Mice cell 1 heparin syndecan 1. Medical search. Frequent questions

Heparan sulfate proteoglycans (HSPGs) are present on the cell surface and in the extracellular matrix in all metazoans. (scielo.br)
The sulfation pattern of heparan sulfate chains influences signaling events mediated by heparan sulfate proteoglycans located on the cell surface. (scielo.br)
Taken together, our data show that proteoglycans are expressed in primary B lymphocytes whereas they are not or only partly expressed in EBV-carrying cell lines, depending on their latency type program. (oncotarget.com)
Proteoglycans (PGs) are complex macromolecules composed of a core protein and covalently linked polysaccharide chain(s) which play a critical role in cell-cell and cell-matrix interactions. (oncotarget.com)
Recently, it was shown that a Mouse monoclonal to STAT3 basic amino acid sequence close to the N terminus of mature APRIL was required for binding to the APRIL-specific receptor, identified as sulphated glycosaminoglycan side chains of proteoglycans. (cancer-ecosystem.com)
Heparan sulfate (HS) proteoglycans are expressed on cell surfaces and in the extracellular matrix, and take part in developmental, regenerative, as well as pathological processes. (exbio.cz)
N-sulfated heparan sulfate proteoglycans are located in specific microdomains in the plasma membrane, independent on those formed around N-acetyl-rich heparan sulfate, and play different role in the cell signaling. (exbio.cz)
This review will summarize our current state of knowledge of the structure, biochemical properties and functions of syndecans, a family of transmembrane heparan sulphate proteoglycans. (scienceopen.com)
The sulfated saccharide domains provide numerous docking sites for protein ligands and are abundantly expressed at cell surfaces and in the extracellular matrix as part of proteoglycans (PGs). (silverchair.com)
This growth factor also stimulates production of collagens, proteoglycans, elastin, fibronectin, tenascin and thrombospondin, diminishes production of extracellularly active neutral endoproteinases belonging to the matrix metalloproteinase (MMP) and serine proteinase families, and stimulates production of endogenous MMP inhibitors (tissue inhibitor of metallo-proteinase [TIMP]) and serpins (plasminogen activator inhibitor-1). (biomedcentral.com)
Thereby, LMWH induced sensitization by transcriptional reprogramming of A2780cis cells via not yet elucidated mechanisms that depend on cellular proteoglycans. (oncotarget.com)
Among glycans that play a critical role in stromal tumor cell interactions are glycosaminoglycans (GAGs) attached to proteoglycans (PGs). (biomedcentral.com)

The TACI intracellular domain interacts with TRAF-2, TRAF-5 and TRAF-6 and activates NF-B and JNK.25 BAFF, but not APRIL, binds a third receptor named BAFF-R or BR3.31C33 BAFF-R was first identified in A/WySnJ mice that are deficient in B cells and present a mutated gene, (B-cell maturation deficiency) in comparison with the parental A/J mice. (cancer-ecosystem.com)
C-type lectin (CTL) is a protein that binds to saccharides and plays an important role in parasite adhesion, host cell invasion and immune evasion. (bvsalud.org)
The aim of this study was to investigate whether rTsCTL binds to SDC-1 on IEC, and the binding of rTsCTL with SDC-1 promotes larval invasion and its mechanism. (bvsalud.org)
Lipscombe RJ, Nakhoul AM, Sanderson CJ, Coombe DR: Interleukin-5 binds to heparin/heparan sulfate. (exbio.cz)

At each point, blood was collected for hyaluronan, syndecan-1, vascular cell adhesion molecule (VCAM-1), and von Willebrand factor (vWF), and a PBR measurement was performed. (scienceopen.com)
hyaluronan (HA), chondroitin sulfate (CS) and dermatan sulfate (DS), heparin and heparan sulphate (HS), and keratan sulfate (KS). (hindawi.com)
Fragments of the GCX, such as syndecan-1 and/or hyaluronan (HA), have been examined, and their validity is now being examined. (biomedcentral.com)

Laminin 5 is thought to be involved in cell adhesion, signal transduction and differentiation of keratinocytes. (wikipedia.org)
Heparanase also augments cell adhesion and signaling cascades leading to enhanced phosphorylation of selected protein kinases and increased transcription of genes associated with aggressive tumor progression. (pafr-signal.com)
Syndecans have been proposed to play a role in a variety of cellular functions, including cell proliferation and cell-matrix and cell-cell adhesion. (scienceopen.com)
Tumor-associated glycans play a significant role in promoting aggressive and metastatic behavior of malignant cells [ 1 - 5 ], participating in cell-cell and cell-extracellular matrix interactions that promote tumor cell adhesion and migration. (biomedcentral.com)
In previous studies we found that CS/DS-GAGs are expressed on the cell surface of murine and human breast cancer cell lines with high metastatic capacity and that they play a major role in P-selectin binding and P-selectin-mediated adhesion of cancer cells to platelets and endothelial cells [ 24 ]. (biomedcentral.com)

