for sedation and pain management, including fentanyl, midazolam and propofol, increased by 100 percent, 70 percent and 60 percent respectively. (americanpatient.org)

The Ohio Department of Rehabilitation and Correction announced Jan. 8 that the state will stop using an execution method that utilizes a combination of the sedative midazolam and the painkiller hydromorphone. (citybeat.com)
Ohio made history yesterday by becoming the first state to use the two-drug combination of midazolam and hydromorphone in the execution of Dennis McGuire . (aclu.org)
Arizona man Joseph Rudolph Wood took almost two hours to die after being injected with the drugs midazolam and hydromorphone. (bioedge.org)
The drug midazolam causes unconsciousness in a patient, while hydromorphone shuts down breathing and induces cardiac arrest. (bioedge.org)
McGuire was put to death by a lethal injection mixture of midazolam, a sedative, and hydromorphone, an opiod derived from morphine. (ibtimes.co.uk)
From the anesthesiologist's point of view, it doesn't seem surprising that the combination of drugs used-midazolam and hydromorphone-might take nearly two hours to cause death. (apennedpoint.com)
Doctors at several hospitals have been using a combination of midazolam, hydromorphone and ketamine. (americanpatient.org)

This study assessed the effects of sedation using a combination of fentanyl, midazolam and medetomidine in comparison to ketamine. (biomedcentral.com)
This study compared the effects of a combination of fentanyl-midazolam-medetomidine (FMM), followed by reversal with naloxone and atipamezole, with ketamine (KET) in rhesus macaques. (biomedcentral.com)

Midazolam is in a class of medications called benzodiazepines. (nih.gov)
The benzodiazepines such as midazolam (Versed) and diazepam (Valium) are also metabolized by the CYP 3A4 isoenzymes. (liposuction.com)

Although drug-induced sedation endoscopy (DISE) represents the most widespread diagnostic tool for upper airway endoscopic evaluation of snoring and obstructive sleep apnea hypopnea syndrome (OSAHS), many controversies exist about how to perform the sedation, the indications for DISE, and how to report DISE findings. (nih.gov)
Various drugs, including ketamine and midazolam, are used for sedation in children. (brieflands.com)
Children were injected with 0.05 mg/kg midazolam and 1 mg/kg ketamine for sedation and analgesia. (brieflands.com)
The present study showed that the intravenous midazolam and ketamine combination provides suitable sedation and analgesia to children, with low and negligible side effects. (brieflands.com)
For this purpose, in addition to psychological support programs, drugs are used for sedation and analgesia in these children ( 2 ). (brieflands.com)
These drugs are used in much lower doses for minimal sedation than when they are used alone or in combination for anesthetic induction. (rrcus.org)
They used only drugs that produce sedation and depress breathing. (apennedpoint.com)
On May 3, 2013, Ethicon Endo-Surgery, Inc. announced that the Food and Drug Administration (FDA) granted Premarket Approval for the SEDASYS® system, a computer-assisted personalized sedation system. (theanesthesiaconsultant.com)
In Ethicon's pivotal study supporting SEDASYS, 1,000 ASA class I to III adults had routine colonoscopy or esophagogastroduodenoscopy, and were randomized to either sedation with the SEDASYS System (SED) or sedation with each site's current standard of care (CSC) i.e. benzodiazepine/opioid combination. (theanesthesiaconsultant.com)
The purpose of this study was to assess anxiety in 2 to 4 year-old children, treated under conscious sedation with midazolam. (bvsalud.org)
Midazolam is a popular drug for conscious sedation in pediatric dentistry and the safety and efficacy of oral and nasal midazolam in infants and children has been reported 2-3,5 . (bvsalud.org)

midazolam, rocuronium bromide and potassium chloride. (wikipedia.org)
The state uses a combination of three drugs -- midazolam, vecuronium bromide, and potassium chloride -- to render an inmate unconscious, and then to stop the inmate's breathing, and finally, his (or her) beating heart. (wonkette.com)
Based on his belief that Lockett was conscious when the second and third drugs were administered, Lubarsky said it's likely Lockett felt a progressive suffocation and then an intense pain once the potassium chloride was injected. (ksl.com)
Ohio's method of execution is to inject the condemned with a combination of three drugs: midazolam (as a sedative), a paralytic drug, and potassium chloride to stop their heart. (typepad.com)

