Mice cell proliferation. Medical search. Frequent questions

Dnmt3a regulates both proliferation and differentiation of mouse neural stem cells. (ca.gov)
DNA methylation is known to regulate cell differentiation and neuronal function in vivo. (ca.gov)
Here we examined whether deficiency of a de novo DNA methyltransferase, Dnmt3a, affects in vitro differentiation of mouse embryonic stem cells (mESCs) to neuronal and glial cell lineages. (ca.gov)
Early-passage neural stem cells (NSCs) derived from Dnmt3a-deficient ESCs exhibited a moderate phenotype in precocious glial differentiation compared with wild-type counterparts. (ca.gov)
Thus, our work revealed a novel role for Dnmt3a in regulating both the timing of neural cell differentiation and the cell proliferation in the paradigm of mESC-derived-NSCs. (ca.gov)
The hallmark of embryonic stem (ES) cells is their ability for self-renewal (capability of unlimited cell division without the loss of pluripotency) as well as for differentiation into all cell types of the adult organism. (uni-muenchen.de)
A high expression of Pes1, Bop1 and WDR12 was observed in ES cells, which strongly decreased during in vitro differentiation. (uni-muenchen.de)
Since interleukin-7 is a crucial cytokine for proliferation and differentiation of T cells in the thymus, the present study indicates that interleukin-7 may contribute to the disturbance of immune regulatory T cells in ulcerative colitis. (elsevierpure.com)
Furthermore, differentiation of naïve CD4+ T cells into Th1 and Th17 cells was significantly suppressed by decitabine in vivo and in vitro. (mdc-berlin.de)
Though in vitro studies showed decitabine could induce Treg differentiation, there was no obvious change in the percentage of Tregs in Dec-treated EAE mice. (mdc-berlin.de)
While substantial progress has been made to delineate the developmental pathway of T-cell lineage commitment, still little is known about the relationship between differentiation competence and the remarkable expansion of the earliest (DN1 stage) T-cell progenitors. (lu.se)
To satisfy differentiation kinetics and overall cell yield data, our models require that adult DN1 cells divide multiple times before becoming competent to progress into DN2 stage. (lu.se)
Hematopoiesis, in particular the genetic control of hematopoietic cell proliferation and differentiation is also studied in human cell cultures and transgenic mouse model systems. (lu.se)
Many existing protocols for neuronal differentiation of human pluripotent cells result in heterogeneous cell populations and unsynchronized differentiation, necessitating the development of methods for labeling specific cell populations. (lu.se)
We provide detailed protocols for lentiviral transduction, neural differentiation, and subsequent analysis of human embryonic stem cells. (lu.se)

She is known for her work on neuronal and mesenchymal stem and precursor cells and how they can promote tissue repair and regeneration. (nature.com)
Using pharmacological approaches along with in vitro and in vivo experiments, we found that Nogo-A/NgR1 signaling regulates the pace of neuronal neogeneration by reducing NSC proliferation. (jneurosci.org)
Adult neurogenesis is a complex process whereby neural progenitor cells adopt a neuronal fate, migrate, and mature over several weeks. (jneurosci.org)

Expression of constitutively active RhoG promoted NPC proliferation and incorporation of bromodeoxyuridine (BrdU) in vitro, and the proportion of Ki67-positive cells in vivo. (elsevierpure.com)
An in vivo CRISPR screen of T cell infiltration in a rat model of MS now identifies the genetic modules that control this key step in the immunopathology of MS. (nature.com)
Most importantly, we found that T cell proliferation was potently inhibited in vivo and in vitro by higher-dose decitabine through increased gene expression of the DNA dioxygenase TET2 which facilitated the expression of several cell cycle inhibitors. (mdc-berlin.de)
In vivo , mice were divided into three groups: control group, diabetes mellitus (DM) group, and RSV-treated DM group. (hindawi.com)
In the present study, therefore, we aimed to determine whether RSV treatment attenuated renal inflammation and mesangial cell proliferation under diabetic condition both in vivo and in vitro . (hindawi.com)
Co-incubation of OVA-specific B3Z hybridoma T cells with OVA-loaded dendritic cells (DC) exposed to GO or fullerenes resulted in altered IL-2 production by B3Z cells, suggesting that modified T cells responses seen in vivo can be partially attributed to a direct modulation of DC functions by GO. (cdc.gov)
Zong C, Bronckaers A, Vande Velde G, Willems G, Cadenas de Llano-Pérula M. (2022) In Vivo Micro-Computerized Tomography Tracking of Human Periodontal Ligament Stem Cells Labeled with Gold Nanocomplexes. (uhasselt.be)
In vivo studies showed fruquintinib inhibited tumor growth in a tumor xenograft mouse model of colon cancer. (centerwatch.com)
The chromosomal aberrations have been studied in vivo in rat and mice using the chromosomal aberrations test and the micronucleus test. (europa.eu)
Gene mutations induction in vivo have been studied using a transgenic mouse test. (europa.eu)
This study aimed to investigate the effects of xanthoxyletin, a plant-derived coumarin, on human oral squamous cancer cells in vitro and in mouse xenografts in vivo . (medscimonit.com)
Mouse xenografts were used for the in vivo evaluation of the effects of xanthoxyletin. (medscimonit.com)