Syndecans bind a variety of extracellular ligands via their covalently attached heparan sulphate chains. (scienceopen.com)

Implications of Heparanase on Heparin Synthesis and Metabolism in Mast Cells. (uu.se)
ß-Xyloside (a syndecan-1 synthesis inhibitor) and Stattic (a STAT3 inhibitor) significantly inhibited rTsCTL binding to syndecan-1 in Caco-2 cells and activation of the STAT3 pathway, abrogated the effects of rTsCTL on the expression of gut tight junctions, and impeded larval invasion. (bvsalud.org)
Other profibrotic, collagen synthesis stimulating cytokines include endothelin, interleukin (IL)-1 and mast cell tryptase. (biomedcentral.com)
This study was performed to identify the carrier proteoglycan (PG) and the sulfotransferase gene involved in synthesis of the surface P-selectin-reactive CS-GAGs in human breast cancer cells with high metastatic capacity, as well as to determine a direct role for CS-GAGs in metastatic spread. (biomedcentral.com)
We found that (1) arsenite stimulated TF synthesis and activated the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in HASMCs, (2) sulforaphane, an Nrf2 activator, also stimulated TF synthesis in HASMCs, and (3) arsenite-induced upregulation of TF synthesis was prevented by Nrf2 knockdown in HASMCs. (go.jp)

Inhibition of Tumor-Host Cell Interactions Using Synthetic Heparin Mimetics. (uu.se)
This idea is certainly reinforced by research indicating a proclaimed inhibition of tumor development in mice treated with heparanase-inhibiting heparin-like substances (i.e. (nihvp.org)
We have investigated the inhibition by sulodexide and its components of Heparanase-1 by an ELISA assay. (biomedcentral.com)

5′-aza-dC and/or Trichostatin A resulted in transcriptional upregulation of the genes, suggesting that low expression of ECM components, proteoglycan core proteins and HS biosynthetic system is due to epigenetic suppression in type I cells. (oncotarget.com)
By interaction with extracellular matrix components, growth factors, enzymes, and their inhibitors, they regulate and influence tissue distribution of the cells and biological activities of the proteins. (exbio.cz)
Principal functions of the syndecan core proteins are to target the heparan sulphate chains to the appropriate plasma-membrane compartment and to interact with components of the actin-based cytoskeleton. (scienceopen.com)
The spiral of Ca2+ in H+ requirements is prescribed to routes which are phosphorylated proteins and frequently listen Ca2+ audiences in absent XH2A( as 1 TGN). (erik-mill.de)
The GCX, which is major constituent of the ESL, forms a luminal mesh that provides endothelial cells with a framework to bind plasma proteins and soluble GAGs. (biomedcentral.com)
The type II alveolar (ATII) cells produce pulmonary Rabbit polyclonal to PAI-3 surfactant that is required to prevent alveolar collapse and proteins that participate in innate defense of the lung (Mason, 2006). (cancercurehere.com)

Placental syndecan-1 and sulphated glycosaminoglycans are decreased in preeclampsia. (mdx.ac.uk)
Importantly, cell-associated and tumor microenvironment glycosaminoglycans (GAGs)/proteoglycan (PG) content and distribution are markedly altered during tumor pathogenesis and progression. (hindawi.com)
Free glycosaminoglycans (GAGs) and proteoglycan- (PG-) containing GAGs, key effectors of cell surface, pericellular and extracellular microenvironments, perform multiple functions in cancer by virtue of their coded structure and their ability to interact with both ligands and receptors that regulate cancer growth [ 1 - 4 ]. (hindawi.com)
Glycosaminoglycans (GAGs) comprise a class of linear, negatively charged polysaccharides composed of repeating disaccharide units of acetylated hexosamines (N-acetyl-galactosamine in the case of chondroitin sulphate and dermatan sulfate or N-acetyl-glucosamine in the case of heparin sulphate and heparin) and mainly of uronic acids (d-glucuronic acid or l-iduronic acid) being sulfated at various positions. (hindawi.com)
We have previously demonstrated that chondroitin sulfate glycosaminoglycans (CS-GAGs) on breast cancer cells function as P-selectin ligands. (biomedcentral.com)

both ligands induce NF-B activation in GSK 2334470 these cells.24 Binding of BAFF to TACI also stimulates NF-B activation in B-lymphoma cells, whereas a soluble form of TACI inhibits this induction and also the production of immunoglobulin M (IgM) by peripheral B lymphocytes. (cancer-ecosystem.com)
Previous studies showed that recombinant T. spiralis C-type lectin (rTsCTL) promotes larval invasion of intestinal epithelium cells (IEC), whereas anti-rTsCTL antibodies inhibits larval invasion. (bvsalud.org)
The aim of this work was to investigate whether sulodexide inhibits HPSE, and whether this mechanism can prevent FGF-2-induced EMT in renal tubular cells. (biomedcentral.com)
s.c. for 4 days) significantly inhibits the FGF-induced angiogenesis in mice [2] . (medchemexpress.com)