Second, the District Court did not commit clear error when it found that the prisoners failed to establish that Oklahoma's use of a massive dose of midazolam in its execution protocol entails a substantial risk of severe pain. (wonkette.com)
But a Florida anesthesiologist, Dr. David Lubarsky, testified that midazolam has a ceiling effect, and that increasing the dose does not increase the effect. (ksl.com)
em G2 procedeu-se da mesma forma que em G1 elevando-se, porém, a dose de midazolam durante a manutenção. (unesp.br)
A elevação da dose de midazolam resultou em discretas variações paramétricas, estas, acentuadas pelo uso da xilazina, que causou hipoxemia, bradiarritmia, diminuição da freqüência respiratória e volume minuto. (unesp.br)
plus an increase in the midazolam dose during maintenance. (unesp.br)
The increase in midazolam dose brought about little parametric variations which were greater when xylazine was used, with a consequent hypoxemia, bradyarrhytmia, and decrease in respiratory frequency and minute volume. (unesp.br)
Waisel said given the timeline and drugs used, 'it is possible that he received enough midazolam to make him sleepy, but not the full intended dose. (typepad.com)
If concurrent use of codeine and buspirone is imperative, reduce the dose of one or both drugs. (pdr.net)
If hydrocodone is used with buspirone, the dose of one or both drugs should be reduced. (pdr.net)
This study is a single-center, open-label, 3-group, fixed-sequence drug-drug interaction study to assess the effect of coadministration of multiple-dose itraconazole or diltiazem on the single-dose PK of AZD3293 and the effects of coadministration of single- and multiple-dose AZD3293 on the single-dose PK of midazolam. (astrazenecaclinicaltrials.com)
PREZCOBIX is a fixed-dose combination tablet containing darunavir and cobicistat. (rxlist.com)
Sedative-hypnotic withdrawal is treated by substituting drugs that have a long duration of action, either a benzodiazepine or phenobarbital, in a maintenance dose for a few days followed by a gradually decreasing dose over 2-3 weeks. (medscape.com)
In making its decision, the Committee reviewed the latest clinical evidence and the information about licensing in several countries of the fixed-dose combination tablet. (who.int)

If paramedics determine that the patient requires medical management to ensure their safety and the safety of others, they initiate treatment, which can include a sedative called Midazolam, administered by nasal spray or injection. (publicceo.com)

Midazolam is given to children before medical procedures or before anesthesia for surgery to cause drowsiness, relieve anxiety, and prevent any memory of the event. (nih.gov)
This article will discuss anesthesia and the drugs used for its maintenance in general, the potential reasons for using an anesthetic protocol for our pets when undergoing diagnostic and/or emergency radiographs for various conditions, as well as the use of anesthesia in obtaining OFA view and Penn-Hip diagnostic radiographs. (rrcus.org)
An important concept to keep in mind is that simple, one-drug anesthesia is not necessarily safer, and may actually be more detrimental, than combination-drug anesthesia. (rrcus.org)
Premedicating the patient, pre-oxygenating prior to induction, and maintaining an intravenous catheter and administering IV fluids during general anesthesia can improve the relative safety of any drug or drug combination. (rrcus.org)
A senior doctor at one large New York City hospital said the institution, like some others, was running low on the drugs they commonly use to induce anesthesia and then paralysis in patients on ventilators. (americanpatient.org)

The state maintains that Lockett's problematic execution was an anomaly caused by an improperly set intravenous line and not the result of using the sedative midazolam as the first in a three-drug combination. (ksl.com)
The objective of this study was to evaluate the physical stability and chemical compatibility of midazolam hydrochloride and atracurium besylate for intravenous coadministration at concentrations normally encountered in clinical practice. (ijpc.com)
Sedative and Analgesic Effects of Intravenous Midazolam and Ketamine Combin. (brieflands.com)
Tabatabaei S M N , Miri-Aliabad G, Borjian Boroojeny S, Arab A. Sedative and Analgesic Effects of Intravenous Midazolam and Ketamine Combination in Bone Marrow Aspiration and Biopsy of Childhood Cancer. (brieflands.com)
This study aimed to evaluate the effectiveness of intravenous midazolam and ketamine combination in bone marrow aspiration and biopsy in children with cancer. (brieflands.com)
PURPOSE: To evaluate the parameters of dogs anesthetized by different dissociative drugs protocols through continuous intravenous infusion. (unesp.br)
G1 was administered with methotrimeprazine as a pre-anesthetic medication, intravenously midazolam-ketamine as bolus for induction and midazolam-ketamine by continuous intravenous infusion for a 60 minute-period of maintenance. (unesp.br)

