Mice inbred dba. Medical search. Frequent questions

To explore this concept, MMTV-PyMT mice were crossed with 25 AKXD (AKR/J x DBA/2J) recombinant inbred strains to produce F1 progeny. (nih.gov)

The first inbred strain, DBA (dilute brown agouti), was developed in 1909. (wikipedia.org)
A Patient Derived Xenograft (PDX) is generated by the implantation of human tumor tissue in an immunodeficient or humanized host mouse strain. (wikipedia.org)
To characterize ocular abnormalities associated with iris atrophy in DBA/2J mice and to determine whether mice of this strain develop elevated intraocular pressure (IOP) and glaucoma. (nih.gov)
This mouse strain represents a useful model to evaluate mechanisms of pressure-related ganglion cell death and optic nerve atrophy, and to evaluate strategies for neuroprotection. (nih.gov)
Continuity of a particular inbred strain implies that mice must live long enough to produce offspring, but beyond that minimal requirement there are great differences between strains in characteristic lifespan. (jax.org)
Annotation of mouse strain DBA/2J genome assembly provided by GENCODE consortium. (jax.org)
J:259852 Mouse Genome Informatics and the WTSI Mouse Genomes Project, MGI Strain Genome Feature and Gene Model Load. (jax.org)
Prof. Dr. Hanno Würbel initiated a multi-laboratory study together with two colleagues and their co-workers to compare the effects of enriched housing in female mice on the expression of strain differences in standard behavioural tests. (forschung3r.ch)
Each replicate involved eight mice per strain and housing condition, amounting to 48 mice per replicate and 432 mice in total. (forschung3r.ch)
An inbred strain of mouse. (nih.gov)
The effect on sensory inhibition was investigated in DBA/2 mice, a strain with reduced sensory inhibition under standard experimental conditions. (nih.gov)
Three weeks of CUS increased the helplessness expressed in the Forced Swimming Test (FST) and the Tail Suspension Test by RCF-exposed female mice of the D2 strain. (uniroma1.it)
The origin of this strain can be traced back to a cross between a Bagg albino female and a DBA male conducted by Strong in 1920. (hylascobio.in)
C57BL/6 mice are a commonly used laboratory mouse strain that have a wide range of research applications, including as a general multipurpose model, for studying diet-induced obesity, developing transgenic/knockout models, and for safety and efficacy testing. (hylascobio.in)
They were first developed in 1921 and have undergone several generations of inbreeding to create a genetically stable and uniform strain. (hylascobio.in)
CB6F1 mice are a hybrid strain resulting from the crossbreeding of female BALB/c mice and male C57BL/6 mice. (hylascobio.in)
CD2F1 mice are a widely used hybrid strain resulting from a cross between female BALB/c mice and male DBA/2 mice. (hylascobio.in)
B6C3F1 mice are a hybrid strain obtained by crossing female C57BL/6 mice with male C3H mice, resulting in mice designated as B6C3F1/Crl. (hylascobio.in)
B6D2F1 mice are a hybrid strain of laboratory mice, which are produced by crossing female C57BL/6 mice with male DBA/2 mice. (hylascobio.in)
Overall, the B6D2F1 mouse strain has proven to be a valuable tool for researchers in a wide range of scientific fields. (hylascobio.in)

Figure 1 shows one of these tools, the Tumor Frequency Grid, which displays the frequency of different types of tumors across different inbred strains. (wikipedia.org)
Large colonies of mice from many different inbred strains, all descended from mice in the Foundation Stocks of The Jackson Laboratory, are maintained on a common regimen in the Pedigreed Expansion Stocks (PES) of The Jackson Laboratory ( Green, 1964 ). (jax.org)