Re-expression of glucuronyl C5-epimerase in the mutant MEF cells increases heparan sulfate epimerization but has no influence on the Golgi localization and enzymatic activity of 2-O-sulfotransferase. (uu.se)
Syndecan-1 (SDC-1) is a member of the heparan sulfate proteoglycan family which is mainly expressed on the surface of IEC and in extracellular matrices where they interact with a plethora of ligands. (bvsalud.org)
The mouse monoclonal antibody HepSS-1 (also known as HepSS1) recognizes N-sulfated heparan sulfate (extracellular antigen) present in many species. (exbio.cz)
Separation of EA.hy926 cells (red-filled) from EA.hy926 cells treated with heparinase (1 hour, 1 UI per ml of cell suspension) stained using anti-N-sulfated heparan sulfate (HepSS-1) PE antibody (concentration in sample 10 μg/ml). (exbio.cz)
Kure S, Yoshie O: A syngeneic monoclonal antibody to murine Meth-A sarcoma (HepSS-1) recognizes heparan sulfate glycosaminoglycan (HS-GAG): cell density and transformation dependent alteration in cell surface HS-GAG defined by HepSS-1. (exbio.cz)
Chung JS, Shiue LH, Duvic M, Pandya A, Cruz PD Jr, Ariizumi K: Sézary syndrome cells overexpress syndecan-4 bearing distinct heparan sulfate moieties that suppress T-cell activation by binding DC-HIL and trapping TGF-beta on the cell surface. (exbio.cz)
Heparanase-1, an endoglycosidase that cleaves heparan sulfate, is implicated in the pathogenesis of diabetic nephropathy and is necessary to FGF-2 for the induction of tubular cells transition. (biomedcentral.com)
Almost every type of animal cell has the capacity to synthesize heparan sulfate (HS). (silverchair.com)
Some cytokines act as competence rather than progression factors, some lack secretory signals, and some must be processed and released from the pericellular matrix or basement membranes (eg transforming growth factor beta [TGF-β ] binding to chondroitin or the keratan sulfate of biglycan, decorin and fibromodulin, or basic fibroblast growth factor and platelet derived growth factor binding to the heparin sulfate of glypican, perlecan and syndecan). (biomedcentral.com)
Transient transfection of the human breast cancer cell line MDA-MB-231 with the siRNAs for carbohydrate (chondroitin 4) sulfotransferase-11 ( CHST11 ) and chondroitin sulfate proteoglycan 4 ( CSPG4 ) was used to investigate the involvement of these genes in expression of surface P-selectin ligands. (biomedcentral.com)

The proliferation and differentiation of satellite cells are regulated by a number of extracellular signals ( Wang & Rudnicki, 2012 Wang YX, Rudnicki MA. (scielo.br)
The possible role of PGs has so far been largely neglected, both during B-cell differentiation and as a factor in EBV-driven lymphomagenesis [ 1 , 2 ]. (oncotarget.com)
Tightly regulated HSPGs expression is a requirement for normal B cell maturation, differentiation and function [ 4 ] and the conformation of their HS polysaccharide chains is crucial for recruitment of factors that control plasma cell survival [ 5 ]. (oncotarget.com)
The membrane expression of BAFF persists during differentiation in macrophages but decreases during maturation in dendritic cells. (cancer-ecosystem.com)
Glial cell line-derived neurotrophic factor family receptor alpha (GFRα) members have been widely connected to the mechanisms contributing to cell growth, differentiation, cell migration and tissue maturation. (medsci.org)
The glial cell line-derived neurotrophic factors (GDNFs), a family of neurotrophic factors, were initially thought to be able to regulate the growth, survival, and differentiation of neural-derived cell types. (medsci.org)
Based on whether it cooperates with the second receptor RET, GFRα has also been widely linked to the mechanisms that contribute to cell growth, differentiation and migration and tissue maturation. (medsci.org)
We subsequently discuss how β-TCP can regulate osteogenic processes to aid bone repair/healing, namely osteogenic differentiation of mesenchymal stem cells, formation of blood vessels, release of angiogenic growth factors, and blood clot formation. (frontiersin.org)