Ketamine is one of the most commonly used anesthetic induction drugs in veterinary medicine. (rrcus.org)

When Warner is put to death Thursday night, his executioners will be using the same lethal drug combination that failed in Lockett's case. (msnbc.com)
An independent autopsy report into Lockett's execution found that it wasn't the drug combination that triggered his death. (msnbc.com)
Oklahoma was the first state ever to use 100 milligrams of midazolam as part of a three-drug protocol during Lockett's execution. (ksl.com)
He said if the second and third drugs were administered directly to Lockett's blood stream through a vein 'he would have died right away. (typepad.com)
Waisel said because so many minutes had elapsed between administering of the midazolam and Lockett's violent reaction, 'clearly this sounds like a new injection of something that was very painful. (typepad.com)
But Lockett's attorney David Autry had questions about the amount of the sedative, midazolam, used in the procedure, arguing that the 100 milligrams called for in Oklahoma's execution protocol was "an overdose quantity. (socialistworker.org)

After I inject one or two milligrams of midazolam into the IV, they're often smiling and relaxed, and they have no memory later of coming into the operating room at all. (apennedpoint.com)

Since the execution of Van Hook, there has been an unofficial moratorium on capital punishment in the state, as a result of the impossibility to acquire drugs needed to carry out lethal injection. (wikipedia.org)
Because of this, Governor Mike DeWine, who assumed office as the governor of Ohio (also in January 2019), ordered the Ohio prison system to look at alternative lethal injection drugs that could be used in any future execution. (wikipedia.org)
He later froze all executions in Ohio indefinitely as the state struggled to find any new lethal injection drugs. (wikipedia.org)
Lethal injection opponents have raised concerns that midazolam does not adequately sedate inmates. (msnbc.com)
New lethal injection drugs being introduced, then taken away. (wkbn.com)
Commercially available midazolam hydrochloride injection (Versed®) and atracurium besylate injection (Tracrium,® Glaxo Wellcome) were used to prepare four different drug combinations in 5% dextrose injection. (ijpc.com)
Ohio has halted executions until 2017 due to limited lethal injection drugs supply. (ibtimes.co.uk)
CNN reported the state announced the delay of execution for seven death row inmates earlier this year due to a lethal injection drugs shortage. (ibtimes.co.uk)
The state changed the drugs it uses for lethal injection after the January 2014 execution of Dennis B. McGuire took more than 25 minutes. (typepad.com)
Vascular lesions in the hand may be secondary to local pathology (e.g. tumour, malformation, trauma, iatrogenic cause, or drug injection), a proximal source of emboli (e.g. dissections or aneurysms), or systemic diseases with vascular compromise (e.g. rheumatic and vaso-occlusive diseases). (springer.com)
These drugs are usually administered as a subcutaneous (under the skin) or intramuscular injection around 15 to 20 minutes prior to anesthetic induction in non-emergency procedures. (rrcus.org)
The convicted murderer didn't receive one component of the usual mixture of drugs used in lethal injection: a muscle relaxant. (apennedpoint.com)
On April 29, prison officials declared 38-year-old Clayton Lockett unconscious 10 minutes after they had begun administering three drugs in the state's new lethal injection procedure. (socialistworker.org)
In 2014, Kasich signed a bill into law shielding the names of companies that provide the state with lethal injection drugs. (dailyadvocate.com)
A study performed in 24 healthy male subjects comparing the I.M. Injection of 10 mg of diazepam in the mid-anterior/lateral thigh by the autoinjector versus 10 mg I.M. by a syringe (operated manually) indicates that the mean percent availability of the drug from the autoinjector is 100% of that obtained from the syringe. (hhs.gov)