Our results show a novel role for DDX5 in cancer cell proliferation and suggest DDX5 as a therapeutic target in breast cancer treatment. (aacrjournals.org)

Induction of p16 inhibits cell proliferation and thus can help to block the growth of tumors in a specific manner. (foxchase.org)

Although a series of studies have revealed the process of neurogenesis, the molecular mechanisms regulating NPC proliferation are still largely unknown. (elsevierpure.com)
Our findings reveal a new unprecedented function for Nogo-A and NgR1 in the homeostatic regulation of the pace of neurogenesis in the adult mouse SVZ and in the migration of neuroblasts along the RMS. (jneurosci.org)
The most well characterized regulatory steps of adult hippocampal neurogenesis are the rate of progenitor cell proliferation and the survival rate of new DGCs. (jneurosci.org)
Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. (bvsalud.org)

In addition, a recent report [ 15 ] revealed that SSc autoantibodies bind to CMV late protein UL94 and induce apoptosis in endothelial cells therefore implicating molecular mimicry as a potential mechanism accounting for the link between SSc and CMV. (biomedcentral.com)
show that loss of GluN2A in adult mice is sufficient to elicit antidepressant-like responses without evoking psychomimetic effects, and that GluN2A is necessary for ketamine and MK-801 to induce rapid antidepressant-like effects. (nature.com)
Although nicotine is generally thought to have limited ability to initiate cancer, it can induce cell proliferation and angiogenesis in a variety of systems. (nih.gov)
Our earlier results indicated that nicotine could induce invasion and epithelial-mesenchymal transition (EMT) in cultured lung, breast and pancreatic cancer cells. (nih.gov)
Quinoline was mitogen in rat and mouse and could consequently induce cell proliferation. (europa.eu)
We believe that this analysis of several mouse anti-CD40 antibodies can be used to develop strategies for producing new human anti-CD40 antibodies that can more effectively induce or block B-cell proliferation. (lu.se)

IB4(+) and TRPV1(+) sensory neurons mediate pain but not proliferation in a mouse model of squamous cell carcinoma. (atsbio.com)
Ye Y, Bae S, Viet CT, Troob S, Bernabe D, Schmidt BL (2014) IB4(+) and TRPV1(+) sensory neurons mediate pain but not proliferation in a mouse model of squamous cell carcinoma. (atsbio.com)
Objective: To evaluate subtypes of sensory neurons involved in cancer pain and proliferation. (atsbio.com)
In early cortical development, neural progenitor cells (NPCs) expand their population in the ventricular zone (VZ), and produce neurons. (elsevierpure.com)
show in mice that tiredness triggers neurons in the prefrontal cortex to instruct the hypothalamus to initiate nesting and then sleep itself, ensuring that sleep occurs in a safe place. (nature.com)
This is consistent with a negative-feedback loop, in which newly generated neurons modulate cell division of SVZ stem cells. (jneurosci.org)
Given the increasing role of adult-generated new neurons in the function of the dentate gyrus, we also compare the response of newborn and mature granule cells following lesioning of the perforant path. (frontiersin.org)
This classic lesion provided some of the first evidence for structural plasticity following injury in the CNS, and also provides an opportunity to examine the injury response of some of the most highly plastic neurons in the brain, adult-generated newborn granule cells. (frontiersin.org)
Finally, neurons developing within a highly active environment exhibited a delayed maturation when their intrinsic electrical activity was reduced by the cell-autonomous overexpression of Kir2.1, an inward-rectifying potassium channel. (jneurosci.org)
Astrocytes mediate cell non-autonomous correction of aberrant firing in human FXS neurons. (ncbs.res.in)
However, current protocols for deriving neurons from human pluripotent stem cells give rise to heterogeneous cell populations both in regard to the temporal aspects and the cellular composition. (lu.se)
We provide detailed protocols for the generation of lentiviral vectors, the transduction of hES-cells, and their differentia- tion into neurons. (lu.se)

In this study, we generated a transgenic mouse line that expresses membrane-anchored GCaMP6s in OPCs and used longitudinal two-photon microscopy to monitor OPC calcium (Ca 2+ ) dynamics in the cerebral cortex. (nature.com)