Balb/C, C3H, DBA/2) are also highly susceptible to infection ( 1 , 6 , 7 ). (cdc.gov)
Twenty-eight normal and splenectomized rabbits were injected intravenously or intraperitoneally for from 7 to 14 courses of 4 biweekly injections with erythrocytes of BALB/c, C57B, and DBA inbred strains of mice. (aai.org)
While oxidative tension Pyroxamide (NSC 696085) appears to have an effect on cell enlargement enhances following ADSC-mediated angiogenesis enlargement and oxidative stress resistance of ADSCs isolated from three genetically diverse inbred strains of adult female mice: C57BL/6J (B6) BALB/cByJ (BALB) and DBA/2J (D2) mice. (academicediting.org)
BALB/c mice are a widely used general-purpose model in biomedical research. (hylascobio.in)
Additionally, BALB/c mice have been used extensively in hybridoma development and monoclonal antibody production. (hylascobio.in)

A study in erythroblasts from eight strains of inbred mice found that approximately 1/3 of variable open chromatin sites can be explained by single nucleotide variants and that these variants were associated with complex traits and disease [ 7 ]. (biomedcentral.com)

Objectives: We evaluated the utility of genetically diverse mouse strains for estimating toxicokinetic population variability for risk assessment, using trichloroethylene (TCE) metabolism as a case study. (nih.gov)
Conclusions: Population PBPK modeling of genetically diverse mouse strains can provide useful quantitative estimates of toxicokinetic population variability. (nih.gov)
Three genetically diverse inbred mouse strains - C57BL/6J, A/J, and DBA/2J - differ significantly in their genomes (∼7 million variants), motor and cognitive behavior, and susceptibility to neurotoxins. (lih.lu)
Our findings suggest that genetic diversity introduced by crossing B6 and D2 inbred backgrounds influences proteomic changes related to disease in the 5XFAD model, and that proteomic analysis of other genetic backgrounds in transgenic and knock-in AD mouse models is warranted to capture the full range of molecular heterogeneity in genetically diverse models of AD. (emory.edu)

The spontaneous miniature excitatory postsynaptic current (mEPSC) frequency was substantially reduced (about 60%), and mEPSCs were significantly slower (about 115%) and smaller (about 70%) in high-frequency regions of old (average age 45 days) DBA mice compared with tonotopically matched regions of young (average age 22 days) DBA mice. (nih.gov)
Among the earliest references to the use of inbred mice in cancer was the observed susceptibility of the A family of inbred mice to spontaneous lung tumors. (wikipedia.org)
Molecular analysis of spontaneous nephrotropic anti-laminin antibodies in an autoimmune MRL-lpr/lpr mouse. (musc.edu)
Autoimmune lpr/lpr mice deficient in CD40 ligand: spontaneous Ig class switching with dichotomy of autoantibody responses. (musc.edu)

On the other hand, TH female mice do not exhibit this triglyceride spike although they maintain hypertriglyceridemia compared with age- and sex-matched C57BL/6J (B6) mice. (biomedcentral.com)
The present results support genotype-dependent additive effects of early experiences and adult adversities on behavioral and neural responses to stress by female mice. (uniroma1.it)

MMHCdb contains genetic and genomic information about inbred mouse strains, genetically engineered mouse models (GEMMs) and Patient Derived Xenograft (PDX) models of human cancer. (wikipedia.org)
We used the Hamilton Eye Institute (HEI) retinal dataset ( www.genenetwork.org ) to identify genomic loci that modulate expression of genes in the p53 pathway in recombinant inbred BXD mouse strains using a QTL systems biology-based approach. (transhumanist.ru)
We also applied a genetical genomic approach using a subset of the F2 mice to seek candidate genes underlying the QTLs. (biomedcentral.com)
Forty-three sequences containing simple sequence repeats or microsatellites were generated from an M13 library of total genomic mouse DNA. (ox.ac.uk)
Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma. (ox.ac.uk)
The candidate genes and genomic loci identified in the mouse were then directly compared with the summary data from a human POAG genome wide association study (NEIGHBORHOOD) to determine if any genomic elements modulating mouse CCT are also risk factors for POAG.This analysis revealed one significant QTL on Chr 13 and a suggestive QTL on Chr 7. (ox.ac.uk)