On Monday, federal appeals panel rejected arguments that the use of midazolam poses a risk to Warner and other death-row inmates scheduled to be executed in quick succession in Oklahoma. (msnbc.com)
Ohio used the former drug to put inmates to death from 1999 to 2011 but stopped when manufacturers ceased producing it in the United States. (citybeat.com)
Death row inmates say they fear the state is conducting human experiments on them by using newly approved drug combinations during executions. (ksl.com)
The state also used midazolam in McGuire's execution, making it disappointing that Ohio would again turn to that drug, said Allen Bohnert, a federal public defender representing several death row inmates. (dailyadvocate.com)
In 2014, former federal Judge Gregory Frost sided with the state, saying the prisons agency's need to obtain the drugs outweighed concerns by death row inmates that the information was needed to meaningfully challenge the source of the drugs. (dailyadvocate.com)

Sedative and anti-anxiety drugs include medications like acepromazine, chlorpromazine, and valium or midazolam. (rrcus.org)
It is usually used in combination with an alpha- 2 agonists (such as xylazine) or a benzodiazepine (such as valium/diazepam) to improve anesthetic induction. (rrcus.org)

However, determining the potential for clinically significant drug interactions with milk thistle products has been complicated by inconsistencies between in vitro and in vivo study results. (aspetjournals.org)
Lidocaine Toxicity Lidocaine Toxicity with Tumescent Liposuction A Case Report of Probable Drug Interactions JEFFREY A. KLEIN, MD NORMA KASSARJDIAN, MD We report a case of mild lidocaine toxicity. (liposuction.com)
This new information permits a knowledgeable clinician to anticipate some adverse drug interactions. (liposuction.com)
Due to system maintenance, the drug interactions feature you are attempting to access is temporarily unavailable. (medscape.com)
The objective in this study was to survey the potential pairs of drug interactions administered at the same time at a psychiatric emergency service of a general hospital during the first twenty-four hours of care. (bvsalud.org)
The database Drugs® informed that, of all pairs administered during that period, 559 (36%) presented possible interactions, while 978 (64%) had no signs of interaction risk. (bvsalud.org)
Based on the findings, a figure was elaborated with the main care for possible interactions between drugs used in psychiatric emergency care. (bvsalud.org)

The traditional cocktail includes a drug such as pancuronium or vecuronium, which paralyzes muscles and stops breathing. (apennedpoint.com)

Hadden noted that Lubarsky also testified in a Florida case challenging the use of midazolam, in which a judge determined that state's protocol was constitutional. (ksl.com)

What Drugs, Substances, or Supplements Interact with Prezcobix? (rxlist.com)
Withdrawal syndrome can occur with a wide range of substances, including ethanol and many illicit drugs and prescription medications. (medscape.com)
In the announcement, the FDA concluded that prescribing information did not provide adequate warnings about the serious risks and harms associated with these drugs, thus increasing the risk of adverse effects, especially when BZDs are used with some other medicines and substances. (medscape.com)

The final concentration of midazolam (as the hydrochloride salt) and of atracurium (as the besylate salt) was 0.1 or 0.5 mg/mL and 1 or 5 mg/mL, respectively. (ijpc.com)
The chemical stability of midazolam and atracurium in combination was evaluated using a stability-indicating high-performance liquid chromatography assay, capable of simultaneous analysis of both compounds, developed in our laboratory. (ijpc.com)
Midazolam was detected using an ultraviolet detector and atracurium with a fluorescence detector. (ijpc.com)
Midazolam hydrochloride and atracurium besylate are physically stable and chemically compatible for up to three hours at room temperature under normal fluorescent lighting at the concentrations used in this study and may be coinfused at a ysite without loss of potency. (ijpc.com)

Midazolam is a benzodiazepine drug with anti-anxiety and sedative properties commonly used in both children and adults for various diagnostic and therapeutic procedures due to its short duration and rapid onset of action. (brieflands.com)

But there is some evidence that a combination of Panax ginseng and ginkgo leaf extract can improve memory in otherwise healthy people between the ages of 38 and 66. (emedicinehealth.com)

Etomidate 0.3 mg/kg IV, a nonbarbiturate hypnotic, may be the preferred drug. (msdmanuals.com)

The choice of these drugs depends on the procedure location (ward or operating room), procedure type (bone marrow biopsy, aspiration, or lumbar puncture), child's age, and whether the patient is outpatient or inpatient. (brieflands.com)