These results demonstrate that ChoK plays an essential role in both normal human mammary epithelial cell proliferation and breast tumor progression. (aacrjournals.org)

Generally, cells have to closely coordinate growth and cell cycle progression during proliferation to prevent premature division. (uni-muenchen.de)
Here we show that nicotine significantly promotes the progression and metastasis of tumors in mouse models of lung cancer. (nih.gov)
CNOT6L couples the selective degradation of maternal transcripts to meiotic cell cycle progression in mouse oocyte. (nih.gov)
Increasing evidence has proven the importance of epigenetic modification in the progression of MS. Recent studies revealed that low-dose decitabine (Dec, 5-Aza-2'-deoxycytidine), which incorporates into replicating DNA and inhibits DNA methylation, could prevent experimental autoimmune encephalomyelitis (EAE) development by increasing the number of regulatory T cells (Tregs). (mdc-berlin.de)
Accumulated data suggest that the predicted evolution of diabetic glomerulopathy is comprised of an early, transient mesangial cell proliferation and subsequent hypertrophy of these cells that herald the slow progression into glomerulosclerosis [ 2 ]. (hindawi.com)
Although the role of inflammatory lipid-mediators in CRC progression is well known, their role in the promotion of cancer-initiating cells remains to be elucidated. (lu.se)
We showed that LTD4 and PGE2 enriched the ALDH+ cell population and augmented the colonies formation and tumor progression in xenograft mice model. (lu.se)

The factor isolated from the patient sera by a combination of gel filtration and anion-exchange chromatography induced proliferation of CD4 + CD8 - intrathymic T cells in the organ-cultured embryonic mouse thymus. (elsevierpure.com)
The study included SCC-1 human oral cancer cells and EBTr normal embryonic bovine tracheal epithelial cells, which were treated with 0 µM, 5 µM, 10 µM, and 20 µM of xanthoxyletin for 24 hours. (medscimonit.com)
1994. Ah receptor in embryonic mouse palate and effects of TCDD on receptor expression. (cdc.gov)
Given this, human pluripotent stem cells, such as human embryonic stem cells (hESCs) and induced pluripo- tent stem cells (hiPSCs), have become a unique cell source for study- ing early human brain development. (lu.se)

Now, researchers from Washington University School of Medicine in St. Louis have identified an RNA molecule that suppresses prostate tumors in mice. (genengnews.com)
In this study, we identified a long noncoding RNA (lncRNA), NXTAR (LOC105373241), that is located convergent with the AR gene and is repressed in human prostate tumors and cell lines. (genengnews.com)
The researchers demonstrated restoring NXTAR expression caused the tumors to shrink using human prostate tumor samples implanted in mice. (genengnews.com)
These studies on transplanted tumors were extended to a mouse model where the tumors were induced by the tobacco carcinogen, NNK. (nih.gov)
These alterations could make tumors more sensitive to DNA damage and cell death radiation therapy for cancer," said senior author André Nussenzweig, Ph.D., senior investigator in NCI's Experimental Immunology Branch. (nih.gov)
Given the high frequency of DDX5 amplification in breast cancer, our results highlight DDX5 as a promising candidate for targeted therapy of breast tumors with DDX5 amplification, and indeed we show that DDX5 inhibition sensitizes a subset of breast cancer cells to trastuzumab. (aacrjournals.org)
The biosynthesis and storage of catecholamines in chromaffin cell tumors may differ from the biosynthesis and storage in the normal medulla. (medscape.com)
in an inhalation study and only equivocal evidence of metabolism to SO is below the limit of detection in nearly all samples, and the most active sample of lung lung tumors in two of four chronic toxicity/oncogenicity was approximately 100-fold less active than mouse studies by gavage in mice (reviewed in Cruzan et al . (cdc.gov)
The ability of ALDH+ cells to form tumors in immunodeficient mice could not be challenged by radiation therapy. (lu.se)

These results suggest that RSV prevents diabetes-induced renal inflammation and mesangial cell proliferation possibly through Akt/NF- κ B pathway inhibition. (hindawi.com)
demonstrated that RSV prevented high glucose-induced kidney mesangial cell proliferation and fibronectin expression through inhibition of high glucose-induced JNK and NF- B activation, NADPH oxidase activity elevation, and reactive oxygen species production [ 10 ]. (hindawi.com)
Even when immune cells from Atm-S1987A-rescued mice are treated with radiation, several signs of normal cell cycle inhibition were observed, including decreased rate of DNA synthesis and decreased cell proliferation. (nih.gov)
Other mechanisms may exist as well, such as inhibition of leukotriene synthesis, lysosomal enzyme release, lipoxygenase activity, neutrophil aggregation, and various cell-membrane functions. (medscape.com)