In mice with CIA, HAMC treatment decreased the production of various inflammatory cytokines and chemokines in the joints, impaired antigen-specific Th1/Th17 cell expansion in the lymph nodes, and generated peripheral antigen-specific Treg cells. (unicatt.it)
Histologic analysis of arthritic joints from anti-NKG2D-treated mice demonstrated significant joint protection, compared with control mice. (ox.ac.uk)
DBA/1 mice were immunized with type II collagen and an immunohistochemical analysis of expression of proinflammatory cytokines [tumour necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6] and anti-inflammatory cytokines [IL-10, IL-1ra, transforming growth factor (TGF)-beta1, TGF-beta2 and TGF-beta3] in joints was carried out over the course of the disease. (ox.ac.uk)

The genetic background of genetically modified animals can influence the observed phenotypes and must be taken into account when mouse models of human cancer are developed and when interpreting the data generated by these models. (wikipedia.org)
When Mendel s laws were rediscovered at the beginning of the 20th century, all they had for reagents were these funny colored mice and ones that had neurological phenotypes. (nih.gov)
To further dissect the underlying molecular networks responsible for these variable phenotypes, we generated RNA-seq and ChIP-seq data from ventral midbrains of the 3 mouse strains. (lih.lu)
Finally, the comparative analyses of behavioral and neural phenotypes expressed by B6 and D2 mice suggest some translationally relevant hypotheses of genetic risk factors for psychiatric disorders. (uniroma1.it)

Molecular biology and genome editing technologies transformed the use of mice in cancer research by allowing researchers to develop animal models with specific mutations or that expressed human genes (transgenics). (wikipedia.org)
The genetically controlled immune response to calf skin collagen type I in mice could be demonstrated to be governed by at least two genes. (elsevierpure.com)
As anxiety is an evolutionarily conserved response, mouse models can be used to carry out genome-wide searches for specific genes in a setting that controls for the environmental factors. (biomedcentral.com)
Several methods, such as quantitative trait locus mapping, gene expression profiling, and proteomics, have been used in various mouse models of anxiety to identify genes that regulate anxiety or play a role in maintaining pathological anxiety. (biomedcentral.com)
We then describe how several genes have been identified through genome-wide methods in mouse models and subsequently investigated in human anxiety disorder samples as candidate genes. (biomedcentral.com)
To complement human genetic studies several groups have used mouse models of anxiety-like behavior for identification of genes and biological pathways that regulate anxiety. (biomedcentral.com)
In this review, we will concentrate on genome-wide approaches in mice, which have resulted in the identification of genes regulating anxiety. (biomedcentral.com)
Advances in genetic methods and the completed sequencing of the human and mouse genomes make it feasible to detect, genetically map and identify the genes underlying these complex disorders. (jax.org)
QTL and genes identified by QTL analysis in mouse models often correlate with homologous regions in the human genome. (jax.org)
Thus, connecting phenotype and genotype in mice may translate into identification of genes responsible for human complex diseases such as atherosclerosis, diabetes, obesity, asthma, autoimmunity and hypertension. (jax.org)

Copeland says the mouse fanciers bred coat color mutants such as ' dilute ,' ' brown ,' and ' nonagouti . (nih.gov)
The first paper we ever published together at JAX was a 1981 article in Nature that showed that dilute was caused by the integration of a retrovirus into the mouse genome that happened hundreds of years ago. (nih.gov)

METHODS: Arthritis was induced in DBA/1 mice by immunization with type II collagen. (ox.ac.uk)
METHODS: DBA/1 mice were immunized with bovine type II collagen in adjuvant, and treated daily after disease onset with recombinant murine IL-10 or with saline as a control. (ox.ac.uk)
Arthritis was induced in DBA/1 mice by immunization with type II collagen, and mice were treated intraperitoneally with a blocking anti-NKG2D antibody (CX5) on days 1, 5, and 8 after clinical onset and were monitored for 10 days. (ox.ac.uk)
Immunization of genetically susceptible strains of mice with heterologous type II collagen leads to the induction of a self-limiting polyarthritis that begins to subside around 10 days after onset of clinical disease. (ox.ac.uk)