Ohio pioneered use of the two drugs in executions when it began using them last year. (citybeat.com)
many are small businesses that fear backlash from consumers and activists if it is revealed that they supply drugs for executions. (citybeat.com)
Officials say other executions might be delayed as well as the state sources the third drug or an alternative. (citybeat.com)
The US state has struggled to acquire the legal drugs needed for lethal injections and has decided to put executions on hold until at least 2017. (ibtimes.co.uk)
However, ongoing difficulties in attaining the drugs has forced the state to delay all executions. (ibtimes.co.uk)
However, the Food and Drug Administration said it was illegal for states to import drugs for executions. (ibtimes.co.uk)
On 19 October, the DRC released a statement saying: "DRC continues to seek all legal means to obtain the drugs necessary to carry out court ordered executions, but over the past few years it had become exceedingly difficult to secure those drugs because of severe supply and distribution restrictions. (ibtimes.co.uk)
State governments that use the death penalty are experimenting with new drugs after several pharmaceutical companies withdrew their supplies of chemicals previously used in executions . (socialistworker.org)
COLUMBUS, Ohio - Ohio plans to resume executions in January with a new three-drug combination after an unofficial three-year moratorium blamed on shortages of lethal drugs, an attorney representing the state told a federal judge Monday. (dailyadvocate.com)
Complicating matters, neither of those drugs - sodium thiopental and pentobarbital - is available in the United States after their manufacturers put them off-limits for executions. (dailyadvocate.com)
Supporters said such confidentiality is necessary to obtain supplies of the drugs, and the measure is needed to restart Ohio executions. (dailyadvocate.com)

Sedative Doses of Midazolam Depress Hypoxic Ventilatory Responses in Humans. (benzo.org.uk)

Just like we're seeing shortages of other materials, like masks and ventilators, medications are right there in the mix of things that we don't always have enough of on hand," said Erin Fox, a drug shortage expert at the University of Utah. (americanpatient.org)
Maraviroc tablets must be given in combination with other antiretroviral medications. (drugs.com)

The drug under particular scrutiny is midazolam, a sedative designed to first knock an inmate unconscious. (msnbc.com)

The FDA granted Emergency Use Authorization ( EUA ) for the oral antiviral drugs Paxlovid (nirmatrelvir + ritonavir) and Legevrio (molnupiravir) to treat COVID-19 in December, 2021. (peoplespharmacy.com)

Since 1994 there has been a rapid expansion of information about the specificity of hepatic microsomal enzymes of the cytochrome P450 family for the metabolism of different drugs. (liposuction.com)

Our Prezcobix (darunavir and cobicistat) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
Medication interaction happens when the power or efficiency of one drug is altered by the presence of another. (bvsalud.org)

Be cautious with this combination. (medlineplus.gov)

Anesthetic drugs may be grouped into categories by their mode of action and/or their purpose in an anesthetic protocol. (rrcus.org)

Lockett was supposed to die within minutes after the lethal drugs began pumping through his veins. (msnbc.com)
After McGuire's execution, the longest ever in Ohio using lethal drugs, the prisons agency changed its policies to allow for single doses of two alternative drugs. (dailyadvocate.com)

Drugs with analgesic effects, such as opioids and drugs with sedative effects (including phenothiazine tranquilizers) are often included in a premedication scenario. (rrcus.org)

The downside is that these supplements can cause the side effects of statin drugs, such as muscle pain, weakness, and liver damage. (medscape.com)

The two-drug mixture soon came under fire when it took 26 minutes to put convicted killer Dennis McGuire to death. (citybeat.com)

Presumably, Ohio is acquiring thiopental from a compounding pharmacy since the drug can no longer be purchased from international sources," Deborah Denno, a law professor from Fordham University told ABC News last week. (citybeat.com)
According to the Times, the state obtained a license to import sodium thiopental from the federal Drug Enforcement Administration. (ibtimes.co.uk)

Sedative-hypnotic drugs are the primary agents for treatment of alcohol withdrawal syndrome because they are cross-tolerant drugs that modulate GABA functions. (medscape.com)
The sedative/hypnotic drugs agents selected for intubation should provide optimal intubating conditions with minimum hemodynamic disturbances. (e-jnic.org)

