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Synovial MembraneSynovitisArthritis, RheumatoidSynovial FluidOsteoarthritisRheumatoid NoduleTemporomandibular JointMembranesKnee JointMembrane LipidsCell MembraneArthritisIntracellular MembranesMembrane PotentialsArthritis-Encephalitis Virus, CaprineMembranes, ArtificialArthritis, ReactiveGold Sodium ThiomalateCartilage, ArticularArthroscopyErythrocyte MembraneMembrane FluidityChondromatosis, SynovialArthritis, ExperimentalInjections, Intra-ArticularJointsImmunoenzyme TechniquesJoint CapsuleMicroscopy, ElectronCell Membrane PermeabilityLentivirus InfectionsWrist JointArthritis, InfectiousBasement MembraneCells, CulturedGoatsFibroblastsImmunohistochemistrySpondylitis, AnkylosingMacrophagesTemporomandibular Joint Dysfunction SyndromeArthritis, PsoriaticOsteoarthritis, KneeMatrix Metalloproteinase 13Antibodies, MonoclonalRNA, MessengerVisna-maedi virusMembrane Transport ProteinsFluorescent Antibody TechniqueInterleukin 1 Receptor Antagonist ProteinT-LymphocytesCollagenasesRabbitsMembrane GlycoproteinsGadolinium DTPAInterleukin-1SialoglycoproteinsLipid BilayersCartilageAntigens, Differentiation, MyelomonocyticTumor Necrosis Factor-alphaMitochondrial MembranesJoint DiseasesMatrix Metalloproteinase 1Protein TransportCytokinesSynaptic MembranesTime FactorsAntirheumatic AgentsReverse Transcriptase Polymerase Chain ReactionCulture TechniquesAntigens, CDBase SequenceCell LineLiposomesChondrocytesGene ExpressionMagnetic Resonance ImagingProtein BindingCalciumModels, BiologicalHLA-DR AntigensCell FractionationImage Processing, Computer-AssistedCollagenB-LymphocytesProtein Structure, TertiaryCarrier ProteinsExtraembryonic MembranesLymphocytesHydrogen-Ion ConcentrationDetergentsEscherichia coliIn Situ HybridizationElectrophoresis, Polyacrylamide GelEndoplasmic ReticulumClone CellsInterleukin-6PhosphatidylcholinesGolgi Apparatus
CartilageFibroblastsTissueMacrophagesFluidOsteoarthritisRheumatoid arthritis patientsInflammatoryJointsMucous membranesEffusionHypertrophyChondrocytesTendonMacrophageSynovitisPatientsBiopsyKnee jointEvaluateErosionThicknessJointInflammationSpinal cordRetrospective studyTherapyTemperatureCellProgressionExpressionInjectionBloodRatsAnalysisPrimarilyMultipleSurgical
Cartilage9
Fibroblasts5
Tissue16
  • To address this, we developed a 3D-printed, low-cost droplet microfluidic control instrument and deploy it in a clinical environment to perform single-cell transcriptome profiling of disaggregated synovial tissue from five rheumatoid arthritis patients. (nih.gov)
  • Objectives (1) To compare spontaneous and stimuli-induced adipocytokine secretion by articular adipose tissue (AAT) and synovial membrane (SM) explants obtained from patients with rheumatoid arthritis (RA). (bmj.com)
  • 1 In RA, numerous cytokines play a fundamental role in inflammation and joint destruction and are thought to originate primarily from synoviocytes and leucocytes that massively infiltrate synovial tissue. (bmj.com)
  • A dramatic increase in rheumatoid factor (RF) blood levels, as well as considerable synovial tissue damage and inflammatory cell infiltration of the synovial membrane, were used to validate the onset of RA following COII immunization. (intjmorphol.com)
  • Methods: Multiple clinical sites collected cryopreserved synovial tissue fragments from arthroplasty and synovial biopsy in a 10% DMSO solution. (biu.ac.il)
  • Results: Upon dissociation, cryopreserved synovial tissue fragments yielded a high frequency of viable cells, comparable to samples undergoing immediate processing. (biu.ac.il)
  • Optimization of synovial tissue dissociation across six clinical collection sites with ~ 30 arthroplasty and ~ 20 biopsy samples yielded a consensus digestion protocol using 100 μg/ml of Liberase™ TL enzyme preparation. (biu.ac.il)
  • Conclusions: We have established a robust protocol to acquire viable cells from cryopreserved synovial tissue with intact transcriptomes and cell surface phenotypes. (biu.ac.il)