A population of inflammatory-type dendritic cells was dramatically expanded in the lymph nodes of mice that rejected the tumor and correlated with CD4-dependent infiltration, in tumor bed, of tumor-specific CD8+ T lymphocytes. (ox.ac.uk)

Furthermore, JN403 shows anticonvulsant potential in the audiogenic seizure paradigm in DBA/2 mice. (nih.gov)
The genetics of sound induced seizure in inbred mice. (jax.org)

Synaptic transmission in hearing-impaired high-frequency areas of the AVCN was altered in old DBA mice. (nih.gov)
Moreover, synaptic release probability was about 30% higher in high-frequency regions of young DBA than that in old DBA mice. (nih.gov)
No similar age-related changes in synaptic release or EPSCs were found in age-matched, normal hearing young and old CBA mice. (nih.gov)

Mice with collagen-induced arthritis (CIA) were treated with HAMCs after disease onset, and clinical scores and joint levels of mediators of inflammation were evaluated. (unicatt.it)
Blockade of NKG2D ameliorates disease in mice with collagen-induced arthritis: a potential pathogenic role in chronic inflammatory arthritis. (ox.ac.uk)

The C57BL/6J (B6) and DBA/2J (D2) inbred strains of mice exhibit an age-related hearing loss (AHL) due to a recessive gene (Ahl) that maps to Chromosome 10. (cdc.gov)
The present study demonstrates segregation for the putative Ahl gene and mapping of such a gene to Chromosome 10, consistent with other independent mapping of Ahl for AHL in 10 strains of mice [Johnson et al. (cdc.gov)
The current data lend additional support for Taar1 as a quantitative trait gene on mouse chromosome 10 that impacts risk for MA intake. (nih.gov)
They include panels of recombinant inbred (RI) and chromosome substitution (CS) strains, also known as consomic strains. (jax.org)

The laboratory mouse has physiology and genetic characteristics very similar to humans providing powerful models for investigation of the genetic characteristics of disease. (wikipedia.org)
In this review, we discuss translational approaches that aim to bridge results from unbiased genome-wide screens using mouse models to anxiety disorders in humans. (biomedcentral.com)
These studies have led to the identification of completely novel biological pathways that regulate anxiety in mice and humans, and that can be further investigated as targets for therapy. (biomedcentral.com)

Genetic background influences the 5XFAD Alzheimer's disease mouse model brain proteome. (emory.edu)
Introducing genetic background diversity in AD mouse models has been proposed as a way to increase validity and enable discovery of previously uncharacterized genetic contributions to AD susceptibility or resilience. (emory.edu)
However, the extent to which genetic background influences the mouse brain proteome and its perturbation in AD mouse models is unknown. (emory.edu)
Here we crossed the 5XFAD AD mouse model on a C57BL/6J (B6) inbred background with the DBA/2J (D2) inbred background and analyzed the effects of genetic background variation on the brain proteome in F1 progeny. (emory.edu)
Due to their well-defined genetic background, CD2F1 mice are valuable tools in biomedical research and have been used as a model for studying diseases and conditions such as cancer and immunological disorders. (hylascobio.in)
Due to their well-characterized genetic background, these mice have proven to be valuable tools in biomedical research. (hylascobio.in)