The data recorded included age, sex, weight, type of procedure, drugs and doses used, procedural success, complications and if the patient was observed to grimace or groan. (bmj.com)
Due to the short duration of these measures, it is necessary to use drugs that effectively relieve patients' anxiety and pain and act shortly, with significant drowsiness or side effects for the patient after the procedure ( 3 ). (brieflands.com)
This drug prevents unpleasant memory of the painful procedure with antegrade amnesia. (brieflands.com)
Drugs are selected based upon the health status of the patient, expected duration of the procedure, and the degree of pain anticipated. (rrcus.org)
This was the first time that midazolam, which is supposed to make the person being put to death unconscious, has been used in Oklahoma's execution procedure. (socialistworker.org)
Ohio hasn't put anyone to death since January 2014, when Dennis McGuire repeatedly gasped and snorted during a 26-minute procedure using a never-before-tried two-drug combo. (dailyadvocate.com)

The most commonly reported shortages include drugs that are used to keep patients' airways open, antibiotics, antivirals and sedatives. (americanpatient.org)
In a recent survey of 377 hospitals and 100 long-term care, home infusion and retail pharmacies, Premier found that drug shortages were pervasive in acute care settings, where 70 percent of respondents reported at least one shortage for coronavirus drugs. (americanpatient.org)
Even before this crisis emerged, the Food and Drug Administration noted shortages of well over 100 drugs in the United States. (americanpatient.org)

What [HA770 trade name] is and what it is used for [HA770 trade name] is a combination of three antiviral medicines used to treat human immunodeficiency virus (HIV) infection in adults and adolescents weighing at least 30 kg. (who.int)
The Committee noted, however, that appropriate doses of both medicines can also be achieved using combinations of the single-component products, including co-blistered presentations. (who.int)

The β1-subunit homologous mutant β2(V436T) substantially diminished the efficacy of both drugs to a third of that obtained with wild-type β2 subunit combinations, but without changing potency. (researchgate.net)

Dr. Joseph Cohen, a pathologist hired by the inmate's lawyer, said that recently released witness statements corroborate his belief that Clayton Lockett was conscious when given drugs to stop his heart and breathing. (ksl.com)
in conscious patients, a short-acting IV drug with sedative or combined sedative and analgesic properties is mandatory. (msdmanuals.com)

However, due to the lack of analgesic properties, this drug should be used during painful procedures in combination with an analgesic drug ( 4 , 5 ). (brieflands.com)
This drug has sedative and analgesic properties that can be used alone or in combination with other drugs to cause analgesia during diagnostic and therapeutic measures in children. (brieflands.com)

In other words, the petitioners failed to prove that there's a chance the three-drug cocktail method of execution might cause 'severe pain,' and besides, they haven't identified any less painful methods, so whatcha gonna do? (wonkette.com)

Induction drugs are chosen with the intent of providing the smoothest induction possible with the least amount of undesired effects. (rrcus.org)

The U.S. Supreme Court upheld the use of such a combination in a ruling last year regarding Oklahoma's execution protocols. (dailyadvocate.com)

Serious adverse effects and emergency department visits related to BZD overdose usually involve concomitant ingestions of other drugs. (medscape.com)

The aim of the present study was to determine the effect of a standardized milk thistle supplement on major P450 drug-metabolizing enzymes after a 14-day exposure period. (aspetjournals.org)

The maximal level of enhancement seen with either CBD or 2-AG were on α2-containing GABAA receptor subtypes, with approximately a 4-fold enhancement of the GABA EC5 evoked current, more than twice the potentiation seen with other α-subunit receptor combinations. (researchgate.net)
Maraviroc tablet is a CCR5 co-receptor antagonist indicated in combination with other antiretroviral agents for the treatment of only CCR5-tropic HIV-1 infection in adults and pediatric patients 2 years of age and older weighing at least 10 kg. (drugs.com)

Limitation of Use: Patients should have disease progression on trastuzumab prior to initiation of treatment with Tykerb in combination with capecitabine. (hdkino.org)
Dr. David Waisel associate professor of anesthesiology at Harvard Medical School, said midazolam is typically used in small doses to patients before surgery. (typepad.com)
Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. (medscape.com)
Dr. Patrizia Cavazzoni, Director of the agency's Center for Drug Evaluation and Resarch (CDER) announced that state-licensed pharmacists can now prescribe these pills for high-risk patients over 12 years old. (peoplespharmacy.com)
Allgulander C, Borg S, Vikander B. A 4-6 Year Follow-Up of 50 Patients with Primary Dependence on Sedative and Hypnotic Drugs. (benzo.org.uk)
Prezcobix (darunavir and cobicistat) is a combination of a human immunodeficiency virus ( HIV -1) protease inhibitor and a CYP3A inhibitor and is indicated for the treatment of HIV-1 infection in adult patients. (rxlist.com)
Other patients are given sedating and paralytic drugs to minimize discomfort and facilitate intubation (termed rapid sequence intubation). (msdmanuals.com)
Different sedative states may be obtained with the use of drugs in pediatric patients. (bvsalud.org)