When skeletal muscle is injured due to physical or chemical insult, a pool of self-renewing muscle stem cells residing within the skeletal muscles, called satellite cells, can give rise to differentiated myofibers to repair injured muscle ( Charge & Rudinicki, 2004 Chargé SBP, Rudnicki MA. (scielo.br)
Günther S, Kim J, Kostin S, Lepper C, Fan CM, Braun T. Myf5-positive satellite cells contribute to Pax7-dependent long-term maintenance of adult muscle stem cells. (scielo.br)
We have demonstrated that human embryonic stem cells (hESC) - derived microenvironment provide a niche which enables the growth of important subsets of ovarian cancer stem cells, which evade growth in conventional systems. (pafr-signal.com)
Particularly, we have found that Wnt signaling dysregulates mammary stem cells, and that this precedes the formation of differentiated, bilineal tumors. (wisc.edu)
The Martino group combines research in immunology, stem cells, and bioengineering in order to understand the mechanisms governing tissue repair and regeneration. (emblaustralia.org)
For instance, tissue injury and the healing process is usually accompanied by the activation of the immune system and the mobilization of endogenous stem cells. (emblaustralia.org)
For example, we found that inflammatory pathways involving the cytokine IL-1β inhibit the regenerative capacity of endogenous and transplanted stem cells. (emblaustralia.org)
Stem cells and morphogens, such as growth factors, are obviously very promising for regenerative medicine. (emblaustralia.org)
However, how can we actually create efficient and safe regenerative therapeutics based on stem cells or growth factors? (emblaustralia.org)
For example, stem cells need to survive and integrate into the host tissue after implantation, while morphogens need to signal in a controlled manner to stimulate endogenous regenerative pathways. (emblaustralia.org)
In addition, both stem cells and morphogens must display very limited side effects. (emblaustralia.org)
To tackle these challenges, our group is developing delivery systems for stem cells and growth factors that are designed to maximize their therapeutic potential while limiting their side effects. (emblaustralia.org)
For example, bone regeneration induced by mesenchymal stem cells has been significantly improved by limiting the inflammatory effect on stem cells. (emblaustralia.org)
Aggressive, transformed or transfected mesenchymal cells containing proto-oncogenes can act in the absence of lymphocytes, but whether these cells represent regressed fibroblasts, chondrocytes or bone marrow stem cells is unclear. (biomedcentral.com)
In this review, we introduce the broad application of β-TCP in tissue engineering and discuss the different approaches that β-TCP scaffolds are customized, including physical modification (e.g., pore size, porosity and roughness) and the incorporation of metal ions, other materials (e.g., bioactive glass) and stem cells (e.g., mesenchymal stem cells). (frontiersin.org)
The main challenge for large bone defect repair and regeneration remains the inadequate recruitment of mesenchymal stem cells (MSCs), reduced vascularization, and decreased growth factors stimulation within the scaffold construct to support cell viability and tissue growth. (frontiersin.org)

Heparanase Expression Propagates Liver Damage in CCL4-Induced Mouse Model. (uu.se)
The functional repertoire of heparanase is further expanded by its regulation of syndecan clustering and shedding. (pafr-signal.com)
Studies applying heparanase over-expressing and knock-out mice emphasize its ALK inhibitor role in tissue morphogenesis and as a master regulator of other ECM degrading enzymes. (pafr-signal.com)
Heparanase is certainly upregulated in response to chemotherapy in cancers patients as well as the making it through cells acquire chemoresistance, attributed, at least partly, to autophagy. (nihvp.org)
Heparin-like substances that inhibit heparanase activity are getting evaluated in scientific trials for numerous kinds of cancers. (nihvp.org)
Collectively, the rising premise is certainly that heparanase portrayed by tumor cells, innate immune system cells, turned on endothelial cells and also other cells from the tumor microenvironment is certainly a get good at regulator from the intense phenotype of cancers, a significant contributor to the indegent outcome of cancers sufferers and a leading focus on for therapy. (nihvp.org)
A causal function of heparanase in tumor metastasis was confirmed by the elevated lung, Mouse monoclonal antibody to Protein Phosphatase 3 alpha bone tissue and liver organ colonization of cancers cells pursuing overexpression from the heparanase gene, and by a proclaimed reduction in the metastatic potential of cells put through heparanase gene silencing. (nihvp.org)
2008). The pro-tumorigenic aftereffect of heparanase is certainly related to its HS degrading activity mainly, facilitating cell invasion and priming the tumor microenvironment. (nihvp.org)
Well known Heparanase-1 inhibitors are heparin(s) and sulodexide, a low-molecular weight heparin - dermatan sulphate blend, which is effective in the treatment of DN. (biomedcentral.com)
Results show that sulodexide is an effective heparanase-1 inhibitor, exclusively in virtue to the heparin component, with an IC50 of 5 μg/ml. (biomedcentral.com)
Moreover, sulodexide prevents FGF-2 induced heparanase-1 and MMP9 increase switching off the autocrine loop that FGF-2 activates to support its signal. (biomedcentral.com)
The findings highlight the capacity of sulodexide to inhibit heparanase-1 and to control tubular fibrosis triggered by epithelial-mesenchymal transition. (biomedcentral.com)

Dysregulated cell proliferation underlies all forms of oncogenesis. (wisc.edu)
A group of related diseases characterized by an unbalanced or disproportionate proliferation of immunoglobulin-producing cells, usually from a single clone. (lookformedical.com)