Three mammalian species are reservoir competent: the white-footed mouse ( Peromyscus leucopus ), raccoon ( Procyon lotor ), and gray squirrel ( Sciurus carolinensis ), although serologic and molecular evidence has suggested that numerous other small, medium, and large mammals may also be reservoirs ( 1 , 3 ). (cdc.gov)
To gain inside into the molecular correlates of the homeostatic process and its interaction with the circadian process we apply a combination of forward, molecular, and reverse genetic approaches in the mouse. (unil.ch)
We could apply molecular biology to mouse genetics and the combination of the two would hopefully be better than each of the parts,' Copeland says. (nih.gov)
Using the referenced information, molecular geneticists can choose optimal parental strains of mice, and perhaps develop new embryonic stem cell progenitors, for new knockouts and transgenics to investigate gene function, and to serve as animal models in the development of novel therapeutics for human genetic diseases. (elsevierpure.com)
The present study uses the BXD Recombinant Inbred (RI) strains to identify novel quantitative trait loci (QTLs) modulating CCT in the mouse with the potential of identifying a molecular link between CCT and risk of developing POAG. (ox.ac.uk)

The laboratory mouse has been instrumental in investigating the genetics of human disease, including cancer, for over 110 years. (wikipedia.org)
Inbred strains of mice allow researchers to investigate the role that genetics plays in cancer susceptibility and treatment response. (wikipedia.org)
The mouse tumor biology database: a public resource for cancer genetics and pathology of the mouse" (PDF). (wikipedia.org)
The NIH Catalyst spoke with Copeland and Jenkins chief and senior investigator, respectively, of the NCI-Frederick Mouse Cancer Genetics Program shortly before they taught a short course on mouse genetics at the Jackson Laboratory in Bar Harbor, Maine, this past summer. (nih.gov)

In addition, we are now initiating two large scale projects to phenotype and map sleep traits in other mouse reference populations (i.e. (unil.ch)
Most studies have utilized the traditional C57BL/10 (C57) mdx mouse, which exhibits a mild disease phenotype. (ox.ac.uk)

Methods: We used data on oxidative and glutathione conjugation metabolism of TCE in 16 inbred and 1 hybrid mouse strains to calibrate and extend existing physiologically based pharmacokinetic (PBPK) models. (nih.gov)
Methods: Mice from both strains were exposed to an unbiased place- conditioning procedure using 1, 10, or 30 mg/kg cocaine. (elsevierpure.com)
METHODS: We performed cardiac gene expression, whole genome sequencing (WGS), and cardiac function analysis in 40 strains of BXD recombinant inbred mice derived from C57BL/6J (B6) and DBA/2J (D2) strains. (bvsalud.org)
METHODS: Levels of NKG2D and its ligands were determined by fluorescence-activated cell sorting, real-time polymerase chain reaction, and immunohistochemistry in rheumatoid arthritis (RA) synovial membrane tissue and in paw tissue from arthritic mice. (ox.ac.uk)

Inbred and hybrid mice in the NIA colony were derived from NIH pedigreed breeding stock in 1974 and for many years were maintained as closed inbred colonies. (nih.gov)
The B6xD2.F(1) hybrid mice (Ahl/Ahl) are more susceptible to NIHL than the CBxB6.F(1) mice (+/Ahl) [Erway et al. (cdc.gov)

The Mouse Models of Human Cancer database (MMHCdb) is a unique, comprehensive online knowledgebase of mouse models of human cancer hosted by The Jackson Laboratory with funding from the National Cancer Institute (NCI). (wikipedia.org)
Wjl/SzJ) mice developed at The Jackson Laboratory. (wikipedia.org)
The Jackson Laboratory Mouse Genome Informatics National Cancer Institute American Association for Cancer Research Mouse Models of Human Cancer database YouTube channel Naf, Dieter (Mar 2002). (wikipedia.org)
Because of limited numbers of breeding pairs from NIH, and recognizing that many investigators use mice from the Jackson Laboratory, the rederivation of NIA mice that occurred in 1989 used breeding stock from the Jackson Laboratory rather than from NIH. (nih.gov)
Therefore, the mouse genotypes listed above are currently available from either NIH progenitor origin or Jackson Laboratory progenitor origin. (nih.gov)
The last animals of NIH origin were entered into the NIA colony in March 1993, and when the supply of these mice is exhausted, only mice of Jackson Laboratory origin will be available. (nih.gov)
Data collected at The Jackson Laboratory provide a basis for comparing larger numbers of inbred strains and F 1 hybrids. (jax.org)
DBA/2 (D2/J) mice supplied by The Jackson Laboratory consumed significantly more MA and exhibited higher levels of methamphetamine preference in a two-bottle choice procedure, compared to DBA/2 mice from Charles River, Taconic or Harlan-Sprague Dawley. (nih.gov)