This study aimed to evaluate the effects of the E-twenty six (ETS) factor Ets variant 2 (ETV2) gene expression in angiogenesis and the effect of ETV2 gene therapy in a mouse model of hindlimb ischemia. (vinastemcelllab.com)
Preliminary data showed that ETV2 expression played a role in angiogenesis of endothelial cells. (vinastemcelllab.com)

J Cell Biol (1974) 61 (2): 344-358. (rupress.org)
Nat Cell Biol. (worldhealth.net)
Front Cell Dev Biol. (ncbs.res.in)

Conditional knockout of α1A adrenergic receptors in OPCs suppresses spontaneous and locomotion-induced Ca 2+ increases and reduces OPC proliferation. (nature.com)

Vascular regeneration in mice was indirectly evaluated by changes in mouse survival, necrotic grades of the leg, normal blood oxygen saturation level (SpO 2 ), and blood flow by trypan blue injection assay. (vinastemcelllab.com)
We applied an assay that measures the stability of maintenance of an episomal plasmid in human tissue culture cells to screen for new DNA replication factors. (aacrjournals.org)
Only one test about the gene mutation properties was performed on mammalian cells (mouse lymphoma assay) and considered reliable. (europa.eu)
The MTT assay assessed cell viability, and autophagy was detected by electron microscopy. (medscimonit.com)

In contrast, knockdown of RhoG by RNA interference suppressed the proliferation, BrdU incorporation, and the proportion of Ki67-positive cells in NPCs. (elsevierpure.com)
Description: The CytoSelect BrdU Cell Proliferation ELISA Kit detects BrdU incorporated into cellular DNA during cell proliferation using an anti-BrdU antibody. (gkts.net)
When cells are incubated in media containing BrdU, the pyrimidine analog is incorporated in place of thymidine into the newly synthesized DNA of proliferating cells. (gkts.net)
Once the labeling media is removed, the cells are fixed and the DNA is denatured in one step with a fix/denature solution (denaturation of the DNA is necessary to improve the accessibility of the incorporated BrdU for detection). (gkts.net)
Then an anti-BrdU mouse monoclonal antibody is added followed by an HRP conjugated secondary antibody to detect the incorporated BrdU. (gkts.net)
The magnitude of the absorbance for the developed color is proportional to the quantity of BrdU incorporated into cells and can be directly correlated to cell proliferation. (gkts.net)
In the same animals evaluated for nociceptive responding, paclitaxel also reduced cellular proliferation but not cellular survival in the dentate gyrus of the hippocampus, as measured by immunohistochemistry for Ki67 and BrdU expression, respectively. (iasp-pain.org)
Voluntary running abrogated paclitaxel-induced reductions in cellular proliferation to levels observed in vehicle-treated mice and also increased BrdU expression levels irrespective of chemotherapy treatment. (iasp-pain.org)

Treatment of mouse NIH3T3 cells with 5FU, a potent inhibitor of rRNA maturation, confirmed an activation of this checkpoint, leading to weak induction of the tumor suppressor p53, induction of the Cdk-inhibitor p21, an increase in active, hypo-phosphorylated Rb, and to accumulation of cells in the G1- and S-phase with an increase of cells in G1-phase. (uni-muenchen.de)
In contrast, ES cells showed strong induction of p53, but no induction of its target gene p21. (uni-muenchen.de)
Because of microbody proliferation and catalase induction with increasing number of hypolipidemic compounds, additional studies are necessary to determine the interrelationships of microbody proliferation, catalase induction, and hypolipidemia. (rupress.org)
Our transcriptome analysis revealed in bladder cancer (BCa) tissues a significant induction of lysosomal-associated multispanning membrane protein 5 (LAPTM5), a lysosomal membrane protein preferentially expressing in immune cells and hematopoietic cells. (spandidos-publications.com)
We used the autologous uterine tissue transfer mouse model and studied the mRNA and protein expression of ERα, ERβ, GPER1, and PR in ectopic lesions at 2, 4, and 8 weeks of induction of endometriosis. (springer.com)
In addition to these genotoxicity/mutagenesis tests, some mitogenesis tests (replicative DNA synthesis, and S-phase induction) have been carried out on hepatocytes of rats, mice and guinea pigs. (europa.eu)
In vitro studies based on MCF-7 cell proliferation and induction of vitellogenin in primary culture of rainbow trout hepatocytes. (cdc.gov)

Taken together, these results indicate that RhoG promotes NPC proliferation through PI3K in cortical development. (elsevierpure.com)