Emerging techniques using the analysis of circulating tumor cells show promising results in predicting and identifying the early stages of breast cancer metastasis in patients. (iiarjournals.org)
An emerging method to detect metastasis is the analysis of circulating tumor cells (CTCs), which has shown promise in filling the gaps left by other diagnostic methods. (iiarjournals.org)
CTCs are tumor cells originating from primary sites or metastases that circulate in the patients' bloodstream and are very rarely found in healthy individuals ( 9 , 10 ) ( Figure 1 ). (iiarjournals.org)
Morphological-based isolation separates CTCs according to size discrepancies, using isolation by size of epithelial tumor cells (ISET) or according to density, using density-gradient separation ( 4 ). (iiarjournals.org)
This method uses either epithelial cell-specific markers which are generally expressed in all tumor cells, or tumor markers expressed by specific types of cancer ( 13 ). (iiarjournals.org)
Circulating tumor cells in the blood stream. (iiarjournals.org)
The consecutive stages of cancer growth and dissemination are obligatorily perpetrated through specific interactions of the tumor cells with their microenvironment. (hindawi.com)
The consecutive steps of tumor growth, local invasion, intravasation, extravasation, and invasion of anatomically distant sites are obligatorily perpetrated through specific interactions of the tumor cells with their microenvironment. (hindawi.com)
A cell line derived from cultured tumor cells. (lookformedical.com)

The GDNF family ligands (GFLs) function through a glycosyl-phosphatidylinositol-(GPI) anchored coreceptor, GDNF family receptor alpha (GFRα), and rearranged during transfection (RET), a well-known receptor tyrosine kinase involved in kidney development, spermatogonial stem cell maintenance, and the development and maintenance of the sympathetic, parasympathetic, and enteric nervous systems [ 1 , 2 ]. (medsci.org)

We could significantly improve stem cell-driven bone regeneration by engineering a stem cell delivery system that integrates an inhibitor of the IL-1β signalling pathway. (emblaustralia.org)

Lymphoblastoid EBV+ B cell lines (LCLs) showed specific PG expression with down-regulation of CD44 and ECM components and up-regulation of serglycin and perlecan/HSPG2. (oncotarget.com)
For Burkitt's lymphoma cells (BL), serglycin was down-regulated in BL type III cells and perlecan in type I BL cells. (oncotarget.com)

Description: Quantitativesandwich ELISA kit for measuring Human Syndecan-3(SDC3) in samples from serum, plasma, tissue homogenates. (hudsen.org)
Description: A sandwich ELISA kit for detection of Glutathione Peroxidase 1 from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (jsce-ip.com)

Disruption of innate defense responses by endoglycosidase HPSE promotes cell survival. (uu.se)
Insulin-like growth factor-II and heparin are anti-apoptotic survival factors in human villous cytotrophoblast. (mdx.ac.uk)
LNPG significantly prolonged the survival time of LPS-treated mice compared with the other treatments. (bvsalud.org)
We tested liposomal nanocarriers of preassembled glycocalyx (LNPG) in vivo and ex vivo to establish for the first time their expeditious therapeutic efficacy in improving survival of lipopolysaccharides (LPS)-treated mice, as achieved by the restoration of EG and recovery of endothelial function. (bvsalud.org)
Such defects are often associated with changes in cellular signal transduction pathways, such as the Ras-Raf-MEK-ERK kinase cascade, which promotes cell survival and growth. (wisc.edu)

Further variety of the pathogenesis of heparin on food or eRF3 activation novo increases characterised for the unidentified blood, since responses between foreign mitochondria and the vacuolar agonist bind Generally previously often endocytosed. (erik-mill.de)
Cell-associated and tumor microenvironment GAG content and distribution is markedly altered during tumor pathogenesis and progression [ 11 , 12 ]. (hindawi.com)
This model will be critical for future studies to determine the roles of these specialized cell types in the pathogenesis of respiratory Roflumilast N-oxide viral infection. (cancercurehere.com)
models that can be used to delineate cell type-specific mechanisms that contribute to disease pathogenesis in the lung. (cancercurehere.com)

Low molecular weight heparin (LMWH), the guideline based drug for prophylaxis and treatment of cancer-associated thrombosis, was recently shown to sensitize cisplatin resistant A2780cis human ovarian cancer cells for cisplatin cytotoxicity upon 24 h pretreatment with 50 μg × mL -1 of the LMWH tinzaparin in vitro , equivalent to a therapeutic dosage. (oncotarget.com)
Here we aim to illuminate the underlying molecular mechanisms of LMWH in sensitizing A2780cis cells for cisplatin. (oncotarget.com)
Glypican-3 (GPC3) is upregulated in A2780cis cells in response to LMWH treatment, probably as counter-regulation to sustain the high Wnt activity against LMWH. (oncotarget.com)
Hence, LMWH reduces the cisplatin-induced rise in Wnt activity and TCF-4 expression in A2780cis cells, but keeps sensitive A2780 cells unaffected. (oncotarget.com)
Consequently, Wnt signaling pathway appears as primary target of LMWH in sensitizing A2780cis cells for cisplatin toxicity. (oncotarget.com)
According to clinical guidelines for antithrombotic prophylaxis or treatment of patients in oncology, low molecular weight heparin (LMWH) is the drug of choice [ 2 ]. (oncotarget.com)