These mutations were incorporated into early inbred strains, such as 'DBA,' which had all three traits. (nih.gov)

2020. A mouse model for vitamin D-induced human cathelicidin antimicrobial peptide gene expression. . (oregonstate.edu)

Induction of anti-DNA antibodies in non autoimmune mice by immunization with a DNA-DNAase I complex. (musc.edu)

This finding contrasts with other studies showing greater sensitivity of DBA/2J mice to the rewarding effects of ethanol and morphine in the place conditioning task. (elsevierpure.com)

Differences in lifespan have been found between lines of mice selected for large and small body size, with large mice surviving longer in one experiment ( Chai, 1959 ), and selected small mice in another ( Roberts, 1961 ). (jax.org)
This material, previously unpublished, may be suitable for demonstrating: (1) range of lifespans characteristic of mice in single genetically homogeneous populations, (2) differences between inbred strains in means and range of lifespan, (3) effects of sex, breeding, environmental conditions, and hybrid vigor on lifespan. (jax.org)
In contrast, we used a multi-laboratory approach involving nine independent replicates (three in each of three laboratories) to study the effects of enriched versus barren housing on (i) variation in behavioural endpoints and (ii) reproducibility of behavioural differences between three strains of mice across these independent replicates. (forschung3r.ch)
Our findings show that 8- to 12-week-old C57 mdx mice did not display any differences in exploration time when challenged with a novel object recognition test. (ox.ac.uk)

Systemic autoimmunity in LG/J mice. (musc.edu)

Inbred mouse strains are the result of at least 20 generations of successive brother/sister matings which lead to a population with minimal segregating genetic variation. (wikipedia.org)
The second purpose of this chapter, particularly pertinent to mouse pathology, is to present a discussion of the aging patterns of mice and of variation between genetic groups of mice in the incidence of particular pathological conditions. (jax.org)
and 53% showed variation between inbred strains. (ox.ac.uk)
Taken together, our results show that Pttg1 contributes to gene regulatory variation between mouse strains and influences mouse midbrain transcriptome during aging. (lih.lu)
We profiled chromatin accessibility in liver from seven strains of mice with phenotypic diversity in response to a high-fat/high-sucrose (HF/HS) diet and identified reproducible chromatin variation across the individuals. (biomedcentral.com)
SNP variation data for RI strains and gene expression data for the ILSXISS RI set are also available at Mouse Phenome Database. (jax.org)

For example, transgenic mice on a mixed C57BL/6J and SJL background expressing human HRAS have a mammary gland carcinoma frequency of 45-50% whereas the same transgene expressed in FVB/N mice result in 100% of the animals having mammary gland carcinomas. (wikipedia.org)
Protein co-expression network analysis identified 16 modules of highly co-expressed proteins common across hippocampus and cortex in 5XFAD and non-transgenic mice. (emory.edu)
The full induction of human apoprotein A-I gene expression by the experimental nephrotic syndrome in transgenic mice depends on cis-acting elements in the proximal 256 base-pair promoter region and the trans-acting factor early growth response factor 1. (musc.edu)

However, one male in a line (NS) selected for low body weight survived 1330 days, which possibly is the longest recorded lifespan for the laboratory mouse ( Roberts, 1961 ). (jax.org)
In the present study, we performed a genome-wide scan to search for quantitative trait loci (QTLs) affecting hypertriglyceridemia in TH mice using male F2 mice from a cross of B6 × TH. (biomedcentral.com)