What U.S. state used an untested combination of two drugs in the execution of Dennis McGuire yesterday? (aclu.org)
The New York Times reported that the state has not executed an inmate since the 16 January 2014 execution of Dennis McGuire, who gasped and clenched his fist for over 20 minutes before dying of a drug combination not used before in the US. (ibtimes.co.uk)
Ohio prisoner Dennis McGuire was the first person in the country to be executed with this combination of drugs earlier this year. (socialistworker.org)
Following the McGuire execution debacle, they very deliberately and specifically refused to use midazolam any longer for an execution," Bohnert said. (dailyadvocate.com)

Not long after Lockett was deemed unconscious from the first of three drugs, he began "writhing on the gurney," according to the Associated Press. (wonkette.com)

State officials decided to use this experimental combination of powerful sedatives and painkillers after supplies of approved execution drugs ran dry. (aclu.org)

Boceprevir should not be combined with alfuzosin ( Uroxatral ), doxazosin ( Cardura ), sildosin (Rapaflo), tamsulosin ( Flomax ), sildenafil ( Viagra ), and tadalafil ( Cialis ) because it can increase their blood levels, leading to increased side effects from these drugs. (medicinenet.com)
Antipsychotics, an association commonly used in psychiatric emergencies, alerting to the need to monitor the possible adverse effects of these drugs. (bvsalud.org)
Don't use drugs while you are pregnant or breastfeeding as it can have harmful effects on your unborn child/baby. (who.int)

It was the first time the state had used the sedative midazolam. (msnbc.com)
In December, Gov. John Kasich signed into law a measure aimed at making it easier for the state to obtain execution drugs by stipulating that the identities of labs creating the drugs are not public information for a period of 20 years. (citybeat.com)
Currently, it's illegal for the state to execute someone with drugs from an undisclosed source. (citybeat.com)
This agitated state is often the result of alcohol intoxication, the influence of drugs, mental illness, uncontrolled anger or a combination of factors. (publicceo.com)

These drugs are called direct-acting antiviral agents because they act directly on hepatitis C virus. (medicinenet.com)

When two or three drugs are each substrates for the same enzyme, there is a possibility for an adverse drug reaction when used simultaneously. (liposuction.com)

Assistant Attorney General John Hadden said Oklahoma and other states have been forced to look for other drug alternatives after more commonly used short-acting barbiturates became scarce because of manufacturers' opposition to the death penalty. (ksl.com)

In 2020, the US Food and Drug Administration (FDA) updated the required boxed warnings and package inserts for all BZDs to include information on the potential for abuse, addiction, and other serious risks. (medscape.com)
[ 1 ] Because the US Food and Drug Administration (FDA) doesn't regulate dietary supplements like it does drugs, consumers often have a difficult time knowing whether the products they buy are safe or effective. (medscape.com)

Anatomy1

Chemicals and Drugs58

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Psychiatry and Psychology1

Phenomena and Processes11

Technology, Industry, Agriculture2

Health Care4

Propofol1

Hydromorphone7

Fentanyl2

Benzodiazepines2

Sedation11

Potassium chloride4

Dose13

Nasal spray1

Anesthesia5

Intravenous7

Ketamine1

Lockett's6

Milligrams1

Injection15

Inmates5

Valium2

Interactions7

Vecuronium1

State's1

Substances3

Atracurium4

Benzodiazepine1

Panax1

Etomidate1

Inpatient1

Executions11

Humans1

Medications2

Inmate unconscious1

Ritonavir1

Cytochrome1

Medication2

Cautious1

Anesthetic1

Lethal drugs2

Opioids1

Statin drugs1

Mixture1

Thiopental2

Sedative-hypnotic2

Procedure6

Shortages3

Medicines2

Efficacy1

Conscious2

Analgesic2

Severe1

Induction1

Oklahoma's1

Overdose1

Study1

Receptor2

Patients8

McGuire4

Unconscious1

Powerful sedatives1

Effects3

State4

Hepatitis1

Reaction1

Commonly1

Food and Drug Admin2