Syndecan-1-positive plasma cells and proteoglycan-rich non-haematopoietic cells displayed specific, heparin-sensitive binding to APRIL. (cancer-ecosystem.com)
Syndecan-1 (SDC-1) was a critical membrane proteoglycan and an important component of the glycocalyx in endothelial cells, but its role in atherosclerosis remains unknown. (bvsalud.org)
The carrier proteoglycan CSPG4 was highly expressed on the aggressive breast cancer cell lines and contributed to the P-selectin binding and CS-A expression. (biomedcentral.com)

Syndecans: multifunctional cell-surface co-receptors. (scienceopen.com)
The main function of syndecans appears to be to modulate the ligand-dependent activation of primary signalling receptors at the cell surface. (scienceopen.com)

We induced endotoxemia in C57BL/6J mice using lipopolysaccharides (LPS) and treated them with LNPG, saline, syndecan-1, or liposomes. (bvsalud.org)

2005). Notch1 and syndecan-1 potent human embryonic stem (ES) cells. (lu.se)
The axonemal site of NOTCH1 and the collagen Ligand-binding WD40 cell of 40kDa are different benefits of pumps in accumulation epithelial Endoplasmic development - T-ALL( Welcker and Clurman 2008). (evakoch.com)

Bober E, Franz T, Arnold HH, Gruss P, Tremblay P. Pax-3 is required for the development of limb muscles:a possible role for the migration of dermomyotomal muscle progenitor cells. (scielo.br)
Our hypothesis is that the transforming potential of Wnt signaling is unique to stem/progenitor cells. (wisc.edu)
1983) and the multipotent progenitor cells from fetal disease (Bjorklund and Lindvall, 2000). (lu.se)

Specifically, these extracellular matrix (ECM) components critically modulate the tumor cell "motile phenotype" affecting their adhesive/migratory abilities which are directly correlated to the metastatic cascade [ 5 , 6 ]. (hindawi.com)
Cell type and tissue specific alterations in fine GAG structure, which are strictly predetermined [ 8 - 10 ], allow these molecules to modulate with high specificity different cellular processes [ 7 ]. (hindawi.com)

IL-6, interestingly, does not seem to stimulate the production of collagenase, but is a potent inducer of TIMP-1. (biomedcentral.com)

Cell Metabolism 2013;17(2):210-24. (scielo.br)

Glucuronyl C5-epimerase is crucial for epithelial cell maturation during embryonic lung development. (uu.se)

The heparin fraction has a molecular weight of 7000 D and a low degree of sulfation. (biomedcentral.com)

Cell Biol. (wikipedia.org)
Eur J Obstet Gynecol Reprod Biol:163(1):11-6. (mdx.ac.uk)
J Cell Biol (2006) 174 (3): 323-327. (silverchair.com)

The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
GRP75-driven, cell-cycle-dependent macropinocytosis of Tat/pDNA-Ca2+ nanoparticles underlies distinct gene therapy effect in ovarian cancer. (uu.se)
A lead compound (non-anticoagulant glycol-split heparin), highly effective 4-Aminobutyrate aminotransferase against myeloma tumors, was selected toward a clinical trial in cancer patients. (pafr-signal.com)
Israel Institute of Technology, Haifa, Israel One of the main stumbling blocks in establishing personalized cancer therapy has been the paucity of pre-clinical experimental models in which the actual cancer cells from a patient can be successfully grown in a manner which mimics growth in the human body for testing of anti-cancer treatments tailored to the individual patient. (pafr-signal.com)
Six different subpopulations of ovarian cancer cells from one patient have been generated and characterized. (pafr-signal.com)
Breast cancer is the most common type of cancer and the primary cause of cancer mortality in women ( 1 ). (iiarjournals.org)
Quantitative real-time PCR (qRT-PCR) and flow cytometry assays were used to detect the expression of genes involved in the sulfation and presentation of chondroitin in several human breast cancer cell lines. (biomedcentral.com)
The CHST11 gene was highly expressed in aggressive breast cancer cells but significantly less so in less aggressive breast cancer cell lines. (biomedcentral.com)
CSPG4 serves as a P-selectin ligand through its CS chain and participates in P-selectin binding to the highly metastatic breast cancer cells. (biomedcentral.com)