In the adult mammalian subventricular zone (SVZ), GFAP-positive neural stem cells (NSCs) generate neuroblasts that migrate tangentially along the rostral migratory stream (RMS) toward the olfactory bulb (OB). (jneurosci.org)
Cancer stem cells are a population of slow-cycling cells within the tumour bulk, with self-renewal capacity that attracts interest as a therapeutic target. (lu.se)
In highly heterogeneous tumours, like pancreatic ductal adenocarcinoma (PDAC) however, the characterisation of cancer stem cells has led to controversial results due to the lack of consensus on specific markers. (lu.se)
Besides stroke, my lab has also a main interest in using (dental) stem cells for tissue regeneration . (uhasselt.be)
Hereby we focus on the use of extracellular vesicles derived from dental pulp stem cells, a project with dr. (uhasselt.be)
A stem cell capable of regenerating both bone and cartilage has been identified in bone marrow of mice. (sciencedaily.com)
The cells, called osteochondroreticular (OCR) stem cells, were discovered by tracking a protein expressed by the cells. (sciencedaily.com)
Researchers also showed that OCR stem cells, when transplanted to a fracture site, contribute to bone repair. (sciencedaily.com)
The researchers believe that OCR stem cells will be found in human bone tissue, as mice and humans have similar bone biology. (sciencedaily.com)
Our findings raise the possibility that drugs or other therapies can be developed to stimulate the production of OCR stem cells and improve the body's ability to repair bone injury--a process that declines significantly in old age," says Timothy C. Wang, MD, the Dorothy L. and Daniel H. Silberberg Professor of Medicine at CUMC, who initiated this research. (sciencedaily.com)
Previously, Dr. Wang found an analogous stem cell in the intestinal tract and observed that it was also abundant in the bone. (sciencedaily.com)
The study also showed that the adult OCRs are distinct from mesenchymal stem cells (MSCs), which play a role in bone generation during development and adulthood. (sciencedaily.com)
The CUMC study suggests that OCR stem cells actually fill this function and that both OCR stems cells and MSCs contribute to bone maintenance and repair in adults. (sciencedaily.com)
Oct. 8, 2021 Researchers have identified a subpopulation of mesenchymal stem cells in the bone marrow that express the marker CD73. (sciencedaily.com)
Jan. 29, 2020 Scientists used molecular motors to manipulate the protein matrix on which bone marrow-derived mesenchymal stem cells are grown. (sciencedaily.com)
The Division of Molecular Hematology (DMH) aims to generate new knowledge about the regulation of blood cell development by applying recent advances in stem cell technology, in order to dissect the molecular regulation of hematopoiesis. (lu.se)
This strategy provides a useful tool for visualization and identification of neural progeny derived from human pluripotent stem cells. (lu.se)
These strat- egies provide a robust way to visualize and isolate specific cell pop- ulations of differentiated pluripotent stem cells. (lu.se)
Here we describe how this system can be used for human embry- onic stem cells. (lu.se)

However, the results on TA100 are quite obvious and were obtained in a lot of different laboratories: quinoline induces gene mutation (missense mutations, by base pair substitution) with metabolic activation from liver of rat, mice, human or hamster. (europa.eu)

This study demonstrates for the first time that administration of nicotine either by i.p. injection or through over-the-counter dermal patches can promote tumor growth and metastasis in immunocompetent mice. (nih.gov)
The patient-derived xenograft (PDX) mouse model is highly relevant to real human tumor growth. (tmu.edu.tw)
The PDX mice were treated with EGCG (50 mg/kg), and the results indicated that EGCG significantly inhibited PDX tumor growth (*p ¼ 0.013). (tmu.edu.tw)
In immunodeficient mice, LTD4 or PGE2 treatment amplified CIC-induced tumor growth. (lu.se)

Trang chủ Công trình KHCN Bài báo ngoài nước ETV-2 activated proliferation of endothelial cells and attenuated acute hindlimb ischemia in. (vinastemcelllab.com)
ETV2 overexpression could trigger and stimulate proliferation of skeletal endothelial cells. (vinastemcelllab.com)

In these transgenic mice, the nucleic acid sequence encoding human p16INK4a has been linked to an inducible promoter or an operon capable of activation by the reverse tetracycline-controlled transactivator (rtTA), mediating p16 transcription. (foxchase.org)
DDX5 is required for cell proliferation by controlling the transcription of genes expressing DNA replication proteins in cancer cells in which the DDX5 locus is amplified, and this has uncovered a dependence on DDX5 for cell proliferation. (aacrjournals.org)

The protein p16INK4a is a potent cell cycle inhibitor and is a relatively selective CDK inhibitor. (foxchase.org)
In this study, mouse gubernaculum testis cells were pretreated with phospholipase C (PLC) inhibitor U-73122 and then treated with DES. (bvsalud.org)
In vitro , RSV attenuated high glucose-induced plasminogen activator inhibitor (PAI-1) expression and mesangial cell proliferation, as well as Akt and nuclear factor-kappa B (NF- κ B) activation. (hindawi.com)
Xiao and his colleagues think an mRNA inhibitor could dial back miR-155's response when T cell proliferation and antibody production is in overdrive. (medicalnewstoday.com)
The researchers attempted to mitigate the tamoxifen-driven increase in PI3K pathway activity by treating mice with the PI3K inhibitor alpelisib in conjunction with tamoxifen. (eurekalert.org)