Specific substrains are used in a variety of areas of BIOMEDICAL RESEARCH such as DBA/1J, which is used as a model for RHEUMATOID ARTHRITIS . (nih.gov)
C3H/HeNCrl mice are a widely used animal model in biomedical research. (hylascobio.in)
CB6F1 mice have a diverse range of applications in biomedical research, making them a valuable tool in various fields. (hylascobio.in)

The F2 mice were genotyped genome-wide and used for quantitative trait locus (QTL) mapping. (biomedcentral.com)

To avoid charges, cancellations for timed mated rats, mice, guinea pigs, and hamsters must be received one week prior to mating date, however, cancelled orders for timed mated rabbits will be charged at full price regardless of the amount of notice supplied. (inotivco.com)

Role of the H-2 haplotype in Fas-intact lupus-prone MRL mice: association with autoantibodies but not renal disease. (musc.edu)

Sequencing analysis revealed polymorphisms of Apoa2 in TH mice, suggesting Apoa2 as the candidate gene for the hyperlipidemia QTL. (biomedcentral.com)

The white-footed mouse serves as a natural reservoir for AP-ha, and laboratory studies have shown that numerous inbred strains of mice (e.g. (cdc.gov)

Characterization of Alzheimer's disease-like neuropathology in Duchenne's muscular dystrophy using the DBA/2J mdx mouse model. (ox.ac.uk)
The TALLYHO/JngJ (TH) mice are a polygenic model for T2D characterized by obesity, hyperinsulinemia, impaired glucose uptake and tolerance, hyperlipidemia, and hyperglycemia. (biomedcentral.com)
In addition, these POU6F2 RGCs die early in the DBA/2J model of glaucoma than most RGCs. (ox.ac.uk)
Toxicity of DBP was revealed by a decrease in body and organ weight of mice while no apparent cell death was observed on P815 mastocytoma cells (allograft model) in vitro. (oregonstate.edu)

In contrast, AP-Variant 1 does not infect the white-footed mouse, DBA/2, and severely immunocompromised (SCID) mice ( 8 ). (cdc.gov)

Results: In general, C57BL/6J mice displayed a significant conditioned place preference that was relatively unaffected by cocaine dose or trial duration. (elsevierpure.com)

HAMCs also protected the mice from experimental sepsis, inflammatory bowel disease, and autoimmune encephalomyelitis. (unicatt.it)

In 1996 he joined Mehdi Tafti at the University of Geneva where he used QTL analysis to map sleep and EEG traits in mice. (unil.ch)
Choosing the best genetic strains of mice for developing a new knockout or transgenic mouse requires extensive knowledge of the endogenous traits of inbred strains. (elsevierpure.com)
The present overview summarizes the literature on a wide variety of behavioral traits for the 129, C57BL/6, DBA/2, and many other inbred strains of mice. (elsevierpure.com)

Finally, using mathematical modeling we are now quantifying the complex relationship between changes in clock gene expression in the forebrain and the sleep-wake distribution in a similar way as we previously have quantified the relationship between the sleep-wake distribution and the EEG correlates of sleep need in mice. (unil.ch)
All of the available evidence supports a role for the Ahl gene in both AHL and NIHL among these strains of mice. (cdc.gov)
The other gene(s) is not linked to the H-2 complex and high-responder allele(s) are found in the genome of B10 mice but not in the genome of DBA mice. (elsevierpure.com)
For the Chr 13 QTL in the mouse, only one gene in the region (Pou6f2) contained nonsynonymous SNPs. (ox.ac.uk)

Treatment of DBA/2 mice bearing P815 mastocytoma with cyclophosphamide induced rejection and long-term protection in a CD4- and CD8-dependent manner. (ox.ac.uk)

DBA/2NCrl mice were developed by C.C. Little in 1909 from stock mice with coat color segregation. (hylascobio.in)

In this chapter I will deal with relationships between lifespan and the incidence of pathological conditions and will discuss genetic and environmental influences on longevity of mice. (jax.org)