These data provided evidence that HPV-positive tumors may be more sensitive to chemotherapy and molecular inhibitors that specifically target cell cycle. (moffitt.org)
Fibroblasts produce TIMPs (1-4), which were previously called human fibroblast collagenase inhibitors. (biomedcentral.com)

Any discrete, presumably solitary, mass of neoplastic PLASMA CELLS either in BONE MARROW or various extramedullary sites. (lookformedical.com)
Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells. (lookformedical.com)

Upon increasing culture times in chicken´s primary skeletal muscle satellite cells, SULF1 and SULF2 expression in 1-week-old chickens was significantly higher than in 2-week-old chickens, suggesting that sulfatases play a key role in satellite cell development. (scielo.br)
Specifically the research showed that the most significantly deregulated genes in the HPV-positive tumors are cell cycle regulators. (moffitt.org)
Enzymatic removal of tumor-cell surface CS-GAGs significantly inhibited lung colonization of the 4T1 murine mammary cell line ( P = 0.0002). (biomedcentral.com)

Disruptions of such interactions might affect B cell interaction with surrounding stroma and may thus perturb the cell phenotypes. (oncotarget.com)
Our studies integrate molecular genetics, genomics, biochemistry and cell biology to address fundamental questions in virus replication and virus-cell interactions. (wisc.edu)
Over the past decade, insight has been gained into the role of the glycocalyx in vascular physiology and pathology, including mechanotransduction, hemostasis, signaling, and blood cell-vessel wall interactions. (scienceopen.com)
Interactions with HS contribute to or modify the various protein functions, which are of particular interest in relation to growth factor/morphogen translocation and signaling ( Fig. 1 ). (silverchair.com)
Primary cultures of differentiated alveolar epithelial cells are a valuable model to study virusChost interactions in physiologically relevant cell types (Corti et al. (cancercurehere.com)

Nature Reviews Molecular Cell Biology 2012;13(2):127-33. (scielo.br)
We are studying aspects of mammary gland biology and neoplasia using transgenic mouse models. (wisc.edu)
While originally trained in engineering, he completed a 5 year "re-training" in cell biology via an NIH K25 award which transitioned his lab to more biology and medically focused work. (wisc.edu)

molecules by B-CLL cells, their regulation, transduction pathways and their effects on leukaemic cells. (cancer-ecosystem.com)
It will discuss the expression of these molecules by B-CLL cells, their regulation, transduction pathways and their effects on leukaemic cells. (cancer-ecosystem.com)
Regulation at the protein level includes modulation of its cell surface expression, cathepsin L-mediated processing, cellular uptake, secretion, and cytoplasmic vs. nuclear localization. (pafr-signal.com)
Q2986 Kesanakurti,D., Chetty,C., Maddirela,D.R., Gujrati,M., Rao,J.S. Essential role of cooperative NF-kappaB and Stat3 recruitment to ICAM-1 intronic consensus elements in the regulation of radiation-induced invasion and migration in glioma. (alzet.com)

A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. (lookformedical.com)
Conditions characterized by the presence of M protein (Monoclonal protein) in serum or urine without clinical manifestations of plasma cell dyscrasia. (lookformedical.com)

Description: A sandwich quantitative ELISA assay kit for detection of Human Syndecan 3 (SDC3) in samples from tissue homogenates or other biological fluids. (hudsen.org)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Syndecan 3 (SDC3) in Tissue homogenates and other biological fluids. (hudsen.org)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Simian Interleukin 2 (IL2) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (gkts.net)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Simian Interleukin 2 (IL2) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (gkts.net)

Inducible depletion of satellite cells in adult, sedentary mice impairs muscle regenerative capacity without affecting sarcopenia. (scielo.br)

The purpose of this review is to provide a latest summary of biomarkers associated with endothelial cell activation in COVID-19 and offer mechanistic insights into the molecular basis of endothelial activation/dysfunction in macro- and micro-vasculature of COVID-19 patients. (nature.com)
Background: A major clinical feature of severe coronavirus diease 2019 (COVID-19) is microvascular thrombosis linked to endothelial cell activation. (imperial.ac.uk)

We have analyzed its effect on the epithelial-mesenchymal transition of tubular cells by real time gene expression analysis, zymography and migration assay. (biomedcentral.com)
Cell surface P-selectin binding depends on CHST11 gene expression. (biomedcentral.com)

Urate crystals induce macrophage PAF-AH secretion which is differentially regulated by TGFb-1 and hydrocortisone. (mdx.ac.uk)
Using phosphoproteomic approaches, they are mapping downstream effectors of TFG-NTRK1 and TFG-ALK that simultaneously drive cell transformation and regulate vesicle secretion. (wisc.edu)

2007). MHV-1.a mmc3.docx (50K) GUID:?C2C991D5-9ACE-434F-A66C-0B0336579774 Abstract Severe respiratory viral infections are associated with spread to the alveoli of the lungs. (cancercurehere.com)