Moreover, the Dnmt3a(-/-) NSC proliferation rate was significantly increased compared with control from P6 onward. (ca.gov)
The present study found that the tea polyphenol epigallocatechin-3-gallate (EGCG) significantly inhibited PRODH and its regulated proteins, such as alpha-smooth muscle actin (alpha-SMA) expression in TNBC cells. (tmu.edu.tw)
Additionally, immunohistochemistry results indicated that RSV treatment reduced the density of proliferating cell nuclear antigen-positive cells significantly in glomeruli of diabetic mice. (hindawi.com)
Furthermore, we established a BCa cell model with downregulated LAPTM5, revealing a significantly delayed growth rate in the BCa cells with knockdown of LAPTM5. (spandidos-publications.com)
Xanthoxyletin significantly inhibited the proliferation of oral cancer cells (IC₅₀, 10-30 µM) with lower cytotoxicity for normal cells. (medscimonit.com)

The PI 3-kinase PI3KC2α regulates mouse platelet membrane structure and function independently of membrane lipid composition. (nih.gov)

Voluntary exercise reduces both chemotherapy-induced neuropathic nociception and deficits in hippocampal cellular proliferation in a mouse model of paclitaxel-induced peripheral neuropathy. (iasp-pain.org)
We evaluated whether voluntary running would suppress both neuropathic pain and deficits in hippocampal cell proliferation in a mouse model of CIPN induced by the taxane chemotherapeutic agent paclitaxel. (iasp-pain.org)

Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability. (nih.gov)
Taken together, our results suggested that decreased LAPTM5 inhibited proliferation and viability, as well as induced G0/G1 cell cycle arrest possibly via deactivation of ERK1/2 and p38 in BCa cells. (spandidos-publications.com)

These findings demonstrate that expression of a proexendin-4 transgene may be associated with activation of humoral and cellular immune responses in mice. (diabetesjournals.org)
If the damage cannot be accurately fixed, the cell may commit cellular suicide rather than lose control of growth. (nih.gov)
The purpose of this study was to determine the ontogeny of cellular changes in the expression of estrogen receptors (ERα, ERβ), G protein-coupled estrogen receptor 1 (GPER1), and progesterone receptors (PRs) in endometriosis using a mouse model. (springer.com)
In this study we have profiled a panel of mouse antihuman CD40 monoclonal antibodies (MoAbs), regarding their CD40 binding affinity and epitope-specificity relative to the CD40L binding in relation to their cellular activating potential. (lu.se)

Furthermore, lymphocytes isolated from MT-Exendin mice proliferate in response to proexendin-4 but not after exposure to Ex-4 or ENTP. (diabetesjournals.org)
At this time, cells called T follicular helpers proliferate and migrate to a different area of the lymph organs to interact with B cells. (medicalnewstoday.com)
The cell cycle is a carefully regulated process by which cells proliferate. (nih.gov)

The results demonstrated that PRODH induced epithelial-mesenchymal transition in cancer cells and increased cell proliferation. (tmu.edu.tw)

Cell Rep, 2021 Nov 16. (nih.gov)

Hence, ribosomal stress does not lead to checkpoint activation via the p53-p21-Rb pathway in ES cells. (uni-muenchen.de)
In conclusion, these data suggest that the effects of DES on mouse gubernaculum testis cells are mediated by PLC-Ca2+ -CREB pathway. (bvsalud.org)
Our findings provide the first evidence that PLC-Ca2+ -CREB signalling pathway mediates the nongenomic effects of diethylstilbestrol on gubernaculum testis cells . (bvsalud.org)
These findings support the targeting of the PRODH signaling pathway as a potential therapeutic strategy in preventing cancer cell metastasis. (tmu.edu.tw)
To investigate the mechanisms of decreased PI3K pathway mutations in TA-UCs, the researchers examined uterine tissue from tamoxifen-treated mice. (eurekalert.org)
These data revealed a significant increase in PI3K pathway activation among tamoxifen-treated mice, as compared with mice treated vehicle control. (eurekalert.org)

Studies on cell proliferation are usually associated with deleterious side effects such as DNA damage and inflammation. (foxchase.org)
The present study was to investigate the protection of resveratrol (RSV) in diabetes associated with kidney inflammation and cell proliferation. (hindawi.com)