  • A centralized pipeline to generate multiple high-dimensional analyses of synovial tissue samples collected across a collaborative network was developed. (biu.ac.il)
  • Rheumatoid arthritis (RA) is a systemic chronic disease with synovial membrane, tendon and articular tissue inflammation. (sanabel.ir)
  • Both diseases are characterized by the extravasation of leukocytes from the vascular endothelium into the synovial tissue, a process that involves numerous chemokines and their receptors acting as synovial chemotactic mediators (5). (researchsquare.com)
  • Nonoperative treatments directed at management of inflammation and future trials targeting the synovial tissue for treating KOA should consider these 2 factors as potential inclusion criteria. (ox.ac.uk)
  • The injected radiopharmaceuticals are phagocytized by the superficial macrophages of the synovial membrane, resulting in sclerosis and fibrosis of the formerly inflamed tissue, finally leading to reduced joint effusion and alleviation of joint pain. (ognmb.at)
  • The present study revealed that obese OA patients and Apoe −/− mice showed a more pronounced synovitis and enhanced macrophage infiltration in synovial tissue, accompanied by dominant M1 macrophage polarization. (elifesciences.org)
  • Synovial membrane - Another tissue that lines the joint. (druggenius.com)
  • Other procedures can be executed aiming to increase the bone volume, such as osteogenic distraction (surgical induction of the bone fracture and splitting into two fragments so that a new bone is formed between them), osteoinduction with growth factors and/or stem cells, osteoconduction by the use of substrates for cellular development (scaffolds) and guided tissue regeneration (GTR) with the aid of membranes 18 . (bvsalud.org)
Macrophages5
  • METHODS: Macrophages were isolated from the pseudocapsule and pseudomembrane of loose cemented and uncemented hip arthroplasties at the time of revision surgery and then co-cultured on glass coverslips and dentine slices with UMR 106 rat osteoblast-like cells, both in the presence and absence of 1,25 dihydroxyvitamin D3 [1,25(OH)2D3]. (ox.ac.uk)
  • Macrophages isolated from the synovial membrane of patients with osteoarthritis (OA) undergoing hip replacements were similarly studied as a control group. (ox.ac.uk)
  • The present study found that synovial macrophages infiltrated and polarized in the obesity microenvironment and identified the essential role of M1 macrophages in impaired macrophage efferocytosis using pathology analysis of obesity-associated OA. (elifesciences.org)
  • Enhanced M1-polarized macrophages in obese synovium decreased growth arrest-specific 6 (GAS6) secretion, resulting in impaired macrophage efferocytosis in synovial ACs. (elifesciences.org)
  • Intra-articular injection of GAS6 restored the phagocytic capacity of macrophages, decreased synovial cell apoptosis, and prevented OA progression in obese-OA mice. (elifesciences.org)
Fluid5
  • Nearly all diarthroidal joints were enlarged and contained yellow-gray turbid synovial fluid and large yellow fibrin clots. (cdc.gov)
  • Chemokines are abundant in RA synovial fluid, while OA synovial fluid also reveals the presence of chondrocytes, synovial cells and other cells capable of both expressing and responding to chemokines (2-4). (researchsquare.com)
  • OBJECTIVE: In rheumatoid arthritis (RA) synovial fluid, levels of the endocannabinoids anandamide (AEA) and 2-arachidonylglycerol are elevated. (uni-regensburg.de)
  • It secretes a clear, sticky fluid called the synovial fluid, which surrounds the joint to provide lubrication. (druggenius.com)
  • The decision to recommend HIV postexposure prophylaxis must take into account the nature of the exposure (e.g., needlestick or potentially infectious fluid that comes in contact with a mucous membrane) and the amount of blood or body fluid involved in the exposure. (cdc.gov)
Osteoarthritis3
  • METHODS: Patients with symptomatic KOA were enrolled into the randomized, double-blind, Vitamin D Evaluation in Osteoarthritis (VIDEO) trial. (ox.ac.uk)