Rationale: In previous comparisons with C57BL/6J mice, DBA/2J mice have been characterized as 'hyporesponsive' to cocaine's rewarding effect in the conditioned place-preference paradigm. (elsevierpure.com)
In contrast, DBA/2J mice showed no place conditioning at the shortest trial duration, but an increasing level of preference as trial duration increased. (elsevierpure.com)
One possible interpretation of these findings is that short trial durations produce conditioned activity responses that interfere more with expression of conditioned place preference in DBA/2J mice than in C57BL/6J mice. (elsevierpure.com)

We used mice of two inbred strains (C57Bl/6J, DBA/2) and their F1-hybrids (B6D2F1). (forschung3r.ch)
The resulting mice are designated as B6D2F1/Crl. (hylascobio.in)

When miR-290, containing both miR-290-3p and miR-290-5p, was ectopically expressed in the metastatic breast cancer cell line Mvt-1 and orthotopically injected into FVB/N mice, a 70% reduction in mammary tumor burden and a complete suppression of lung metastasis was observed. (nih.gov)

Here we show for the first time that systemic exposure to DBP causes DNA damage in mouse lung tissue. (oregonstate.edu)

Systemic administration of JN403 restores sensory gating in DBA/2 mice, both in anaesthetized and awake animals. (nih.gov)
The majority of DNA adducts formed in lungs of mice after systemic exposure to DBP were contributed by (-)-anti-DBPDE. (oregonstate.edu)
Short term administration of costimulatory blockade and cyclophosphamide induces remission of systemic lupus erythematosus nephritis in NZB/W F1 mice by a mechanism downstream of renal immune complex deposition. (musc.edu)

In order to determine the genetic factors that contribute to these T2D related characteristics in TH mice, we interbred TH mice with C57BL/6J (B6) mice. (biomedcentral.com)
The advantage of mouse models is that the environmental factors can be controlled for, or specifically administered. (biomedcentral.com)

MMHCdb is part of the Mouse Genome Informatics consortium (MGI) and was first released in 1998 as the Mouse Tumor Biology (MTB) database. (wikipedia.org)

We determined Th1/Th17-mediated autoreactive responses in the mice by measuring the proliferation and the cytokine profile of lymph node cells restimulated with collagen. (unicatt.it)
To this aim, we evaluated whether Chronic Unpredictable Stress (CUS) differently affected coping and mesoaccumbens dopamine (DA) responses to stress challenge by adult mice of the C57BL/6J (B6) and DBA/2J (D2) inbred strains depending on early life experience (Repeated Cross Fostering, RCF). (uniroma1.it)

The present studies describe: (1) the development of a poorly regenerative macrocytic anemia in mice exposed to AZT or ddC. (nih.gov)

Natural resistance to infection with mouse cytomegalovirus (MCMV) is controlled by a dominant locus, Cmv1 . (silverchair.com)

Anatomy1

Organisms5

Diseases5

Chemicals and Drugs2

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes1

Health Care1

Recombinant inbred strains1

Strain20

Different inbred strains2

BALB5

Strains of inbred1

Genetically diverse4

Spontaneous4

Female mice2

Genomic6

Joints3

Phenotypes4

Genes10

Dilute2

Type II colla4

Lymph nodes1

Seizure2

Synaptic3

Collagen-induced arthritis2

Chromosome4

Humans3

Genetic Background6

Molecular5

Genetics4

Phenotype2

Methods4

Hybrid mice2

Jackson Laboratory8

Mutations1

20201

Immunization1

Effects of ethanol1

Differences4

Autoimmunity1

Variation6

Transgenic mice3

Male2

BIOMEDICAL RESEARCH3

Quantitative1

Hamsters1

Haplotype1

Polymorphisms1

Laboratory1

Model4

Scid1

Cocaine1

Experimental1

Traits3

Gene4

P8151

19091

Influences1

Preference3

B6D2F12

Mammary1

Lung1

Systemic3

Factors2

Tumor biology1

Responses2

Poorly1

Locus1