LAPMT5 is a lysosomal membrane protein preferentially expressed in immune cells ( 5 , 6 ) and hematopoietic cells ( 7 ), having a close interaction with the Nedd4 ( 8 ), a member of the E3 ubiquitin ligases family ( 8 ). (spandidos-publications.com)
The department focuses on research that aims to develop gene therapy for hematopoietic cells using viral vectors. (lu.se)

High choline intake during gestation and early postnatal development in rat and mouse models improves cognitive function in adulthood, prevents age-related memory decline, and protects the brain from the neuropathological changes associated with Alzheimer's disease (AD), and neurological damage associated with epilepsy, fetal alcohol syndrome, and inherited conditions such as Down and Rett syndromes. (mdpi.com)

Analysis of the changes of migration and invasion, showed significant reduced LAPTM5 suppressed cell metastasis. (spandidos-publications.com)

Bone-marrow-derived progenitors must continually enter the thymus of an adult mouse to sustain T-cell homeostasis, yet only a few input cells per day are sufficient to support a yield of 5 ⋅ 10 7 immature T-cells per day and an eventual output of 1-2 ⋅ 10 6 mature cells per day. (lu.se)

We established stable PRODH-overexpressing TNBC (HS578T) cells, and the malignant phenotypes were evaluated using soft agar colony formation and Transwell migration assays. (tmu.edu.tw)

Overall, the results suggest that ES cells use different mechanisms as mature cells to coordinate their proliferation rate with ribosome biogenesis. (uni-muenchen.de)
Here we explore potential mechanisms how the proliferation and contractility of gubernaculum testis cells are regulated by diethylstilbestrol . (bvsalud.org)
Although enzyme mechanisms may differ between humans and mice, gaining a better understanding of DNA damage repair might someday allow us to specifically alter ATM in cancer cells. (nih.gov)

Dr. Greg Enders developed TetOp16 transgenic mice which would allow for cell, tissue or organ-specific expression of p16INK4a, thereby allowing a broad control of cell proliferation in mice. (foxchase.org)
TetOp16 mice can be mated to mice carrying rtTA transgenes in the tissue of interest. (foxchase.org)
Thus, this mouse model is a very useful tool in research studies of cancer, development, tissue renewal, aging, and a variety of chronic diseases that involve cell proliferation. (foxchase.org)
The latter findings point to the participation of Nogo-A/NgR1 signaling in the regulation of other aspects of growth, such as tissue expansion or turnover by cell proliferation. (jneurosci.org)
The present study demonstrated that the proline dehydrogenase (PRODH) mRNA level in paired (tumor vs. normal) human breast tissue samples (n ¼ 234) was 6.6-fold greater than normal cells (*p ¼ 0.021). (tmu.edu.tw)
We now report that MT-Exendin mice develop extensive tissue lymphocytic infiltration with increased numbers of CD4 + and CD8a + cells in the liver and/or kidney and increased numbers of B220 + cells present in the pancreas and liver. (diabetesjournals.org)
The researchers also suspect that OCR cells may play a role in soft tissue cancers. (sciencedaily.com)

TetOp16 transgenic mice allow for the inducible expression of p16INK4a. (foxchase.org)
p16 expression can be induced in a regulated fashion in the doubly transgenic mice by administering antibiotic doxycycline or tetracycline. (foxchase.org)
TetOp16 transgenic mice offer a way to selectively manipulate cell proliferation by allowing for temporal and spatial regulation of p16INK4a expression. (foxchase.org)
They found that tamoxifen increased the expression of Ki67, a marker of cell proliferation. (eurekalert.org)
Here we describe how microRNA-regulated lentiviral vectors can be used to visualize specific cell populations by exploiting endogenous microRNA expression patterns. (lu.se)
When a microRNA is present in the cell, it binds to the target sites and downregulates GFP expression, while in cells that do not express the microRNA GFP, it is expressed. (lu.se)

Here we report that MCMV infections of gene-targeted mice lacking IFN-γR and subjected to whole body irradiation develop vascular lesions that over 4 months progress to severe vasculopathy characterized by significant neointima formation, a prominent feature of autoimmune vasculopathies in humans. (biomedcentral.com)
Mice engineered to lack the ATM gene are also defective in growth and are predisposed to cancer. (nih.gov)
The symptoms that result from a missing ATM gene can be alleviated by providing the mice with a new copy of the gene. (nih.gov)
Based on these tests, quinoline didn't induced gene mutation in testis, spleen, kidneys and bone marrow of the mouse. (europa.eu)

A second lumbar puncture (on day 17) showed an increased cell count (70 cells/mL, mostly lymphocytes), and CSF was negative for Zika virus RNA by rRT-PCR. (cdc.gov)