  • SUMMARY: Refixation of the damaged acetabular labrum is a method of surgical treatment of the hip joint that can promote the repair of joint function after injury and prevent premature osteoarthritis. (bvsalud.org)
  • METHODS@#Thirty SD rats were randomly divided into osteoarthritis model group, electro-acupuncture group and control group (n=10), and in the former two groups, early osteoarthritis was induced using a modified DMM surgical modeling method. (bvsalud.org)
Rheumatoid arthritis patients1
Inflammatory2
  • 4 Magnetic resonance imaging (MRI) has been shown to be a more sensitive method than radiography to demonstrate inflammatory and destructive changes in the knee and wrist joints of patients with RA. (bmj.com)
  • Rheumatoid arthritis is an inflammatory synovial disease thought to involve T cells reacting to an antigen within the joint. (bronsonvitamins.com)
Joints3
  • OBJECTIVES To evaluate synovial membrane hypertrophy, tenosynovitis, and erosion development of the 2nd to 5th metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joints by magnetic resonance imaging in a group of patients with rheumatoid arthritis (RA) or suspected RA followed up for one year. (bmj.com)
  • 13-15 Cross sectional studies of the finger joints in RA have been undertaken which applied qualitative methods, 16-19 and, recently, quantitative methods have also been used. (bmj.com)
  • This complex anatomical region is rich in membranes and synovial joints [ 1 ]. (biomedcentral.com)
Mucous membranes1
  • It can infect both animals and humans through direct contact with non-intact skin (such as cuts or wounds) or mucous membranes, inhalation, or ingestion. (cdc.gov)
Effusion3
  • There was a significant increase in lameness, response to joint flexion, and synovial effusion attributable to osteochondral fragmentation, specifically at times denoted by an asterisk. (avma.org)
  • ultrasound criteria included effusion, synovial hypertrophy and increased vascularity in power Doppler, visible in the anterior longitudinal projection parallel to the femoral neck ( Fig. 1 ). (termedia.pl)
  • In this cross-sectional substudy, associations between validated MRI-based semiquantitative synovial scores of the knee and the following markers of inflammation were investigated: self-reported pain and stiffness, effusion, warmth, joint line tenderness, erythrocyte sedimentation rate, radiographic severity, and functional ability tests. (ox.ac.uk)
Hypertrophy2
  • The following MRI variables were assessed at baseline and one year: synovial membrane hypertrophy score, number of erosions, and tenosynovitis score. (bmj.com)
  • MR synovial membrane hypertrophy and scintigraphy scores did not parallel the changes seen over time in clinically assessed swollen and tender joint counts. (bmj.com)
Chondrocytes1
Tendon1
  • In natural disease in cattle, endothelial hyperplasia and perivascular neutrophil infiltrates in venules and capillaries in synovial membranes, tendon sheaths, muscles fascia and skin (2). (cdc.gov)
Macrophage3
  • In contrast, OA synovial macrophage/UMR 106 co-cultures showed little or no evidence of macrophage-osteoclast differentiation and this was only seen when human M-CSF was added to the co-cultures. (ox.ac.uk)
  • In this study, the authors demonstrated that patients with obese-OA and mice with ApoE deficiency showed phenotypes of synovitis and enhanced macrophage infiltration in synovial tissues. (elifesciences.org)
  • GAS6 secretion is decreased during M1 macrophage polarization during obese-OA, leading to impaired macrophage efferocytosis in synovial apoptotic cells. (elifesciences.org)
Synovitis1
Patients4
  • Methods Tissues were obtained from patients undergoing joint replacement surgery. (bmj.com)
  • PATIENTS AND METHODS Fifty five patients were examined at baseline, of whom 34 were followed up for one year. (bmj.com)
  • To determine methotrexate (MTX) concentrations in the synovial membrane (SM) and cortical and trabecular bone of rheumatoid arthritis (RA) patients. (urosario.edu.co)
  • He provides knee arthritis treatment, knee replacements, and other surgical and nonsurgical methods to heal patients with orthopedic knee issues. (g2orthopedics.com)