2017 Dec 7;8(1):1973. (exbio.cz)

Laminins are basement membrane components thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. (wikipedia.org)

Epithelial-mesenchymal transition of tubular cells is a widely recognized mechanism that sustains interstitial fibrosis in diabetic nephropathy (DN). (biomedcentral.com)
In FGF-2 treated tubular cells, sulodexide also prevents the over-expression of the mesenchymal markers αSMA, vimentin and fibronectin and the motility increase, i.e. the epithelial-mesenchymal transition of tubular cells. (biomedcentral.com)
MMPs now comprise a group of 18 different enzymes in man, including the classic fibroblast collagenase MMP-1 (collagenase-1), the mesenchymal form of MMP-8 (collagenase-2) and MMP-13 (collagenase-3). (biomedcentral.com)

Phase separation on cell surface facilitates bFGF signal transduction with heparan sulphate. (uu.se)

Primary cultures of murine alveolar epithelial cells provide a robust model to perform mechanistic studies that can be correlated with studies to identify cell type-specific factors that contribute to pathology within the alveoli of the lung during viral infection. (cancercurehere.com)
In this study, we established an model to compare the responses of type I (ATI) and type II (ATII) alveolar epithelial cells to infection by respiratory viruses used in murine models: mouse-adapted severe acute respiratory syndrome-associated coronavirus (SARS-CoV, v2163), murine coronavirus MHV-1, and influenza A (H1N1) virus, strain PR8. (cancercurehere.com)
Epithelial cells produce cytokines in response to viral infections, thereby activating immune responses. (cancercurehere.com)
Infection of ATI or ATII alveolar epithelial cells of the distal lung has been Roflumilast N-oxide detected in fatal cases of avian (H5N1) and 2009 pandemic (pH1N1) IAV, RSV, and SARS-CoV (Johnson et al. (cancercurehere.com)
2007). Infection of alveolar epithelial cells is also associated with severe disease in murine models of respiratory viral infections, including mouse-adapted IAV and SARS-CoV (Blazejewska et al. (cancercurehere.com)
Alveolar epithelial cells produce inflammatory cytokines and chemokines in response to viral infection and thereby may elicit responses that contribute to both viral clearance and immune-mediated pathology. (cancercurehere.com)

In summary, our findings provide evidence of the therapeutic efficacy of LNPG in the LPS-induced mouse model of sepsis, achieved by expeditiously restoring EG through fusion of LNPG with the endothelial plasma membrane and recovery of endothelial function.NEW & NOTEWORTHY Vascular endothelial cells represent the first line of exposure to bacterial endotoxins. (bvsalud.org)
Here, we propose a novel therapeutic strategy using liposomes to deliver preassembled glycocalyx to vascular endothelial cell surface and consequently restore endothelial glycocalyx (EG). (bvsalud.org)

Description: A sandwich ELISA for quantitative measurement of Human Syndecan 3(SDC3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (hudsen.org)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Glutathione Peroxidase 1 (GPX1) in serum, plasma and other biological fluids. (jsce-ip.com)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Glutathione Peroxidase 1 (GPX1) in samples from Serum, plasma and other biological fluids with no significant corss-reactivity with analogues from other species. (jsce-ip.com)

Comprehensive Landscape of Heparin Therapy for COVID-19. (uu.se)

Murine alveolar cells cultured to maintain an ATII cell phenotype, determined by expression of LBP180, were susceptible to infection by all three viruses. (cancercurehere.com)
In contrast, ATII cells that were cultured to trans-differentiate into an ATI-like cell phenotype were susceptible to MHV-1 and PR8, but not mouse-adapted SARS-CoV. (cancercurehere.com)

Anatomy33

Organisms29

Diseases14

Chemicals and Drugs94

Analytical, Diagnostic and Therapeutic Techniques and Equipment30

Phenomena and Processes61

Disciplines and Occupations1

Information Science4

Health Care3

Proteoglycans12

Binds4

Hyaluronan3

Adhesion5

Variety of extracellular1

Synthesis5

Inhibition3

Proteins6

Glycosaminoglycans5

Inhibits4

Sulfate10

Differentiation8

Stem cells16

Heparanase12

Proliferation2

Tumor cells9

Ligands1

Inhibitor1

Perlecan2

ELISA Kit2

Survival5

Pathogenesis4

LMWH6

Proteoglycan3

Receptors2

Saline1

Notch12

Progenitor cells3

Modulate2

Potent1

Metabolism1

Maturation1

Molecular weight1

Biol3

Cancer9

Inhibitors2

Bone marrow2

Significantly3

Interactions5

Biology3

Regulation4

Monoclonal2

Tissue homogenates4

Regenerative capacity1

Endothelial cell activation2

Gene expression2

Secretion2

ABSTRACT1

20171

Migration1

Mesenchymal3

Signal transduction1

Epithelial cells6

Vascular endothelial2

Serum3

Therapy1

Phenotype2