Nafenopin can, therefore, be used as an inducer of microbody proliferation and of catalase synthesis in both sexes of rats and mice. (rupress.org)
Numerous studies have demonstrated marked differ- fects on terminal bronchioles are seen, but effects in ences in toxicity between rats and mice to styrene ex- the nasal olfactory epithelium do occur, although to posure, especially by inhalation. (cdc.gov)
in styrene metabolism between rats and mice. (cdc.gov)

The pharmaceutical industry currently uses cyclin-dependent kinase (CDK) inhibitors to target cell proliferation for cancer chemotherapy. (foxchase.org)
In the mouse brain, we found that the plasticity inhibitors Nogo-A and Nogo receptor 1 (NgR1) are differentially expressed in the SVZ-OB system, in which Nogo-A identifies immature neuroblasts and NgR1 germinal astrocytes. (jneurosci.org)

In diabetic rodents, GLP-1 increases β-cell mass via proliferative, neogenic, and antiapoptotic actions ( 1 ). (diabetesjournals.org)

We established a TNBC-PDX (F4, n ¼ 4 in each group) mouse model. (tmu.edu.tw)
Rat mesangial cell and streptozotocin-induced type 1 diabetes mouse model were used. (hindawi.com)
Here we investigated the characteristics of a population of pancreatic cancer tumorspheres derived from different human pancreatic cancer cell lines and a primary line from a genetically engineered KPC mouse model, using flow cytometry and western blotting to analyse surface and stemness markers. (lu.se)
The model for how secondary cancers occur after chemotherapy, for example, is that cells acquire driver mutations that lead to clonal outgrowth," said presenter Kirsten Kübler, MD, PhD , an associate scientist at the Broad Institute of MIT and Harvard, research staff at Massachusetts General Hospital, and an instructor at Harvard Medical School, who recently joined the faculty of the Berlin Institute of Health at Charité in Berlin. (eurekalert.org)

These physiological stimuli primarily affect proliferation or survival. (jneurosci.org)

According to the research - conducted in mice implanted with human prostate tumor samples - restoring this so-called long noncoding RNA could be a new strategy to treat prostate cancer that has developed resistance to hormonal therapies. (genengnews.com)
Merckx G, Hosseinkhani B, Kuypers S, Deville S, Irobi J, Nelissen I, Michiels L, Lambrichts I, Bronckaers A. (2020) Angiogenic Effects of Human Dental Pulp and Bone Marrow-Derived Mesenchymal Stromal Cells and their Extracellular Vesicles. (uhasselt.be)
Mouse and human cells with non-functional ATM are also more sensitive to radiation. (nih.gov)
Understanding how DNA replication is regulated in human cells can provide insight into cancer development and may reveal vulnerabilities that can be exploited therapeutically. (aacrjournals.org)
Here, we have investigated the role of ChoK in the development of breast cancer and found that ChoK is both necessary and sufficient for growth factor-induced proliferation in primary human mammary epithelial cells and an absolute requirement for the specific mitogenic response to heregulin in breast tumor-derived cells. (aacrjournals.org)
icologic and metabolic data that explain the nasal and major differences are 4- to 10-fold more ring-oxidation lung differences and their relevance for human risk and phenylacetaldehyde pathways in mice compared assessment. (cdc.gov)
Dysfunctional blood cell development can have fatal consequences on human health, with implications for several key areas of modern medicine, including amongst others the broad research areas of oncology and immunology. (lu.se)
Although possible, these strategies are often complicated to transfer to human cells due to technical issues (9 ), and only a few successful cases have been described ( 10, 11 ). (lu.se)

In vitro studies showed fruquintinib inhibited VEGF-mediated endothelial cell proliferation and tubular formation. (centerwatch.com)

Anatomy40

Organisms20

Diseases12

Chemicals and Drugs91

Analytical, Diagnostic and Therapeutic Techniques and Equipment33

Phenomena and Processes64

Disciplines and Occupations1

Information Science3

Differentiation15

Neuronal3

Vivo12

Cancer cell proliferation1

Inhibits cell proliferation1

Neurogenesis4

Induce6

Neurons12

Cerebral cortex1

Mammary epithelial cell1

Progression7

Embryonic4

Tumors9

Inhibition4

Angiogenesis2

Biol3

Suppresses1

Assay4

BrdU8

Induction7

Cortical1

Stem19

Induces1

Tumor growth4

Endothelial cells2

Transcription2

Inhibitor5

Significantly5

Regulates mouse1

Hippocampal2

Viability2

Cellular4

Proliferate3

Epithelial-mesenchyma1

20211

Pathway6

Inflammation2

Hematopoietic2

Postnatal1

Metastasis1

Progenitors1

Migration1

Mechanisms3

Tissue7

Expression6

Gene4

Lymphocytes1

Rats and mice3

Inhibitors2

Increases1

Model4

Survival1

Human8

Vitro studies1