Biopsy1
  • Ultrasonography-guided synovial biopsy of the second metacarpophalangeal joint of the right hand in a patient with rheumatoid arthritis of the hands. (medscape.com)
Knee joint1
  • The link between the nitrosative stress enzyme inducible nitric oxide synthase (iNOS) and the cytokine interleukin-1 (IL-1β) in RA-induced knee joint synovial membrane damage with and without the incorporation of the GSK3β inhibitor TDZD-8 has never been studied. (intjmorphol.com)
Evaluate3
  • The inverse-variance weighted (IVW) was applied as the primary analysis method, with four sensitivity analysis approaches employed to evaluate the robustness of the primary results. (frontiersin.org)
  • Future animal studies should evaluate the improved fixation method and compare implant performance to current treatment standards, such as allografts. (ru.nl)
  • To evaluate the tensile strength of PLGA membranes at different conditions of humidity and temperature. (bvsalud.org)
Erosion1
  • treatment with ASU reduced the combined erosion and synovial hemorrhage score, had no influence on full-thickness erosion score, and slightly decreased (albeit not significantly) the total erosion score. (avma.org)
Thickness1
Joint3
  • Although joint disease activity may be assessed as quiescent by conventional clinical methods, a more detailed evaluation by MRI may show that a pathological condition is still present within the synovium. (bmj.com)
  • Radiosynovectomy (RSV) is a minimally invasive method of treating and controlling joint inflammation refractory to conventional pharmacotherapy. (termedia.pl)
  • RA is characterized by a typical pattern and distribution of synovial joint involvement. (medscape.com)
Inflammation1
  • This study examined the relationship between clinical and functional markers of localized knee inflammation and CE MRI-based synovial scores. (ox.ac.uk)
Spinal cord1
Retrospective study1
  • This is a retrospective study - case series method. (hpathy.com)
Therapy1
  • Medication Therapy: this method is including both consuming and injection types of medication. (vejthani.com)
Temperature1
  • PLGA membranes were hourglass-shape cut and prepared at three different conditions of temperature and humidity (n = 10): (I) dry membrane at environment temperature of about 20ºC (control group), (II) moist membrane plasticized at 55ºC, (III) moist membrane plasticized at 55ºC, which subsequently underwent cooling. (bvsalud.org)
Cell2
Progression1
  • Progression free survival (PFS) and overall survival (OS) were analyzed from time of first LR using Kaplan-Meier method. (stanfordchildrens.org)
Expression1
  • However, an autocrine stimulation of MMP-3 expression by SF via TGF-β and LN1 seems rather unlikely, as LN1 is not expressed in high amounts in the adult synovial membrane. (biomedcentral.com)
Injection1
  • It consist in intraarticular injection of radioactive colloids which irradiate the inflamed synovial membrane to cause its subsequent involution. (termedia.pl)
Blood2
Rats2
  • As a result, we used active immunization method with collagen type II (COII) for twenty one days to induce RA in rats. (intjmorphol.com)
  • METHODS → 54 rats were used in the experiments, of which 21 were used as control and 23 were subjected to adjuvant-induced monoarthritis. (candidtails.com)
Analysis1
  • Though it is fundamentally evolved from Boenninghausen's philosophy and method, it has its own characteristic as individual approach in case analysis and repertorization. (hpathy.com)
Primarily1
  • While these methods are often successful, they primarily manage symptoms rather than address the underlying degeneration. (stemaidinstitute.com)
Multiple1
  • Oral tolerization, a method of inducing antigen-specific tolerance, suppresses animal models of the autoimmune diseases multiple sclerosis, uveitis, and diabetes (6-11). (bronsonvitamins.com)
Surgical1
  • The membranes should be hard enough to maintain the space and support the tissues of the surgical area. (bvsalud.org)